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Angelique Bordey, PhD

Rothberg Professor of Neurosurgery
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Additional Titles

Vice Chair of Research, Neurosurgery, Neurosurgery

About

Titles

Rothberg Professor of Neurosurgery

Vice Chair of Research, Neurosurgery, Neurosurgery

Biography

Dr. Angélique Bordey holds the rank of Professor of Neurosurgery, and Cellular & Molecular Physiology. Dr. Bordey is an active participant in teaching and training of graduate and medical students at Yale School of Medicine. Dr. Bordey is an Editor for several journals and on the advisory board of CURE epilepsy and the TSC Alliance preclinical consortium. She has served as a permanent member on several grant review committees and NIH study sections. Finally, she is a McKnight awardee and holds several federal and foundation grants as well as patents for the treatment of epilepsy.

Appointments

Education & Training

PhD
Louis Pasteur University, Neuroscience (1995)
MS
University Louis Pasteur, Neurophysiology (1992)
MS
National School of Engineering, Chemistry (1991)
Postdoctoral Fellow
University of Alabama at Birmingham

Research

Overview

Our attention has been focused on the mammalian Target of Rapamycin, mTOR. mTOR is a converging point in cell signaling, or in other terms an intracellular hub, that receives signals from diverse intracellular routes and extracellular ligands. Importantly, mTOR is dysregulated in many neurological disorders. These disorders referred to as mTORopathies include (but are not limited to) Tuberous Sclerosis Complex (TSC), autism, Alzheimer's disease, and Schizophrenia. We have focused on TSC, to better understand the circuit basis of epilepsy and autism.

Our work has the following three lines of research related to the following keywords: mTOR- Neural stem cell- Neurogenesis-Cognitive functions- mTORopathies

1. Understanding how a circuit is formed from neural stem cells to synaptic integration in health and in developmental mTORopathies.

2. Preventing the formation of brain malformations and associated neurological symptoms in TSC and other developmental mTORopathies.

3. Understanding the circuit and molecular basis of autism in TSC. For this we are developing novel rodent models of autism in TSC.

Medical Subject Headings (MeSH)

Autistic Disorder; Central Nervous System Diseases; Diseases; Nervous System Diseases; Nervous System Malformations; Neurologic Manifestations; Neurosurgery; Physiology; Stem Cells

Research at a Glance

Yale Co-Authors

Frequent collaborators of Angelique Bordey's published research.

Publications

Featured Publications

2024

2023

Academic Achievements & Community Involvement

  • honor

    Blavatnik Award

  • honor

    Scientific Innovations Award

  • honor

    NARSAD Distinguished Investigator award

  • honor

    McKnight Neuroscience of brain Disorder Award

  • activity

    Neurobiology

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