Publications

2023

Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer.de Miguel FJ, Gentile C, Feng WW, Silva SJ, Sankar A, Exposito F, Cai WL, Melnick MA, Robles-Oteiza C, Hinkley MM, Tsai JA, Hartley AV, Wei J, Wurtz A, Li F, Toki MI, Rimm DL, Homer R, Wilen CB, Xiao AZ, Qi J, Yan Q, Nguyen DX, Jänne PA, Kadoch C, Politi KA. Cancer Cell. 2023 Aug 14; 2023 Aug 3. PMID: 37541244.
The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression.Wei J, Alfajaro MM, Cai WL, Graziano VR, Strine MS, Filler RB, Biering SB, Sarnik SA, Patel S, Menasche BL, Compton SR, Konermann S, Hsu PD, Orchard RC, Yan Q, Wilen CB. PLoS Pathog. 2023 Jul; 2023 Jul 6. PMID: 37410700.
Design of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexes.Zahid H, Costello JP, Li Y, Kimbrough JR, Actis M, Rankovic Z, Yan Q, Pomerantz WCK. ACS Chem Biol. 2023 Jun 16; 2023 Jun 1. PMID: 37260298.
DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner.Strine MS, Cai WL, Wei J, Alfajaro MM, Filler RB, Biering SB, Sarnik S, Chow RD, Patil A, Cervantes KS, Collings CK, DeWeirdt PC, Hanna RE, Schofield K, Hulme C, Konermann S, Doench JG, Hsu PD, Kadoch C, Yan Q, Wilen CB. PLoS Biol. 2023 Jun; 2023 Jun 13. PMID: 37310920.
Epigenetic markers and therapeutic targets for metastasis.Kravitz CJ, Yan Q, Nguyen DX. Cancer Metastasis Rev. 2023 Jun; 2023 Jun 7. PMID: 37286865.
The Crossroads of Cancer Epigenetics and Immune Checkpoint Therapy.Micevic G, Bosenberg MW, Yan Q. Clin Cancer Res. 2023 Apr 3. PMID: 36449280.
Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection.Wei J, Patil A, Collings CK, Alfajaro MM, Liang Y, Cai WL, Strine MS, Filler RB, DeWeirdt PC, Hanna RE, Menasche BL, Ökten A, Peña-Hernández MA, Klein J, McNamara A, Rosales R, McGovern BL, Luis Rodriguez M, García-Sastre A, White KM, Qin Y, Doench JG, Yan Q, Iwasaki A, Zwaka TP, Qi J, Kadoch C, Wilen CB. Nat Genet. 2023 Mar; 2023 Mar 9. PMID: 36894709.
KDM5 Lysine Demethylases in Pathogenesis, from Basic Science Discovery to the Clinic.Zhang SM, Cao J, Yan Q. Adv Exp Med Biol. 2023. PMID: 37751138.
Lysine Demethylation in Pathogenesis.Cao J, Yan Q. Adv Exp Med Biol. 2023. PMID: 37751133.
Epigenetically suppressed tumor cell intrinsic STING promotes tumor immune escape.Zheng H, Wu L, Xiao Q, Meng X, Hafiz A, Yan Q, Lu R, Cao J. Biomed Pharmacother. 2023 Jan; 2022 Nov 24. PMID: 36436495.

