Discovering the 'Cytokine Language' That Activates Immune Responses
Using a new computational method based on a causal inference framework, CINEMA-OT, the Yale team studied how individual immune cells react to combinations of cytokines, or small proteins released by cells that regulate inflammation. They discovered that certain cytokines have a synergistic effect, inducing unique gene activation programs compared to their individual effects. This cryptography of cytokine signals acts as a language, instructing immune cells.
Stephania Libreros, PhD, Receives NIH Pathway to Independence Award
Stephania Libreros, PhD, a newly appointed Assistant Professor of Pathology and a member of the Vascular Biology Therapeutics Program at Yale School of Medicine, was recently awarded a National Institute of Health (NIH) K99-R00 Award from National Heart Lung and Blood Institute, to support her independent research as she moves into a full-time tenure track faculty position.
New Mouse Model Provides Unprecedented Look at Human Immune System
Despite the critical role of neutrophils in the human immune system, no one has been able to study them in a living context, limiting investigations of their properties. But now, a team of Yale researchers has developed the first humanized mouse model that will permit research on neutrophils in vivo.
ExPath Grad Student Madeline Mayday Awarded Grant from the NIDDK Cooperative Centers of Excellence in Hematology
Madeline Mayday, BS, a fourth-year Experimental Pathology graduate student in the Laboratory of Diane Krause, MD, PhD, was recently awarded a 2022 National Institute of Diabetes and Digestive and Kidney Diseases Hematology Centers Program Type B Pilot and Feasibility grant
How Studying Cellular Senescence Can Help Researchers Learn to Delay Aging
Chronic inflammation, one of the major hallmarks of aging, is thought to be partly caused by senescent cells that may accumulate in older individuals. Now, Yale researchers have received a grant from the National Institutes of Health (NIH) Common Fund’s Cellular Senescence Network Program (SenNet) to study these specialized cells.
What We Learned About COVID-19 and Cold and Flu Season
Day-to-day life changed a lot when COVID-19 hit. To curb the spread of the virus, health experts urged us to social distance, wear a mask, and wash our hands all the time. Then a surprising thing happened. “All the normal respiratory infections we usually get -- from cold and flu viruses -- didn’t happen, which was very dramatic,” says Ellen Foxman, MD, PhD. She’s an immunobiologist at Yale Medicine and an assistant professor of laboratory medicine and immunobiology at Yale School of Medicine.Source: WebMD