Global Aldh2 KO (Aldh2−/−) strain

The Aldh2/ strain was developed and characterized by Isse et al. (1). Thesemice are viable and fertile; they have no detectable capacity to oxidize ACA, and avoid drinking ethanol (just like the humans with the ALDH2*2 polymorphism). They also exhibit increase toxicity following ethanol administration (2) and ACA inhalation (3).

References

  1. Isse T, Oyama T, Kitagawa K, Matsuno K, Matsumoto A, Yoshida A, Nakayama K, Nakayama K, Kawamoto T. (2002). Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. Pharmacogenetics 12: 621-6.
  2. Oyama T, Kim YD, Isse T, Phuong PT, Ogawa M, Yamaguchi T, Kinaga T, Yashima Y, Kim H, Kawamoto T. (2007). A pilot study on subacute ethanol treatment of ALDH2 KO mice. J Toxicol Sci 32: 421-8.
  3. Ogawa M, Oyama T, Isse T, Saito K, Tomigahara Y, Endo Y, Kawamoto T. (2007). A comparison of covalent binding of ethanol metabolites to DNA according to Aldh2 genotype. Toxicol Lett 168: 148-54.