2022

Histone H3 proline 16 hydroxylation regulates mammalian gene expression.Liu X, Wang J, Boyer JA, Gong W, Zhao S, Xie L, Wu Q, Zhang C, Jain K, Guo Y, Rodriguez J, Li M, Uryu H, Liao C, Hu L, Zhou J, Shi X, Tsai YH, Yan Q, Luo W, Chen X, Strahl BD, von Kriegsheim A, Zhang Q, Wang GG, Baldwin AS, Zhang Q. Nat Genet. 2022 Nov; 2022 Nov 8. PMID: 36347944.
Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation.Cai WL, Chen JF, Chen H, Wingrove E, Kurley SJ, Chan LH, Zhang M, Arnal-Estape A, Zhao M, Balabaki A, Li W, Yu X, Krop ED, Dou Y, Liu Y, Jin J, Westbrook TF, Nguyen DX, Yan Q. Elife. 2022 Aug 31; 2022 Aug 31. PMID: 36043466.
Nicotine dose-dependent epigenomic-wide DNA methylation changes in the mice with long-term electronic cigarette exposure.Peng G, Xi Y, Bellini C, Pham K, Zhuang ZW, Yan Q, Jia M, Wang G, Lu L, Tang MS, Zhao H, Wang H. Am J Cancer Res. 2022; 2022 Aug 15. PMID: 36119846.
Author Correction: Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis.Farshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Nat Commun. 2022 May 10; 2022 May 10. PMID: 35538087.
Editorial: Epigenetic Regulation and Tumor Immunotherapy.Sun H, Huang B, Cao J, Yan Q, Yin M. Front Oncol. 2022; 2022 May 5. PMID: 35600405.
Awakening KDM5B to defeat leukemia.Chan LH, Yan Q. Proc Natl Acad Sci U S A. 2022 Mar 29; 2022 Mar 21. PMID: 35312367.
Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis.Farshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Nat Commun. 2022 Feb 23; 2022 Feb 23. PMID: 35197475.
CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression.Zhang M, Liu ZZ, Aoshima K, Cai WL, Sun H, Xu T, Zhang Y, An Y, Chen JF, Chan LH, Aoshima A, Lang SM, Tang Z, Che X, Li Y, Rutter SJ, Bossuyt V, Chen X, Morrow JS, Pusztai L, Rimm DL, Yin M, Yan Q. Sci Transl Med. 2022 Feb 2; 2022 Feb 2. PMID: 35108062.
Tick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock.Minteer C, Morselli M, Meer M, Cao J, Higgins-Chen A, Lang SM, Pellegrini M, Yan Q, Levine ME. Aging Cell. 2022 Feb; 2022 Feb 1. PMID: 35104377.

2021

MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells.Jeong J, Shin JH, Li W, Hong JY, Lim J, Hwang JY, Chung JJ, Yan Q, Liu Y, Choi J, Wysolmerski J. Cell Rep. 2021 Dec 28. PMID: 34965434.
DNA methylation markers in esophageal cancer: an emerging tool for cancer surveillance and treatment.Wang H, DeFina SM, Bajpai M, Yan Q, Yang L, Zhou Z. Am J Cancer Res. 2021; 2021 Nov 15. PMID: 34873485.
KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements.Zhang SM, Cai WL, Liu X, Thakral D, Luo J, Chan LH, McGeary MK, Song E, Blenman KRM, Micevic G, Jessel S, Zhang Y, Yin M, Booth CJ, Jilaveanu LB, Damsky W, Sznol M, Kluger HM, Iwasaki A, Bosenberg MW, Yan Q. Nature. 2021 Oct; 2021 Oct 20. PMID: 34671158.
The roles of epigenetics in cancer progression and metastasis.Chen JF, Yan Q. Biochem J. 2021 Sep 17. PMID: 34520519.
KDM2B promotes cell viability by enhancing DNA damage response in canine hemangiosarcoma.Gulay KCM, Aoshima K, Shibata Y, Yasui H, Yan Q, Kobayashi A, Kimura T. J Genet Genomics. 2021 Jul 20; 2021 Mar 10. PMID: 34023294.
5-Fluorouracil efficacy requires anti-tumor immunity triggered by cancer-cell-intrinsic STING.Tian J, Zhang D, Kurbatov V, Wang Q, Wang Y, Fang D, Wu L, Bosenberg M, Muzumdar MD, Khan S, Lu Q, Yan Q, Lu J. EMBO J. 2021 Apr 1; 2021 Feb 22. PMID: 33615517.
Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.Wei J, Alfajaro MM, DeWeirdt PC, Hanna RE, Lu-Culligan WJ, Cai WL, Strine MS, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Ravindra NG, Gasque V, de Miguel FJ, Patil A, Chen H, Oguntuyo KY, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach BD, Politi K, van Dijk D, Kadoch C, Simon MD, Yan Q, Doench JG, Wilen CB. Cell. 2021 Jan 7; 2020 Oct 20. PMID: 33147444.

