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  • Albertus Magnus Cancer Research Student Science Day

    On Friday, October 28, Albertus Magnus College Professors Mark Barreuther and Rebecca Brogan brought 7 Albertus Magnus undergraduate students to Yale Cancer Center for the first Albertus Magnus Cancer Research Student Science Day.

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  • Paid Child Rearing Leave Extended

    Yale School of Medicine has extended its paid child rearing leave for eligible faculty from eight weeks to 12 weeks thanks to support from Valerie Horsley, PhD, and Megan King, PhD.

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  • How can a cytosolic autophagy machinery "eat" parts of the nucleus? New work from LusKing and Melia labs provide an answer.

    It is known that pathological protein aggregates can accumulate within the nucleus and can be cleared by a cytosolic autophagy machinery. However, the underlying mechanisms that allow the autophagosome to "see" aberrant proteins that are hidden by the double membrane of the nuclear envelope remains unknown. In a collaborative work, Sunandini Chandra, Philip Mannino and David Thaller provide compelling new evidence for an outside-in mechanism where a transmembrane cargo adaptor localizes at the outer nuclear membrane and reaches across the nuclear envelope lumen to capture the inner nuclear membrane into vesicles that can be ultimately captured by the autophagosome.

    Source: Journal of Cell Biology
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  • A DNA-origami NanoTrap for studying the diffusion barriers

    DNA nanotechnology provides a versatile and powerful tool to dissect the structure-function relationship of biomolecular machines like the nuclear pore complex (NPC), an enormous protein assembly that controls molecular traffic between the nucleus and cytoplasm. To understand how the intrinsically disordered, Phe-Gly-rich nucleoporins (FG-nups) within the NPC’s central transport channel impede the diffusion of macromolecules, Yale researchers built a DNA-origami NanoTrap. The NanoTrap comprises precisely arranged FG-nups in an NPC-like channel, which sits on a baseplate that captures macromolecules that pass through the FG network. The DNA-origami based nuclear pore mimics can now trap molecules and test how FG-nups form diffusion barriers within nanopore confinement. Published in the BioRxiv, Qi Shen leading the collaboration with Chenxiang Lin (Cell Biology & Nanobiology Institute) and Patrick Lusk (Cell Biology).

    Source: BioRxiv
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