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Farida Ahangari, MD

Assistant Professor of Medicine (Pulmonary)

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Research & Publications
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Selected Publications

Noninvasive assessment of the lung inflammation-fibrosis axis by targeted imaging of CMKLR1Mannes P, Adams T, Farsijani S, Barnes C, Latoche J, Day K, Nedrow J, Ahangari F, Kaminski N, Lee J, Tavakoli S. Noninvasive assessment of the lung inflammation-fibrosis axis by targeted imaging of CMKLR1. Science Advances 2024, 10: eadm9817. PMID: 38896611, PMCID: PMC11186491, DOI: 10.1126/sciadv.adm9817.
Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis.Unterman A, Zhao A, Neumark N, Schupp J, Ahangari F, Cosme C, Sharma P, Flint J, Stein Y, Ryu C, Ishikawa G, Sumida T, Gomez J, Herazo-Maya J, Dela Cruz C, Herzog E, Kaminski N. Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2024 PMID: 38717443, DOI: 10.1164/rccm.202306-0979oc.
Single-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injuryYuan Y, Sharma L, Tang W, Raredon M, Ahangari F, Khoury J, Wu D, Niklason L, Kaminski N. Single-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injury. Physiology 2024, 39: 1314. DOI: 10.1152/physiol.2024.39.s1.1314.
Nebulizable Conjugates to Sustain Retention, Delivery, and Efficacy of Galectin-3 Inhibitory Drug TD139 in the Alveolar SpaceMarti Munoz J, Khoury J, Ahangari F, Deiuliis G, Kaminski N, Pandit A. Nebulizable Conjugates to Sustain Retention, Delivery, and Efficacy of Galectin-3 Inhibitory Drug TD139 in the Alveolar Space. 2024, a3218-a3218. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3218.
Alveolar Type 2 Cells With Impaired Proteostasis Signal to Monocyte-derived Macrophages Via a MIF/DDT-CD74 Signaling Network to Promotes Pulmonary Fibrosis in IPFKim S, Nouws J, Cooley J, Ahangari F, Leng L, Elias J, Kaminski N, Lee P, Redente E, Kang M, Sun H, Herzog E, Bucala R, Prasse A, Sauler M. Alveolar Type 2 Cells With Impaired Proteostasis Signal to Monocyte-derived Macrophages Via a MIF/DDT-CD74 Signaling Network to Promotes Pulmonary Fibrosis in IPF. 2024, a3001-a3001. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3001.
Anti-inflammatory Roles of Type I Interferon Signaling in the LungFeng J, Liu Y, Kim J, Ahangari F, Kaminski N, Bain W, Jie Z, Dela Cruz C, Sharma L. Anti-inflammatory Roles of Type I Interferon Signaling in the Lung. 2024, a6230-a6230. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6230.
VEGF-D Is Enriched in the Human Lung Microvascular Niche and Improves Vascular Integrity During Acute Lung InjuryYuan Y, Sharma L, Tang W, Raredon M, Ahangari F, Khoury J, Wu D, Niklason L, Kaminski N. VEGF-D Is Enriched in the Human Lung Microvascular Niche and Improves Vascular Integrity During Acute Lung Injury. 2024, a4694-a4694. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4694.
Profibrotic Role of GPR87 in Pulmonary FibrosisKhoury J, Ahangari F, Manning E, Justet A, barnthaler T, Adams T, Necola F, Alysandratos K, Beermann M, Kotton D, Kaminski N. Profibrotic Role of GPR87 in Pulmonary Fibrosis. 2024, a5183-a5183. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5183.
Applying Single Cell Profiling to Assess Drug Anti Fibrotic Properties in the Human Precision Cut Lung Slice Model of FibrosisJustet A, Mitash N, Pineda R, Adams T, Balayev A, Abu Hussein N, Ishizuka M, Kim H, Khoury J, Ahangari F, Yan X, Kaminski N, Koenigshoff M. Applying Single Cell Profiling to Assess Drug Anti Fibrotic Properties in the Human Precision Cut Lung Slice Model of Fibrosis. 2024, a4906-a4906. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4906.
Fibrotic cocktail treated human precision lung slices replicate the cellular diversity of the IPF lungJustet A, Pineda H, Adams T, Balayev A, Mitash N, Ishizuka M, Kim H, Khoury J, Cala-García J, Flint J, Schupp J, Ahangari F, Yan X, Rosas I, Kaminski N, Königshoff M. Fibrotic cocktail treated human precision lung slices replicate the cellular diversity of the IPF lung. Revue Des Maladies Respiratoires 2024, 41: 218. DOI: 10.1016/j.rmr.2024.01.074.
Anti-inflammatory roles of type I interferon signaling in the lungFeng J, Liu Y, Kim J, Ahangari F, Kaminski N, Bain W, Jie Z, Dela Cruz C, Sharma L. Anti-inflammatory roles of type I interferon signaling in the lung. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2024, 326: l551-l561. PMID: 38375579, DOI: 10.1152/ajplung.00353.2023.