2020

KDM5B Is Essential for the Hyperactivation of PI3K/AKT Signaling in Prostate Tumorigenesis.Li G, Kanagasabai T, Lu W, Zou MR, Zhang SM, Celada SI, Izban MG, Liu Q, Lu T, Ballard BR, Zhou X, Adunyah SE, Matusik RJ, Yan Q, Chen Z. Cancer Res. 2020 Nov 1; 2020 Aug 31. PMID: 32868382.
Multi-Omics Investigation of Innate Navitoclax Resistance in Triple-Negative Breast Cancer Cells.Marczyk M, Patwardhan GA, Zhao J, Qu R, Li X, Wali VB, Gupta AK, Pillai MM, Kluger Y, Yan Q, Hatzis C, Pusztai L, Gunasekharan V. Cancers (Basel). 2020 Sep 8; 2020 Sep 8. PMID: 32911681.
Cancer Epigenetics, Tumor Immunity, and Immunotherapy.Cao J, Yan Q. Trends Cancer. 2020 Jul; 2020 Mar 31. PMID: 32610068.
Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection.Wei J, Alfajaro MM, Hanna RE, DeWeirdt PC, Strine MS, Lu-Culligan WJ, Zhang SM, Graziano VR, Schmitz CO, Chen JS, Mankowski MC, Filler RB, Gasque V, de Miguel F, Chen H, Oguntuyo K, Abriola L, Surovtseva YV, Orchard RC, Lee B, Lindenbach B, Politi K, van Dijk D, Simon MD, Yan Q, Doench JG, Wilen CB. bioRxiv. 2020 Jun 17; 2020 Jun 17. PMID: 32869025.
Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction.Yin M, Guo Y, Hu R, Cai WL, Li Y, Pei S, Sun H, Peng C, Li J, Ye R, Yang Q, Wang N, Tao Y, Chen X, Yan Q. Nat Commun. 2020 Apr 14; 2020 Apr 14. PMID: 32286255.
Correction to: Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA.Wang M, Mao C, Ouyang L, Liu Y, Lai W, Liu N, Shi Y, Chen L, Xiao D, Yu F, Wang X, Zhou H, Cao Y, Liu S, Yan Q, Tao Y, Zhang B. Cell Death Differ. 2020 Apr. PMID: 31383984.
Specific chromatin landscapes and transcription factors couple breast cancer subtype with metastatic relapse to lung or brain.Cai WL, Greer CB, Chen JF, Arnal-Estapé A, Cao J, Yan Q, Nguyen DX. BMC Med Genomics. 2020 Mar 6; 2020 Mar 6. PMID: 32143622.
Annotation and cluster analysis of long noncoding RNA linked to male sex and estrogen in cancers.Liu S, Lai W, Shi Y, Liu N, Ouyang L, Zhang Z, Chen L, Wang X, Qian B, Xiao D, Yan Q, Cao Y, Liu S, Tao Y. NPJ Precis Oncol. 2020; 2020 Mar 3. PMID: 32195358.
Cancer progression is mediated by proline catabolism in non-small cell lung cancer.Liu Y, Mao C, Wang M, Liu N, Ouyang L, Liu S, Tang H, Cao Y, Liu S, Wang X, Xiao D, Chen C, Shi Y, Yan Q, Tao Y. Oncogene. 2020 Mar; 2020 Jan 7. PMID: 31911619.
Acquired Resistance to HER2-Targeted Therapies Creates Vulnerability to ATP Synthase Inhibition.Gale M, Li Y, Cao J, Liu ZZ, Holmbeck MA, Zhang M, Lang SM, Wu L, Do Carmo M, Gupta S, Aoshima K, DiGiovanna MP, Stern DF, Rimm DL, Shadel GS, Chen X, Yan Q. Cancer Res. 2020 Feb 1; 2019 Nov 5. PMID: 31690671.

