2024
Therapeutic nanobodies against SARS-CoV-2 and other pathogenic human coronaviruses
Yang Y, Li F, Du L. Therapeutic nanobodies against SARS-CoV-2 and other pathogenic human coronaviruses. Journal Of Nanobiotechnology 2024, 22: 304. PMID: 38822339, PMCID: PMC11140877, DOI: 10.1186/s12951-024-02573-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, NeutralizingAntibodies, ViralBetacoronavirusCoronavirus InfectionsCOVID-19HumansMiddle East Respiratory Syndrome CoronavirusPandemicsPneumonia, ViralSARS-CoV-2Severe acute respiratory syndrome-related coronavirusSingle-Domain AntibodiesSpike Glycoprotein, CoronavirusVirus InternalizationConceptsReceptor-binding domainPathogenic human CoVsHeavy-chain antibodiesSARS-CoV-2Development of nanobiotechnologiesPathogenic human coronavirusesSingle-domain antibodiesSARS-CoV-2 variantsS proteinViral entry processHuman CoVsViral spikeReemerging pathogensEvaluation of therapeutic agentsSARS-CoVVirus pathogenesisVariable domainsNanobodiesViral structuresPandemic potentialMERS-CoVPathogenic coronavirusesViral entryBinding affinityHuman coronaviruses
2023
Structural basis for translation inhibition by MERS-CoV Nsp1 reveals a conserved mechanism for betacoronaviruses
Devarkar S, Vetick M, Balaji S, Lomakin I, Yang L, Jin D, Gilbert W, Chen S, Xiong Y. Structural basis for translation inhibition by MERS-CoV Nsp1 reveals a conserved mechanism for betacoronaviruses. Cell Reports 2023, 42: 113156. PMID: 37733586, DOI: 10.1016/j.celrep.2023.113156.Peer-Reviewed Original ResearchMeSH KeywordsHumansMiddle East Respiratory Syndrome CoronavirusRNA, MessengerSARS-CoV-2Severe acute respiratory syndrome-related coronavirusViral Nonstructural ProteinsConceptsMERS-CoV nsp1Translation inhibitionRibosomal subunitΒ-CoVsModest sequence conservationMRNA entry channelEssential pathogenicity factorHost gene expressionHuman 40S ribosomal subunitSARS-CoV-2 nsp1Cryogenic electron microscopySequence conservationNon-structural protein 1Terminal domainPathogenicity factorsStructural basisGene expressionDevelopment of antiviralsNSP1Entry channelProtein 1Potential therapeutic targetSubunitsExtensive interactionsTherapeutic targetDYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner
Strine M, Cai W, Wei J, Alfajaro M, Filler R, Biering S, Sarnik S, Chow R, Patil A, Cervantes K, Collings C, DeWeirdt P, Hanna R, Schofield K, Hulme C, Konermann S, Doench J, Hsu P, Kadoch C, Yan Q, Wilen C. DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner. PLOS Biology 2023, 21: e3002097. PMID: 37310920, PMCID: PMC10263356, DOI: 10.1371/journal.pbio.3002097.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin-Converting Enzyme 2AnimalsCOVID-19Dipeptidyl Peptidase 4HumansMiddle East Respiratory Syndrome CoronavirusSARS-CoV-2Severe acute respiratory syndrome-related coronavirusVirus InternalizationConceptsGenome-wide CRISPR/Cas9 screenCRISPR/Cas9 screenPathogenic human coronavirusesKinase-independent mannerRegulated kinase 1AProviral host factorNovel drug targetsMultiple cell typesDNA accessibilityHost factorsKinase functionHuman coronavirusesHost genesDistal enhancerNovel regulatorCas9 screenKinase 1AGene expressionNeuronal developmentDYRK1ADrug targetsDiverse coronavirusesProviral activityCell typesSevere acute respiratory syndrome coronavirus 2
2022
A strategy to assess spillover risk of bat SARS-related coronaviruses in Southeast Asia
