2022
Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in Caenorhabditiselegans
Kyani-Rogers T, Philbrook A, McLachlan I, Flavell S, O’Donnell M, Sengupta P. Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in Caenorhabditiselegans. Genetics 2022, 222: iyac143. PMID: 36094348, PMCID: PMC9630977, DOI: 10.1093/genetics/iyac143.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDiacetylGene Expression Regulation, DevelopmentalLarvaOlfactory Receptor NeuronsSmellConceptsChemoreceptor genesDAF-16 FOXO transcription factorODR-10FOXO transcription factorsDistinct gene expression profilesGene expression profilesDauer arrestChemoreceptor expressionDauer stageAWA neuronsDauer larvaeC. elegansTranscription factorsTranscriptional profilingBehavioral plasticityPosttranscriptional mechanismsTranscriptional upregulationAdult physiologyExpression patternsExpression profilesSorted populationsBehavioral preferencesVolatile odorantsCaenorhabditiselegansReceptor regulation
2018
Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans
O’Donnell M, Chao P, Kammenga J, Sengupta P. Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans. PLOS Genetics 2018, 14: e1007213. PMID: 29415022, PMCID: PMC5819832, DOI: 10.1371/journal.pgen.1007213.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsAnimals, Genetically ModifiedBrainCaenorhabditis elegansCaenorhabditis elegans ProteinsGene Expression Regulation, DevelopmentalIntestinal MucosaIntestinesMechanistic Target of Rapamycin Complex 2Neuronal PlasticityPhenotypeRapamycin-Insensitive Companion of mTOR ProteinSensory Receptor CellsSignal TransductionTemperatureConceptsQuantitative trait lociDauer larval stageTarget of rapamycinNematode C. elegansExternal cuesInsulin-like peptidesNeuronal functionDAF-7Phenotypic plasticityDaf-28Developmental decisionsC. elegansTrait lociCellular stressorsBacterial foodGenetic variationForaging behaviorRictor/Reproductive growthLarval developmentEnvironmental cuesNeuroendocrine gene expressionGene expressionLarval stagesFood signals
2015
Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling
Neal S, Takeishi A, O'Donnell M, Park J, Hong M, Butcher R, Kim K, Sengupta P. Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling. ELife 2015, 4: e10110. PMID: 26335407, PMCID: PMC4558564, DOI: 10.7554/elife.10110.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCalcium-Calmodulin-Dependent Protein Kinase Type 1Gene Expression Regulation, DevelopmentalInsulinsReceptor, InsulinSensory Receptor CellsSignal TransductionTransforming Growth Factor betaConceptsNeuroendocrine signalingDevelopmental plasticityInsulin-like peptide genesDynamic subcellular localizationDauer decisionDauer formationILP genesDauer stageDevelopmental decisionsSubcellular localizationNutrient availabilityState-dependent regulationPeptide genesReproductive cycleUnknown mechanismCaMKICMK-1SignalingGenesSensory neuronsPlasticityExpressionAWCCaenorhabditisSmall neuronal networks
2006
Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development
Wu J, O'Donnell M, Gitler A, Klein P. Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development. Development 2006, 133: 3651-3660. PMID: 16914488, DOI: 10.1242/dev.02547.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCell ProliferationCell SurvivalEyeGene Expression Regulation, DevelopmentalImmunoblottingImmunoprecipitationIn Situ HybridizationIn Situ Nick-End LabelingInsulin-Like Growth Factor INerve Tissue ProteinsPhenotypeProtein BindingProto-Oncogene Proteins c-aktReceptor, IGF Type 1Reverse Transcriptase Polymerase Chain ReactionSignal TransductionXenopusXenopus ProteinsConceptsXenopus eye developmentEye developmentPDZ domain-containing proteinsHigh amino acid similarityActive PI3-kinaseAmino acid similarityIGF1 receptorFunction phenotypesMembrane proteinsPI3-kinaseEctodermal explantsEmbryonic developmentXenopus embryosDistinct functionsEye formationNeural crestNovel componentEndogenous functionsGIPCAkt activationVivo lossPhysiological significanceIGF pathwayProteinFunction analysis