2019

PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth.Cai W, Su L, Liao L, Liu ZZ, Langbein L, Dulaimi E, Testa JR, Uzzo RG, Zhong Z, Jiang W, Yan Q, Zhang Q, Yang H. Nat Commun. 2019 Dec 20; 2019 Dec 20. PMID: 31863007.
Mitochondrial DNA Stress Signalling Protects the Nuclear Genome.Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS. Nat Metab. 2019 Dec; 2019 Dec 9. PMID: 32395698.
Oxygen sensing and adaptability won the 2019 Nobel Prize in Physiology or medicine.Zhang Q, Yan Q, Yang H, Wei W. Genes Dis. 2019 Dec; 2019 Oct 19. PMID: 31832511.
GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH.Yang R, Liu N, Chen L, Jiang Y, Shi Y, Mao C, Liu Y, Wang M, Lai W, Tang H, Gao M, Xiao D, Wang X, Zhou H, Tang CE, Liu W, Yu F, Cao Y, Yan Q, Liu S, Tao Y. Oncogene. 2019 Nov; 2019 Aug 15. PMID: 31417184.
Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA.Wang M, Mao C, Ouyang L, Liu Y, Lai W, Liu N, Shi Y, Chen L, Xiao D, Yu F, Wang X, Zhou H, Cao Y, Liu S, Yan Q, Tao Y, Zhang B. Cell Death Differ. 2019 Nov; 2019 Feb 20. PMID: 30787392.
Identification and Validation of a Novel Biologics Target in Triple Negative Breast Cancer.Wali VB, Patwardhan GA, Pelekanou V, Karn T, Cao J, Ocana A, Yan Q, Nelson B, Hatzis C, Pusztai L. Sci Rep. 2019 Oct 17; 2019 Oct 17. PMID: 31624295.
LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer.Yang R, Liu N, Chen L, Jiang Y, Shi Y, Mao C, Liu Y, Wang M, Lai W, Tang H, Gao M, Xiao D, Wang X, Yu F, Cao Y, Yan Q, Liu S, Tao Y. J Exp Clin Cancer Res. 2019 Jun 28; 2019 Jun 28. PMID: 31253190.
Neuronal calcium sensor 1 (NCS1) promotes motility and metastatic spread of breast cancer cells in vitro and in vivo.Apasu JE, Schuette D, LaRanger R, Steinle JA, Nguyen LD, Grosshans HK, Zhang M, Cai WL, Yan Q, Robert ME, Mak M, Ehrlich BE. FASEB J. 2019 Apr; 2018 Dec 28. PMID: 30592625.
High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1.Liao L, Alicea-Velázquez NL, Langbein L, Niu X, Cai W, Cho EA, Zhang M, Greer CB, Yan Q, Cosgrove MS, Yang H. Mol Oncol. 2019 Apr; 2019 Feb 2. PMID: 30585695.
KDM5B Promotes Drug Resistance by Regulating Melanoma-Propagating Cell Subpopulations.Liu X, Zhang SM, McGeary MK, Krykbaeva I, Lai L, Jansen DJ, Kales SC, Simeonov A, Hall MD, Kelly DP, Bosenberg MW, Yan Q. Mol Cancer Ther. 2019 Mar; 2018 Dec 6. PMID: 30523048.