Sánchez C, Li H, Phelps K, Zambrana-Torrelio C, Wang L, Zhou P, Shi Z, Olival K, Daszak P. A strategy to assess spillover risk of bat SARS-related coronaviruses in Southeast Asia. Nature Communications 2022, 13: 4380. PMID: 35945197, PMCID: PMC9363439, DOI: 10.1038/s41467-022-31860-w.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAsia, SoutheasternChiropteraCOVID-19Evolution, MolecularHumansPhylogenySeroepidemiologic StudiesSevere acute respiratory syndrome-related coronavirus
2021
Animal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis
Zeiss CJ, Compton S, Veenhuis RT. Animal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis. ILAR Journal 2021, 62: ilab007-. PMID: 33836527, PMCID: PMC8083356, DOI: 10.1093/ilar/ilab007.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin-Converting Enzyme 2AnimalsChlorocebus aethiopsCOVID-19CricetinaeDisease Models, AnimalFerretsMiceMice, TransgenicModels, AnimalPeptidyl-Dipeptidase ARatsReceptors, VirusSARS-CoV-2Severe acute respiratory syndrome-related coronavirusConceptsSARS-CoV-2SARS-CoVViral sheddingImmune responseSpontaneous modelAnimal modelsDisease pathogenesisSARS-CoV-2 infectionCOVID-19Severe acute respiratory syndrome coronavirusAcute respiratory syndrome coronavirusChimeric SARS-CoVRole of comorbiditiesCoronavirus disease 2019 (COVID-19) pandemicShort-term immune responseWild-type miceSeverity of diseaseOrgan-specific pathologySARS-CoV-2 virusDisease 2019 pandemicAfrican green monkeysTest therapeuticsVaccine approachesNonfatal diseaseTissue involvement
2020
Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 From the Mother to the Infant
Mimouni FB, Gallagher P, Mendlovic J. Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 From the Mother to the Infant. JAMA Pediatrics 2020, 174: 1006-1006. PMID: 32687567, DOI: 10.1001/jamapediatrics.2020.2144.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusChinaCoronavirus InfectionsCOVID-19FemaleHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalMothersPandemicsPneumonia, ViralSARS-CoV-2Severe Acute Respiratory SyndromeSevere acute respiratory syndrome-related coronavirusInflammasomes and Pyroptosis as Therapeutic Targets for COVID-19
Yap JKY, Moriyama M, Iwasaki A. Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19. The Journal Of Immunology 2020, 205: ji2000513. PMID: 32493814, PMCID: PMC7343621, DOI: 10.4049/jimmunol.2000513.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsAntiviral AgentsBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentHumansImmunity, InnateInflammasomesIntercellular Signaling Peptides and ProteinsMacrophages, AlveolarPandemicsPneumonia, ViralPyroptosisSARS-CoV-2Severe acute respiratory syndrome-related coronavirusSignal TransductionConceptsSevere acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infectionSevere acute respiratory syndrome-related coronavirus 2Coronavirus disease 2019 (COVID-19) patientsSevere coronavirus disease 2019Coronavirus 2 infectionAvailable pharmaceutical agentsCoronavirus disease 2019Innate immune pathwaysClinical outcomesCoronavirus 2Inflammatory responseCellular pyroptosisDisease 2019Downstream cytokinesInflammasome activationInflammasome pathwayTherapeutic targetImmune pathwaysPromising targetPharmaceutical agentsCOVID-19PyroptosisPatientsCytokinesInflammasomeSampling bias and incorrect rooting make phylogenetic network tracing of SARS-COV-2 infections unreliable
