2018
Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans
O’Donnell M, Chao P, Kammenga J, Sengupta P. Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans. PLOS Genetics 2018, 14: e1007213. PMID: 29415022, PMCID: PMC5819832, DOI: 10.1371/journal.pgen.1007213.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsAnimals, Genetically ModifiedBrainCaenorhabditis elegansCaenorhabditis elegans ProteinsGene Expression Regulation, DevelopmentalIntestinal MucosaIntestinesMechanistic Target of Rapamycin Complex 2Neuronal PlasticityPhenotypeRapamycin-Insensitive Companion of mTOR ProteinSensory Receptor CellsSignal TransductionTemperatureConceptsQuantitative trait lociDauer larval stageTarget of rapamycinNematode C. elegansExternal cuesInsulin-like peptidesNeuronal functionDAF-7Phenotypic plasticityDaf-28Developmental decisionsC. elegansTrait lociCellular stressorsBacterial foodGenetic variationForaging behaviorRictor/Reproductive growthLarval developmentEnvironmental cuesNeuroendocrine gene expressionGene expressionLarval stagesFood signals
2015
Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling
Neal S, Takeishi A, O'Donnell M, Park J, Hong M, Butcher R, Kim K, Sengupta P. Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling. ELife 2015, 4: e10110. PMID: 26335407, PMCID: PMC4558564, DOI: 10.7554/elife.10110.Peer-Reviewed Original ResearchConceptsNeuroendocrine signalingDevelopmental plasticityInsulin-like peptide genesDynamic subcellular localizationDauer decisionDauer formationILP genesDauer stageDevelopmental decisionsSubcellular localizationNutrient availabilityState-dependent regulationPeptide genesReproductive cycleUnknown mechanismCaMKICMK-1SignalingGenesSensory neuronsPlasticityExpressionAWCCaenorhabditisSmall neuronal networks