Jaime González-Hernández
he/him/his
Graduate School StudentAbout
Research
Publications
2026
A drug–microbiome–drug interaction impacts co-prescribed medications for Parkinson’s disease
Verdegaal A, Oh J, Javdan B, Wang R, Wu Q, Wang T, González-Hernández J, Donia M, Crawford J, Goodman A. A drug–microbiome–drug interaction impacts co-prescribed medications for Parkinson’s disease. Nature Microbiology 2026, 11: 1387-1409. PMID: 41942777, PMCID: PMC13171619, DOI: 10.1038/s41564-026-02299-2.Peer-Reviewed Original ResearchConceptsgut microbiomeantibiotic activityiron starvation responseantibiotic propertiesdrug-drug interactionsstarvation responseCOMT-Imicrobiome compositionindividual-specific mannermicrobial featuressimultaneous prescriptionsensitive bacteriaL-DOPAex vivocatechol-O-methyltransferase inhibitordrug responsemicrobiomeiron availabilityco-prescribed medicationsdisease symptomsintracellular ironprescription of multiple drugsco-prescribed drugsdrugs in vitroextracellular iron
2024
A host–microbiota interactome reveals extensive transkingdom connectivity
Sonnert N, Rosen C, Ghazi A, Franzosa E, Duncan-Lowey B, González-Hernández J, Huck J, Yang Y, Dai Y, Rice T, Nguyen M, Song D, Cao Y, Martin A, Bielecka A, Fischer S, Guan C, Oh J, Huttenhower C, Ring A, Palm N. A host–microbiota interactome reveals extensive transkingdom connectivity. Nature 2024, 628: 171-179. PMID: 38509360, DOI: 10.1038/s41586-024-07162-0.Peer-Reviewed Original Researchniche colonizationhost–microorganism interactionshost-microbiota interactionsinvade host tissuesstrain-specific interactionshost cells in vitroconspecific strainseffect of indigenous microorganismshost biologyhost proteinssecreted proteinscommensal microorganismsexoproteinsbacterial strainsdiverse phylogenymolecular basismyriad microorganismstissue of origintissue isolationcells in vitrointeractomebinding patternshost tissuesbiological logichost immune system in vivo
2023
Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions
Chen H, Rosen C, González-Hernández J, Song D, Potempa J, Ring A, Palm N. Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions. Cell 2023, 186: 3095-3110.e19. PMID: 37321219, PMCID: PMC10330796, DOI: 10.1016/j.cell.2023.05.024.Peer-Reviewed Original Research
2022
Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites
Cao Y, Oh J, Xue M, Huh WJ, Wang J, Gonzalez-Hernandez JA, Rice TA, Martin AL, Song D, Crawford JM, Herzon SB, Palm NW. Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites. Science 2022, 378: eabm3233-eabm3233. PMID: 36302024, PMCID: PMC9993714, DOI: 10.1126/science.abm3233.Peer-Reviewed Original ResearchConceptscolorectal cancerinflammatory bowel disease patientsbowel disease patientsinflammatory bowel diseaseindigenous gut microbesbowel diseasedisease patientscommensal microbiotaDNA damagecolon tumorigenesiselicit DNA damagegut microbesgenotoxic metabolitesgut commensalsMorganella morganiipatientsgenotoxic chemicalsdiseasemicrobiotametabolitesgenotoxicitycancermicefull spectrumdamageHigh-throughput identification of autoantibodies that target the human exoproteome
Wang EY, Dai Y, Rosen CE, Schmitt MM, Dong MX, Ferré EMN, Liu F, Yang Y, González-Hernández JA, Meffre E, Hinchcliff M, Koumpouras F, Lionakis MS, Ring AM. High-throughput identification of autoantibodies that target the human exoproteome. Cell Reports Methods 2022, 2: 100172. PMID: 35360706, PMCID: PMC8967185, DOI: 10.1016/j.crmeth.2022.100172.Peer-Reviewed Original ResearchConceptssystemic lupus erythematosusautoimmune polyglandular syndrome type 1specific clinical manifestationspatient health outcomessyndrome type 1numerous autoantibodiesunidentified autoantibodieslupus erythematosusclinical manifestationshuman extracellular proteinsAPS-1potent biological effectsautoantibodieshealth outcomesdisease severityantigen profilingtype 1patient samplesfunctional effectspatientsbiological effectsyeast surface display librarydisplay librarycell signalingsurface display library