Mavian C, Pond SK, Marini S, Magalis BR, Vandamme AM, Dellicour S, Scarpino SV, Houldcroft C, Villabona-Arenas J, Paisie TK, Trovão NS, Boucher C, Zhang Y, Scheuermann RH, Gascuel O, Lam TT, Suchard MA, Abecasis A, Wilkinson E, de Oliveira T, Bento AI, Schmidt HA, Martin D, Hadfield J, Faria N, Grubaugh ND, Neher RA, Baele G, Lemey P, Stadler T, Albert J, Crandall KA, Leitner T, Stamatakis A, Prosperi M, Salemi M. Sampling bias and incorrect rooting make phylogenetic network tracing of SARS-COV-2 infections unreliable. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 12522-12523. PMID: 32381734, PMCID: PMC7293693, DOI: 10.1073/pnas.2007295117.Peer-Reviewed Original ResearchBetacoronavirusCoronavirus InfectionsCOVID-19HumansPandemicsPhylogenyPneumonia, ViralSARS-CoV-2Selection BiasSevere acute respiratory syndrome-related coronavirusIntroduction: A New Coronavirus Emerges, This Time Causing a Pandemic
DiMaio D, Enquist L, Dermody T. Introduction: A New Coronavirus Emerges, This Time Causing a Pandemic. Annual Review Of Virology 2020, 7: 1-4. PMID: 32315256, DOI: 10.1146/annurev-vi-07-042020-100001.Peer-Reviewed Original ResearchBetacoronavirusClinical Laboratory TechniquesCommunicable Disease ControlContact TracingCoronavirus InfectionsCOVID-19COVID-19 TestingHumansInfectious Disease Incubation PeriodInformation DisseminationInternational CooperationMiddle East Respiratory Syndrome CoronavirusPandemicsPneumonia, ViralPsychological DistanceQuarantineSARS-CoV-2Severe Acute Respiratory SyndromeSevere acute respiratory syndrome-related coronavirusSeverity of Illness IndexSeasonality of Respiratory Viral Infections
Moriyama M, Hugentobler WJ, Iwasaki A. Seasonality of Respiratory Viral Infections. Annual Review Of Virology 2020, 7: 1-19. PMID: 32196426, DOI: 10.1146/annurev-virology-012420-022445.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusCoronavirus InfectionsCOVID-19HumansHumidityInfectious Disease Incubation PeriodInfluenza, HumanOrthomyxoviridaePandemicsPicornaviridae InfectionsPneumonia, ViralRespiratory Tract InfectionsRhinovirusSARS-CoV-2SeasonsSevere Acute Respiratory SyndromeSevere acute respiratory syndrome-related coronavirusSeverity of Illness IndexTemperatureConceptsRespiratory viral infectionsViral infectionSevere acute respiratory syndrome coronavirusAcute respiratory syndrome coronavirusViral respiratory infectionsAdaptive immune responsesRespiratory viral diseasesRespiratory infectionsRespiratory virusesInfluenza diseaseRespiratory tractImmune responseAnnual epidemicsHost responseInfectionMajor contributing factorViral diseasesDiseaseContributing factorVirus stabilityVirusEpidemicRecent studiesYearsHuman population
2008
Signal amplification on a DNA-tile-based biosensor with enhanced sensitivity
Lin C, Nangreave JK, Li Z, Liu Y, Yan H. Signal amplification on a DNA-tile-based biosensor with enhanced sensitivity. Nanomedicine 2008, 3: 521-528. PMID: 18694314, DOI: 10.2217/17435889.3.4.521.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateBiosensing TechniquesDNADNA, ViralNanotechnologyReproducibility of ResultsSevere acute respiratory syndrome-related coronavirusConceptsHybridization chain reactionSignal amplificationSelf-assembled DNAMultiplexed biosensingFluorescence enhancementNanomedical applicationsSensitive detectionDetection probeConfocal fluorescence microscopySignal amplifierImprovement of sensitivityDetection sensitivityOrders of magnitudeEnhanced sensitivityBiosensorBiosensingFluorescence microscopyNanoarraysSuccessful detectionReactionMicroscopyVersatilityDetection targetProbeDetection
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