Julio Silva
About
Research
Publications
2026
Cannabidiol-Enriched Extract Oil for Postoperative Management of Chronic Pelvic Pain Secondary to Endometriosis: A Randomized Clinical Trial-DREAMLAND Study.
Anelli G, Ratochinski R, Oliveira I, Souza I, Nassur M, Candido-Dos-Reis F, Zuardi A, Junior W, Rosa-E-Silva J, Hallak J, Crippa J, Poli-Neto O. Cannabidiol-Enriched Extract Oil for Postoperative Management of Chronic Pelvic Pain Secondary to Endometriosis: A Randomized Clinical Trial-DREAMLAND Study. Cannabis And Cannabinoid Research 2026, 25785125251413989. PMID: 42261989, DOI: 10.1177/25785125251413989.Peer-Reviewed Original ResearchPain intensityPain reductionAdverse eventsPlacebo groupSymptom recurrencePostoperative managementManagement of chronic pelvic painPrimary outcomeInterim analysisHigher frequency of adverse eventsFrequency of adverse eventsSurgically treated endometriosisChronic pelvic painMean pain intensityPlacebo-controlled trialEfficacy of cannabidiolSignificant pain reductionPotential placebo effectMild adverse eventsEffective therapeutic alternativeAdverse-event ratesCannabis-based productsClinically relevant benefitsDose escalationPelvic pain
2025
Prevalence of sexual abuse in women with and without chronic pelvic pain: A systematic review and meta-analysis
Neto J, Silva T, Nogueira M, Lira L, de Sousa Gomes L, Rosa e Silva J, da Cunha Leal P. Prevalence of sexual abuse in women with and without chronic pelvic pain: A systematic review and meta-analysis. Women & Health 2025, 65: 684-693. PMID: 40984724, DOI: 10.1080/03630242.2025.2549983.Peer-Reviewed Original ResearchConceptsChronic pelvic painPelvic painMeta-analysisPrevalence of sexual abuseCase-control studyMeta-analysis of prevalencePrimary screening toolSystematic reviewStatistically significant differenceNoncyclic painHistory of sexual abuseCase-controlPainDebilitating conditionIn adulthoodSignificant differenceWomenPrevalenceScreening toolChildhoodAdulthoodReviewSexual abuseAbuseImpact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID
Grady C, Bhattacharjee B, Silva J, Jaycox J, Lee L, Silva Monteiro V, Sawano M, Massey D, Caraballo C, Gehlhausen J, Tabachnikova A, Mao T, Lucas C, Peña-Hernandez M, Xu L, Tzeng T, Takahashi T, Herrin J, Güthe D, Akrami A, Assaf G, Davis H, Harris K, McCorkell L, Schulz W, Griffin D, Wei H, Ring A, Guan L, Dela Cruz C, Krumholz H, Iwasaki A. Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID. Communications Medicine 2025, 5: 163. PMID: 40346201, PMCID: PMC12064684, DOI: 10.1038/s43856-025-00829-3.Peer-Reviewed Original ResearchSpike protein-specific IgGProtein-specific IgGSelf-antigensImmune response to COVID-19 vaccinationCOVID-19 vaccineAntibody responseResponse to COVID-19 vaccinationT cell expansionSARS-CoV-2-specific antibody responsesAssociated with no improvementLong COVIDAssociated with symptom improvementChest painCirculating cytokinesImmune phenotypeProspective studyImmune featuresTransient improvementPrimary seriesVaccine doseHerpes virusImmune responseSymptom improvementSignificant elevationImpact of COVID-19 vaccination
2024
Sex differences in postacute infection syndromes
Silva J, Iwasaki A. Sex differences in postacute infection syndromes. Science Translational Medicine 2024, 16: eado2102-eado2102. PMID: 39536120, PMCID: PMC12805797, DOI: 10.1126/scitranslmed.ado2102.Peer-Reviewed Original Research12380 US Evaluation of Endometrial Thickness in Postmenopausal Patients as a Predictor of Endometrial Cancer: Systematic Review & Meta-Analysis
