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Michael Paidas, MD

Professor Adjunct


Dr. Paidas is the recipient of The David J. Leffell, M.D. Prize for Clinical Excellence at Yale in 2010, given to one member of Yale Medicine annually. In 2012, Dr. Paidas received the Dean’s Award from the Tufts Medical Alumni Association. Dr. Paidas is included in the top 1% physician by specialty in the nation according to US News and World Report. He has been recognized by the March of Dimes and is included in Best Doctors in America. Dr. Paidas has also received the National Faculty Award by the Counsel on Resident Education in Obstetrics and Gynecology.

Dr. Paidas received his medical degree from Tufts University School of Medicine in 1987 and completed his internship and residency in Obstetrics and Gynecology in 1991 at Pennsylvania Hospital. In 1993, Dr. Paidas completed a Fellowship in Maternal Fetal Medicine at the Mount Sinai School of Medicine in New York. In 2013, Dr. Paidas was awarded a Master of Arts, Honorary Degree, from Yale University.

Dr. Paidas's career in medicine has focused on women’s health with special emphasis on blood disorders, reproduction, pregnancy complications and the latter’s impact on health and disease. His activities span direct patient care, translational research and clinical trials. Dr. Paidas’s research has been supported by federal and non- federal funding agencies. His notable contributions include: description of the regulatory factors of the Protein C system; clinical use of recombinant antithrombin in disease states; elucidation of the subsequent cardiovascular and non-cardiovascular health consequences of hypertensive disorders and preterm delivery in the largest population based studies published to date.

Dr. Paidas and collaborators have described the genomic and proteomic effects of Preimplantation Factor (PIF), a novel mammalian embryo derived factor which regulates maternal receptivity to pregnancy and possesses key immune modulatory properties. Subsequent animal studies using a synthetic analogue of native PIF have shown benefit in animal models related to a variety of immune diseases, including multiple sclerosis and graft versus host disease.

Dr. Paidas is the lead Principal Investigator of a multicenter preeclampsia treatment clinical trial, entitled Prospective Randomized Double-Blind, Placebo Controlled Evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia (PRESERVE-1).

Dr. Paidas has expertise in prenatal ultrasound, invasive fetal diagnostic and therapeutic procedures. His academic profile includes over 500 published manuscripts, abstracts, books, chapters, presentations or courses.

Education & Training

  • MA
    Yale University, Honorary Degree (2013)
  • Fellow
    Mount Sinai Medical Center (1993)
  • Resident
    Pennsylvania Hospital (1991)
  • MD
    Tufts University School of Medicine (1987)
  • BS
    Fairfield University (1982)


  • “Preimplantation factor (PIF): a biomarker for viable embryo selection after in vitro fertilization and for pregnancy outcome.”
    Poissy, IDF, France; Athens, Attica, Greece; New Haven, CT, United States 2012
    This proposal is a multicenter study which investigates the potential role of Preimplantation Factor as a diagnostic test in two settings; namely, to predict IVF success when measured in embryo culture media, and to predict viable pregnancy and a range of placenta mediated complications.
  • Textbook: Hemostasis and Thrombosis in Obstetrics and Gynecology
    Oxford, England, United Kingdom 2011
    Blackwell Publishing, first edition, 2011. Editors: Paidas Michael J., Hossain Nazli, Shamsi Tahir, Rodger M, Langhoff-Roos Jens, Lockwood Charles J. Wiley Blackwell, Oxford, OX4 2DQ, UK
  • “NOICH study”: This study is an international study to determine the breath and experience of antenatal treatment of alloimmune thrombocytopenia.
    Leiden, South Holland, Netherlands 2008
    Research collaboration to determine the optimal management of alloimmune thrombocytopenia during pregnancy
  • Biomarkers for the detection of pregnancy complications, role of anticoagulation in the prevention of placenta mediated complications, use of recombinant factor VIIa to treat postpartum hemorrhage
    Karachi, Sindh, Pakistan 2006
    Research collaboration to investigate causes, prevention strategies and treatment regimens for pregnancy complications, especially preeclampsia and postpartum hemorrhage in a developing country
  • Adverse Pregnancy Outcome, Subsequent Cardiovascular
    Copenhagen, Capital Region, Denmark 2004
    Research collaboration to investigate risk factors for pregnancy complications and subsequent maternal health consequences
  • Multigate Doppler with Global Acquisition and Signal Processing (G.A.S.P.) in the uteroplacental, fetal circulations and gynecologic ultrasound.
    Florence, Italy; Milan, Italy 2001
    Research collaboration to develop and implement an improved, non-invasive Doppler ultrasound technique

