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"Pediatric Obstructive Sleep Apnea: A Surgeon's Perspective" Andrew Scott, MD (02/08/2023)

March 06, 2023
  • 00:03So good afternoon, everyone.
  • 00:05My name is Andre Zinchuk,
  • 00:08and I am an assistant professor
  • 00:10here at Yale University.
  • 00:12And thank you for joining yet
  • 00:14another edition of our joint sleep
  • 00:16seminars that we conduct with folks.
  • 00:19Really sounds like all over the
  • 00:21Northeast now, which is great.
  • 00:23And we have a very special guest today.
  • 00:27And I will let Doctor already Grover
  • 00:30introduce our speaker for the day.
  • 00:32Take it away already.
  • 00:34Alright, thank you.
  • 00:36Good afternoon everyone.
  • 00:37Thank you Doctor Scott for coming in
  • 00:40today from Tufts and Doctor Scott is
  • 00:42going to talk about pediatric obstructive
  • 00:45sleep apnea and he's going to give
  • 00:47us their surgeons perspective on this.
  • 00:49So just by introduction,
  • 00:51Doctor Andrew Scott is an associate
  • 00:53professor of otolaryngology and
  • 00:56pediatric Pediatrics as Tufts University
  • 00:58School of Medicine in Boston.
  • 01:00Uh he serves as a medical director for
  • 01:03cleft and craniofacial team at Tufts
  • 01:06Children's Hospital and Tufts Medical Center.
  • 01:08He attended Uh Vaseline University of
  • 01:11his uh for his undergraduate education,
  • 01:14followed by Harvard Medical School
  • 01:16where he earned his medical degree.
  • 01:19He completed a residency in oral Laryngology,
  • 01:22had a neck surgery through the
  • 01:24Harvard system and additional
  • 01:25subspecialty training and cop complex
  • 01:28and pediatric laryngology through
  • 01:29the University of Minnesota.
  • 01:31He practices the full spectrum
  • 01:34of pediatric auto laryngology,
  • 01:35including open and endoscopic air research,
  • 01:38very the full spectrum of pediatric facial
  • 01:42plastic surgery and craniofacial surgery.
  • 01:45In collaboration with his
  • 01:46colleagues in neurosurgery and
  • 01:48oral and maxillofacial surgery,
  • 01:50doctor Scott also performs transmural
  • 01:52procedures for cranius and stenosis
  • 01:55and orthognathic surgeries.
  • 01:58Again, thank you,
  • 01:59Doctor Scott for doing this today.
  • 02:04Thank you. Thank you for the
  • 02:06kind introduction. Umm, I I.
  • 02:07The format of these is always a
  • 02:10little tricky, but I would like to,
  • 02:12as much as it's possible,
  • 02:14keep this fairly informal.
  • 02:15If you see a typo,
  • 02:18I'd love for you to point it out.
  • 02:19If you have questions or corrections,
  • 02:22that is welcome to.
  • 02:23I think a lot of us are are are
  • 02:26knowledgeable and come at this
  • 02:28from different perspectives
  • 02:29and and I always learn from
  • 02:31the audience and these things.
  • 02:33So so please speak up with
  • 02:35questions as we go.
  • 02:37Forward, I'm going to try to spend
  • 02:39about 45 minutes and then have
  • 02:41time for questions at the end.
  • 02:43I am a surgeon and so I have
  • 02:45a limited attention span.
  • 02:47We are very visual and we like boom boom,
  • 02:49boom, boom, boom.
  • 02:50So this is going to be a little bit of a
  • 02:54MTV TikTok, not quite to that extent,
  • 02:56but lecture with lots of of quick
  • 02:59changes and videos and hopefully
  • 03:00that will be interesting to you.
  • 03:03I have no disclosures,
  • 03:04but I'm always interested in the. Closure.
  • 03:07If anyone has any good ideas and this
  • 03:11is the CME information and whatnot,
  • 03:13I think this is boilerplate for
  • 03:14most of your lectures today,
  • 03:16but for those of you who need it,
  • 03:17this is that information.
  • 03:20Give that a second.
  • 03:22I went to Wesleyan for undergrad
  • 03:24and and Harvard for Med school,
  • 03:27and I'm perfectly aware
  • 03:28that I'm speaking to Yale,
  • 03:29but I have great affection for
  • 03:31anyone on the 91 corridor, so.
  • 03:34So we're all,
  • 03:36I have a lot of Connecticut ties.
  • 03:39So the goals today are to review
  • 03:42current guidelines that we have from
  • 03:44the pediatric allergology literature.
  • 03:46And I think that sometimes is
  • 03:48an interesting perspective to
  • 03:49sort of see where your surgical
  • 03:51colleagues are coming from.
  • 03:52There is a lot of overlap
  • 03:54as you would imagine,
  • 03:55but sometimes there isn't and you
  • 03:57might think somebody is doing something
  • 03:59kind of crazy and it may come from
  • 04:02our guidelines and vice versa.
  • 04:03We'll talk about a off label use of
  • 04:07nasal steroids for adenoid hypertrophy
  • 04:10and I'm going to talk about the
  • 04:13surgical strategies that we have
  • 04:15for addressing patients who still
  • 04:16have residual sleep apnea after
  • 04:18tonsillectomy and adenoidectomy,
  • 04:20which does come up from time to time.
  • 04:23And then we'll talk about some of the
  • 04:26more advanced soft tissue and orthognathic,
  • 04:28so Bony surgeries that we do for
  • 04:31on the maxilla and the mandible.
  • 04:34OK.
  • 04:34So this is the basic outline of
  • 04:36this talk and again I'm going to go
  • 04:39through it pretty quickly given our audience.
  • 04:41I'm not going to go into the
  • 04:44the definitions of sleep apnea.
  • 04:46You are all far more knowledgeable
  • 04:48about that than I am.
  • 04:50But just as a basic review,
  • 04:51we can all agree that this happens
  • 04:54when there's intermittent upper
  • 04:55airway collapse during sleep and
  • 04:56there can be any number of anatomic
  • 04:59or neuromuscular factors and
  • 05:00that's very important for me as a
  • 05:02surgeon to keep in mind because.
  • 05:04Sometimes when you're a hammer,
  • 05:07everything's a nail,
  • 05:08and having us as surgeons treat
  • 05:11everything as an anatomic problem
  • 05:13will lead to failed interventions.
  • 05:16You can't treat hypotonia
  • 05:18with a static surgery,
  • 05:20and so that's really the best way
  • 05:23for us to assess patients for who
  • 05:26are good candidates and who aren't.
  • 05:28But that being said,
  • 05:30there are still many patients
  • 05:32that might be thought of as,
  • 05:33oh, they don't have options,
  • 05:35when in fact they do.
  • 05:36And in the era of sleep endoscopy
  • 05:38and being able to localize the site
  • 05:41of obstruction focused surgical
  • 05:43interventions in those areas,
  • 05:45while not perfect,
  • 05:46are definitely far more efficacious than
  • 05:48when we used to just blindly try something.
  • 05:51It is important to also remember that
  • 05:53the criteria for sleep apnea is quite
  • 05:56different than adults and children.
  • 05:57The bar is much,
  • 05:58much higher.
  • 05:59Kids to say that cure for obstructive
  • 06:02sleep apnea child is bringing
  • 06:05the HIV to below one is very,
  • 06:07very difficult.
  • 06:10But to do so,
  • 06:11to achieve absolute cure and a
  • 06:13child is is not always possible.
  • 06:16But that being said,
  • 06:18when you look at what contributes to
  • 06:21sleep apnea in children and versus adults,
  • 06:24it is far more skewed towards
  • 06:27obesity and other factors such as
  • 06:29that for adults as opposed to just
  • 06:32lymphoid hypertrophy in children.
  • 06:34And while we do have adults with big
  • 06:36tonsils who have their snoring and
  • 06:39sometimes even sleep apnea improved.
  • 06:41By tonsillectomy, it is nowhere near
  • 06:43as efficacious as it is in children.
  • 06:45And a big part of that is because of
  • 06:47just the ratio of the size of the tonsils
  • 06:49to the pharynx and the fact that what's
  • 06:51causing these obstructive symptoms
  • 06:53in kids is different than adults.
  • 06:55But then it's makes it difficult for us
  • 06:58to translate that paradigm for teenagers,
  • 07:00saying that there's still children,
  • 07:01even though, you know,
  • 07:03sometimes we have a teenager in
  • 07:05the office at 6 feet tall.
  • 07:06And yes, they can't vote,
  • 07:08but that doesn't necessarily
  • 07:10make them have to have an HIV.
  • 07:121.0 and doesn't make treating
  • 07:14them as an infant logical,
  • 07:16and so we do have some arbitrary
  • 07:18cut offs that are based on age
  • 07:21rather than developmental status.
  • 07:24So looking at, you know,
  • 07:26the anatomical factors and relevant
  • 07:29anatomy, the mallampati scale
  • 07:30I know you are all aware of.
  • 07:33That's a scale for determining
  • 07:34the difficulty of intubation.
  • 07:36It's been hijacked for use for thinking about
  • 07:39examining soft palate length and whatnot,
  • 07:41and it can be a bit of a surrogate,
  • 07:43but it is important for us all to remember
  • 07:45that that's not what this was designed for.
  • 07:48This is simply to decide whether
  • 07:49you know you're going to be
  • 07:51a tricky intubation or not,
  • 07:52or what your mask airway might be like.
  • 07:55The tonsil grading scale in children
  • 07:57zero or the surgically absent are
  • 08:00are practically not there.
  • 08:01One, they're there but they're super small.