Peixoto, Garcia R, Sanches T, Fins R, Costa F, Reis F, Herren H, Poli-Neto O, Rosa-e-Silva J. 12380 US Evaluation of Endometrial Thickness in Postmenopausal Patients as a Predictor of Endometrial Cancer: Systematic Review & Meta-Analysis. Journal Of Minimally Invasive Gynecology 2024, 31: s154. DOI: 10.1016/j.jmig.2024.09.973.Peer-Reviewed Original ResearchEvaluation of endometrial thicknessTransvaginal ultrasound evaluationTransvaginal ultrasound assessmentCut-off pointEndometrial thicknessAsymptomatic patientsPositive predictive valueMenopausal patientsVaginal bleedingMalignant findingsPredictive valueUS evaluationPredictors of endometrial cancerAssessment of endometrial thicknessNewcastle Ottawa toolPostmenopausal vaginal bleedingAnatomopathological findingsTransvaginal ultrasound examinationHormone replacement therapyMeta-analysisNegative predictive valueSystematic reviewInclusion criteria articlesParticipant eligibility criteriaPostmenopausal patientsSelection of reference miRNAs for RT-qPCR assays in endometriosis menstrual blood-derived mesenchymal stem cells
Hacimoto S, Cressoni A, da Silva L, Padovan C, Ferriani R, Rosa-e-Silva J, Meola J. Selection of reference miRNAs for RT-qPCR assays in endometriosis menstrual blood-derived mesenchymal stem cells. PLOS ONE 2024, 19: e0306657. PMID: 39078824, PMCID: PMC11288454, DOI: 10.1371/journal.pone.0306657.Peer-Reviewed Original ResearchConceptsMenstrual blood-derived mesenchymal stem cellsMesenchymal stem cellsStem cellsRetrograde menstruation theoryMiR-103a-3pMiR-24-3pTwo-dimensional cultureMiRNA expressionHealthy womenReference genesMiR-191EndometriosisMiR-24RT-qPCRReproducibility of gene expression dataInterexperimental reproducibilityMenSCsMenstrual bloodPost-transcriptional regulatory processesRegenerative medicineClassification of miRNAMachine learning as a clinical decision support tool for diagnosing superficial peritoneal endometriosis in women with dysmenorrhea and acyclic pelvic pain
Santos L, Azevedo M, Shimamura L, Nogueira A, Reis F, Schor E, Silva J, Tiezzi D, Poli-Neto O. Machine learning as a clinical decision support tool for diagnosing superficial peritoneal endometriosis in women with dysmenorrhea and acyclic pelvic pain. Medical Research Archives 2024, 12 DOI: 10.18103/mra.v12i12.6204.Peer-Reviewed Original ResearchSuperficial peritoneal endometriosisHistory of pelvic inflammatory diseaseAcyclic pelvic painPelvic floor tendernessBladder pain syndromePelvic inflammatory diseasePeritoneal endometriosisIrregular menstrual cyclesPelvic painIrritable bowel syndromePain syndromeIntraoperative findingsMenstrual cyclePre-operative clinical dataInflammatory diseasesBowel syndromeMonths of hormone treatmentAbnormal ultrasound findingsTrigger pointsPreoperative diagnostic accuracySurgical decision-makingSevere dysmenorrheaNon-invasive diagnosisAbnormal findingsUltrasound findings
2023
Distinguishing features of long COVID identified through immune profiling
