2006
Functional analysis of Sox8 during neural crest development in Xenopus
O'Donnell M, Hong C, Huang X, Delnicki R, Saint-Jeannet J. Functional analysis of Sox8 during neural crest development in Xenopus. Development 2006, 133: 3817-3826. PMID: 16943273, DOI: 10.1242/dev.02558.Peer-Reviewed Original ResearchConceptsNeural crest developmentNeural crest progenitorsNeural plate borderCrest developmentNeural crest cellsCrest cellsSOX8 expressionExpression domainsPlate borderCranial crest cellsTrunk neural crest cellsMorpholino-mediated knockdownNeural crest specificationNeural crest formationMid-gastrula stageSpecies-specific differencesSox proteinsProgenitor specificationSoxE proteinsCrest formationTranscription factorsChick orthologPharyngeal archesMultiple lineagesNeural plateKermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development
Wu J, O'Donnell M, Gitler A, Klein P. Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development. Development 2006, 133: 3651-3660. PMID: 16914488, DOI: 10.1242/dev.02547.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCell ProliferationCell SurvivalEyeGene Expression Regulation, DevelopmentalImmunoblottingImmunoprecipitationIn Situ HybridizationIn Situ Nick-End LabelingInsulin-Like Growth Factor INerve Tissue ProteinsPhenotypeProtein BindingProto-Oncogene Proteins c-aktReceptor, IGF Type 1Reverse Transcriptase Polymerase Chain ReactionSignal TransductionXenopusXenopus ProteinsConceptsXenopus eye developmentEye developmentPDZ domain-containing proteinsHigh amino acid similarityActive PI3-kinaseAmino acid similarityIGF1 receptorFunction phenotypesMembrane proteinsPI3-kinaseEctodermal explantsEmbryonic developmentXenopus embryosDistinct functionsEye formationNeural crestNovel componentEndogenous functionsGIPCAkt activationVivo lossPhysiological significanceIGF pathwayProteinFunction analysis
2005
The doublesex-related gene, XDmrt4, is required for neurogenesis in the olfactory system
Huang X, Hong C, O'Donnell M, Saint-Jeannet J. The doublesex-related gene, XDmrt4, is required for neurogenesis in the olfactory system. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 11349-11354. PMID: 16061812, PMCID: PMC1183594, DOI: 10.1073/pnas.0505106102.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBasic Helix-Loop-Helix Transcription FactorsCloning, MolecularDNA PrimersGene Expression RegulationIn Situ HybridizationMolecular Sequence DataMorphogenesisNerve Tissue ProteinsOlfactory PathwaysOligonucleotide ProbesReverse Transcriptase Polymerase Chain ReactionSequence Analysis, DNATranscription FactorsXenopusXenopus ProteinsConceptsDmrt genesTranscription factorsHelix transcription factorAnterior neural ridgeNeural cell adhesion molecule expressionAnterior neural plateCell adhesion molecule expressionAdhesion molecule expressionInhibitory mutantAnimal explantsMorpholino oligonucleotideDevelopmental processesNeural inducersNeural plateExpression patternsFunctional analysisNeural ridgePlacodal markersSimilar phenotypeNeuronal differentiationMolecule expressionImportant regulatorSpecific disruptionOlfactory epitheliumLarge family