James Jeanne, PhD
Assistant Professor in NeuroscienceCards
Appointments
Additional Titles
Assistant Professor, Neuroscience
Contact Info
Appointments
Additional Titles
Assistant Professor, Neuroscience
Contact Info
Appointments
Additional Titles
Assistant Professor, Neuroscience
Contact Info
About
Titles
Assistant Professor in Neuroscience
Assistant Professor, Neuroscience
Biography
Jamie received a B.S.E. in Electrical Engineering from Princeton University in 2005 and a Ph.D. in Computational Neuroscience from UC San Diego in 2012. As a graduate student with Dr. Timothy Gentner and Dr. Tatyana Sharpee, he investigated plasticity in neural population codes in the auditory cortex of the European Starling, a common species of songbird with an exceptional capacity for learning. As a postdoctoral fellow with Dr. Rachel Wilson at Harvard Medical School, he studied the functional roles of convergent and divergent neural circuit motifs in the olfactory system of the fruit fly. Subsequently, using 2-photon optogenetic circuit mapping, he has begun to reveal the functional organization of higher-order olfactory circuits. He joined the Department of Neuroscience at Yale School of Medicine in the Fall of 2017.
The Jeanne Lab is broadly interested in understanding how neural circuits implement the computations that support behavior. We study the fruit fly because of its tractability: the brain contains only 100,000 neurons, neural circuits are stereotyped from fly to fly (down to the level of individual neurons), and large libraries of genetic driver lines enable precise targeting of individual neurons for physiology experiments. Current research aims to understand the circuit and computational mechanisms of sensory processing, working memory, and decision making.
Appointments
Neuroscience
Assistant ProfessorPrimary
Other Departments & Organizations
- Interdepartmental Neuroscience Program
- Molecular Medicine, Pharmacology, and Physiology
- Neuroscience
- Neuroscience Track
- Swartz Program in Theoretical Neurobiology
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- Postdoctoral Fellow
- Harvard Medical School (2017)
- PhD
- University of California, San Diego, Neuroscience (2012)
- BS
- Princeton University, Electrical Engineering (2005)
Research
Overview
Medical Research Interests
ORCID
0000-0001-7657-202X- View Lab Website
Jeanne Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Gizem Sancer
Pasha Davoudian
Neurons
Drosophila melanogaster
Synapses
Publications
2024
Olfactory sensory neuron population expansions influence projection neuron adaptation and enhance odour tracking
Takagi S, Sancer G, Abuin L, Stupski S, Roman Arguello J, Prieto-Godino L, Stern D, Cruchet S, Álvarez-Ocaña R, Wienecke C, van Breugel F, Jeanne J, Auer T, Benton R. Olfactory sensory neuron population expansions influence projection neuron adaptation and enhance odour tracking. Nature Communications 2024, 15: 7041. PMID: 39147786, PMCID: PMC11327376, DOI: 10.1038/s41467-024-50808-w.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsOlfactory sensory neuronsPopulation expansionSpecies-specific expansionSensory neuronsProjection neuronsConnections of sensory neuronsOlfactory sensory neuron numbersSpecies-specific behaviorsD. sechelliaDrosophila sechelliaEcologically-relevantProportion of neuronsEnvironmental cuesMultigenic changesEvolutionary expansionIncreased synaptic connectivityFunctional impactPN sensitivityNeuronal adaptationOdor trackingNeuronsSechelliaLateral inhibitionInhibitionSpecies
2021
Connectomic features underlying diverse synaptic connection strengths and subcellular computation
Liu TX, Davoudian PA, Lizbinski KM, Jeanne JM. Connectomic features underlying diverse synaptic connection strengths and subcellular computation. Current Biology 2021, 32: 559-569.e5. PMID: 34914905, PMCID: PMC8825683, DOI: 10.1016/j.cub.2021.11.056.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSomatic postsynaptic potentialsSingle presynaptic spikeElectrical compartmentalizationPostsynaptic potentialsSynapse densityDiverse neuronsSynaptic connectionsSynaptic connection strengthsOlfactory networkPresynaptic spikesNeural tissueDrosophila brainNeuronal biophysicsConnectivity mapsNeuronsBrainSynapsesDecision making: An analogue implementation of a drift-diffusion computation in the Drosophila mushroom body
Buerkle N, Jeanne JM. Decision making: An analogue implementation of a drift-diffusion computation in the Drosophila mushroom body. Current Biology 2021, 31: r1479-r1482. PMID: 34813753, DOI: 10.1016/j.cub.2021.09.039.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsAn ammonium transporter is a non-canonical olfactory receptor for ammonia