  • 08:042 They're there and they're about average,
  • 08:063 they're big and four they're
  • 08:08enormous and touching and then four
  • 08:10plus plus would be like if they're
  • 08:13practically overlapping and whatnot.
  • 08:15Our literature does not clearly show
  • 08:17much of a correlation between tonsil
  • 08:19size and severity of sleep apnea,
  • 08:22and that's important because a lot
  • 08:23of kids are sent. Or big tonsils.
  • 08:25Ohh, it's gotta be bad.
  • 08:27But sometimes the tonsils are exophytic,
  • 08:30meaning they're almost pedicled
  • 08:31and what you see looks huge,
  • 08:33and other times they look small.
  • 08:35One plus or two plus and they're very
  • 08:37endophytic and they go very laterally.
  • 08:38But when you're asleep,
  • 08:40that same Mass Effect is apparent either way.
  • 08:42And so you can have a child with two plus
  • 08:45tonsils that is terribly obstructing,
  • 08:47and one with four plus tonsils who snores
  • 08:49but actually doesn't have any sleep apnea.
  • 08:51And so it's an approximation,
  • 08:53but none of this is is perfect.
  • 08:56I just want to show you an example.
  • 08:57I put sleep inducing quotation
  • 08:58because this is a child that I saw.
  • 09:00This is a pretty old video.
  • 09:02It's from like maybe 8-10 years ago.
  • 09:04But he was in my office for sleep apnea
  • 09:07and came in and was asleep in the chair.
  • 09:10And so just for Giggles,
  • 09:12I put a scope in him and he was still asleep.
  • 09:15And this is not under anesthesia,
  • 09:17this is in the office,
  • 09:17just with excessive daytime somnolence.
  • 09:20And as we scope him now,
  • 09:21we're looking at the tonsils that are
  • 09:24collapsing almost completely on themselves.
  • 09:27Posterior is up top,
  • 09:28anterior is in the bottom of
  • 09:306:00 o'clock of the screen.
  • 09:31And now you'll see the larynx way down here,
  • 09:34that the tonsils are sitting on
  • 09:36the larynx and that's the cricoid,
  • 09:38and the vocal folds are just about to
  • 09:40come into view right there and now.
  • 09:41He startles as I wake him up and
  • 09:43watch how different this airway looks
  • 09:45when he coughs and he's awake of how
  • 09:49dramatically different this will look.
  • 09:51He coughs and now everything
  • 09:52opens up and that's him.
  • 09:54Whoops, that's what he looks like when awake.
  • 09:57And so it's a pretty big
  • 10:00difference to see this.
  • 10:02You could very much underestimate how
  • 10:05bad his obstruction would be just by
  • 10:07looking at him awakened clinic and that's
  • 10:10why sleep endoscopy is so helpful.
  • 10:12So looking at the epidemiology and children,
  • 10:14the prevalence in kids in my clinic, I mean,
  • 10:16I think the whole world has sleep apnea.
  • 10:17Every single child must be
  • 10:19having this because they're
  • 10:20the ones who show up to see me.
  • 10:21But in reality, it's actually pretty low.
  • 10:23It's probably higher now than it used to be,
  • 10:25but but it it it's under 10%.
  • 10:30And these children often present in
  • 10:32their preschool years and of that has
  • 10:34to do with the size of the tonsils to
  • 10:36the caliber of the pharyngeal airway.
  • 10:38It's that ratio.
  • 10:39And many times these kids are
  • 10:40in normal weight.
  • 10:41Obesity certainly can contribute,
  • 10:43but the scariest sleep apnea patient to
  • 10:46me in my clinic is the underweight child,
  • 10:49the one who has large tonsils and is skinny,
  • 10:52because that tells me that that
  • 10:55kid is burning more calories at
  • 10:57night to stay alive than they're
  • 10:59able to consume during the day.
  • 11:01When a child has airway obstruction
  • 11:04that is bad,
  • 11:05they will develop failure to thrive
  • 11:07just from caloric expenditure and
  • 11:09sometimes dysphasia if the airway
  • 11:11obstruction is contributing to that.
  • 11:13And so those kids that are really skinny
  • 11:16and small are are often the ones that
  • 11:18have the worst airway obstruction.
  • 11:23So when we think about the Natural
  • 11:25History of this, it would be nice
  • 11:27in adults if you could just say,
  • 11:28oh, just wait, wait six months
  • 11:30and your sleep apnea will go away.
  • 11:32I mean that doesn't happen.
  • 11:34I gain weight every year it feels like.
  • 11:35So, I mean that's that what
  • 11:37happens to us adults.
  • 11:38But in children,
  • 11:39they're growing and they can sort
  • 11:41of auto UN grow their tonsils,
  • 11:43outgrow their tonsils.
  • 11:43And so when we look at the Natural
  • 11:46History of untreated sleep apnea in
  • 11:48children and this was a very happy
  • 11:50thing to know about when the COVID.
  • 11:52Pandemic struck is that although untreated,
  • 11:56sleep apnea is obviously a problem
  • 11:58and certainly severe sleep apnea
  • 11:59can cause all the downstream effects
  • 12:01that you are all well aware of.
  • 12:03Spontaneous resolution can occur in
  • 12:05kids and that's up to 42% of children
  • 12:09will go from mild OSA or moderate OSA.
  • 12:13Again remember the pediatric
  • 12:14criteria are much lower,
  • 12:15moderate OSA being 5HI510 with
  • 12:19with a growth spurt and their
  • 12:21tonsils going down they can be.
  • 12:23Care of their sleep apnea by doing nothing,
  • 12:26absolutely nothing.
  • 12:27And that happens 42% of the time by
  • 12:30the numbers within seven months.
  • 12:32Now it's need to understand that
  • 12:35these are kids often with mild OSA
  • 12:37and a low HIV and they're not obese.
  • 12:40And if you look at their pediatric
  • 12:42Sleep Questionnaire scores,
  • 12:43that Michigan questionnaire,
  • 12:43I'm not sure if you guys still use it,
  • 12:45but we love it. It's from 2000.
  • 12:48They are often ones that are like in the 33,
  • 12:52you know, under 50%.
  • 12:54Score of that index.
  • 12:56Not the ones that are off the charts.
  • 12:58But this is just another reason
  • 12:59why sometimes if you just wait,
  • 13:01things will get better.
  • 13:02The tonsils are lymph nodes,
  • 13:04and in the same way that a lymph node in
  • 13:06your neck can get swollen when you get sick.
  • 13:08And then it takes a little
  • 13:09while to go back down,
  • 13:09but eventually it might.
  • 13:11Same thing happens to tonsils.
  • 13:13If you get 6 over and over again in
  • 13:15daycare and your tonsils are enormous,
  • 13:16summer comes around and they shrink.
  • 13:19And if you do that tonsillectomy in the
  • 13:21spring or you don't do it come the fall,
  • 13:23everyone's cure of sleep apnea.
  • 13:25So those are things to think about.
  • 13:29Let's see.
  • 13:29I'm just seeing what's in the chat,
  • 13:31making sure there's no questions there,
  • 13:33OK?
  • 13:37So moving through here. So diagnosis.
  • 13:41And again, I'm going to gloss over this
  • 13:43because you were all very well aware of this.
  • 13:45But for patients who appear to us in in
  • 13:48clinic, and I always make the point to my
  • 13:50trainees that there's a difference between
  • 13:52sleep apnea and sleep disorder breathing.
  • 13:54And so most of the kids that we
  • 13:55see have sleep disorder breathing.
  • 13:57They have symptoms of sleep apnea,
  • 13:59but if they don't have a sleep study,
  • 14:00you can't say they have sleep apnea.
  • 14:02And the most common symptom is snoring.
  • 14:05Witness pauses or arousals
  • 14:08that the parent sees.
  • 14:10Often if the adenoids are large
  • 14:12or the turbinates are enlarged,
  • 14:13or there's chronic rhinitis,
  • 14:14they will have constant open mouth breathing.
  • 14:17Open mouth breathing is now
  • 14:19this like Internet, you know,
  • 14:22horror epidemic,
  • 14:23that some very well educated and affluent
  • 14:27families will come in and terrified
  • 14:29that their child is mouth breathing,
  • 14:32they've been taping their mouth
  • 14:33shut at night and there's what's
  • 14:34going to happen to the palate.
  • 14:36This is been a lot driven by the
  • 14:38dentist and the orthodontist.
  • 14:40Umm, we don't have evidence that
  • 14:42shows that this really matters
  • 14:44at all from a sleep standpoint.
  • 14:46Yes,
  • 14:46if your palette is narrow,
  • 14:48your nasal cavities are slightly narrower,
  • 14:51and if you do palatal expansion,
  • 14:53it will slightly decrease nasal resistance.
  • 14:56But from a sleep study standpoint,
  • 14:57and certainly in adults,
  • 14:58it has not been shown to make a
  • 15:01meaningful difference in HIV.
  • 15:02That actually is the difference
  • 15:04between having sleep apnea
  • 15:05and not having sleep apnea.
  • 15:07But powerful expansion will improve
  • 15:09your nasal airway resistance,
  • 15:11and it can help with snoring.
  • 15:14But these kids will have restless sleep and
  • 15:15a lot of chronic nasal obstruction symptoms.
  • 15:18And what we do is is is administer
  • 15:20that Michigan questionnaire,
  • 15:22which often will ask parents the
  • 15:24questions in just the right way.
  • 15:26I'm always amazed that they will answer
  • 15:29one way on the questionnaire and then
  • 15:32their response to me asking the same
  • 15:34question will sometimes be different.
