Global Cyp2e1 KO (Cyp2e1−/−) strain
The Cyp2e1 KOstrain was developed and characterized by Gonzalez’s lab at NCI and backcrossed into a B6 background by Song at NIAAA (1). The Cyp2e1 KOmice appear normal but are less sensitive to acetaminophen-induced hepatotoxicities (1) and protected from ethanol-induced fatty liver and oxidative damage (2). These findings support a major role for CYP2E1 in mediating toxicant-induced liver injuries. This mouse strain represents an important animal model for the study of CYP2E1 enzyme in ethanol-associated tissue damage.
- Lee SS, Buters JT, Pineau T, Fernandez-Salguero P, Gonzalez FJ. (1996). Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem 271: 12063-7.
- Lu Y, Zhuge J, Wang X, Bai J, Cederbaum AI. (2008). Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology 47: 1483-94.