G-coupled Protein 87 (GPR87) a Cell Surface Orphan Receptor Expressed in Aberrant Basaloid Cells in IPF Mediates LPA Induced Fibrotic Gene Expression in Human iPSC Derived Basal CellsKhoury J, Ahangari F, Barnthaler T, McDonough J, Justet A, Adams T, Schupp J, Alysandratos K, Beermann M, Kotton D, Gomez J, Kaminski N. G-coupled Protein 87 (GPR87) a Cell Surface Orphan Receptor Expressed in Aberrant Basaloid Cells in IPF Mediates LPA Induced Fibrotic Gene Expression in Human iPSC Derived Basal Cells. 2023, a6762-a6762. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6762.
Fibrotic Cocktail Treated Human Precision Lung Slices Replicate the Cellular Diversity of the IPF LungJustet A, Pineda R, Adams T, Balayev A, Mitash N, Ishizuka M, Kim H, Cala Garcia J, Flint J, Schupp J, Ahangari F, Yan X, Rosas I, Koenigshoff M. Fibrotic Cocktail Treated Human Precision Lung Slices Replicate the Cellular Diversity of the IPF Lung. 2023, a4698-a4698. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4698.
SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung FibroblastsKarampitsakos T, Galaris A, Barbayianni I, DeIuliis G, Ahangari F, Sampsonas F, Sotiropoulou V, Aidinis V, Bennett A, Herazo-Maya J, Xylourgidis N, Bakakos P, Bouros D, Kaminski N, Tzouvelekis A. SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts. Diagnostics 2023, 13: 1166. PMID: 36980473, PMCID: PMC10047203, DOI: 10.3390/diagnostics13061166.
microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosisAhangari F, Price N, Malik S, Chioccioli M, Bärnthaler T, Adams T, Kim J, Pradeep S, Ding S, Cosme C, Rose K, McDonough J, Aurelien N, Ibarra G, Omote N, Schupp J, DeIuliis G, Nunez J, Sharma L, Ryu C, Dela Cruz C, Liu X, Prasse A, Rosas I, Bahal R, Fernandez-Hernando C, Kaminski N. microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis. JCI Insight 2023, 8: e158100. PMID: 36626225, PMCID: PMC9977502, DOI: 10.1172/jci.insight.158100.
Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis.Ahangari F, Becker C, Foster DG, Chioccioli M, Nelson M, Beke K, Wang X, Justet A, Adams T, Readhead B, Meador C, Correll K, Lili LN, Roybal HM, Rose KA, Ding S, Barnthaler T, Briones N, DeIuliis G, Schupp JC, Li Q, Omote N, Aschner Y, Sharma L, Kopf KW, Magnusson B, Hicks R, Backmark A, Dela Cruz CS, Rosas I, Cousens LP, Dudley JT, Kaminski N, Downey GP. Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 1463-1479. PMID: 35998281, PMCID: PMC9757097, DOI: 10.1164/rccm.202010-3832oc.
A lung targeted miR-29 mimic as a therapy for pulmonary fibrosisChioccioli M, Roy S, Newell R, Pestano L, Dickinson B, Rigby K, Herazo-Maya J, Jenkins G, Ian S, Saini G, Johnson SR, Braybrooke R, Yu G, Sauler M, Ahangari F, Ding S, DeIuliis J, Aurelien N, Montgomery RL, Kaminski N. A lung targeted miR-29 mimic as a therapy for pulmonary fibrosis. EBioMedicine 2022, 85: 104304. PMID: 36265417, PMCID: PMC9587275, DOI: 10.1016/j.ebiom.2022.104304.
Endothelial Thrombopoietin Receptor Controls Eosinophil Trafficking in Asthma and Chronic RhinosinusitisKorde A, Haslip M, Ahangari F, Pober J, Chupp G, Manes P, Gonzalez A, Takyar S. Endothelial Thrombopoietin Receptor Controls Eosinophil Trafficking in Asthma and Chronic Rhinosinusitis. 2022, a5684-a5684. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5684.
Antifibrotic Effects of Sobetirome, a Thyroid Hormone Receptor Beta AgonistBaernthaler T, Ding S, Chioccioli M, Poli F, Justet A, Rose K, Cosme Jr. C, Adams T, Ahangari F, Rosas I, Kaminski N. Antifibrotic Effects of Sobetirome, a Thyroid Hormone Receptor Beta Agonist. 2022, a3722-a3722. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3722.
GPR87 - a G-Coupled Protein Receptor Overexpressed in Human and Murine Pulmonary Fibrosis, Localizes to Aberrant Basaloid Cells in the IPF LungKhoury J, Ahangari F, Barnthaler T, McDonough J, Kothapalli N, Adams T, Schupp J, DeIuliis G, Gomez J, Kaminski N. GPR87 - a G-Coupled Protein Receptor Overexpressed in Human and Murine Pulmonary Fibrosis, Localizes to Aberrant Basaloid Cells in the IPF Lung. 2022, a2325-a2325. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2325.