  • 15:36So occasionally you have to
  • 15:37sort of double check that.
  • 15:41Just seeing if there's any.
  • 15:43I just saw a text thing come up
  • 15:45for the chat but I'm not seeing
  • 15:47able to read it I guess OK.
  • 15:52Let's listen to this kid.
  • 15:59So she's asleep in her car seat.
  • 16:01You can see her abdominal retraction,
  • 16:05super sternal retractions.
  • 16:07She's clearly pretty obstructive.
  • 16:09This is the child of a physician who brought
  • 16:12in this video sort of as a curiosity.
  • 16:15She wasn't particularly worried.
  • 16:18So sometimes parents are pretty
  • 16:20underwhelmed by this sort of thing,
  • 16:22and other times they are.
  • 16:24They're terrified.
  • 16:25But parents will tolerate this for a while.
  • 16:29They kind of think it's cute,
  • 16:30and we have to sort of let them
  • 16:32know that this is not normal.
  • 16:33Children shouldn't be snoring,
  • 16:35and the sound that you're hearing there is.
  • 16:39You can describe it as Strider,
  • 16:41but the it's probably more
  • 16:42accurate to call it sturdier,
  • 16:44which is a term that everyone knows or uses.
  • 16:46But that's basically the sound of snoring.
  • 16:48And especially the sound of
  • 16:50snoring when you're awake.
  • 16:50So someone who's.
  • 16:53In your office and you think they're snoring,
  • 16:54you turn around in their
  • 16:56wake that's sturdier,
  • 16:57that's sort of the open mouth breathing
  • 17:00nasal obstruction and and that's really
  • 17:02what we're looking for and asking about.
  • 17:03Strider is at the laryngeal level
  • 17:06and that's more musical like a
  • 17:09sound like what we call the Ringo
  • 17:11Malaysia in the in the infants.
  • 17:13Starter is often caused by nasal obstruction,
  • 17:16obstruction of the soft palate level.
  • 17:18And so here you can see
  • 17:20in the lateral neck film,
  • 17:21which we actually don't get that often now,
  • 17:22but you always can.
  • 17:23If you have a patient that
  • 17:24can't tolerate nasal endoscopy,
  • 17:26you will see that adenoid which is
  • 17:28is partially blocking the nasal
  • 17:30pharyngeal airway right here.
  • 17:32So we can see the borders of the
  • 17:33adenoid here in the soft palate here
  • 17:35and there's a column of air and that
  • 17:36patient is able to breathe there.
  • 17:38But the adenoid really should be about
  • 17:39half the size and so this will cause
  • 17:42some degree of nasal obstruction.
  • 17:43Good.
  • 17:44And so this is a view on nasal endoscopy
  • 17:47of a three to four plus adenoid,
  • 17:49it's it's four plus would
  • 17:51be completely obstructed,
  • 17:52but it's pretty close.
  • 17:53And so this is the patients left
  • 17:56nasal cavity.
  • 17:57So this is the nasal septum and the
  • 17:59adenoid is filling that area and this
  • 18:01is pretty much the same view but with
  • 18:04the adenoid removed or shrunk back
  • 18:06that we would call this A1 plus adenoid.
  • 18:08It's present but it isn't larger obstructive.
  • 18:11So you can see that's a pretty
  • 18:13big hole that is plugged.
  • 18:14By that adenoid and in children
  • 18:17who are obligate nasal breathers,
  • 18:19they they really want to
  • 18:20breathe through their nose.
  • 18:20A large adenoid is is debilitating.
  • 18:23It's hard,
  • 18:23they can't chew because they can't,
  • 18:25and they can't drink because
  • 18:26they need to be able to breathe
  • 18:28through their nose while they eat,
  • 18:29and that can cause coughing and
  • 18:31dysphasia because they can't coordinate
  • 18:33their suck swallow breed sequence.
  • 18:35This is the Eustachian tube Orpheus.
  • 18:37What's popping your ears on the airplane?
  • 18:40Why?
  • 18:40When you swallow or chew gum it will open
  • 18:42your ears and you can see it's
  • 18:44completely blocked by the adenoid.
  • 18:46So many of these kids will have
  • 18:48a serious effusions, you know,
  • 18:50fluid behind their eardrums.
  • 18:51And so the overlap of children that have
  • 18:54conductive hearing loss because of ear
  • 18:55fluid or recurrent otitis media and also
  • 18:58have large adenoids is very, very high.
  • 19:00And that's why if you're looking at past
  • 19:01medical history or past surgical history,
  • 19:03you'll see a lot of these kids have had
  • 19:06tubes and adenoids at the same time or
  • 19:09adenoids and tonsils with ear tubes.
  • 19:11That's why, because that's
  • 19:13where they overlap is.
  • 19:15So sleep study.
  • 19:16I would argue is not really
  • 19:18necessary in healthy children
  • 19:20with sleep disorder breathing,
  • 19:21if they have a high enough score and
  • 19:24they're struggling to breathe enough
  • 19:25and it's disrupting their sleep and
  • 19:27leading to what we can all guess
  • 19:29is at least sleep fragmentation,
  • 19:30then you have what you need to do surgery.
  • 19:33That's what insurance says.
  • 19:35And so if a child is otherwise healthy,
  • 19:37we will take their tonsils and
  • 19:39adenoids out based on those symptoms.
  • 19:40You don't have to necessarily
  • 19:42get a sleep study.
  • 19:43That matters because you guys know how
  • 19:46long the wait is for sleep studies.
  • 19:48And in the era of RSV,
  • 19:50and every kid is now sick with
  • 19:52that calling at the last minute and
  • 19:54all the cancellations are COVID.
  • 19:55The access for sleep studies is very,
  • 19:58very difficult.
  • 19:59And so if we send every single snoring
  • 20:03healthy child for a sleep study,
  • 20:05there would never be the opportunity
  • 20:07to to assess those that really need it.
  • 20:11Of course it's important for adults
  • 20:12and older kids if you're going
  • 20:14to use it for CPAP titration,
  • 20:15but if the answer is the kid is big tonsils,
  • 20:17we're going to take them out.
  • 20:18You're probably not going to get a post
  • 20:20op sleep study if all symptoms resolved,
  • 20:22so we don't reflexively get it.
  • 20:25Hartfield in otolaryngology says these
  • 20:28are the absolute, like essential.
  • 20:31Instances in which one must
  • 20:33get a sleep study.
  • 20:35If you do not get a sleep
  • 20:36study in these cases,
  • 20:37you are out of left field and probably
  • 20:40not practicing the standard of care.
  • 20:42And so that's important I think
  • 20:43for you guys to know, you know,
  • 20:45if you're in charge of a sleep center,
  • 20:47understand like why is this kid getting this?
  • 20:50If their BMI for age is above the
  • 20:5298th percentile and some say 95th,
  • 20:54they have to get a sleep study.
  • 20:55If I take that kid to the OR
  • 20:57without a sleep study,
  • 20:59that is not,
  • 21:00that's a direct violation of our guidelines.
  • 21:03And the reason why is because the pretest
  • 21:06probability of patients with these issues,
  • 21:08the pretest probability of they're
  • 21:10having severe OSA is very high.
  • 21:12And so if you just turn a blind eye to it
  • 21:14and go and take out the tonsils or adenoids,
  • 21:17your complication rate afterwards,
  • 21:18your likelihood of needing to all of a
  • 21:21sudden go to the ICU minimally to admit
  • 21:23them afterwards is very, very high.
  • 21:25So patients with sickle cell anemia,
  • 21:28obesity of mucopolysaccharidosis or some
  • 21:30sort of storage disease, craniosynostosis.
  • 21:33Cleft lip and palate rail ban sequence,
  • 21:36micrognathia, craniofacial stuff,
  • 21:38anyone with hypotonia, Charcot,
  • 21:41Marie Tooth, cerebral palsy,
  • 21:43those kids all need sleep studies.
  • 21:45And then there's the
  • 21:47recommendation that like look,
  • 21:48if they're under two that's that's
  • 21:49pretty young to take their tonsils out.
  • 21:51You probably want to sleep study
  • 21:52that says it's OK to do that.
  • 21:54I would just make the argument that
  • 21:55by the time you get the sleep study
  • 21:56and it comes back, they're over too,
  • 21:58because they rarely are.
  • 22:00Are are presenting that young,
  • 22:02it can be helpful for the infants,
  • 22:04especially if there's something
  • 22:05else happening.
  • 22:06And then the big one, and I had a
  • 22:08a perfect example of it on Friday,
  • 22:10is parental disagreement.
  • 22:11So Dad's an engineer and he's
  • 22:13super data-driven and he wants to
  • 22:15know exactly what we're treating
  • 22:17and why and how bad it is.
  • 22:19And Mom is like this kid can't get up and
  • 22:22to for school in the morning and you are,
  • 22:25you know,
  • 22:25asleep on the couch, dad.
  • 22:26But I'm watching them obstruct all the time.
  • 22:28I don't need a sleep study,
  • 22:29like let's just make this go away.
  • 22:31The wait time for sleep study and then
  • 22:34surgery as opposed to surgery alone
  • 22:36is a on average four to five months.
  • 22:40So it's a significant delay and that.
  • 22:42Matter to some families.
  • 22:45So.
  • 22:46Why we get sleep studies is to determine
  • 22:48and risk stratify who has to get
  • 22:51admitted to our hospitals afterwards.
  • 22:53And so the three hard recommendations
  • 22:54for kids who must get admitted after
  • 22:57tonsillectomy and adenoidectomy,
  • 22:58this is not for adenoids alone.
