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“Novel mechanisms of PIEZO1 dysfunction in hereditary xerocytosis
"Various mechanisms of PIEZO1 dysfunction lead to the phenotype of hereditary xerocytosis (HX) including altered membrane protein trafficking. The image shows intracellular retention of HX-associated mutant R2088G PIEZO1 protein in the endoplasmic reticulum (yellow).” This image from the report “Novel mechanisms of PIEZO1 dysfunction in hereditary xerocytosis” was featured on the cover of the October 19, 2017 issue of BLOOD. (Glogowska E, Schneider ER, Maksimova Y, Schulz VP, Lezon-Geyda K, Wu J, Radhakrishnan K, Keel SB, Mahoney D, Freidmann AM, Altura RA, Gracheva EO, Bagriantsev SN, Kalfa TA, Gallagher PG.. Blood. 2017; 130(16):1845-1856. PMID:28716860.)
Source: BLOOD