2024
Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons
Philbrook A, O’Donnell M, Grunenkovaite L, Sengupta P. Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons. PLOS Biology 2024, 22: e3002892. PMID: 39591402, PMCID: PMC11593760, DOI: 10.1371/journal.pbio.3002892.Peer-Reviewed Original ResearchConceptsIntraflagellar transportOrganization of signaling moleculesASH nociceptive neuronsAWA olfactory neuronsCiliary traffickingNociceptive neuronsCilia baseOlfactory neuronsCaenorhabditis elegansOdor responsesSignaling proteinsCilia organizationSensory neuronsCilium structurePrimary ciliaCilia structureSignaling moleculesAcute inhibitionSegregation of receptorsRegulation of responsesChemosensory neuronsNeuron typesCilium lengthNeuronal responsesEctopic branching
2020
A neurotransmitter produced by gut bacteria modulates host sensory behaviour
O’Donnell M, Fox B, Chao P, Schroeder F, Sengupta P. A neurotransmitter produced by gut bacteria modulates host sensory behaviour. Nature 2020, 583: 415-420. PMID: 32555456, PMCID: PMC7853625, DOI: 10.1038/s41586-020-2395-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvoidance LearningCaenorhabditis elegansCaenorhabditis elegans ProteinsFeeding BehaviorGastrointestinal MicrobiomeIntestinesMetabolomicsMutationNeurotransmitter AgentsOctanolsOctopamineProvidenciaReceptors, Biogenic AmineReceptors, G-Protein-CoupledSensory Receptor CellsSmellTyramineTyrosine DecarboxylaseConceptsTyramine biosynthesisFood choice assaysASH nociceptive neuronsDiverse organismsCaenorhabditis elegansMutualistic relationshipComplex communitiesChoice assaysMechanistic basisHost behaviourOlfactory responsesPhysiological relevanceOctopamine receptorsGut bacteriaElegansBioactive neurotransmittersBacteriaBiosynthesisHost controlGenesNervous system activitySensory behaviorsOctopamineNociceptive neuronsProvidencia