  • 22:59This for tonsils and adenoids is age
  • 23:02under three years and HI above 10 and
  • 23:05assassinator that's 80 or below or below 80.
  • 23:09And so the ones I showed you are are
  • 23:11that we say must get a sleep study.
  • 23:13They're the ones that the highest likelihood
  • 23:15of having a high HIV and a saturator.
  • 23:18And so that's sort of how we determine that.
  • 23:22Treatment options.
  • 23:23Cpap is probably the first
  • 23:25line treatment in adults.
  • 23:27I mean, I think that's fair to say
  • 23:29that PAP therapy is is is there.
  • 23:32We don't commonly use it in kids,
  • 23:33but you can. I have multiple
  • 23:35children on CPAP and they love it.
  • 23:37I have a couple of like morbidly obese kids,
  • 23:40one of them who was on bypass and
  • 23:42she used to come home and put her
  • 23:44Bipap mask on to do homework because
  • 23:46she just felt so much better.
  • 23:48The poor thing was so pickwickian that
  • 23:51when she had her PAP on, she just felt.
  • 23:55Better breathe better and she would just
  • 23:57do her homework with her PAP on awake,
  • 23:58so many of them feel like it really,
  • 24:00really helps.
  • 24:02She had big tonsils too,
  • 24:05but she was so large that it enters.
  • 24:08HI was so high that if she
  • 24:09did make it through surgery,
  • 24:11she was still going to end up
  • 24:12needing to be on PAP therapy,
  • 24:13and so it isn't really worth the
  • 24:16risk of putting a kid with multiple
  • 24:19comorbidities through surgery.
  • 24:20In fact,
  • 24:21the way I got to meet her was that
  • 24:23some other doctor tried to do a
  • 24:25T&A on her and she had horrible
  • 24:28post obstructive pulmonary edema
  • 24:30right as they were intubating her
  • 24:32before they even did surgery.
  • 24:33And so in that setting they
  • 24:35never even touched her tonsils,
  • 24:36they never did surgery and
  • 24:38they transported her to our ICU
  • 24:40in fulminant pulmonary edema.
  • 24:41And by the time we checked our A1C
  • 24:44and saw the degree of of right sided
  • 24:48hypertrophy and whatnot all you know.
  • 24:50Downstream secondary effects of
  • 24:52her sort of metabolic syndrome.
  • 24:53It was tapped.
  • 24:54Therapy's been the best for her.
  • 24:57And so those are who we decide to do that.
  • 24:59If you do have to desensitize this
  • 25:01child as CPAP, for lack of a better term,
  • 25:03this is how it works.
  • 25:04You've met them to the hospital.
  • 25:05You put the PAP mask on them,
  • 25:06the kid takes it off,
  • 25:07you put it on, they take it off,
  • 25:08you put it on, they take it off.
  • 25:09And you do this for like 2-3 nights in
  • 25:11a row until you finally break the child.
  • 25:14And then they wear their CPAP.
  • 25:15And so that's what an admission
  • 25:17for CPAP looks like.
  • 25:18These are the surgeries that we do.
  • 25:21And so these are tonsils and adenoids
  • 25:24and then the other sleep procedures.
  • 25:27TNA cures 65% of pediatric OSA,
  • 25:30higher rate of improvement and curing,
  • 25:34snoring.
  • 25:34But if you really stick them back in
  • 25:37your sleep center and really look
  • 25:39to get their HI below one is 65%.
  • 25:42The others go from an HIV of 14 to
  • 25:45an HIV 1.6, but that's not cure.
  • 25:47So technically if you're really
  • 25:49looking for that it's 65%.
  • 25:51But in terms of responding to for
  • 25:53all intensive purposes being much,
  • 25:54much better that's that's higher
  • 25:56that's probably. Close to 90%.
  • 25:58The recovery is rough from tonsillectomy.
  • 26:01A lot of my colleagues undersell it,
  • 26:03but it's brutal.
  • 26:04It's especially for a teenager.
  • 26:06It's two weeks of eating glass.
  • 26:08The bleeding rate for a teenager is 10 to to.
  • 26:13Is probably close to 10%.
  • 26:15For a younger child who's three to six,
  • 26:18it's probably closer to 3%.
  • 26:21But children die every
  • 26:22year from tonsillectomy.
  • 26:23So you got to be sure you really need to
  • 26:25do it and it's the right thing to do.
  • 26:27There are other surgeries you can do
  • 26:29for those that fail and that's what the
  • 26:31rest of this talk is going to be about.
  • 26:32And those run the gamut from
  • 26:35just nasal stuff.
  • 26:36Sometimes we do that just to
  • 26:37improve nasal resistance to CPAP
  • 26:39therapy so people can come down
  • 26:40on their PAP settings and that
  • 26:42may be the difference between,
  • 26:43you know belching and feeling
  • 26:45like you're you're,
  • 26:46you're feeling your stomach with air
  • 26:48because your PAP levels are so high,
  • 26:49but then when you fix the septum and.
  • 26:51Leave the terminates.
  • 26:52You don't clear their sleep apnea,
  • 26:53but now they can come down to maybe
  • 26:55like 6 or 8 centimeters of water,
  • 26:57and then they don't get all
  • 26:59of that swallowing of air.
  • 27:00And they're not,
  • 27:01they're not opening their
  • 27:03upper esophageal sphincter.
  • 27:04So for a preop assessment,
  • 27:06we look at their comorbidities,
  • 27:08decide if they need inpatient
  • 27:09or outpatient based on age,
  • 27:10whether they need a sleep study
  • 27:12and then based on that whether
  • 27:13they need to pick your bed and
  • 27:15you run the risk of bleeding.
  • 27:16You ask about, you know,
  • 27:18risk factors in the family,
  • 27:19people who have bleeding after surgery.
  • 27:21And then you counsel people on, you know,
  • 27:23how the recovery is going to be.
  • 27:25So here's your typical case,
  • 27:263 year old girl,
  • 27:27she's got a pectus excavatum
  • 27:29and she's got some asthma,
  • 27:30but otherwise she's pretty healthy.
  • 27:32She gets her TNA,
  • 27:33she stays overnight for airway observation.
  • 27:35Because she's just over three
  • 27:37and she had bad asthma.
  • 27:39She does great, goes home the next day.
  • 27:41She's seen four weeks post-op.
  • 27:42She's was back to herself at seven days.
  • 27:44They're snoring completely gone,
  • 27:45and now the parents have to go
  • 27:47into a room and make sure she's
  • 27:49alive because they can't hear her
  • 27:50from outside of her room anymore.
  • 27:51She never gets a sleep study
  • 27:53before the surgery,
  • 27:54and she never gets a sleep
  • 27:55study after the surgery.
  • 27:56And that's how most of these things go.
  • 27:58But what do we do if that kid
  • 28:00comes back a few years later
  • 28:02and the TNA doesn't help?
  • 28:04So then we need to do a thorough exam
  • 28:06and we scope them in clinic with
  • 28:08laryngoscopy or we consider doing a
  • 28:10sleep endoscopy in the operating room.
  • 28:12And this is very important to localize
  • 28:14the site of obstruction and make
  • 28:16sure that we know what is happening.
  • 28:18You do not have to do this for a
  • 28:20child prior to TNA because almost
  • 28:22all the time it's the tonsils and
  • 28:24adenoids that are causing the issue.
  • 28:26And so it's just unnecessary
  • 28:27prolonging of anesthesia and everything
  • 28:29to do this from a resource standpoint.
  • 28:31But if I see a kid with OSA
  • 28:33who's got teeny tiny tonsils.
  • 28:34And they're sleep studies positive.
  • 28:37I will book them for a T&A,
  • 28:38but a sleep endoscopy prior
  • 28:40and sometimes make a game time
  • 28:42decision and switch things up.
  • 28:43So what are the frequent culprits for this?
  • 28:46So severe septal deviation
  • 28:47or enlarged turbinates?
  • 28:48That's usually snoring more than sleep apnea.
  • 28:51The other one is something
  • 28:52called tubal tonsil hypertrophy,
  • 28:53which is when if you remove the adenoids.
  • 28:57And umm, you are you,
  • 29:00you finished taking those out.
  • 29:02The adenoids will not grow back necessarily,
  • 29:04but the lateral pharyngeal wall here
  • 29:06where this you station tube Warface
  • 29:08says we'll grow lymphoid tissue
  • 29:10and that can become obstructive.
  • 29:12And so they come back for ohh,
  • 29:14my adenoids grew back.
  • 29:14And you're like really my adenoids
  • 29:16usually go back but OK and then you look,
  • 29:18and that's what the problem is,
  • 29:19we give them nasal steroids
  • 29:20and makes them a little better.
  • 29:22It often doesn't completely
  • 29:23solve the problem.
  • 29:25You can then take them back to the
  • 29:26operating room and cauterize and resurface.
  • 29:28That area with something called the
  • 29:29collator and then when you put them
  • 29:31on nasal steroids to prevent the
  • 29:33lymphoid tissue from coming back,
  • 29:34that usually does the trick.
  • 29:36Then you could have lingual
  • 29:38tonsil hypertrophy.
  • 29:38So these are the tonsils at the base
  • 29:41of the tongue that are now huge.
  • 29:43Because we've removed the
  • 29:44tonsils and the adenoids.
  • 29:45The body is determined to grow lymphoid
  • 29:47tissue somewhere so it grows it in
  • 29:49the back of the tongue where it can.
  • 29:50Then the bottom here is a child
  • 29:52with tongue based obstruction.
  • 29:54So the lingual tonsils are not large.
