2018
Altered vector competence in an experimental mosquito-mouse transmission model of Zika infection
Uraki R, Hastings AK, Gloria-Soria A, Powell JR, Fikrig E. Altered vector competence in an experimental mosquito-mouse transmission model of Zika infection. PLOS Neglected Tropical Diseases 2018, 12: e0006350. PMID: 29505571, PMCID: PMC5854422, DOI: 10.1371/journal.pntd.0006350.Peer-Reviewed Original ResearchConceptsZIKV transmissionZika virus infectionNatural transmission routeInfected miceZIKV infectionZika infectionTesting vaccinesVirus infectionIntrathoracic injectionAnimal modelsZIKVInfectionMiceTransmission routesBlood mealVector competenceVector competencyMosquitoesTransmission modelVertebrate hostsMosquito modelPathogenesisVaccine
2003
Adaptation of Borrelia burgdorferi in the vector and vertebrate host
Pal U, Fikrig E. Adaptation of Borrelia burgdorferi in the vector and vertebrate host. Microbes And Infection 2003, 5: 659-666. PMID: 12787742, DOI: 10.1016/s1286-4579(03)00097-2.Peer-Reviewed Original ResearchConceptsComplex enzootic cycleUnique adaptive featuresDifferent host environmentsAdaptation of BorreliaMolecular adaptationsRegulatory mechanismsB. burgdorferiHost environmentSensu latoEnzootic cycleExtracellular pathogensDomestic animalsAdaptive featuresBorrelia burgdorferi sensu latoHostBurgdorferi sensu latoCausative agentDiverse rangeArthropodsAdaptationLatoBurgdorferiPathogensLyme diseaseBorrelia
1998
Granulocytic Ehrlichiosis in the Laboratory Mouse
Hodzic E, IJdo J, Feng S, Katavolos P, Sun W, Maretzki C, Fish D, Fikrig E, Telford S, Barthold S. Granulocytic Ehrlichiosis in the Laboratory Mouse. The Journal Of Infectious Diseases 1998, 177: 737-745. PMID: 9498456, DOI: 10.1086/514236.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisMouse passageGranulocytic ehrlichiosisHL-60 cell culturesPeripheral bloodC3H miceLate infectionEarly infectionCell culturesDay 17Day 5Blood smearsNormal valuesDay 24Polymerase chain reaction amplificationHGE agentChain reaction amplificationSpleen smearsMiceInfectionInfectivity assaysBloodLaboratory miceSmearsReaction amplification
1997
Arthropod- and host-specific gene expression by Borrelia burgdorferi.
de Silva AM, Fikrig E. Arthropod- and host-specific gene expression by Borrelia burgdorferi. Journal Of Clinical Investigation 1997, 99: 377-379. PMID: 9022068, PMCID: PMC507808, DOI: 10.1172/jci119169.Peer-Reviewed Original ResearchAnimalsAntigens, BacterialAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial ProteinsBacterial VaccinesBorrelia burgdorferi GroupClinical Trials, Phase III as TopicDisease ReservoirsDisease VectorsGene Expression Regulation, BacterialHeminHost-Parasite InteractionsHumansIxodesLipoproteinsLyme DiseaseMicePlaguePlasminogen ActivatorsSiphonapteraVaccines, SyntheticYersinia pestis
1987
Epidemiology of American Cutaneous Leishmaniasis Due to Leishmania braziliensis brasiliensis
Jones T, Johnson W, Barretto A, Lago E, Badaro R, Cerf B, Reed S, Netto E, Tada M, Franca F, Wiese K, Golightly L, Fikrig E, Costa J, Cuba C, Marsden P. Epidemiology of American Cutaneous Leishmaniasis Due to Leishmania braziliensis brasiliensis. The Journal Of Infectious Diseases 1987, 156: 73-83. PMID: 3598227, DOI: 10.1093/infdis/156.1.73.Peer-Reviewed Original ResearchConceptsPrimary lesionMucosal diseaseCutaneous leishmaniasisFive-year prospective studyLeishmania braziliensis braziliensisYears of ageAmerican cutaneous leishmaniasisAntimony therapyAnnual incidenceSkin testingProspective studyRecent lesionsSkin testSkin lesionsEndemic areasPatientsLesionsDiseaseMost diseasesLeishmaniasisYearsTherapyEpidemiologyPrevalenceIncidence