2018

KDM5A Regulates a Translational Program that Controls p53 Protein Expression.Hu D, Jablonowski C, Cheng PH, AlTahan A, Li C, Wang Y, Palmer L, Lan C, Sun B, Abu-Zaid A, Fan Y, Brimble M, Gamboa NT, Kumbhar RC, Yanishevski D, Miller KM, Kang G, Zambetti GP, Chen T, Yan Q, Davidoff AM, Yang J. iScience. 2018 Nov 30; 2018 Oct 17. PMID: 30388705.
Immunological differences between primary and metastatic breast cancer.Szekely B, Bossuyt V, Li X, Wali VB, Patwardhan GA, Frederick C, Silber A, Park T, Harigopal M, Pelekanou V, Zhang M, Yan Q, Rimm DL, Bianchini G, Hatzis C, Pusztai L. Ann Oncol. 2018 Nov 1. PMID: 30203045.
Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer.Liao L, Liu ZZ, Langbein L, Cai W, Cho EA, Na J, Niu X, Jiang W, Zhong Z, Cai WL, Jagannathan G, Dulaimi E, Testa JR, Uzzo RG, Wang Y, Stark GR, Sun J, Peiper S, Xu Y, Yan Q, Yang H. Elife. 2018 Oct 25; 2018 Oct 25. PMID: 30355451.
KDM5 histone demethylases repress immune response via suppression of STING.Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q. PLoS Biol. 2018 Aug; 2018 Aug 6. PMID: 30080846.
The multiplexed CRISPR targeting platforms.Cao J, Xiao Q, Yan Q. Drug Discov Today Technol. 2018 Aug; 2018 Feb 4. PMID: 30205881.
Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Pohida K, Fang Y, Hu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Yan Q, Cheng X. J Med Chem. 2018 Apr 12; 2018 Mar 23. PMID: 29537847.

2017

High-Throughput Deep Sequencing for Mapping Mammalian DNA Methylation.Lizardi PM, Yan Q, Wajapeyee N. Cold Spring Harb Protoc. 2017 Dec 1; 2017 Dec 1. PMID: 27852842.
Methyl-Cytosine-Based Immunoprecipitation for DNA Methylation Analysis.Lizardi PM, Yan Q, Wajapeyee N. Cold Spring Harb Protoc. 2017 Dec 1; 2017 Dec 1. PMID: 27852840.
Analysis of DNA Methylation in Mammalian Cells.Lizardi PM, Yan Q, Wajapeyee N. Cold Spring Harb Protoc. 2017 Dec 1; 2017 Dec 1. PMID: 27852839.
Methylation-Specific Polymerase Chain Reaction (PCR) for Gene-Specific DNA Methylation Detection.Lizardi PM, Yan Q, Wajapeyee N. Cold Spring Harb Protoc. 2017 Dec 1; 2017 Dec 1. PMID: 27852838.
DNA Bisulfite Sequencing for Single-Nucleotide-Resolution DNA Methylation Detection.Lizardi PM, Yan Q, Wajapeyee N. Cold Spring Harb Protoc. 2017 Nov 1; 2017 Nov 1. PMID: 27852843.
Illumina Sequencing of Bisulfite-Converted DNA Libraries.Lizardi PM, Yan Q, Wajapeyee N. Cold Spring Harb Protoc. 2017 Nov 1; 2017 Nov 1. PMID: 27852841.
Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis.Zheng C, Wang Y, Yang L, Zhou S, Gao Y, Li F, Feng Y, Wang Z, Zhan L, Yan Q, Zhu X, Wong KK, Chen Z, Ji H. Sci Rep. 2017 Sep 4; 2017 Sep 4. PMID: 28871124.
EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes.Jiang Y, Mao C, Yang R, Yan B, Shi Y, Liu X, Lai W, Liu Y, Wang X, Xiao D, Zhou H, Cheng Y, Yu F, Cao Y, Liu S, Yan Q, Tao Y. Theranostics. 2017; 2017 Jul 23. PMID: 28900510.
The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation.Brier AB, Loft A, Madsen JGS, Rosengren T, Nielsen R, Schmidt SF, Liu Z, Yan Q, Gronemeyer H, Mandrup S. Nucleic Acids Res. 2017 Feb 28. PMID: 27899593.

