1992
Resistance to host antimicrobial peptides is necessary for Salmonella virulence.
Groisman EA, Parra-Lopez C, Salcedo M, Lipps CJ, Heffron F. Resistance to host antimicrobial peptides is necessary for Salmonella virulence. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 11939-11943. PMID: 1465423, PMCID: PMC50673, DOI: 10.1073/pnas.89.24.11939.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBiological EvolutionBlood ProteinsChromosome MappingCytoplasmic GranulesDefensinsGenes, BacterialGenotypeGranulocytesHumansIn Vitro TechniquesMagaininsMiceMutagenesisPeptidesProtaminesSalmonella InfectionsSalmonella typhimuriumXenopus ProteinsConceptsDifferent phenotypic classesTransposon insertion mutantsHost defense strategiesSalmonella virulence genesBacterium Salmonella typhimuriumResistance mechanismsAntimicrobial peptidesDefensin NP-1Antimicrobial peptide protamineInsertion mutantsResistance lociHost antimicrobial peptidesSalmonella virulencePhenotypic classesMutantsSuccessful pathogenDefective lipopolysaccharideAntibacterial peptidesVirulence genesPeptide mastoparanCecropin P1Defense strategiesUbiquitous typeVirulence propertiesGenes
1989
A Salmonella Locus that Controls Resistance to Microbicidal Proteins from Phagocytic Cells
Fields P, Groisman E, Heffron F. A Salmonella Locus that Controls Resistance to Microbicidal Proteins from Phagocytic Cells. Science 1989, 243: 1059-1062. PMID: 2646710, DOI: 10.1126/science.2646710.Peer-Reviewed Original ResearchConceptsIntracellular pathogen Salmonella typhimuriumPhagocytic cellsImportant health problemProfessional phagocytic cellsFacultative intracellular pathogenPrimary defense mechanismHealth problemsMicrobicidal mechanismsPathogen Salmonella typhimuriumIntracellular survivalIntracellular pathogensMicrobicidal proteinsDefense mechanismsSalmonella typhimuriumCells