Modeling HIV-1 nuclear entry with DNA-origami nuclear pore mimics
Entering nucleus is a complicated process critical to the infectivity of HIV. Shen et al. built DNA-origami-based nuclear pore complex mimics to elucidate important capsid-nucleoporin interactions that underlie the nuclear entry of HIV-1 core.Source: Nature Structural & Molecular Biology
Biology of Aging Study Shows Why Curbing Calories Counts
The Director of the National Institutes of Health notes two recent studies, including one from the Yale Center for Research on Aging (Y-Age), that suggest that calorie restriction may improve immune function and reduce chronic inflammation.Source: National Institute of Health Director's Blog
Pietro De Camilli Selected for 2021 E.B. Wilson Medal
Pietro De Camilli, professor of Neuroscience and Cell Biology at Yale University and a Howard Hughes Medical Institute investigator, has been chosen by ASCB to receive the 2021 E.B. Wilson Medal. De Camilli is also the director of the Kavli Institute of Neuroscience at the Yale University School of Medicine.Source: American Society for Cell Biology
Simple Change to Microscope Opens Up a Complex Panorama of Cells
Yale researchers in the lab of Joerg Bewersdorf have developed a way to visualize extremely tiny structures by using standard light microscopy, a world previously only accessible by expensive and cumbersome electron microscopy.Source: YaleNews
Yale Researchers Take Stem Cells One Step Closer to Replacing Parathyroid Gland Function
Yale investigators have developed a multistep process that models the biological instructions to create parathyroid gland cells from pluripotent stem cells, a significant milestone along the path toward helping people who lack the hormones released by parathyroid glands.
Position Openings in the Zhang lab
The Zhang lab at the Department of Cell Biology, Yale University, uses single-molecule approaches, especially high-resolution optical tweezers, to study folding dynamics of proteins involved in fundamental biological processes and human diseases. The lab is now seeking graduate students and postdocs for research in the following three areas: • Regulated SNARE folding and assembly. • Membrane protein folding, stability, and protein-membrane interactions. • Instrumental development. Prior research experience in single-molecule biophysics is not required. However, postdoc candidates should have strong quantitative skills and solid training in biophysics, molecular biology, or physics. If you are interested in these positions, please contact Dr. Yongli Zhang at email@example.com.
Scientists find many gene 'drivers' of cancer, but warn: Don't ignore 'passengers'
A massive analysis of the entire genomes of 2,658 people with 38 different types of cancer has identified mutations in 179 genes and gene regulators as “drivers” — variations in DNA sequences that lead to the development of cancer.
In the right (lab) culture, mentorship flourishes — and science benefits
You might imagine a science lab looking a bit sterile and impersonal — little sunlight, masked figures in white coats pouring neon-colored liquid into beakers, all business. You might not expect to hear a science lab referred to as familial, where badminton tournaments, movie nights and barbeques are commonplace.