2003
The ShiA protein encoded by the Shigella flexneri SHI‐2 pathogenicity island attenuates inflammation
Ingersoll MA, Moss JE, Weinrauch Y, Fisher PE, Groisman EA, Zychlinsky A. The ShiA protein encoded by the Shigella flexneri SHI‐2 pathogenicity island attenuates inflammation. Cellular Microbiology 2003, 5: 797-807. PMID: 14531895, DOI: 10.1046/j.1462-5822.2003.00320.x.Peer-Reviewed Original Research
2000
The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri
Moss J, Fisher P, Vick B, Groisman E, Zychlinsky A. The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri. Cellular Microbiology 2000, 2: 443-452. PMID: 11207599, DOI: 10.1046/j.1462-5822.2000.00065.x.Peer-Reviewed Original ResearchConceptsWild-type strainPhoP mutantPhoP/PhoQ systemTwo-component regulatory systemRegulatory protein PhoPHost cell phagosomesPhoP/PhoQKey virulence genesMutant bacteriaEnteric bacteriumPathogen escapeCell phagosomesHost cellsMutantsWild-type ShigellaPolymorphonuclear leucocytesRegulatory systemVirulence genesAntimicrobial moleculesAntimicrobial peptidesPhoPExtreme acidInflammatory responseEpithelial cellsPhagosomes
1999
The selC‐associated SHI‐2 pathogenicity island of Shigella flexneri
Moss J, Cardozo T, Zychlinsky A, Groisman E. The selC‐associated SHI‐2 pathogenicity island of Shigella flexneri. Molecular Microbiology 1999, 33: 74-83. PMID: 10411725, DOI: 10.1046/j.1365-2958.1999.01449.x.Peer-Reviewed Original ResearchMeSH KeywordsBacterial ProteinsChromosome MappingChromosomes, BacterialCloning, MolecularColicinsDNA Transposable ElementsDNA, BacterialEnterobacteriaceaeEscherichia coliGenes, BacterialHydroxamic AcidsIntegrasesOperonSequence AlignmentSequence Homology, Nucleic AcidShigella flexneriSpecies SpecificityTransposasesVirulenceConceptsPathogenicity islandSHI-2Different pathogenicity islandsChromosomal gene clusterRelated non-pathogenic speciesMultiple mobile genetic elementsMobile genetic elementsNon-pathogenic speciesSite of integrationTRNA genesSelC locusTRNA locusGene clusterNovel proteinGenetic elementsKb downstreamSiderophore systemStressful environmentsEscherichia coliVirulence factorsEnterohaemorrhagic E. coliE. coliUropathogenic Escherichia coliSalmonella entericaGenes
1993
Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri.
Groisman EA, Ochman H. Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri. The EMBO Journal 1993, 12: 3779-3787. PMID: 8404849, PMCID: PMC413660, DOI: 10.1002/j.1460-2075.1993.tb06056.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigens, BacterialAntigens, SurfaceBase SequenceBlotting, SouthernChromosomes, BacterialDNAEpithelial CellsEpitheliumGenes, BacterialGenetic Complementation TestHumansMiceMolecular Sequence DataMultigene FamilyMutationRestriction MappingSalmonella typhimuriumSequence Homology, Amino AcidShigella flexneriTumor Cells, CulturedConceptsEpithelial cellsEnteric pathogen Salmonella typhimuriumHost epithelial cellsSurface antigenSalmonella typhimuriumPathogen Salmonella typhimuriumConstellation of genesInvasion propertiesShigella flexneriVirulence plasmidShigellaVirulence attributesAntigenSalmonellaBacterial entryProtein secretion
1987
Cloning of genes from members of the family Enterobacteriaceae with mini-Mu bacteriophage containing plasmid replicons
Groisman EA, Casadaban MJ. Cloning of genes from members of the family Enterobacteriaceae with mini-Mu bacteriophage containing plasmid replicons. Journal Of Bacteriology 1987, 169: 687-693. PMID: 3542967, PMCID: PMC211834, DOI: 10.1128/jb.169.2.687-693.1987.Peer-Reviewed Original ResearchConceptsSensitive recipient strainFamily EnterobacteriaceaeHigh phage titersC. freundiiProteus mirabilisPlasmid repliconsCitrobacter freundiiS. typhimuriumDrug-resistant transductantsSpecific mutationsMu derivativesE. coliSalmonella typhimuriumEnterobacteriaceaeFreundiiRecipient strainPhage titerTyphimuriumEscherichia coli bacteriophageInfectionTiters
1986
crp genes of Shigella flexneri, Salmonella typhimurium, and Escherichia coli
Cossart P, Groisman EA, Serre MC, Casadaban MJ, Gicquel-Sanzey B. crp genes of Shigella flexneri, Salmonella typhimurium, and Escherichia coli. Journal Of Bacteriology 1986, 167: 639-646. PMID: 3525518, PMCID: PMC212937, DOI: 10.1128/jb.167.2.639-646.1986.Peer-Reviewed Original ResearchConceptsE. coli crp geneNucleotide sequenceCatabolite gene activator proteinCRP geneGene activator proteinCrp gene productCorresponding amino acid sequencesE. coli CRPComplete nucleotide sequenceAmino acid divergenceEscherichia coli KAmino acid sequenceBase pair changesAmino acid differencesSalmonella typhimurium LT2S. typhimuriumRegulatory genesCodon usageActivator proteinRegulatory regionsGene productsAcid sequenceColi KPair changesAcid differences