Decellularized Lung Tissue Proteomics Showed Decreased Surfactant and Increased Inflammatory Proteins in the Aged LungMcdonough J, Cosme Jr. C, Rupert C, Schupp J, Ahangari F, DeIuliis G, Yan X, Hagood J, Vanaudenaerde B, Niklason L, Hansen K, Kaminski N. Decellularized Lung Tissue Proteomics Showed Decreased Surfactant and Increased Inflammatory Proteins in the Aged Lung. 2022, a3903-a3903. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3903.
Single Nuclei RNA Sequencing of Differentially Affected Regions in IPF Lungs Suggests a Central Role of Aberrant Basaloid Cells in Disease ProgressionSchupp J, Clair G, Adams T, Mcdonough J, Flint J, Kothapalli N, De Sadeleer L, Justet A, Melchior J, Paurus V, Olson H, Deluliis G, Ahangari F, Bar-Joseph Z, Yan X, Ding J, Wuyts W, Vanaudenaerde B, Kaminski N. Single Nuclei RNA Sequencing of Differentially Affected Regions in IPF Lungs Suggests a Central Role of Aberrant Basaloid Cells in Disease Progression. 2022, a4975-a4975. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4975.
A Probabilistic Graphical Model for Understanding Cellular Dynamics in Idiopathic Pulmonary Fibrosis ProgressionDing J, Zheng Y, Schupp J, Adams T, Ahangari F, Yan X, Hasen P, Bar-Joseph Z, De Sadeleer L, Mcdonough J, Vanaudenaerde B, Wuyts W, Kaminski N. A Probabilistic Graphical Model for Understanding Cellular Dynamics in Idiopathic Pulmonary Fibrosis Progression. 2022, a4986-a4986. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4986.
Deconvolution of Spatial Transcriptomic Allows to Predict the Spatial Location of Each Cell Type of Interest in the Fibrotic LungJustet A, Adams T, Balayev A, Bärnthaler T, Cosme Jr C, Mcdonough J, Flint J, Schupp J, Zhao A, Deluliis J, Ahangari F, Yan X, Kaminski N. Deconvolution of Spatial Transcriptomic Allows to Predict the Spatial Location of Each Cell Type of Interest in the Fibrotic Lung. 2022, a4991-a4991. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4991.
Integrated Single-Cell Atlas of Endothelial Cells of the Human LungSchupp JC, Adams TS, Cosme C, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe’er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Circulation 2021, 144: 286-302. PMID: 34030460, PMCID: PMC8300155, DOI: 10.1161/circulationaha.120.052318.
RNA-Seq Reveals Antifibrotic Effects of Sobetirome in Human Lung FibroblastsRose K, Adams T, Ahangari F, Ding S, DeIuliis G, Kaminski N. RNA-Seq Reveals Antifibrotic Effects of Sobetirome in Human Lung Fibroblasts. 2021, a4247-a4247. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4247.
The Thyroid Hormone Receptor Beta Agonist Sobetirome Exerts Beneficial Effects in Pulmonary FibrosisBaernthaler T, Ahangari F, Chioccioli M, Adams T, Rose K, Ding S, Kaminski N. The Thyroid Hormone Receptor Beta Agonist Sobetirome Exerts Beneficial Effects in Pulmonary Fibrosis. 2021, a4449-a4449. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4449.
Single Cell RNA Velocity Analysis of Aberrant Basaloid Cells in Pulmonary Fibrosis Reveals Trajectory Towards an Alveolar Type I Like Cell StateSchupp J, Adams T, Ahangari F, McDonough J, DeIuliis G, Poli S, Rosas I, Yan X, Kaminski N. Single Cell RNA Velocity Analysis of Aberrant Basaloid Cells in Pulmonary Fibrosis Reveals Trajectory Towards an Alveolar Type I Like Cell State. 2021, a4350-a4350. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4350.
Single-Cell RNAseq of Aging Lungs from Nlrp3 -/- Mice Reveals Genotype- and Cell Type-Specific Effects of Aging on the Transcriptomes of Several Myeloid-Derived CellsCosme Jr. C, Adams T, Schupp J, Mcdonough J, Ahangari F, DeIuliis G, Omote N, Dixit V, Kaminski N. Single-Cell RNAseq of Aging Lungs from Nlrp3 -/- Mice Reveals Genotype- and Cell Type-Specific Effects of Aging on the Transcriptomes of Several Myeloid-Derived Cells. 2021, a4402-a4402. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4402.
Macrophage Specific Regulatory Role of miR-33 in Pulmonary FibrosisAhangari F, Chioccioli M, Malik S, Baernthaler T, Price N, Ding S, Rose K, Mcdonough J, Omote N, Schupp J, Adams T, Sharma L, DeIuliis G, Dela Cruz C, Prasse A, Bahal R, Fernandez-Hernando C, Kaminski N. Macrophage Specific Regulatory Role of miR-33 in Pulmonary Fibrosis. 2021, a4452-a4452. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4452.
Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation stateOmote N, Sakamoto K, Li Q, Schupp JC, Adams T, Ahangari F, Chioccioli M, DeIuliis G, Hashimoto N, Hasegawa Y, Kaminski N. Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state. Physiological Reports 2021, 9: e14727. PMID: 33527707, PMCID: PMC7851438, DOI: 10.14814/phy2.14727.
Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergeticsBlumental-Perry A, Jobava R, Bederman I, Degar A, Kenche H, Guan B, Pandit K, Perry N, Molyneaux N, Wu J, Prendergas E, Ye Z, Zhang J, Nelson C, Ahangari F, Krokowski D, Guttentag S, Linden P, Townsend D, Miron A, Kang M, Kaminski N, Perry Y, Hatzoglou M. Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics. Communications Biology 2020, 3: 626. PMID: 33127975, PMCID: PMC7603330, DOI: 10.1038/s42003-020-01322-4.
Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosisAdams TS, Schupp JC, Poli S, Ayaub EA, Neumark N, Ahangari F, Chu SG, Raby BA, DeIuliis G, Januszyk M, Duan Q, Arnett HA, Siddiqui A, Washko GR, Homer R, Yan X, Rosas IO, Kaminski N. Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. Science Advances 2020, 6: eaba1983. PMID: 32832599, PMCID: PMC7439502, DOI: 10.1126/sciadv.aba1983.
Long Non-Coding RNA TINCR Is a Novel Regulator of Human Bronchial Epithelial Cell DifferentiationOmote N, Sakamoto K, Li Q, Schupp J, Adams T, Ahangari F, Chioccioli M, Hashimoto N, Hasegawa Y, Kaminski N. Long Non-Coding RNA TINCR Is a Novel Regulator of Human Bronchial Epithelial Cell Differentiation. 2020, a5987-a5987. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5987.
Saracatinib Is a Potential Novel Therapeutic for Pulmonary FibrosisAhangari F, Becker C, Foster D, Chioccioli M, Nelson M, Beke K, Meador C, Wang X, Corell K, Roybal H, DeIuliis G, Rose K, Schupp J, Li Q, Adams T, Aschner Y, Lilli L, Readhead B, Cousens L, Dudley J, Kaminski N, Downey G. Saracatinib Is a Potential Novel Therapeutic for Pulmonary Fibrosis. 2020, a2784-a2784. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2784.
Single Cell Transcriptomics Reveals Novel COL15A1+ Endothelial Population in Pulmonary Fibrosis and Lung CancerSchupp J, Adams T, Ahangari F, Poli De Frias S, DeIuliis G, Yan X, Rosas I, Homer R, Kaminski N. Single Cell Transcriptomics Reveals Novel COL15A1+ Endothelial Population in Pulmonary Fibrosis and Lung Cancer. 2020, a6142-a6142. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6142.
Single-Cell RNAseq of Aging Mouse Lungs Reveals Global and Cell-Specific Inflammatory AberrationsCosme Jr. C, McDonough J, Adams T, Schupp J, Omote N, Ahangari F, DeIuliis G, Sakamoto K, Kaminski N. Single-Cell RNAseq of Aging Mouse Lungs Reveals Global and Cell-Specific Inflammatory Aberrations. 2020, a4389-a4389. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4389.
Deconvolution of Bulk RNAseq Datasets Confirms Substantial Cellular Population Shifts in the Distal Lung in IPFAdams T, Schupp J, McDonough J, Ahangari F, DeIuliis G, Yan X, Rosas I, Kaminski N. Deconvolution of Bulk RNAseq Datasets Confirms Substantial Cellular Population Shifts in the Distal Lung in IPF. 2020, a2248-a2248. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2248.
Endothelial Thrombopoietin Receptor Regulates the Severity of Type 2 Inflammation by Controlling Platelet-Eosinophil EngagementKorde A, Ahangari F, Haslip M, Chupp G, Pober J, Gonzalez A, Gomez J, Takyar S. Endothelial Thrombopoietin Receptor Regulates the Severity of Type 2 Inflammation by Controlling Platelet-Eosinophil Engagement. 2020, a7635-a7635. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7635.
An endothelial microRNA-1–regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitisKorde A, Ahangari F, Haslip M, Zhang X, Liu Q, Cohn L, Gomez JL, Chupp G, Pober JS, Gonzalez A, Takyar SS. An endothelial microRNA-1–regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis. Journal Of Allergy And Clinical Immunology 2020, 145: 550-562. PMID: 32035607, PMCID: PMC8440091, DOI: 10.1016/j.jaci.2019.10.031.
Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung ProgenitorsHurley K, Ding J, Villacorta-Martin C, Herriges MJ, Jacob A, Vedaie M, Alysandratos KD, Sun YL, Lin C, Werder RB, Huang J, Wilson AA, Mithal A, Mostoslavsky G, Oglesby I, Caballero IS, Guttentag SH, Ahangari F, Kaminski N, Rodriguez-Fraticelli A, Camargo F, Bar-Joseph Z, Kotton DN. Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors. Cell Stem Cell 2020, 26: 593-608.e8. PMID: 32004478, PMCID: PMC7469703, DOI: 10.1016/j.stem.2019.12.009.
An Endothelial-specific MicroRNA-driven Network Regulates Eosinophil Trafficking in Airway Type 2 Inflammationhttps://doi.org/10.1016/j.jaci.2019.10.031
Transcriptional regulatory model of fibrosis progression in the human lungMcDonough JE, Ahangari F, Li Q, Jain S, Verleden SE, Herazo-Maya J, Vukmirovic M, DeIuliis G, Tzouvelekis A, Tanabe N, Chu F, Yan X, Verschakelen J, Homer RJ, Manatakis DV, Zhang J, Ding J, Maes K, De Sadeleer L, Vos R, Neyrinck A, Benos PV, Bar-Joseph Z, Tantin D, Hogg JC, Vanaudenaerde BM, Wuyts WA, Kaminski N. Transcriptional regulatory model of fibrosis progression in the human lung. JCI Insight 2019, 4 PMID: 31600171, PMCID: PMC6948862, DOI: 10.1172/jci.insight.131597.
Single Cell RNA Sequencing profiles Distinct BAL Cell Subpopulations in SarcoidosisSchupp J, Adams T, Jäger B, Deluiis G, Ahangari F, Kaminski N, Prasse A. Single Cell RNA Sequencing profiles Distinct BAL Cell Subpopulations in Sarcoidosis. 2019, oa5154. DOI: 10.1183/13993003.congress-2019.oa5154.
SH2 domain-containing Phosphatase-(SHP)-2 blunts fibrotic responses through regulation of fibroblast mitochondrial metabolism and autophagyTzouvelekis A, Yu G, Ahangari F, Bennett A, Karampitsakos T, Bouros D, Bouros E, Kaminski N. SH2 domain-containing Phosphatase-(SHP)-2 blunts fibrotic responses through regulation of fibroblast mitochondrial metabolism and autophagy. 2019, pa583. DOI: 10.1183/13993003.congress-2019.pa583.
Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosisXylourgidis N, Min K, Ahangari F, Yu G, Herazo-Maya JD, Karampitsakos T, Aidinis V, Binzenhöfer L, Bouros D, Bennett AM, Kaminski N, Tzouvelekis A. Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosis. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2019, 317: l678-l689. PMID: 31483681, PMCID: PMC6879900, DOI: 10.1152/ajplung.00264.2018.
Integrating multiomics longitudinal data to reconstruct networks underlying lung developmentDing J, Ahangari F, Espinoza CR, Chhabra D, Nicola T, Yan X, Lal CV, Hagood JS, Kaminski N, Bar-Joseph Z, Ambalavanan N. Integrating multiomics longitudinal data to reconstruct networks underlying lung development. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2019, 317: l556-l568. PMID: 31432713, PMCID: PMC6879899, DOI: 10.1152/ajplung.00554.2018.
Single Cell RNA Sequencing of Human Lung Explants Identifies the Cell-Specific Contributions of Extracellular Matrix-Related Gene ExpressionPoli De Frias S, Adams T, Schupp J, Chu S, Neumark N, Ahangari F, Waskho G, Raby B, Kaminski N, Rosas I. Single Cell RNA Sequencing of Human Lung Explants Identifies the Cell-Specific Contributions of Extracellular Matrix-Related Gene Expression. 2019, a2550-a2550. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2550.
Whole Lung Single Cell RNAseq Reveals a Unique IPF-Specific Epithelial Cell PopulationSchupp J, Adams T, Neumark N, Poli De Frias S, Ahangari F, Omote N, Chioccioli M, Xylourgidis N, DeIuliis G, Chu S, Yan X, Rosas I, Kaminski N. Whole Lung Single Cell RNAseq Reveals a Unique IPF-Specific Epithelial Cell Population. 2019, a4017-a4017. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4017.
Archetype Analysis Reveals Distinct Disease-Specific Archetypes of Fibroblast and Myofibroblast Co-Occurring Within the IPF LungAdams T, Schupp J, Neumark N, Poli De Frias S, Ahangari F, DeIuliis G, Chu S, Raredon M, Yan X, Rosas I, Kaminski N. Archetype Analysis Reveals Distinct Disease-Specific Archetypes of Fibroblast and Myofibroblast Co-Occurring Within the IPF Lung. 2019, a4018-a4018. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4018.
Macrophage Programs in BAL and Lung Parenchyma of the Healthy and in IPF PatientsSchupp J, Adams T, Neumark N, Poli De Frias S, Ahangari F, DeIuliis G, Chu S, Yan X, Kaminski N, Prasse A, Rosas I. Macrophage Programs in BAL and Lung Parenchyma of the Healthy and in IPF Patients. 2019, a5247-a5247. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5247.