  • 29:56But you can see the epiglottis is
  • 29:57plastered to the posterior pharyngeal wall,
  • 29:59not from lymphoid tissue,
  • 30:00just from the tongue falling backwards.
  • 30:02And then that's causing some degree of
  • 30:05airway obstruction if you jaw thrust
  • 30:06them or got them an oral appliance
  • 30:08that would pull things forward.
  • 30:10But oral appliances are tricking
  • 30:12kids because they're constantly
  • 30:13growing and they're losing teeth
  • 30:14and it's not covered by insurance.
  • 30:16And so that is a tricky thing for a kid,
  • 30:20but sometimes I have had one or
  • 30:22two over my career pay for and
  • 30:24get an oral appliance,
  • 30:25have it adjusted and it
  • 30:27helps them a little bit.
  • 30:28And then finally, Laryngo Malaysia,
  • 30:30tracheal Malaysia.
  • 30:30And so this is a sleep endoscopy of
  • 30:33a child who's storing like crazy but
  • 30:35didn't have any tonsils or adenoids.
  • 30:37They've got some lymphoid tissue
  • 30:38with the tonsils used to be,
  • 30:39but now you can see there are retinoids
  • 30:42or prolapsing in every time they're
  • 30:44breathing and that's sleep dependent.
  • 30:46Laryngo Malaysia.
  • 30:47So or state dependent depending on
  • 30:49on how you say it, where you're from.
  • 30:52And so if we do what's called a super
  • 30:54glodo plasty and open up the larynx,
  • 30:56that will take care of that problem.
  • 30:59All right. So let's look at some other cases.
  • 31:02So this is an 8 year old boy
  • 31:03who had a T&A when he was five.
  • 31:05He did great and now he's back in
  • 31:07your clinic. Three years later,
  • 31:08symptoms have returned.
  • 31:10We scope them in clinic.
  • 31:11This is the scope view.
  • 31:12In clinic, it's upside down from the sleep
  • 31:15endoscopy videos that I've been showing you.
  • 31:17So in general, when an otolaryngologist
  • 31:18talks to you about airway and you're like,
  • 31:21why are you showing me a
  • 31:23disorientation and this orientation,
  • 31:24we're hardwired to think of our clinic
  • 31:27exams this way, where the posterior.
  • 31:29Andrew Wall is at 12:00 o'clock and
  • 31:32the tongue is at. 6:00 o'clock.
  • 31:33But in the operating room we
  • 31:36switch it around 180 degrees.
  • 31:37We'll show you these videos
  • 31:38and nothing twice about it.
  • 31:40We don't even see it.
  • 31:41But I try to as I was putting the
  • 31:43stock together, I'm like, Oh yeah,
  • 31:44I should try to keep that straight.
  • 31:45So that's why you will sometimes see this.
  • 31:48So he's a little overweight and not obese.
  • 31:50He has no adenoids, no tonsils.
  • 31:51And then he's got this tongue
  • 31:53based obstruction.
  • 31:53And so now in the OR when you
  • 31:55do your sleep endoscopy again
  • 31:56the orientation switched here.
  • 31:58Now you can see like it looks even
  • 32:00worse and this is that epiglottis
  • 32:01getting pushed backwards by those.
  • 32:03Big, heavy, lingual tonsils.
  • 32:06This is a video from my friend Vikash Modi.
  • 32:09I do a bunch of these surgeries,
  • 32:10but I'll be honest with you,
  • 32:11I I don't always video them.
  • 32:13But he's great about taking videos.
  • 32:16And so I asked him to borrow this
  • 32:18and he's he has great videos.
  • 32:19So these are large lingual tonsils,
  • 32:21and this is exactly what I do.
  • 32:23So we take this thing called a poblador
  • 32:25that kind of liquefies the lymphoid tissue.
  • 32:27And sometimes you've got to readjust
  • 32:30your laryngoscope to get all the
  • 32:32different areas and nooks and crannies.
  • 32:34And so here he's ablating all
  • 32:36that lymphoid tissue down to
  • 32:38the actual tongue musculature.
  • 32:40And this is a lingual tonsillectomy.
  • 32:43You can find a plane and dissect it all off,
  • 32:46but it's challenging and you run
  • 32:47the risk of a lingual artery bleed,
  • 32:49which is a very bad problem.
  • 32:50And so most of us just ablade it like this.
  • 32:53And when you're done now all that
  • 32:55lymphoid tissue has been released
  • 32:57and now this is your epiglottis.
  • 32:59And that lymphoid tissue is better
  • 33:01in cases where the epiglottis is
  • 33:03prolapsed backwards and you remove this
  • 33:05lingual tonsil and it doesn't just
  • 33:07spring back to where it needs to be.
  • 33:09You can resuspend the epiglottis,
  • 33:11and this is called an epiglottis apexing.
  • 33:13And we take sutures and we grab the base
  • 33:15of tongue and this is all operating
  • 33:17down the shaft of the laryngoscope.
  • 33:20So it's tricky.
  • 33:21It's like operating through a
  • 33:23toilet paper roll and then you grab
  • 33:27the mucosa over the epiglottis.
  • 33:29And you tighten these sutures down
  • 33:31and it pulls that epiglottis up
  • 33:33into the base of tongue and lifts it
  • 33:35forward so it can open your airway.
  • 33:38And so this is after you've cut your
  • 33:40knots and that's sort of now what
  • 33:42your airway is going to look like.
  • 33:44And then this is in clinic again,
  • 33:45orientation switched and that epiglottis
  • 33:47is now pulled upwards and you can
  • 33:51now see the airway much better.
  • 33:53Um, here's another kid, 2 year old girl.
  • 33:56She's snoring.
  • 33:57Apneic pauses at night, occasional gagging.
  • 33:58You ready to do your tonsillectomy?
  • 34:00She's got no tonsils, no adenoids.
  • 34:01What's going on?
  • 34:02So you scope her and now she's got this
  • 34:04big cyst called the molecular cyst
  • 34:06that's sitting by the base of her tongue.
  • 34:08So we take her to the OR, we remove that.
  • 34:10It's going to solve all your
  • 34:12problems and she's better.
  • 34:13But she's still snoring a lot and now
  • 34:15this is what's happening to reply glottis.
  • 34:17Every time she breathes,
  • 34:18it gets pulled down.
  • 34:20And the reason it's prolapsing is because of.
  • 34:23That cyst has weakened the epiglottis.
  • 34:25It's not as strong as it normally is.
  • 34:27And so then this is a case when we
  • 34:29would do that epiglottic paxi again,
  • 34:31which I just showed you here.
  • 34:34There's no lingual tonsils,
  • 34:35so you don't have to do that
  • 34:37Co bladder removal.
  • 34:38Here you would just in the operating
  • 34:41room put this laryngoscope in and
  • 34:43then with a laser or cautery roughen
  • 34:46up the area of the vallecula,
  • 34:49which is what's right in there.
  • 34:51And then so this is where the
  • 34:53CO2 laser removing that mucosa,
  • 34:55making it raw and sticky.
  • 34:57And then now you place your sutures
  • 34:59and that will pull that epiglottis
  • 35:00up towards the tongue and remove
  • 35:02that retro lingual obstruction.
  • 35:06Then we can get into the syndromic kids,
  • 35:08and these are the population
  • 35:09that I take care of the most of.
  • 35:10And so this is a child with
  • 35:12Treacher Collins syndrome,
  • 35:13with he has mild Treacher Collins,
  • 35:15but still causing significant
  • 35:17obstructive sleep apnea.
  • 35:19A lot of times these
  • 35:20kids will have a high IQ,
  • 35:21but they're saturator is
  • 35:22really what scares you.
  • 35:23He's completely unable to tolerate
  • 35:25CPAP and he was supposed to have
  • 35:27a trick at another institution.
  • 35:28They came to see me the day before
  • 35:30the track as like a last ditch
  • 35:31effort from like some creature
  • 35:33Collins Facebook outreach because
  • 35:34I take care of a lot of kids with
  • 35:36TCS and I saw him and actually
  • 35:38he just had four plus adenoids.
  • 35:40That was his main problem.
  • 35:41He had basal tongue obstruction but
  • 35:42the adenoids were the real issue
  • 35:44so we removed his adenoids and now
  • 35:45he doesn't need to track it was
  • 35:47that simple but he's still snoring.
  • 35:48And so we repeat the SLEEP study and
  • 35:51the ADENOIDECTOMY has helped him.
  • 35:52Hi of 44 to 27 still severe.
  • 35:55Sat Nader is like nominally better
  • 35:57if not at the same and he's
  • 35:59hypoventilating and so he needs a
  • 36:01surgery and this is all tongue based
  • 36:03obstruction and he has a small jaw.
  • 36:05And so with a sleep endoscopy,
  • 36:07this is what things look like.
  • 36:08And if you jaw thrust him you can
  • 36:10see how this would open his airway.
  • 36:11So we need to do a surgical job thrust
  • 36:13and the way we do that is something
  • 36:15which is an orthognathic surgery
  • 36:17which is called mandibular distraction.
  • 36:19And so this is his.
  • 36:20CT scan and we will plan a osteotomy
  • 36:22through the mandible here and we
  • 36:24attach hardware on either side and we
  • 36:27then are done in the operating room
  • 36:29and we wait for two or three days.
  • 36:31And as the bone is starting to
  • 36:33heal but not fully healed,
  • 36:35we then start to slowly separate
  • 36:37the bone and the millimeter a day.
  • 36:39We extend that mandible forward and
  • 36:41as long as you do it slowly enough,
  • 36:43you stretch the nerve within here
  • 36:45and you let that bone keep growing,
  • 36:47growing,
  • 36:47growing and then you can basically
  • 36:48jaw thrust him and move that jaw.