Honors & Recognition

AwardAwarding OrganizationDate
Distinguished Alumni at 25th Class Reunion, Tufts University School of Medicine (speaker)Tufts University School of Medicine2012
Distinguished Alumni at 25th Class Reunion, Tufts University School of Medicine (speaker)Tufts University School of Medicine2012
US News and World Report, Top 1% Physician In Nation (by specialty)US News and World Report2012
America's Top Doctor, Castle Connolly, 11th EditionCastle Connolly2012
US News and World Report, Top 1% Physicians In NationUS News and World Report2012
New York Magazine, Best Doctors, Castle ConnollyNew York Magazine2012
Tufts Medical Alumni Association, Dean's Award, RecipientTufts University School of Medicine2012
Board of Permanent Officers, Yale University School of MedicineYale University School of Medicine2012
The David J. Leffell, M.D. Prize for Clinical Excellence at YaleYale School of Medicine2010
The National Institutes of Health and the Canadian Institutes of Health Research, 5th Annual Summer Institute in Maternal- Fetal Pharmacology, La Sapiniere, Val-David, Quebec, graduateNICHD and CIHR2009
National Faculty Award, CREOGCREOG2009
Co-Director National Hemophila Foundation - Baxter Clinical Fellowship at YaleNational Hemophilia Foundation2009
National Hemophilia FoundationMedical Advisory Board Member2009
Hemostasis and Thrombosis Research SocietyResearch Subcommittee Member (past - Board of Director)2008
Best Doctors, New York MagazineNew York Magazine2007
Flagship Referral Network Member2006
Best Doctors in AmericaBest Doctors in America2005
MemberAmerican Society of Hematology2004
The New York Obstetrical Society, FellowThe New York Obstetrical Society2000
Frontiers in Reproduction: Molecular and Cellular Concepts and Applications. Marine Biological Laboratory, Woods Hole graduateNICHD1998
Bellevue Obstetrical and Gynecological Society, MemberBellevue Obstetrical and Gynecological Society, New York University1998
Teaching AwardTufts University School of Medicine1995
Globus Award, Prize Paper for 1994The Mount Sinai Journal of Medicine1995
4th Annual NICHD Aspen Conference, participantNICHD1992
S. Leon Israel Prize Paper AwardPhiladelphia Obstetrical Society1991
Thomas R. Boggs Award - Outstanding Obstetrical Resident in Intensive Care Nursery Pennsylvania Hospital1988
Alpha Epsilon Delta, TreasurerAlpha Epsilon Delta, Fairfield University1982
Headmaster’s Scholarship, Fairfield UniversityFairfield University1978

Professional Service

National Heart, Lung, and Blood Institute Special Emphasis Panel“Pregnancy Outcomes as Predictors of Cardiovascular Disease Risk Factors” April 16, 20132013 - Present
Society for Maternal Fetal Medicine and American College of Obstetrician GynecologistsSociety for Maternal Fetal Medicine and American College of Obsetrician Gynecologists Working Group for Deep Venous Thrombosis Prevention Patient Safety Bundle. 61st Annual Clinical Meeting, The American College of Obstetricians and Gynecologists2013 - Present
NIH/NIHLBIWorking Group on Mechanistic Perspectives on Hormone-Induced Thrombosis in Women, sponsored by NIH/NIHLBI. Presenter. Sept 13-14, 20122012 - Present
NHLBI WorkshopParticipant, NHLBI Workshop: Bridging Preeclampsia and Future Cardiovascular Disease. Sponsored by Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute. September 16-17, 2010. 6701 Rockledge Drive, Bethesda, MD, Room 100912010 - Present
Society for Maternal Fetal MedicineContributor2009 - Present
Yale Womena and Children's Center for Blood DisordersMentor for Pietro Barretta, 4th year medical student, Univ. Milan, Bicocca. Thesis: Multigate Doppler and Prediction of Adverse Pregnancy Outcome.2008
National Institutes of HealthNational Institutes of Health, invited member of a voluntary registry for reviewers2008 - Present
Yale Women and Children’s Center for Blood DisordersMentor for Jacob Lykke, M.D., Ph.D candidate, Yale Women and Children’s Center for Blood Disorders Department of Obstetrics, Gynecology and Reproductive Sciences Yale University School of Medicine. Thesis dissertation: ‘Adverse outcome and subsequent cardiovascular disease’ 2007 - 2008
International Stillbirth AllianceScientific Advisory Committee, member, International Stillbirth Alliance 2007 - Present
American College of Obstetricians and GynecologistsAmerican College of Obstetricians and Gynecologists: Task force on Pulmonary Embolism in Pregnancy, Representative 2007 - Present
Yale Women and Children’s Center for Blood DisordersMentor for Nazli Hossain, MBBS, FCPS, Visiting Associate Professor Yale Women and Children’s Center for Blood Disorders 2006 - 2007
Society for Gynecologic InvestigationSociety for Gynecologic Investigation, Member2006 - Present
Department of Obstetrics, Gynecology, Reproductive Sciences, YaleMentor for Gabriele Urban, M.D., from Department of Obstetrics and Gynecology at the University of Milano Bicocca, Italy, as Visiting Research Fellow 2005 - 2006
Canadian Institutes of Health ResearchRandomized Controlled Trials Committee, CIHR (Canadian Institutes of Health Research), Invited Reviewer 2005 - Present
Center for Disease ControlRare Bleeding Disorder Committee, Centers for Disease Control, member 2003 - 2013
Centers for Disease ControlFetal and Infant Mortality Review (FIMR) of Greater New Haven, member 2003 - Present
New Haven Obstetrical SocietyNew Haven Obstetrical Society, Member2002 - 2014
Yale Women and Children's Center for Bood DisordersAnnual Summer High School Scholars Program at Yale Women and Children's Center for Bood Disorders2002 - Present
American Institute of Ultrasound in MedicineAmerican Institute of Ultrasound in Medicine1996 - 2014
Society for Maternal Fetal MedicineSociety for Maternal Fetal Medicine, Member1991 - 2014
American College of Obstetricians and Gynecologists,American College of Obstetricians and Gynecologists, Fellow1988 - 2014