When it comes to unlocking the secrets of DNA repair, Yale Cancer Center has an armamentarium at work. In the last two years, Yale’s team has made significant advances in targeting the BRCA-dependent DNA repair axis for cancer therapy and determined that both BRCA1 and BRCA2 protein are involved in DNA repair, but they have fundamentally different mechanisms.
- February 08, 2021Source: BioRxiv
DNA nanotechnology provides a versatile and powerful tool to dissect the structure-function relationship of biomolecular machines like the nuclear pore complex (NPC), an enormous protein assembly that controls molecular traffic between the nucleus and cytoplasm. To understand how the intrinsically disordered, Phe-Gly-rich nucleoporins (FG-nups) within the NPC’s central transport channel impede the diffusion of macromolecules, Yale researchers built a DNA-origami NanoTrap. The NanoTrap comprises precisely arranged FG-nups in an NPC-like channel, which sits on a baseplate that captures macromolecules that pass through the FG network. The DNA-origami based nuclear pore mimics can now trap molecules and test how FG-nups form diffusion barriers within nanopore confinement. Published in the BioRxiv, Qi Shen leading the collaboration with Chenxiang Lin (Cell Biology & Nanobiology Institute) and Patrick Lusk (Cell Biology).
- December 14, 2020Source: BioRxiv
Small holes in the nuclear membranes lead to the recruitment of the endosomal sorting complexes required for transport (ESCRT), which seal the holes and protect the integrity of the nucleus. New work from the LusKing group has discovered that a key element of this surveillance pathway is the directly binding of a key nuclear envelope ESCRT, Chm7 to phosphatidic acid rich membranes.
- December 07, 2020Source: Yale News
Dr. Lusk and Dr. King, co-leaders of the "LusKing Lab" in the Department of Cell Biology were awarded Yale's Postdoctoral Mentoring prize for their commitment to the success of their trainees.
- October 08, 2020
Megan C. King, PhD, associate professor of cell biology and of molecular, cellular and developmental biology, and Simon Mochrie, PhD, professor of physics and of applied physics, have been named Allen Distinguished Investigators by The Paul G. Allen Frontiers Group, a division of the Allen Institute.
- October 08, 2020Source: The Paul G. Allen Frontiers Group
Collaborative projects funded by the awards will address important questions about neurodegenerative disease, nucleus biology, and protein turnover
- February 13, 2020
You might imagine a science lab looking a bit sterile and impersonal — little sunlight, masked figures in white coats pouring neon-colored liquid into beakers, all business. You might not expect to hear a science lab referred to as familial, where badminton tournaments, movie nights and barbeques are commonplace.
- October 10, 2019Source: The American Society for Cell Biology
ASCB’s Award Selection Committee has chosen Meng-meng Fu, a postdoctoral fellow at Stanford University, and David Thaller, a PhD candidate from the Lusk lab at Yale University, as the 2019 winners of the Porter Prizes for Research Excellence.
- August 30, 2019
Yale Cancer Center (YCC) is proud to announce several leadership appointments, including two new senior positions to help bolster YCC’s research mission in the coming years.
- January 17, 2019
Yale Cancer Center is proud to announce the Basser BRCA Initiative grant. The $1 million, three-year gift was awarded to YCC by the Gray Foundation to advance the next generation of cancer therapies.