Klein J, Wood J, Jaycox J, Dhodapkar R, Lu P, Gehlhausen J, Tabachnikova A, Greene K, Tabacof L, Malik A, Silva Monteiro V, Silva J, Kamath K, Zhang M, Dhal A, Ott I, Valle G, Peña-Hernández M, Mao T, Bhattacharjee B, Takahashi T, Lucas C, Song E, McCarthy D, Breyman E, Tosto-Mancuso J, Dai Y, Perotti E, Akduman K, Tzeng T, Xu L, Geraghty A, Monje M, Yildirim I, Shon J, Medzhitov R, Lutchmansingh D, Possick J, Kaminski N, Omer S, Krumholz H, Guan L, Dela Cruz C, van Dijk D, Ring A, Putrino D, Iwasaki A. Distinguishing features of long COVID identified through immune profiling. Nature 2023, 623: 139-148. PMID: 37748514, PMCID: PMC10620090, DOI: 10.1038/s41586-023-06651-y.Peer-Reviewed Original ResearchConceptsLong COVIDSARS-CoV-2Infection syndromeExaggerated humoral responseSoluble immune mediatorsEpstein-Barr virusPost-exertional malaiseCross-sectional studyHigher antibody responseImmune mediatorsImmune phenotypingImmune profilingHumoral responseAntibody responseLymphocyte populationsCOVID statusUnbiased machineCortisol levelsLC statusRelevant biomarkersViral pathogensSyndromeCOVIDFuture studiesBiological featuresAge-dependent impairment in antibody responses elicited by a homologous CoronaVac booster dose
Filardi B, Monteiro V, Schwartzmann P, do Prado Martins V, Zucca L, Baiocchi G, Malik A, Silva J, Hahn A, Chen N, Pham K, Pérez-Then E, Miric M, Brache V, Cochon L, Larocca R, Della Rosa Mendez R, Silveira D, Pinto A, Croda J, Yildirim I, Omer S, Ko A, Vermund S, Grubaugh N, Iwasaki A, Lucas C, Initiative Y, Vogels C, Breban M, Koch T, Chaguza C, Tikhonova I, Castaldi C, Mane S, De Kumar B, Ferguson D, Kerantzas N, Peaper D, Landry M, Schulz W. Age-dependent impairment in antibody responses elicited by a homologous CoronaVac booster dose. Science Translational Medicine 2023, 15: eade6023. PMID: 36791210, DOI: 10.1126/scitranslmed.ade6023.Peer-Reviewed Original ResearchConceptsBooster doseAntibody responseNeutralization titersVirus-specific IgG titersOlder adultsAntiviral humoral immunityPlasma antibody responsesHigh-risk populationSARS-CoV-2 spikeYears of ageAge-dependent impairmentHeterologous regimensBooster dosesBooster vaccineCoronaVac vaccineIgG titersProtective immunityHumoral immunityHumoral responseCoronaVacOmicron waveBooster strategyAge groupsEarly controlVaccine
2022
Association between primary or booster COVID-19 mRNA vaccination and Omicron lineage BA.1 SARS-CoV-2 infection in people with a prior SARS-CoV-2 infection: A test-negative case–control analysis
Lind M, Robertson A, Silva J, Warner F, Coppi A, Price N, Duckwall C, Sosensky P, Di Giuseppe E, Borg R, Fofana M, Ranzani O, Dean N, Andrews J, Croda J, Iwasaki A, Cummings D, Ko A, Hitchings M, Schulz W. Association between primary or booster COVID-19 mRNA vaccination and Omicron lineage BA.1 SARS-CoV-2 infection in people with a prior SARS-CoV-2 infection: A test-negative case–control analysis. PLOS Medicine 2022, 19: e1004136. PMID: 36454733, PMCID: PMC9714718, DOI: 10.1371/journal.pmed.1004136.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionBooster vaccinationPrior infectionOmicron infectionPrimary vaccinationMRNA vaccinationOdds ratioAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionPrior SARS-CoV-2 infectionTest-negative case-control analysisYale New Haven Health SystemTest-negative case-control studyCOVID-19 mRNA vaccinationSyndrome coronavirus 2 infectionOmicron variant infectionPrior infection statusCoronavirus 2 infectionCase-control studyCase-control analysisOdds of infectionRisk of infectionRace/ethnicityBooster dosesDate of test
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