  • 36:50Forward now we overcorrect him
  • 36:52and he will need a surgery on
  • 36:54his maxilla when he's older.
  • 36:56But remember these are all baby
  • 36:57teeth and so they fall out and
  • 36:59the new ones come in and they
  • 37:01often align in a better position.
  • 37:02And so here he is after 10.5 millimeters
  • 37:05of advancement of his mandible.
  • 37:07This is his scar on his jaws.
  • 37:09Now forward and we go back,
  • 37:11remove the hardware and this
  • 37:12is the bone that we've grown.
  • 37:13You can actually see it.
  • 37:15And that's brought his jaw forward
  • 37:17to centimeter and now it's really
  • 37:19just tongue based obstruction.
  • 37:20And then you repeat your sleep study
  • 37:22and you think it's going to be better,
  • 37:24probably not cured.
  • 37:25And you see this and you're like,
  • 37:26that's awesome.
  • 37:27Let's never get another sleep study.
  • 37:28So that's a kid who's gone from 27 to .9.
  • 37:31That's a mic drop as a surgeon.
  • 37:33And then, you know, 6872 to 91%.
  • 37:36And so he no longer snores
  • 37:38and he's doing great.
  • 37:40Now as he gets older and
  • 37:42starts to outgrow his jaw,
  • 37:44he will start to have some symptoms.
  • 37:46And then we follow him with sleep studies.
  • 37:47And if it's bad enough,
  • 37:48we do another surgery.
  • 37:49But this is a child.
  • 37:50It was supposed to have a tracheotomy
  • 37:52and now he has cured sleep apnea
  • 37:55with that orthognathic surgery.
  • 37:56And you can see now as time goes on,
  • 37:59his front teeth are on,
  • 38:01his upper teeth are in
  • 38:02front of his bottom teeth,
  • 38:03so he actually does not have
  • 38:05an underbite anymore here.
  • 38:06He does a little bit on the sides,
  • 38:08but he's able to eat normally.
  • 38:10This is a kid with Piero band
  • 38:12sequence and Down syndrome,
  • 38:13which is pretty remarkable.
  • 38:15He was trached but behaviorally difficult,
  • 38:18so he just pulled his tricked out
  • 38:19and threw it across the room.
  • 38:21And refuses to wear it.
  • 38:22And so now severe sleep apnea.
  • 38:25So we do this jaw distraction that will
  • 38:27lengthen both this part of the jaw,
  • 38:29the raymus and the body.
  • 38:31And this is how much we grew for him.
  • 38:33And he still has a small
  • 38:34jaw and a small shin,
  • 38:35but this was the difference between
  • 38:37severe obstructive sleep apnea and
  • 38:39getting him down to like an HIV.
  • 38:40And I think he was like 7 and he's 20.
  • 38:44And so for Down syndrome HIV,
  • 38:467 satinath or if it was
  • 38:5088 will will tolerate.
  • 38:52And he's a candidate,
  • 38:53you know, later he could have a
  • 38:55hypoglossal nerve stimulator.
  • 38:56That could be a possibility, though.
  • 38:58He would take off his,
  • 39:00his, you know, magnet,
  • 39:01throw it across the room
  • 39:03and that would be that.
  • 39:04And then finally,
  • 39:05uh,
  • 39:05nonsyndromic 16 year old girl I've
  • 39:07been following since she was eight
  • 39:09when I did a tonsil and adenoidectomy.
  • 39:12She still was snoring so we did sleep
  • 39:14endoscopy and she had laryngomalacia
  • 39:16and tongue based obstruction.
  • 39:18Um,
  • 39:19and she got another sleep study at age 12,
  • 39:22mild sleep apnea,
  • 39:23and we just sort of limped along like that.
  • 39:26And she did OK.
  • 39:27But then she started to get worse,
  • 39:30tied daytime somnolence.
  • 39:31And so she was on CPAP not
  • 39:33tolerating it by age 16.
  • 39:35And then
  • 39:36when we do our sleep endoscopy,
  • 39:38she has bad airway obstruction
  • 39:39to the point where I have to
  • 39:41put a nasal trumpet in her.
  • 39:43And here I'm feeling for the thyroid
  • 39:46medical, so and the distance.
  • 39:49On the thyroid. To the mandible.
  • 39:52And you can see on your CT scan
  • 39:54they're like right on top of each
  • 39:55other and that's why she has
  • 39:57this tongue based substance. And
  • 39:59so in this case the best thing
  • 40:00to do is bring her jaw forward.
  • 40:01And you could do that with the
  • 40:03distraction like I showed you,
  • 40:04but in an older kid who's 16
  • 40:06and pretty much done growing,
  • 40:08you can just do an MMA mandibular
  • 40:11maxillary advancement.
  • 40:12And so there we bring both jaw
  • 40:14and maxilla forward and this is
  • 40:16one of the only surgeries in the
  • 40:17sleep literature that's shown
  • 40:19to be pretty high reliability.
  • 40:21Success.
  • 40:21And so we do that for her and then
  • 40:24bring everything forward and played
  • 40:26her maxilla or mandible to maintain
  • 40:28her occlusion and that cured her sleep apnea.
  • 40:31All right.
  • 40:32We are almost done.
  • 40:33I just want to say a couple
  • 40:35things about infants.
  • 40:36Because infant sleep apnea is different
  • 40:38than older kids sleep apnea and
  • 40:41very much different than adult sleep apnea.
  • 40:43Infants are obligate nasal breathers.
  • 40:45If you have an adult and you just.
  • 40:48Clothes pin their nose shot at night.
  • 40:50They will open their mouth.
  • 40:52They'll be miserable and uncomfortable.
  • 40:54They'll wish they had Afrin or something to
  • 40:55open them up because it's a terrible cold.
  • 40:57But they're fine in a baby.
  • 40:59If you plug their nose completely,
  • 41:01they will die.
  • 41:03They are obligate nasal breathers.
  • 41:05They absolutely must be able
  • 41:06to breathe through their nose,
  • 41:08at least a little bit.
  • 41:09When we have babies born with a rinia,
  • 41:11meaning no nose,
  • 41:12they obstructed birth and they are.
  • 41:15They can't eat and we have
  • 41:16to do a tracheotomy for them.
  • 41:19And so the nose is very important
  • 41:20in the baby in a way that we don't
  • 41:23think about it as mattering so much.
  • 41:25In older kids and adults.
  • 41:28When a baby has nasal obstruction
  • 41:30and they often present to me,
  • 41:32I see at least three a day with bad
  • 41:34nasal obstruction, obstructing,
  • 41:36stopping, eating.
  • 41:37We usually just put them on some
  • 41:40nasal saline or nasal steroids and
  • 41:43infants will get this sort of progesterone,
  • 41:46maternal estrogen withdrawal.
  • 41:48Thing that happens where their
  • 41:51noses will get very,
  • 41:52very swollen and sometimes will,
  • 41:54they'll have a lot of problems.
  • 41:55We call it rhinitis of infancy.
  • 41:56It usually wears off around three
  • 41:58to six months of age,
  • 42:00but if you can't wait that long,
  • 42:01if you give them nasal steroids,
  • 42:02fluticasone,
  • 42:03it often just completely eliminates
  • 42:05it within two weeks.
  • 42:06And so that's a that's a nice move
  • 42:08in your back pocket for infants with
  • 42:11nasal obstruction that's related to edema.
  • 42:13On those that can't breathe
  • 42:15and eat and have Strider,
  • 42:16we do a supraglottic plasty
  • 42:18for those with narrowed.
  • 42:19Interform apertures,
  • 42:20the openings of the nose.
  • 42:22Here we will do a drill out of
  • 42:24that to open their nose up.
  • 42:26If they've coined latricia,
  • 42:27so a dead end in the back of their nose,
  • 42:30then we will fix that and then
  • 42:32you can expand their pallets.
  • 42:34And I just told you how it
  • 42:36helps with snoring.
  • 42:36It's not going to make a big
  • 42:38difference for sleep apnea
  • 42:39in adults and older kids,
  • 42:40but it helps in younger kids and it
  • 42:43really helps in infants if that's
  • 42:45actually what their problem is.
  • 42:46And then there's baby jaw distraction.
  • 42:48I showed you a 17 month.
  • 42:50But we do it in newborns
  • 42:52and of course tracheotomy,
  • 42:54this is a newborn with Piero
  • 42:56band sequence in Micronesia.
  • 42:58And you can see the tongue is so far back,
  • 43:01it's in the baby's nose,
  • 43:02it's actually prolapse through a
  • 43:04cleft palate and that's the nasal
  • 43:06septum in the midline back there.
  • 43:09And that tongue is touching the nasal
  • 43:12septum through the powerful flap.
  • 43:14And now the baby is 100% obstructed.
  • 43:16That happened this year.
  • 43:19Oh good, that's
  • 43:20genuine apnea. Yeah,
  • 43:21that's genuine happiness after
  • 43:22we do our jaw distraction, this
  • 43:24is the same baby four days later.
  • 43:296 millimeters of activation
  • 43:31that we brought his jaw forward,
  • 43:326 millimeters at this point and
  • 43:34now he's supine hanging out,
  • 43:36giving me the side eye.
  • 43:38So bringing that baby's jaw forward
  • 43:40just 6 millimeters at that point
  • 43:42will make that much of a difference.
  • 43:44Piriform aperture stenosis.
  • 43:45This is the normal pyriform aperture,
  • 43:48pear shaped. That's why it's pure form.
