2006
γδ T Cells Facilitate Adaptive Immunity against West Nile Virus Infection in Mice
Wang T, Gao Y, Scully E, Davis CT, Anderson JF, Welte T, Ledizet M, Koski R, Madri JA, Barrett A, Yin Z, Craft J, Fikrig E. γδ T Cells Facilitate Adaptive Immunity against West Nile Virus Infection in Mice. The Journal Of Immunology 2006, 177: 1825-1832. PMID: 16849493, DOI: 10.4049/jimmunol.177.3.1825.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsCD8-Positive T-LymphocytesGenetic Predisposition to DiseaseImmunity, CellularImmunity, InnateImmunization, SecondaryImmunoglobulin GImmunoglobulin MImmunologic MemoryLymphocyte DepletionMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-Cell, gamma-deltaRecurrenceT-Lymphocyte SubsetsWest Nile FeverWest Nile virusConceptsGammadelta T cellsWild-type miceT cellsWN virus infectionPrimary infectionVirus infectionWN virusNaive miceSecondary challengeImmune responseAdaptive immunityCD8 memory T cellsWest Nile virus infectionMemory T cellsProtective immune responseAdaptive immune responsesAdoptive transferWest Nile virusAb responsesLethal infectionViral challengeFatal meningoencephalitisSecondary infectionInfectionMice
1991
Protection of Mice from Lyme Borreliosis by Oral Vaccination with Escherichia coli Expressing OspA
Fikrig E, Barthold S, Kantor F, Flavell R. Protection of Mice from Lyme Borreliosis by Oral Vaccination with Escherichia coli Expressing OspA. The Journal Of Infectious Diseases 1991, 164: 1224-1227. PMID: 1955724, DOI: 10.1093/infdis/164.6.1224.Peer-Reviewed Original ResearchConceptsOral vaccinationRecombinant OspARecombinant outer surface protein AProtection of miceSerum IgG antibodiesSurface protein ALast boostOuter surface protein AControl miceChallenge infectionIgG antibodiesIntraperitoneal injectionLive Escherichia coliOral preparationsC3H/Day 10Lyme borreliosisVaccinationMiceInfectionBorrelia burgdorferiOspAAntibodiesProtein AGavage