Alveolar and Fibroblast Foci Specific Genome-Wide Gene Expression Profiling Identifies Common Dysregulated Expression of CREB1, a Regulator Across Cell Types, in IPFVukmirovic M, Brereton C, Yan X, Xylourgidis N, Deluliis G, Woolard T, Hu B, Mihaljinec A, Homer R, Maya J, Ahangari F, Fabre A, Smart D, Conforti F, Marshall B, Alzetani A, Davies D, Richeldi L, Kaminski N, Jones M. Alveolar and Fibroblast Foci Specific Genome-Wide Gene Expression Profiling Identifies Common Dysregulated Expression of CREB1, a Regulator Across Cell Types, in IPF. 2019, a5262-a5262. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5262.
TINCR, a Long Intergenic Noncoding RNA Decreased in IPF, Is a Novel Regulator of Airway Epithelial Cell DifferentiationOmote N, Sakamoto K, Li Q, Schupp J, Adams T, Ahangari F, Chioccioli M, Xylourgidis N, DeIuliis G, Hashimoto N, Hasegawa Y, Kaminski N. TINCR, a Long Intergenic Noncoding RNA Decreased in IPF, Is a Novel Regulator of Airway Epithelial Cell Differentiation. 2019, a5406-a5406. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5406.
Profibrotic Effects of Mir-33 - Role of Autophagy and Mitochondrial Homeostasis in Macrophages, and Therapeutic ImplicationsAhangari F, Price N, Schupp J, Rose K, Ibarra G, DeIuliis G, Xylourgidis N, Prasse A, Fernandez-Hernando C, Kaminski N. Profibrotic Effects of Mir-33 - Role of Autophagy and Mitochondrial Homeostasis in Macrophages, and Therapeutic Implications. 2019, a7222-a7222. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7222.
Epigenetic Age Acceleration in Idiopathic Pulmonary FibrosisKurbanov D, Ahangari F, Xylourgidis N, McDonough J, Wuyts W, Vanaudenaerde B, Levine M, Kaminski N. Epigenetic Age Acceleration in Idiopathic Pulmonary Fibrosis. 2019, a5265-a5265. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5265.
Single Cell RNA-seq reveals ectopic and aberrant lung resident cell populations in Idiopathic Pulmonary Fibrosishttps://doi.org/10.1101/759902
Single-cell time-series mapping of cell fate trajectories reveals an expanded developmental potential for human PSC-derived distal lung progenitorshttps://doi.org/10.1101/782896
Spatial distribution of marker gene activity in the mouse lung during alveolarizationLjungberg MC, Sadi M, Wang Y, Aronow BJ, Xu Y, Kao RJ, Liu Y, Gaddis N, Ardini-Poleske ME, Umrod T, Ambalavanan N, Nicola T, Kaminski N, Ahangari F, Sontag R, Corley RA, Ansong C, Carson JP. Spatial distribution of marker gene activity in the mouse lung during alveolarization. Data In Brief 2018, 22: 365-372. PMID: 30596133, PMCID: PMC6307338, DOI: 10.1016/j.dib.2018.10.150.
WNT5A in Extracellular Vesicles. A New Frontier for Pulmonary FibrosisAhangari F, Kaminski N. WNT5A in Extracellular Vesicles. A New Frontier for Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2018, 198: 1468-1470. PMID: 30092145, DOI: 10.1164/rccm.201807-1321ed.
A role for telomere length and chromosomal damage in idiopathic pulmonary fibrosisMcDonough JE, Martens DS, Tanabe N, Ahangari F, Verleden SE, Maes K, Verleden GM, Kaminski N, Hogg JC, Nawrot TS, Wuyts WA, Vanaudenaerde BM. A role for telomere length and chromosomal damage in idiopathic pulmonary fibrosis. Respiratory Research 2018, 19: 132. PMID: 29986708, PMCID: PMC6038197, DOI: 10.1186/s12931-018-0838-4.
Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial functionYu G, Tzouvelekis A, Wang R, Herazo-Maya JD, Ibarra GH, Srivastava A, de Castro JPW, DeIuliis G, Ahangari F, Woolard T, Aurelien N, Arrojo e Drigo R, Gan Y, Graham M, Liu X, Homer RJ, Scanlan TS, Mannam P, Lee PJ, Herzog EL, Bianco AC, Kaminski N. Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Nature Medicine 2017, 24: 39-49. PMID: 29200204, PMCID: PMC5760280, DOI: 10.1038/nm.4447.
Feasibility, distribution, and efficacy of an inhaled oligonucleotide mimic of miR-29 for pulmonary fibrosis induced by bleomycin in ratsMontgomery R, Yu G, Ahangari F, Herazo-Maya J, Pestano L, Dalby C, Dickinson B, Nicholas C, Gallant-Behm C, Brower J, Kuehl P, McDonald J, Kaminski N. Feasibility, distribution, and efficacy of an inhaled oligonucleotide mimic of miR-29 for pulmonary fibrosis induced by bleomycin in rats. 2017, pa3480. DOI: 10.1183/1393003.congress-2017.pa3480.
