Loss of JAK1 Function Causes G2/M Cell Cycle Defects Vulnerable to KIF18A Inhibition.
Kelley V, Baro M, Gasperi W, Ader N, Lea H, Lee H, Phoomak C, Kabeche L, King M, Contessa J. Loss of JAK1 Function Causes G2/M Cell Cycle Defects Vulnerable to KIF18A Inhibition. Cancer Research 2026 PMID: 41591363, DOI: 10.1158/0008-5472.can-25-1423.Peer-Reviewed Original Research
High-risk head-and-neck squamous cell carcinomaG2/M cell cycle arrestCell cycle arrestHead and neck squamous cell carcinomaNeck squamous cell carcinomaSensitive to radiation therapyTumor cell radioresistanceRadiation-induced mitotic catastropheSquamous cell carcinomaRadiation-induced micronucleiCycle arrestNF-kB signalingRadiation therapyRadiotherapy responseCell carcinomaTherapeutic radiationDNA damageCell radioresistanceEfficacy of radiationResistance to DNA damageMitotic catastropheMitotic stressNF-kBCRISPR-Cas9 screensKinase inhibition