2012
Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection
Sukumaran B, Ogura Y, Pedra JH, Kobayashi KS, Flavell RA, Fikrig E. Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection. Pathogens And Disease 2012, 66: 211-219. PMID: 22747758, PMCID: PMC3530031, DOI: 10.1111/j.1574-695x.2012.01001.x.Peer-Reviewed Original ResearchConceptsRip2-deficient miceHuman granulocytic anaplasmosisNOD-like receptorsPhagocytophilum infectionTick-borne infectious diseaseNOD1/NOD2Obligate intracellular bacterium Anaplasma phagocytophilumInflammatory protein-2Host immune responseInnate immune pathwaysProtein 2Anaplasma phagocytophilum infectionHuman primary neutrophilsBacterium Anaplasma phagocytophilumHigh bacterial loadWild-type controlsImmune controlIL-12Immune clearanceImmune responseImmune pathwaysHost responseKC responsesHost defenseInfectious diseases
2011
Innate interleukin-22 confers protection during acute liver infection (114.8)
Zenewicz L, Pedra J, Booth C, Fikrig E, Flavell R. Innate interleukin-22 confers protection during acute liver infection (114.8). The Journal Of Immunology 2011, 186: 114.8-114.8. DOI: 10.4049/jimmunol.186.supp.114.8.Peer-Reviewed Original ResearchLTi-like cellsIL-22Liver infectionLiver immune responseObligate intracellular bacterium Anaplasma phagocytophilumInnate immune cellsLymphoid tissue inducerIL-22 receptorRole of innateIL-22-dependent mannerTissue responseImportant protective roleBacterium Anaplasma phagocytophilumA. phagocytophilum infectionIL-23Liver injuryImmune cellsLymphoid tissueInterleukin-22Immune responseGastrointestinal tractImportant cytokineConfer protectionProtective roleBacterial infections
2005
Infection with Anaplasma phagocytophilum Inhibits Proliferation and Differentiation of Myeloid Progenitors: New Insight into Infection-Related Pancytopenia.
Gaines P, Thomas V, Fikrig E, Berliner N. Infection with Anaplasma phagocytophilum Inhibits Proliferation and Differentiation of Myeloid Progenitors: New Insight into Infection-Related Pancytopenia. Blood 2005, 106: 3065. DOI: 10.1182/blood.v106.11.3065.3065.Peer-Reviewed Original ResearchHuman granulocytic anaplasmosisBone marrow progenitorsStem cell factorMarrow progenitorsA. phagocytophilumG-CSFMyeloid progenitorsCell linesObligate intracellular bacterium Anaplasma phagocytophilumOccurrence of thrombocytopeniaPeripheral blood neutrophilsFatal tick-borne diseaseBacterium Anaplasma phagocytophilumBone marrow cellsMarrow suppressionTick-borne diseaseCell line modelsClinical symptomsPhagocyte respiratory burstHematologic abnormalitiesInfection causesBlood neutrophilsCytokine secretionInhibition of apoptosisInfected individuals