News

Yale researchers identified human gut microbes that metabolize over 150 therapeutic drugs, a finding that highlights the role bacteria play in determining how well individuals respond to medications, they report June 3 in the journal Nature.

A Yale-led team has discovered yet another molecular trick HIV uses to survive immune system attacks, a finding that may influence efforts to develop an effective vaccine against HIV/AIDS.

People sometimes suffer toxic side effects from drugs that help many others. Yale scientists have identified a surprising explanation — the gut microbiome. The research, published Feb. 8 in the journal Science, describes how bacteria in the gut can transform three drugs into harmful compounds. “If we can understand the microbiome’s contributions to drug metabolism, we can decide which drugs to give to patients or even alter the microbiome so patients have a better response,” said co-lead author Michael Zimmermann, postdoctoral fellow in the lab of senior author Andrew Goodman in the Department of Microbial Pathogenesis and the Microbial Sciences Institute.

A Yale team led by Pradeep Uchil and Walther Mothes found that taking aim at a promising molecular target can combat the spread of retroviruses that can cause blood cancer and AIDS — but at the risk of leaving the host vulnerable to infections by other viral pathogens.

Sugar can silence a key protein required for colonization by a gut bacterium associated with lean and healthy individuals, according to a new Yale study.

When it met on June 8, 2018 the Yale Corporation approved the following medical school faculty for endowed professorships.

Pew has announced that four Yale scientists will receive grants for research in the biomedical sciences.

A Yale-led research team developed a new RNA therapy, delivered through the nose, to treat mice infected with West Nile Virus. The innovative approach reduced the virus in the brain, allowing the immune system to destroy the virus and develop long-term protection against West Nile Virus disease, the researchers said.

Microscopy at Yale has just received a major upgrade. Structural biologists at the School of Medicine and scientists from across the university have begun obtaining three-dimensional images at near-atomic resolutions from what Jorge E. Galán, Ph.D., D.V.M., chair and Lucille P. Markey Professor of Microbial Pathogenesis and professor of cell biology, calls “the mother of all microscopes.” The Titan Krios cryoelectron microscope arrived at West Campus in January and was dedicated in June.