2016

KDM5 lysine demethylases are involved in maintenance of 3'UTR length.Blair LP, Liu Z, Labitigan RL, Wu L, Zheng D, Xia Z, Pearson EL, Nazeer FI, Cao J, Lang SM, Rines RJ, Mackintosh SG, Moore CL, Li W, Tian B, Tackett AJ, Yan Q. Sci Adv. 2016 Nov; 2016 Nov 18. PMID: 28138513.
An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting.Cao J, Wu L, Zhang SM, Lu M, Cheung WK, Cai W, Gale M, Xu Q, Yan Q. Nucleic Acids Res. 2016 Nov 2; 2016 Jul 25. PMID: 27458201.
Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.Horton JR, Liu X, Gale M, Wu L, Shanks JR, Zhang X, Webber PJ, Bell JSK, Kales SC, Mott BT, Rai G, Jansen DJ, Henderson MJ, Urban DJ, Hall MD, Simeonov A, Maloney DJ, Johns MA, Fu H, Jadhav A, Vertino PM, Yan Q, Cheng X. Cell Chem Biol. 2016 Jul 21; 2016 Jul 14. PMID: 27427228.
Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance.Gale M, Sayegh J, Cao J, Norcia M, Gareiss P, Hoyer D, Merkel JS, Yan Q. Oncotarget. 2016 Jun 28. PMID: 27224921.

2015

High-throughput screening to identify inhibitors of lysine demethylases.Gale M, Yan Q. Epigenomics. 2015. PMID: 25687466.

2014

Significance of glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway.Colavito SA, Zou MR, Yan Q, Nguyen DX, Stern DF. Breast Cancer Res. 2014 Sep 25; 2014 Sep 25. PMID: 25252859.
Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes.Zou MR, Cao J, Liu Z, Huh SJ, Polyak K, Yan Q. J Biol Chem. 2014 Jun 20; 2014 May 6. PMID: 24802759.
Histone demethylase RBP2 is critical for breast cancer progression and metastasis.Cao J, Liu Z, Cheung WK, Zhao M, Chen SY, Chan SW, Booth CJ, Nguyen DX, Yan Q. Cell Rep. 2014 Mar 13; 2014 Feb 27. PMID: 24582965.

2013

Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis.Teng YC, Lee CF, Li YS, Chen YR, Hsiao PW, Chan MY, Lin FM, Huang HD, Chen YT, Jeng YM, Hsu CH, Yan Q, Tsai MD, Juan LJ. Cancer Res. 2013 Aug 1; 2013 May 30. PMID: 23722541.
Histone demethylases set the stage for cancer metastasis.Cao J, Yan Q. Sci Signal. 2013 Apr 30; 2013 Apr 30. PMID: 23633674.
Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.Sayegh J, Cao J, Zou MR, Morales A, Blair LP, Norcia M, Hoyer D, Tackett AJ, Merkel JS, Yan Q. J Biol Chem. 2013 Mar 29; 2013 Feb 13. PMID: 23408432.

2012

Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation.Beshiri ML, Holmes KB, Richter WF, Hess S, Islam AB, Yan Q, Plante L, Litovchick L, Gévry N, Lopez-Bigas N, Kaelin WG Jr, Benevolenskaya EV. Proc Natl Acad Sci U S A. 2012 Nov 6; 2012 Oct 23. PMID: 23093672.
Epigenetic mechanisms in commonly occurring cancers.Blair LP, Yan Q. DNA Cell Biol. 2012 Oct; 2012 Apr 20. PMID: 22519822.
Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer.Cao J, Yan Q. Front Oncol. 2012; 2012 Mar 12. PMID: 22649782.
The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C.Niu X, Zhang T, Liao L, Zhou L, Lindner DJ, Zhou M, Rini B, Yan Q, Yang H. Oncogene. 2012 Feb 9; 2011 Jul 4. PMID: 21725364.

