News

Goodman Is Appointed C.N.H. Long Professor

Andrew Goodman, PhD, recently named C.N.H. Long Professor of Microbial Pathogenesis, focuses his research on the gut microbiome—the collection of bacteria, mostly in the gastrointestinal tract, that every person acquires after birth.

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  • Microbiome could be culprit when good drugs do harm

    People sometimes suffer toxic side effects from drugs that help many others. Yale scientists have identified a surprising explanation — the gut microbiome. The research, published Feb. 8 in the journal Science, describes how bacteria in the gut can transform three drugs into harmful compounds. “If we can understand the microbiome’s contributions to drug metabolism, we can decide which drugs to give to patients or even alter the microbiome so patients have a better response,” said co-lead author Michael Zimmermann, postdoctoral fellow in the lab of senior author Andrew Goodman in the Department of Microbial Pathogenesis and the Microbial Sciences Institute.

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  • Innovative way to block HIV runs into a roadblock

    A Yale team led by Pradeep Uchil and Walther Mothes found that taking aim at a promising molecular target can combat the spread of retroviruses that can cause blood cancer and AIDS — but at the risk of leaving the host vulnerable to infections by other viral pathogens.

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  • Researchers develop a novel RNA-based therapy to target West Nile Virus

    A Yale-led research team developed a new RNA therapy, delivered through the nose, to treat mice infected with West Nile Virus. The innovative approach reduced the virus in the brain, allowing the immune system to destroy the virus and develop long-term protection against West Nile Virus disease, the researchers said.

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  • New imaging facility is a "revolution"

    Microscopy at Yale has just received a major upgrade. Structural biologists at the School of Medicine and scientists from across the university have begun obtaining three-dimensional images at near-atomic resolutions from what Jorge E. Galán, Ph.D., D.V.M., chair and Lucille P. Markey Professor of Microbial Pathogenesis and professor of cell biology, calls “the mother of all microscopes.” The Titan Krios cryoelectron microscope arrived at West Campus in January and was dedicated in June.

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