Decreased expression of FENDRR, a lung mesenchymal long non-coding RNA, regulates fibroblast phenotypes in IPF through NOX4Sakamoto K, Xylourgidis N, Omote N, Adams T, Yu G, Ahangari F, Herazo-Maya J, Kaminski N, Homer R. Decreased expression of FENDRR, a lung mesenchymal long non-coding RNA, regulates fibroblast phenotypes in IPF through NOX4. 2017, oa2909. DOI: 10.1183/1393003.congress-2017.oa2909.
SH2 Domain–Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary FibrosisTzouvelekis A, Yu G, Lino Cardenas CL, Herazo-Maya JD, Wang R, Woolard T, Zhang Y, Sakamoto K, Lee H, Yi JS, DeIuliis G, Xylourgidis N, Ahangari F, Lee PJ, Aidinis V, Herzog EL, Homer R, Bennett AM, Kaminski N. SH2 Domain–Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2016, 195: 500-514. PMID: 27736153, PMCID: PMC5378419, DOI: 10.1164/rccm.201602-0329oc.
Thyroid hormone inhibits pulmonary fibrosis through enhancement of mitochondrial function in alveolar epithelial cellsTzouvelekis A, Yu G, Herazo-Maya J, Wang R, Werneck de Castro J, DeIuliis G, Ahangari F, Woolard T, Arrojo e Drigo R, Homer R, Srivastava A, Herzog E, Lee P, Bianco A, Kaminski N. Thyroid hormone inhibits pulmonary fibrosis through enhancement of mitochondrial function in alveolar epithelial cells. 2016, pa780. DOI: 10.1183/13993003.congress-2016.pa780.
Chitinase 3–like-1 Regulates Both Visceral Fat Accumulation and Asthma-like Th2 InflammationAhangari F, Sood A, Ma B, Takyar S, Schuyler M, Qualls C, Dela Cruz CS, Chupp GL, Lee CG, Elias JA. Chitinase 3–like-1 Regulates Both Visceral Fat Accumulation and Asthma-like Th2 Inflammation. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 746-757. PMID: 25629580, PMCID: PMC4407482, DOI: 10.1164/rccm.201405-0796oc.
Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2He C, Lee C, Dela Cruz C, Lee C, Zhou Y, Ahangari F, Ma B, Herzog E, Rosenberg S, Li Y, Nour A, Parikh C, Schmidt I, Modis Y, Cantley L, Elias J. Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2. Cell Reports 2015, 10: 1433. DOI: 10.1016/j.celrep.2015.02.017.
Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2He C, Lee C, Dela Cruz C, Lee C, Zhou Y, Ahangari F, Ma B, Herzog E, Rosenberg S, Li Y, Nour A, Parikh C, Schmidt I, Modis Y, Cantley L, Elias J. Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2. Cell Reports 2013, 5: 1156. DOI: 10.1016/j.celrep.2013.11.016.
VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axisTakyar S, Vasavada H, Zhang J, Ahangari F, Niu N, Liu Q, Lee C, Cohn L, Elias J. VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axis. Journal Of Cell Biology 2013, 202: 2027oia101. DOI: 10.1083/jcb.2027oia101.
VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axisTakyar S, Vasavada H, Zhang JG, Ahangari F, Niu N, Liu Q, Lee CG, Cohn L, Elias JA. VEGF controls lung Th2 inflammation via the miR-1–Mpl (myeloproliferative leukemia virus oncogene)–P-selectin axis. Journal Of Experimental Medicine 2013, 210: 1993-2010. PMID: 24043765, PMCID: PMC3782056, DOI: 10.1084/jem.20121200.
Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2He CH, Lee CG, Dela Cruz CS, Lee CM, Zhou Y, Ahangari F, Ma B, Herzog EL, Rosenberg SA, Li Y, Nour AM, Parikh CR, Schmidt I, Modis Y, Cantley L, Elias JA. Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2. Cell Reports 2013, 4: 830-841. PMID: 23972995, PMCID: PMC3988532, DOI: 10.1016/j.celrep.2013.07.032.
Chitinase 1 Is a Biomarker for and Therapeutic Target in Scleroderma-Associated Interstitial Lung Disease That Augments TGF-β1 SignalingLee CG, Herzog EL, Ahangari F, Zhou Y, Gulati M, Lee CM, Peng X, Feghali-Bostwick C, Jimenez SA, Varga J, Elias JA. Chitinase 1 Is a Biomarker for and Therapeutic Target in Scleroderma-Associated Interstitial Lung Disease That Augments TGF-β1 Signaling. The Journal Of Immunology 2012, 189: 2635-2644. PMID: 22826322, PMCID: PMC4336775, DOI: 10.4049/jimmunol.1201115.
