2024
Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons
Philbrook A, O’Donnell M, Grunenkovaite L, Sengupta P. Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons. PLOS Biology 2024, 22: e3002892. PMID: 39591402, PMCID: PMC11593760, DOI: 10.1371/journal.pbio.3002892.Peer-Reviewed Original ResearchConceptsIntraflagellar transportOrganization of signaling moleculesASH nociceptive neuronsAWA olfactory neuronsCiliary traffickingNociceptive neuronsCilia baseOlfactory neuronsCaenorhabditis elegansOdor responsesSignaling proteinsCilia organizationSensory neuronsCilium structurePrimary ciliaCilia structureSignaling moleculesAcute inhibitionSegregation of receptorsRegulation of responsesChemosensory neuronsNeuron typesCilium lengthNeuronal responsesEctopic branching
2022
Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in Caenorhabditiselegans
Kyani-Rogers T, Philbrook A, McLachlan I, Flavell S, O’Donnell M, Sengupta P. Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in Caenorhabditiselegans. Genetics 2022, 222: iyac143. PMID: 36094348, PMCID: PMC9630977, DOI: 10.1093/genetics/iyac143.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDiacetylGene Expression Regulation, DevelopmentalLarvaOlfactory Receptor NeuronsSmellConceptsChemoreceptor genesDAF-16 FOXO transcription factorODR-10FOXO transcription factorsDistinct gene expression profilesGene expression profilesDauer arrestChemoreceptor expressionDauer stageAWA neuronsDauer larvaeC. elegansTranscription factorsTranscriptional profilingBehavioral plasticityPosttranscriptional mechanismsTranscriptional upregulationAdult physiologyExpression patternsExpression profilesSorted populationsBehavioral preferencesVolatile odorantsCaenorhabditiselegansReceptor regulationContext-dependent reversal of odorant preference is driven by inversion of the response in a single sensory neuron type
Khan M, Hartmann A, O’Donnell M, Piccione M, Pandey A, Chao P, Dwyer N, Bargmann C, Sengupta P. Context-dependent reversal of odorant preference is driven by inversion of the response in a single sensory neuron type. PLOS Biology 2022, 20: e3001677. PMID: 35696430, PMCID: PMC9232122, DOI: 10.1371/journal.pbio.3001677.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholsAnimalsCaenorhabditis elegansOdorantsOlfactory Receptor NeuronsReceptors, OdorantSensory Receptor CellsSmellConceptsSensory neuron types