2002
Differential Expression of the p44 Gene Family in the Agent of Human Granulocytic Ehrlichiosis
IJdo JW, Wu C, Telford SR, Fikrig E. Differential Expression of the p44 Gene Family in the Agent of Human Granulocytic Ehrlichiosis. Infection And Immunity 2002, 70: 5295-5298. PMID: 12183586, PMCID: PMC128253, DOI: 10.1128/iai.70.9.5295-5298.2002.Peer-Reviewed Original ResearchConceptsP44 geneDifferential expressionHuman granulocytic ehrlichiosisGene familyAntigenic variationHGE bacteriaTransmission feedingGranulocytic ehrlichiosisGenesHypervariable regionInfected C3H miceP44 expressionTick transmissionExpressionSCID miceC3H miceHGE infectionMurine modelInfected ticksSalivary glandsNymphal ticksMiceTicksEhrlichiosisBacteria
2001
Coinfection with Borrelia burgdorferi and the Agent of Human Granulocytic Ehrlichiosis
De Martino S, Carlyon J, Fikrig E. Coinfection with Borrelia burgdorferi and the Agent of Human Granulocytic Ehrlichiosis. New England Journal Of Medicine 2001, 345: 150-151. PMID: 11450674, DOI: 10.1056/nejm200107123450218.Peer-Reviewed Original Research
2000
Detection of Ehrlichia chaffeensis DNA inAmblyomma americanum Ticks in Connecticut and Rhode Island
Ijdo J, Wu C, Magnarelli L, Stafford K, Anderson J, Fikrig E. Detection of Ehrlichia chaffeensis DNA inAmblyomma americanum Ticks in Connecticut and Rhode Island. Journal Of Clinical Microbiology 2000, 38: 4655-4656. PMID: 11101616, PMCID: PMC87657, DOI: 10.1128/jcm.38.12.4655-4656.2000.Peer-Reviewed Original ResearchCutting Edge: Infection by the Agent of Human Granulocytic Ehrlichiosis Prevents the Respiratory Burst by Down-Regulating gp91phox
Banerjee R, Anguita J, Roos D, Fikrig E. Cutting Edge: Infection by the Agent of Human Granulocytic Ehrlichiosis Prevents the Respiratory Burst by Down-Regulating gp91phox. The Journal Of Immunology 2000, 164: 3946-3949. PMID: 10754283, DOI: 10.4049/jimmunol.164.8.3946.Peer-Reviewed Original ResearchConceptsHGE bacteriaNADPH oxidase enzyme complexHL-60 cellsNADPH oxidaseHuman granulocytic ehrlichiosisEnzyme complexPromyelocytic cell lineTick-borne pathogensInfected cellsCell linesOrganismsMRNA levelsGp91phox proteinRT-PCRDirect inhibitionBacteriaFACS analysisPathogensMRNA expressionOxidaseGenerate superoxide anionCellsRespiratory burstSplenic neutrophilsMicrobes
1999
Serodiagnosis of Human Granulocytic Ehrlichiosis by a Recombinant HGE-44-Based Enzyme-Linked Immunosorbent Assay
Ijdo J, Wu C, Magnarelli L, Fikrig E. Serodiagnosis of Human Granulocytic Ehrlichiosis by a Recombinant HGE-44-Based Enzyme-Linked Immunosorbent Assay. Journal Of Clinical Microbiology 1999, 37: 3540-3544. PMID: 10523549, PMCID: PMC85687, DOI: 10.1128/jcm.37.11.3540-3544.1999.Peer-Reviewed Original ResearchConceptsPolyvalent enzyme-linked immunosorbent assaysEnzyme-linked immunosorbent assayRecombinant enzyme-linked immunosorbent assayIndirect fluorescent-antibody assaySerum samplesPatient serum samplesFluorescent-antibody assayCurrent antibodyNormal serum samplesImmunosorbent assayHuman granulocytic ehrlichiosisHuman monocytic ehrlichiosisSuitable antigenHigh costGranulocytic ehrlichiosis
1998
Human Exposure to a Granulocytic Ehrlichia and Other Tick-Borne Agents in Connecticut
Magnarelli L, Ijdo J, Anderson J, Padula S, Flavell R, Fikrig E. Human Exposure to a Granulocytic Ehrlichia and Other Tick-Borne Agents in Connecticut. Journal Of Clinical Microbiology 1998, 36: 2823-2827. PMID: 9738027, PMCID: PMC105071, DOI: 10.1128/jcm.36.10.2823-2827.1998.Peer-Reviewed Original ResearchConceptsHuman monocytic ehrlichiosisWestern blot analysisTick-borne agentsProbable human casesTick-borne infectionsHuman granulocytic ehrlichiosis (HGE) agentBlot analysisSerologic testingMarked leukopeniaSeropositive specimensPositive seraHGE agentLyme borreliosisBabesia microtiHuman casesMonocytic ehrlichiosisEhrlichia equiBorrelia burgdorferiGranulocytic EhrlichiaEhrlichia chaffeensisFrequent detectionHuman exposurePatientsInfectionAntibodies
1997
The Early Humoral Response in Human Granulocytic Ehrlichiosis
IJdo J, Zhang Y, Hodzic E, Magnarelli L, Wilson M, Telford S, Barthold S, Fikrig E. The Early Humoral Response in Human Granulocytic Ehrlichiosis. The Journal Of Infectious Diseases 1997, 176: 687-692. PMID: 9291316, DOI: 10.1086/514091.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialEhrlichia chaffeensisEhrlichiosisGranulocytesHL-60 CellsHumansImmunoglobulin GImmunoglobulin MMiceMice, Inbred C3HConceptsHuman granulocytic ehrlichiosisAntibody responseGranulocytic ehrlichiosisHGE agentC3H/HeJ miceEarly humoral responseEarly antibody responseStrong antibody responseHumoral responseHeJ miceClinical infectionPatientsAntigenHL-60 cellsMiceInfectionIgGEhrlichiosisSerumWeeksResponseIgMAgentsDiseaseDiagnosis