  • 43:50And then this looks like a box
  • 43:52or a keyhole and that makes
  • 43:54very very narrow nasal cavities.
  • 43:57So we drill that out.
  • 43:58Or you can actually make Bony cuts here,
  • 44:01attach hardware and expand the palette.
  • 44:06This is called a Sarpy or a surgically
  • 44:09assisted rapid palatal expansion.
  • 44:10So you make cuts here and here and
  • 44:12right here in the midline attach a
  • 44:15distractor and it will allow you to open it.
  • 44:17I'm showing you a larger patient and this
  • 44:19is a 10 year old with Apert syndrome,
  • 44:21which is craniosynostosis with
  • 44:23premature fusion of the skull sutures.
  • 44:26The suture,
  • 44:27as orthodontist will tell you
  • 44:28in the mid palatal suture here,
  • 44:31is open and stays open until
  • 44:33you're like 1318 years old,
  • 44:35which is why you can attach a paddle.
  • 44:37Spander turned that key.
  • 44:38It hurts like hell,
  • 44:39but it expands your palate.
  • 44:41That says the suture is open in
  • 44:43syndromic children that have
  • 44:44premature fusion of their sutures,
  • 44:46such as this kid with Apert syndrome.
  • 44:48The pallet can't grow or expand
  • 44:50and look at her teeth.
  • 44:52And so the only way to expand them,
  • 44:54since it's completely fused,
  • 44:55is to make these cuts,
  • 44:57reopen that suture with an
  • 44:59osteotomy and attach your hardware.
  • 45:01And now we make that pallet longer, wider.
  • 45:03And that helps a lot with their dentition,
  • 45:05and it does have the side effect
  • 45:07of improving the nasal obstruction.
  • 45:08You can do this to an infant,
  • 45:10but infants don't have teeth.
  • 45:11And so here we are,
  • 45:12having drilled out that pyriform
  • 45:14aperture on this infant.
  • 45:15Here's our this has prematurely
  • 45:17fused in utero, so we reopen it.
  • 45:20There's our cuts and the distractor
  • 45:21that we put on them.
  • 45:22Because they don't have teeth
  • 45:24is a little acrylic plate.
  • 45:25We screw it into the palette
  • 45:27and then we can turn this.
  • 45:30And that will open the palette and that
  • 45:33will relieve their nasal obstruction.
  • 45:35But it's very uncommon.
  • 45:37I think I've done like 3,
  • 45:39but but it, it, it can be used.
  • 45:41And so those are like the most aggressive
  • 45:44Bony orthognathic interventions
  • 45:45in infants and young children.
  • 45:47So we've reviewed the pediatric ENT
  • 45:49perspective regarding the workup and
  • 45:51management of sleep disorder breathing
  • 45:52and if you have a sleep study,
  • 45:54obstructive sleep apnea,
  • 45:55we talked about surgical strategies
  • 45:57for regressing for addressing both
  • 46:00recurrent and persistent airway
  • 46:01obstruction after T&A and we talked
  • 46:04about some orthognathic procedures.
  • 46:06And at that point,
  • 46:07I'm going to stop and open it
  • 46:08up to questions.
  • 46:09Please feel free to unmute yourselves.
  • 46:15Thank you, Andrew.
  • 46:16I just had a quick question since uh,
  • 46:19we do see some of these kids,
  • 46:21uh with you, uh, what you know,
  • 46:23we parents typically ask us about the
  • 46:27regrowth of the tonsils opposed TNA.
  • 46:30But the adenoids we always talk about,
  • 46:32regrowth of adenoids can occur if
  • 46:34they are allergic and have allergies.
  • 46:36Seasonal allergies.
  • 46:37What about the lingular
  • 46:39tonsillar hypertrophy?
  • 46:41How how often do you see big currents
  • 46:43with these or adenoids in general?
  • 46:45Yeah, those those are great questions.
  • 46:48So First off, I think you want to
  • 46:50think about the age of the child.
  • 46:52So the chances of the adenoids growing back,
  • 46:54regardless of the technique you use are much
  • 46:57higher if you remove the adenoids underage 2.
  • 47:00So kids who have adenoidectomy under
  • 47:02two and it's sort of self selects
  • 47:04for those that have some sort of bad
  • 47:06disease or problem to begin with.
  • 47:08Those are the ones who are
  • 47:09more likely to have regrowth.
  • 47:11It's still low,
  • 47:12but it's more common if you're removing
  • 47:14the adenoids than a kid over 2/3, even four.
  • 47:17It would be very unlikely for
  • 47:19those adenoids to come back.
  • 47:21It's really the younger kids that do that.
  • 47:23The tonsils.
  • 47:24We have two ways of removing them.
  • 47:25One is called an extra
  • 47:27capsular tonsillectomy,
  • 47:28which is their standard tonsillectomy.
  • 47:30And then there's something called
  • 47:32a tonsillectomy or an intracapsular
  • 47:34tonsillectomy.
  • 47:35And that's where we shave the tonsils
  • 47:37down and we remove them from the inside out.
  • 47:40So the tonsil is like an egg with a
  • 47:43shell that sits in the tonsillar fossa.
  • 47:45And when you do tonsillectomy,
  • 47:46you remove the entire tonsil,
  • 47:48including the shell like a hard boiled egg.
  • 47:50It all comes out for tonsillectomy.
  • 47:53You leave the shell and you take
  • 47:54out the egg white,
  • 47:55the egg yolk,
  • 47:56everything and that shell stays,
  • 47:58and then you cauterize the shell and
  • 48:01that has a lower bleed rate and a
  • 48:04little bit better pain afterwards.
  • 48:07The downside of it is that it has a higher,
  • 48:11though not high but higher chance
  • 48:14of regrowth.
  • 48:15And I have definitely like a few times a
  • 48:18year I see regrowth from tonsillectomy.
  • 48:21I don't do a lot of tonsillectomy
  • 48:22in younger kids.
  • 48:23Because I've seen so many regrowth and the
  • 48:25parents are pretty unhappy when that happens,
  • 48:27because now you got to go through
  • 48:29the whole thing all over again.
  • 48:31And so, but for those that don't regrow,
  • 48:33you know you've you've got an
  • 48:35easier recovery and and it worked.
  • 48:37So plenty of places will do that but
  • 48:40otherwise the tonsil shouldn't grow back.
  • 48:42If you do an extra capsular tonsillectomy
  • 48:44and then the lingual tonsils,
  • 48:45we you know, ablate them down and
  • 48:47they usually do not come back.
  • 48:49I personally have never seen
  • 48:51lingual tonsils return,
  • 48:52but it can happen.
  • 48:53You're more likely to grow lymphoid
  • 48:55tissue in a weird place than to
  • 48:58regrow your lingual tonsils.
  • 48:59I'm going to get to another question.
  • 49:01Somebody asked about ages of CPAP.
  • 49:04I have started plenty of infants on CPAP.
  • 49:07You will do a super glottic
  • 49:09plasty and they'll get better,
  • 49:10but not good enough.
  • 49:11You put them on CPAP and we can wean
  • 49:14them off cpap by 910 months of age.
  • 49:16And then their sleep studies fine
  • 49:18and they're good to go.
  • 49:19But it really helps them for
  • 49:21gaining weight because if you have
  • 49:23a kid with such bad laryngomalacia
  • 49:25that they're weak and hypotonic
  • 49:27from their failure to thrive
  • 49:28and you do your intervention.
  • 49:30And they still can't quite catch up.
  • 49:31You're catching up to weakness
  • 49:33and hypotonia and that that CPAP
  • 49:35sort of allows them to rest.
  • 49:36And so that's just a few months.
  • 49:38I've had other kids with cerebral palsy
  • 49:41who have been on CPAP for years and years.
  • 49:44The downside of that is that it
  • 49:46can cause mid face retribution if
  • 49:48those straps are tightened up and
  • 49:50you're yanking it back enough.
  • 49:51And that may require an
  • 49:54orthodontic intervention,
  • 49:55but you can do it for a while.
  • 49:56You just want to be able to readjust
  • 49:59your settings, right?
  • 50:00Because like your pressure
  • 50:01settings will change as the child
  • 50:03grows and and and time goes on.
  • 50:05Another question was really we
  • 50:07see patients with an increase in
  • 50:09HIV after TNA in Down syndrome.
  • 50:11Yep, absolutely.
  • 50:12That can happen and is a bummer.
  • 50:17And that's a lot of sort of hypotonia
  • 50:20at play and interval growth at play.
  • 50:23It's less likely that a Down syndrome,
  • 50:26OK with Down syndrome who's done
  • 50:28growing will have a TNA and then.
  • 50:30Be worse.
  • 50:31I suppose it could happen,
  • 50:32but there's also the test retest
  • 50:34reliability of your sleep study.
  • 50:36But often you will see a child who's
  • 50:38younger with downs and then you
  • 50:40do their T&A and they're better.
  • 50:41And then as they grow their
  • 50:44mid face deficiency,
  • 50:45their retro paddle obstruction,
  • 50:46their relative macroglossia because
  • 50:48the rest of their mouth isn't growing,
  • 50:50but their tongue still growing with them.
  • 50:52That contributes more than that's going
  • 50:53to give you more of the severe OSA.
  • 50:55That is a population that needs to
  • 50:57be followed closely and it's also a
  • 50:59population that sometimes you need to decide.
  • 51:02Like how closely do you want
  • 51:03to be doing this?
  • 51:03Because each time you follow
  • 51:05and you get that sleep study,
  • 51:07like you feel obligated to
  • 51:08do something about it.
  • 51:09And for some kids, like wow,
  • 51:11this is really important for
  • 51:12heart strain and whatnot.
