2017
A Tick Antivirulence Protein Potentiates Antibiotics against Staphylococcus aureus
Abraham NM, Liu L, Jutras BL, Murfin K, Acar A, Yarovinsky TO, Sutton E, Heisig M, Jacobs-Wagner C, Fikrig E. A Tick Antivirulence Protein Potentiates Antibiotics against Staphylococcus aureus. Antimicrobial Agents And Chemotherapy 2017, 61: 10.1128/aac.00113-17. PMID: 28438938, PMCID: PMC5487661, DOI: 10.1128/aac.00113-17.Peer-Reviewed Original ResearchConceptsNovel alternative therapeutic strategyAlternative therapeutic strategiesEfficacy of antibioticsTherapeutic strategiesTransgenic miceBacterial infectionsInfection modelDifferent antibioticsAntibioticsAntibiotic resistanceStaphylococcus aureusPotency of antibioticsClinical pathogensPeptides representativeImproved permeationPathogensPotent antibiofilm propertiesIAFGP
2015
Frostbite Protection in Mice Expressing an Antifreeze Glycoprotein
Heisig M, Mattessich S, Rembisz A, Acar A, Shapiro M, Booth CJ, Neelakanta G, Fikrig E. Frostbite Protection in Mice Expressing an Antifreeze Glycoprotein. PLOS ONE 2015, 10: e0116562. PMID: 25714402, PMCID: PMC4340617, DOI: 10.1371/journal.pone.0116562.Peer-Reviewed Original ResearchConceptsAnti-freeze glycoproteinAnti-freeze proteinsTransgenic Drosophila modelReduced cell deathDiverse speciesMammalian cellsDrosophila modelCold stressIAFGPMammalian tissuesCold shockCell deathCold hardinessDiverse mechanismsTick hostsTransgenic mouse modelPrevents tissue damagePrevention of frostbiteCold temperaturesAntifreeze glycoproteinsTransgenic miceGlycoproteinNorthern latitudesProtective functionMouse model
1997
Lyme Borreliosis in Transgenic Mice Tolerant to OspA from Borrelia burgdorferi 25015
Fikrig E, Barthold S, Chen M, Tao H, Ali-Salaam P, Bockenstedt L, Flavell R. Lyme Borreliosis in Transgenic Mice Tolerant to OspA from Borrelia burgdorferi 25015. The Journal Of Infectious Diseases 1997, 175: 1000-1003. PMID: 9086169, DOI: 10.1086/513958.Peer-Reviewed Original ResearchConceptsTransgenic miceLyme borreliosisC3H/HeN miceTolerance of miceSurface protein ABorrelia burgdorferi outer surface protein ASignificant arthritisOuter surface protein ALyme arthritisProtective immunityNontransgenic littermatesHeN miceOspA antibodiesDisease pathogenesisMiceArthritisB. burgdorferi N40OspABorreliosisCellular responsesProtein AResponseImmunizationPathogenesisLittermatesLyme disease in transgenic mice expressing the Borrelia burgdorferi flagellin epitope implicated in human neuroborreliosis
Fikrig E, Barthold S. Lyme disease in transgenic mice expressing the Borrelia burgdorferi flagellin epitope implicated in human neuroborreliosis. FEMS Microbiology Letters 1997, 148: 137-143. PMID: 9084140, DOI: 10.1111/j.1574-6968.1997.tb10279.x.Peer-Reviewed Original ResearchConceptsTransgenic miceAntibody responseNervous systemNon-transgenic miceFlagellin epitopeTypes of miceB. burgdorferi infectionCentral nervous systemMyelin basic proteinBurgdorferi infectionNeurologic diseaseMyelinated regionsNeuroborreliosisLyme diseaseMiceNeural tissueBorrelia burgdorferiEpitopesFlagellin antibodyInfectionDiseaseBasic proteinCarditisArthritisFusion protein
1995
Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B.
Fikrig E, Tao H, Chen M, Barthold SW, Flavell RA. Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B. Journal Of Clinical Investigation 1995, 96: 1706-1714. PMID: 7560061, PMCID: PMC185806, DOI: 10.1172/jci118215.Peer-Reviewed Original ResearchConceptsC3H/HeJTransgenic miceLyme borreliosisImmune responseB. burgdorferi-specific antibodyLyme diseaseMajor histocompatibility complex class IBurgdorferi-specific antibodiesRegression of arthritisCellular immune responsesDevelopment of arthritisHistocompatibility complex class IRole of immunityB. burgdorferi antigensComplex class ISurface protein ABorrelia burgdorferi outer surface protein AOuter surface protein ATolerant miceNontransgenic littermatesB6 miceSCID miceImmunodeficient miceB antibodiesC57BL/6 background