Chitinase 3-Like-1 (Chi3l1) Stimulates The Wnt/²-Catenin Pathway Via An IL-13 Receptor Alpha 2 Dependent MechanismHe C, Lee C, Dela Cruz C, Liu W, Ahangari F, Elias J. Chitinase 3-Like-1 (Chi3l1) Stimulates The Wnt/²-Catenin Pathway Via An IL-13 Receptor Alpha 2 Dependent Mechanism. 2012, a5524-a5524. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5524.
Chitinase 3 Like 1 (CHI3L1) Is A Critical Regulator Of Visceral Adiposity And The PPAR PathwayAhangari F, Takyar S, Herzog E, Dela Cruz C, He C, Lee C, Elias J. Chitinase 3 Like 1 (CHI3L1) Is A Critical Regulator Of Visceral Adiposity And The PPAR Pathway. 2012, a4117-a4117. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4117.
Mpl Is Targeted By MiR-1 In The Lung Endothelial Cells And Regulates Th2 Inflammation By Controlling Adhesion Molecule ExpressionTakyar S, Ahangari F, Vasavada H, Lee C, Elias J. Mpl Is Targeted By MiR-1 In The Lung Endothelial Cells And Regulates Th2 Inflammation By Controlling Adhesion Molecule Expression. 2012, a2453-a2453. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2453.
Chitinase-like Proteins in Lung Injury, Repair, and MetastasisLee CG, Dela Cruz CS, Ma B, Ahangari F, Zhou Y, Halaban R, Sznol M, Elias JA. Chitinase-like Proteins in Lung Injury, Repair, and Metastasis. Annals Of The American Thoracic Society 2012, 9: 57-61. PMID: 22550243, PMCID: PMC3359113, DOI: 10.1513/pats.201112-056ms.
YKL-40, a Chitinase-like Protein at the Intersection of Inflammation and RemodelingLee CG, Dela Cruz CS, Herzog E, Rosenberg SM, Ahangari F, Elias JA. YKL-40, a Chitinase-like Protein at the Intersection of Inflammation and Remodeling. American Journal Of Respiratory And Critical Care Medicine 2012, 185: 692-694. PMID: 22467800, DOI: 10.1164/rccm.201202-0203ed.
Studies of Vascular Endothelial Growth Factor in Asthma and Chronic Obstructive Pulmonary DiseaseLee CG, Ma B, Takyar S, Ahangari F, DelaCruz C, He CH, Elias JA. Studies of Vascular Endothelial Growth Factor in Asthma and Chronic Obstructive Pulmonary Disease. Annals Of The American Thoracic Society 2011, 8: 512-515. PMID: 22052929, PMCID: PMC3359071, DOI: 10.1513/pats.201102-018mw.
YKL-40 Binds To And Signals Via IL-13 Receptor Alpha2 Using A Glycosylation-Dependent MechanismHe C, Lee C, Ma B, Cruz C, Liu W, Zhou Y, Ahangari F, Homer R, Elias J. YKL-40 Binds To And Signals Via IL-13 Receptor Alpha2 Using A Glycosylation-Dependent Mechanism. 2011, a2070-a2070. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2070.
Chitotriosidase (Chitinase 1) Plays An Essential Role In IL-13-Induced Inflammation, Fibrosis And Alternative (M2) Macrophage ActivationAhangari F, Takyar S, Lee C, Vasavada H, Elias J. Chitotriosidase (Chitinase 1) Plays An Essential Role In IL-13-Induced Inflammation, Fibrosis And Alternative (M2) Macrophage Activation. 2011, a2868-a2868. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2868.
Chitotriosidase Contributes To The Pathogenesis Of Bleomycin-Induced Pulmonary FibrosisZhou Y, Lee C, Ahangari F, Herzog E, Elias J. Chitotriosidase Contributes To The Pathogenesis Of Bleomycin-Induced Pulmonary Fibrosis. 2011, a4274-a4274. DOI: 10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4274.
Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and InjuryLee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, Kang MJ, He CH, Takyar S, Elias JA. Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury. Annual Review Of Physiology 2011, 73: 479-501. PMID: 21054166, PMCID: PMC3864643, DOI: 10.1146/annurev-physiol-012110-142250.
MiR-1 Is a Critical Regulator of VEGF-Induced Angiogenesis.Takyar S, Lee C, Hartl D, Liu W, Ahangari F, Elias J. MiR-1 Is a Critical Regulator of VEGF-Induced Angiogenesis. 2009, a2487. DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2487.
Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancerSpring K, Ahangari F, Scott SP, Waring P, Purdie DM, Chen PC, Hourigan K, Ramsay J, McKinnon PJ, Swift M, Lavin MF. Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer. Nature Genetics 2002, 32: 185-190. PMID: 12195425, DOI: 10.1038/ng958.
Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype.Spring K, Cross S, Li C, Watters D, Ben-Senior L, Waring P, Ahangari F, Lu SL, Chen P, Misko I, Paterson C, Kay G, Smorodinsky NI, Shiloh Y, Lavin MF. Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype. Cancer Research 2001, 61: 4561-8. PMID: 11389091.

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