Vulpe A, Kim HS, Ballou S, Wu ST, Grabe V, Nava Gonzales C, Liang T, Sachse S, Jeanne JM, Su CY, Menuz K. An ammonium transporter is a non-canonical olfactory receptor for ammonia. Current Biology 2021, 31: 3382-3390.e7. PMID: 34111404, PMCID: PMC8355169, DOI: 10.1016/j.cub.2021.05.025.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsOlfactory receptorsGenetic model organism Drosophila melanogasterModel organism Drosophila melanogasterAmmonium transporter familyCanonical olfactory receptorsIon channel functionAmmonium transportersInsect speciesDrosophila melanogasterMost insectsMutant fliesFirst transporterParticular olfactory receptorTransporter familyAgricultural pestsHematophagous insectsEctopic expressionDrosophilaInsectsChannel functionWidespread importanceAmmonia sensitivitySpeciesTransportersReceptors
2020
Two-Photon Optogenetic Stimulation of Drosophila Neurons
Fişek M, Jeanne JM. Two-Photon Optogenetic Stimulation of Drosophila Neurons. Methods In Molecular Biology 2020, 2191: 97-108. PMID: 32865741, DOI: 10.1007/978-1-0716-0830-2_7.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConnectomics: Bringing Fly Neural Circuits into Focus
Lizbinski KM, Jeanne JM. Connectomics: Bringing Fly Neural Circuits into Focus. Current Biology 2020, 30: r944-r947. PMID: 32810456, DOI: 10.1016/j.cub.2020.06.068.Peer-Reviewed Original ResearchCitationsAltmetric
2018
The Organization of Projections from Olfactory Glomeruli onto Higher-Order Neurons
Jeanne JM, Fişek M, Wilson RI. The Organization of Projections from Olfactory Glomeruli onto Higher-Order Neurons. Neuron 2018, 98: 1198-1213.e6. PMID: 29909998, PMCID: PMC6051339, DOI: 10.1016/j.neuron.2018.05.011.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2015
Convergence, Divergence, and Reconvergence in a Feedforward Network Improves Neural Speed and Accuracy
Jeanne JM, Wilson RI. Convergence, Divergence, and Reconvergence in a Feedforward Network Improves Neural Speed and Accuracy. Neuron 2015, 88: 1014-1026. PMID: 26586183, PMCID: PMC5488793, DOI: 10.1016/j.neuron.2015.10.018.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAction PotentialsAnimalsAnimals, Genetically ModifiedAntigensAstrocytesBacterial ProteinsDrosophilaDrosophila ProteinsFibroblast Growth Factor 2Glutamic AcidLuminescent ProteinsModels, NeurologicalNerve NetNeuronsOlfactory PathwaysPatch-Clamp TechniquesProteoglycansReaction TimeRNA, Small InterferingSensory Receptor CellsSomatosensory CortexSynaptic Transmission
2013
Associative Learning Enhances Population Coding by Inverting Interneuronal Correlation Patterns
Jeanne JM, Sharpee TO, Gentner TQ. Associative Learning Enhances Population Coding by Inverting Interneuronal Correlation Patterns. Neuron 2013, 78: 352-363. PMID: 23622067, PMCID: PMC3641681, DOI: 10.1016/j.neuron.2013.02.023.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNeural populationsStimulus-specific changesSensory signalsInterneuronal correlationsAssociative learning procedureCortical neuronsRelevant sensory signalsAuditory cortical neuronsTarget of learningAssociative learningCortical encodingNatural acoustic signalsBehavioral relevanceSpecific sensory signalsPopulation codeLearning procedurePopulation codingNeuronsLearningSingle neuronsCoordinated activityEmergent propertiesPopulationAcoustic signalsEncoding
2012
Local inhibition modulates learning-dependent song encoding in the songbird auditory cortex
Thompson JV, Jeanne JM, Gentner TQ. Local inhibition modulates learning-dependent song encoding in the songbird auditory cortex. Journal Of Neurophysiology 2012, 109: 721-733. PMID: 23155175, PMCID: PMC3567384, DOI: 10.1152/jn.00262.2012.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLocal inhibitionInhibitory modulationAuditory cortexMammalian secondary auditory cortexMasking of responsesSecondary auditory cortexResponses of neuronsLearning-related plasticityIontophoretic applicationRole of inhibitionCaudomedial nidopalliumAuditory forebrainInhibitionCortexSpectrotemporal tuningResponse patternsNeural representationResponseGabazineCentral roleForebrainNeurons
Academic Achievements & Community Involvement
activity Neuron
Journal ServiceReviewerDetails2018 - Presentactivity Current Biology
Journal ServiceReviewerDetails2018 - Presentactivity Science Advances
Journal ServiceReviewerDetails2018 - Presentactivity eLife
Journal ServiceReviewerDetails2018 - Presentactivity Journal of Neuroscience
Journal ServiceReviewerDetails2018 - Present
Teaching & Mentoring
Mentoring
Rebecca Ray
Postgrad associate2024 - PresentPoonam Mishra
Postdoc2022 - PresentEvyn Dickinson
Graduate student2021 - PresentKay Ellison
Graduate student2020 - Present
News & Links
Media
- 2-photon optogenetic stimulation of an olfactory neuron in the Drosophila brain. A whole-cell patch clamp recording was made from a single antennal lobe projection neuron (second-order olfactory neuron, filled with red dye). The dendrites of this neuron innervate one olfactory glomerulus (lower right) and the axon projects up and out of the antennal lobe (top). The cell body is not visible. This neuron expresses ReaChR (a red-shifted channelrhodopsin) and 7x7x8 micron "voxels" were stimulated using 2-photon excitation. The voltage response of the neuron to stimulation of each voxel is superimposed in white. Only voxels within the glomerulus elicit spikes in the neuron. The green background is a neuropil counterstain showing other olfactory glomeruli.
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