2011

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG Jr, Yan Q. Proc Natl Acad Sci U S A. 2011 Aug 16; 2011 Jul 25. PMID: 21788502.
Epigenetic Regulation by Lysine Demethylase 5 (KDM5) Enzymes in Cancer.Blair LP, Cao J, Zou MR, Sayegh J, Yan Q. Cancers (Basel). 2011 Mar 1. PMID: 21544224.

2010

Exploiting cellular senescence to treat cancer and circumvent drug resistance.Yan Q, Wajapeyee N. Cancer Biol Ther. 2010 Feb; 2010 Feb 11. PMID: 20118655.

2008

A role for mammalian Sin3 in permanent gene silencing.van Oevelen C, Wang J, Asp P, Yan Q, Kaelin WG Jr, Kluger Y, Dynlacht BD. Mol Cell. 2008 Nov 7. PMID: 18995834.

2007

pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2.Yang H, Minamishima YA, Yan Q, Schlisio S, Ebert BL, Zhang X, Zhang L, Kim WY, Olumi AF, Kaelin WG Jr. Mol Cell. 2007 Oct 12. PMID: 17936701.
Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.Li L, Zhang L, Zhang X, Yan Q, Minamishima YA, Olumi AF, Mao M, Bartz S, Kaelin WG Jr. Mol Cell Biol. 2007 Aug; 2007 May 25. PMID: 17526729.
The retinoblastoma binding protein RBP2 is an H3K4 demethylase.Klose RJ, Yan Q, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG, Zhang Y, Kaelin WG Jr. Cell. 2007 Mar 9; 2007 Feb 22. PMID: 17320163.
The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo.Yan Q, Bartz S, Mao M, Li L, Kaelin WG Jr. Mol Cell Biol. 2007 Mar; 2007 Jan 12. PMID: 17220275.

2004

Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53.Blanchette P, Cheng CY, Yan Q, Ketner G, Ornelles DA, Dobner T, Conaway RC, Conaway JW, Branton PE. Mol Cell Biol. 2004 Nov. PMID: 15485928.
Identification of Elongin C and Skp1 sequences that determine Cullin selection.Yan Q, Kamura T, Cai Y, Jin J, Ivan M, Mushegian A, Conaway RC, Conaway JW. J Biol Chem. 2004 Oct 8; 2004 Jul 27. PMID: 15280393.

2001

Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex.Querido E, Blanchette P, Yan Q, Kamura T, Morrison M, Boivin D, Kaelin WG, Conaway RC, Conaway JW, Branton PE. Genes Dev. 2001 Dec 1. PMID: 11731475.
Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW. J Biol Chem. 2001 Aug 10; 2001 May 30. PMID: 11384984.
Transcription factors TFIIF, ELL, and Elongin negatively regulate SII-induced nascent transcript cleavage by non-arrested RNA polymerase II elongation intermediates.Elmendorf BJ, Shilatifard A, Yan Q, Conaway JW, Conaway RC. J Biol Chem. 2001 Jun 22; 2001 Mar 19. PMID: 11259417.

1999

Dual roles for transcription factor IIF in promoter escape by RNA polymerase II.Yan Q, Moreland RJ, Conaway JW, Conaway RC. J Biol Chem. 1999 Dec 10. PMID: 10585446.
The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2.Kamura T, Conrad MN, Yan Q, Conaway RC, Conaway JW. Genes Dev. 1999 Nov 15. PMID: 10579999.
A role for the TFIIH XPB DNA helicase in promoter escape by RNA polymerase II.Moreland RJ, Tirode F, Yan Q, Conaway JW, Egly JM, Conaway RC. J Biol Chem. 1999 Aug 6. PMID: 10428772.

1998

Mechanism of promoter escape by RNA polymerase II.Conaway JW, Dvir A, Moreland RJ, Yan Q, Elmendorf BJ, Tan S, Conaway RC. Cold Spring Harb Symp Quant Biol. 1998. PMID: 10384300.