  • 51:13But for other kids,
  • 51:15depending on how highly functioning
  • 51:17Down syndrome they are, you know,
  • 51:20the, the, the mild.
  • 51:22Let's admit it.
  • 51:23The mild neurocognitive effects on
  • 51:24the nonverbal Down syndrome kid.
  • 51:26That may not be worth the struggle of
  • 51:29putting that mask on every 10 minutes
  • 51:31all night long on a combative child.
  • 51:34And so one has to think about about that.
  • 51:39That's a broader discussion.
  • 51:42All right, keep them coming.
  • 51:43What else you got?
  • 51:47Hey, Andrew, very nice talk.
  • 51:49Really fun to see the other side of sleep
  • 51:52apnea management when we oftentimes are.
  • 51:55That's not involved in these more
  • 51:57invasive procedures and obviously
  • 51:58they work in the right person.
  • 52:00So one question I have
  • 52:01for you is that you know,
  • 52:03there's in the sleep apnea literature,
  • 52:05there's some data coming up for us to,
  • 52:07you mentioned epiglottic
  • 52:09prolapse or collapse and kids.
  • 52:11And so it's starting to get some
  • 52:13literature showing that you can sort of
  • 52:15pick out who has that collapse in adults.
  • 52:17And we know that those individuals
  • 52:18tend to do worse with CPAP,
  • 52:20you know, makes the collapse
  • 52:21worse and they can't tolerate it.
  • 52:23And so I was trying to think of
  • 52:25what are the surgical options?
  • 52:28You know, for adults,
  • 52:29if you're aware of them and
  • 52:30you know and if so,
  • 52:32do you have a sense of success
  • 52:33of these procedures because at
  • 52:34least personally I have at least a
  • 52:36couple of patients that have that
  • 52:38pattern of epiglottic prolapse and
  • 52:39have a really tough time with CPAP
  • 52:41and maybe they're like better,
  • 52:42a little bit better with oral appliance,
  • 52:44but and So what?
  • 52:47Perhaps is occurring how low it is
  • 52:49that you really have to Jack the
  • 52:50pressure up and then they're the
  • 52:52ones that it's going through their
  • 52:53upper softgel sphincter and they
  • 52:54can't tolerate and they hate it.
  • 52:57So our field is interesting.
  • 53:00So like we all do adult and pediatric
  • 53:03training as our general core residency.
  • 53:06But then if you do a sleep fellowship
  • 53:09that's all adults and if you do Pediatrics,
  • 53:11you don't do any sleep other than
  • 53:13just whatever we just talked about.
  • 53:15Now there is some important overlap.
  • 53:18And I definitely do much more
  • 53:20adult flavored sleep surgeries
  • 53:22than most pediatric allergists.
  • 53:24But there are some pediatric allergology
  • 53:27sleep interventions that are pretty
  • 53:29Mickey Mouse basic to us that sleep
  • 53:32adults sleep otolaryngology trained people
  • 53:34will have never seen and never done and
  • 53:37have no idea what you're talking about.
  • 53:39So if I showed you know Tucker Woodson like
  • 53:42the the lingual tonsillectomy with epilepsy,
  • 53:46he would be like,
  • 53:47I don't even know what that is.
  • 53:48So they don't do that in adults.
  • 53:50They'll do hyoid suspension.
  • 53:52They'll suspend the hyoid to the mandible or
  • 53:56or try to Pepsi the epiglottis up that way.
  • 53:59But the data shows that doesn't work.
  • 54:02If you do you triple P
  • 54:05and a hyoid suspension,
  • 54:06you will lower your HIV more than
  • 54:08any one of those individually,
  • 54:10but you still don't lower it
  • 54:11enough to cure the sleep apnea.
  • 54:13And those with higher BMI and those
  • 54:16with higher HI are predictably.
  • 54:18Gonna fail.
  • 54:19And so those procedures though
  • 54:21still have use.
  • 54:23So you could do them and then
  • 54:25maybe tolerate CPAP more because
  • 54:26your pressures aren't as high.
  • 54:28And so that's where I think that sleep
  • 54:30surgeries are not always a cure all,
  • 54:33but they can be a really helpful
  • 54:35adjuvant to PAP therapy.
  • 54:37And this is where I think like as the
  • 54:40surgeons we want to be the Cowboys
  • 54:41that come in and save the day.
  • 54:43But it isn't always going to be like that.
  • 54:45But there's still an important
  • 54:47use of of helping someone.
  • 54:49Going down on their pressures that
  • 54:50might improve their compliance.
  • 54:52And then in doing that you,
  • 54:54you do this intervention and
  • 54:56it's still useful.
  • 54:57And if it's the difference
  • 54:59between tolerating PAP therapy,
  • 55:00you're not talking about therapy,
  • 55:01then that is a successful surgery.
  • 55:04It's just the definition of success
  • 55:06in surgery is meeting expectations.
  • 55:09That's the definition of success.
  • 55:11So you just got to be honest
  • 55:12about what you can and can't do.
  • 55:14I think that some of these kids
  • 55:15surgeries where you're wrapping up
  • 55:17the base of tongue and your Pepsi,
  • 55:18that epiglottis up, umm,
  • 55:20I think that could be very helpful
  • 55:22for some adults.
  • 55:23But adults are very good at communicating
  • 55:26when they are not happy with you.
  • 55:28So that kid is much tougher.
  • 55:30So the the TNA in a grown man is like
  • 55:33gets a bell and rings it for their spouse.
  • 55:37Bring me I can't talk,
  • 55:39I can't eat too.
  • 55:40Two weeks of agony,
  • 55:42a month of medical leave and the
  • 55:44three-year olds on the playground.
  • 55:46You know, the next day running around
  • 55:47like nothing happened with you.
  • 55:48Saw that epiglottis up on a 40 year old man.
  • 55:51They're going to be like, I'm choking,
  • 55:52I'm dying. I know I would be.
  • 55:54And whereas the child maybe can't
  • 55:57talk yet or is nonverbal and they
  • 55:59just take it and then they're fine.
  • 56:01So I think it,
  • 56:02it could be a leap to do those things.
  • 56:05But I think there are things Pediatrics
  • 56:07could help adults and there's definitely
  • 56:09the adult stuff helps pediatric,
  • 56:10but there's not enough cross pollenization
  • 56:13within our own field in that regard.
  • 56:15So long answer to your question, sorry.
  • 56:18OK. Thank you.
  • 56:22And if anyone else has a question,
  • 56:23please feel free to let us know.
  • 56:25We can unmute you or. You could post one.
  • 56:30I don't see any more questions in the chat.
  • 56:34I'm imagine you guys have had
  • 56:36a lecture on hypoglossal nerve
  • 56:38stimulation and all of that.
  • 56:39You know, that's our latest pancia.
  • 56:42As they expand the indications of that,
  • 56:44you're going to see all
  • 56:46the failures rolling in.
  • 56:47If you haven't already, that's OK.
  • 56:50Just know it's coming.
  • 56:52When you make the criteria so strict,
  • 56:55which you know they inspire does on purpose,
  • 56:58then you know you're going to get your FDA.
  • 57:00It's going to be good.
  • 57:01And as soon as you start
  • 57:02expanding and saying, oh,
  • 57:03let's, let's bend the rules
  • 57:04a little bit on this one,
  • 57:05that's when those start popping up.
  • 57:07So don't be discouraged
  • 57:08when that starts happening.
  • 57:09If you know what's coming,
  • 57:10you will feel better about it.
  • 57:13And so do you do inspire in
  • 57:15adults and kids or just adults.
  • 57:17So I have trained to do it and but
  • 57:20I in practice I have not done it.
  • 57:23My colleague who does PEDs has done
  • 57:27been doing them in adults as well.
  • 57:30So but I in the end was like I don't
  • 57:32want to start seeing adults and filling
  • 57:35my clinic with adult inspire patients,
  • 57:38but I think it could be really helpful in
  • 57:41pediatric cerebral palsy in particular.
  • 57:43We've been doing it in downs
  • 57:45and it's been helpful,
  • 57:46but there are plenty who have failed and
  • 57:48it's it's a good thing to try and downs,
  • 57:50but it's really going to
  • 57:52be the best in hypotonia,
  • 57:54not just there's too much
  • 57:56anatomic issues for downs.
  • 57:58So it will be helpful,
  • 57:59but where it will really
  • 58:01crush it is in CP or people,
  • 58:03hypotonic kids that it's
  • 58:04going to be unbelievable.
  • 58:09Yeah, we get an
  • 58:10IRB in that population and and
  • 58:13compassionate exemption is tricky.
  • 58:15We've been sending our downs kits
  • 58:17to doctor Hartnick and now last
  • 58:21pioneer, yeah. We do it here. So
  • 58:24he's. Yeah. So, you know,
  • 58:26he's done, uh, several.
  • 58:27But in reality when you look at
  • 58:29the numbers, it's not that many.
  • 58:31And he now is getting paid for it,
  • 58:34but for the first, you know,
  • 58:36eight years mass linear,
  • 58:37just ate the cost of every
  • 58:39device in every surgery.
  • 58:43So tricky. OK.
  • 58:46Good to know.
  • 58:47Well, all right, very good.
  • 58:48Well, thank you, Andrew.
  • 58:49I think already and very nice,
  • 58:52very nice session.
  • 58:53Look forward to hearing from you
  • 58:55sometime in the future and I
  • 58:57will see you guys in one month.
  • 59:01Thank you again for the everybody.
  • 59:02Thank you. Great day everyone.
  • 59:05Thank you.