Martin Schwartz

Martin Schwartz, PhD
Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Biomedical Engineering and of Cell Biology
Research Interests
Aneurysm
Cell Biology
Atherosclerosis
Vascular Malformations
Vascular Remodeling
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Schwartz Lab

The main research topics in my laboratory are integrin signaling and mechanotransduction in vascular biology, with emphasis on topics that are relevant to human disease. We use a variety of biophysical and cell biological tools as well as animal models in these studies.

Publications

2020

Actin flow-dependent and -independent force transmission through integrins.Driscoll TP, Ahn SJ, Huang B, Kumar A, Schwartz MA. Proc Natl Acad Sci U S A. 2020 Dec 22; 2020 Dec 1. PMID: 33262280.
Developmental origins of mechanical homeostasis in the aorta.Murtada SI, Kawamura Y, Li G, Schwartz MA, Tellides G, Humphrey JD. Dev Dyn. 2020 Dec 20; 2020 Dec 20. PMID: 33341996.
Laser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues.Herrera JA, Mallikarjun V, Rosini S, Montero MA, Lawless C, Warwood S, O'Cualain R, Knight D, Schwartz MA, Swift J. Clin Proteomics. 2020; 2020 Jun 17. PMID: 32565759.
Endothelial-to-Mesenchymal Transition, Vascular Inflammation, and Atherosclerosis.Chen PY, Schwartz MA, Simons M. Front Cardiovasc Med. 2020; 2020 May 5. PMID: 32478094.

2019

Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity.Solis AG, Bielecki P, Steach HR, Sharma L, Harman CCD, Yun S, de Zoete MR, Warnock JN, To SDF, York AG, Mack M, Schwartz MA, Cruz CSD, Palm NW, Jackson R, Flavell RA. Nature. 2019 Nov. PMID: 31712625.
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis.Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone NA, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz MA, Pober JS, Chittenden TW, Tellides G, Simons M. Nat Metab. 2019 Sep; 2019 Aug 26. PMID: 31572976.
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity.Solis AG, Bielecki P, Steach HR, Sharma L, Harman CCD, Yun S, de Zoete MR, Warnock JN, To SDF, York AG, Mack M, Schwartz MA, Dela Cruz CS, Palm NW, Jackson R, Flavell RA. Nature. 2019 Sep; 2019 Aug 21. PMID: 31435009.
Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis.Yun S, Hu R, Schwaemmle ME, Scherer AN, Zhuang Z, Koleske AJ, Pallas DC, Schwartz MA. J Clin Invest. 2019 Aug 13; 2019 Aug 13. PMID: 31408443.
Filamin A mediates isotropic distribution of applied force across the actin network.Kumar A, Shutova MS, Tanaka K, Iwamoto DV, Calderwood DA, Svitkina TM, Schwartz MA. J Cell Biol. 2019 Aug 5; 2019 Jul 17. PMID: 31315944.
Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation.Ramírez CM, Zhang X, Bandyopadhyay C, Rotllan N, Sugiyama MG, Aryal B, Liu X, He S, Kraehling JR, Ulrich V, Lin CS, Velazquez H, Lasunción MA, Li G, Suárez Y, Tellides G, Swirski FK, Lee WL, Schwartz MA, Sessa WC, Fernández-Hernando C. Circulation. 2019 Jul 16; 2019 Jun 3. PMID: 31154825.
Coarse-Grained Simulation of Full-Length Integrin Activation.Bidone TC, Polley A, Jin J, Driscoll T, Iwamoto DV, Calderwood DA, Schwartz MA, Voth GA. Biophys J. 2019 Mar 19; 2019 Feb 22. PMID: 30851876.
Translocating transcription factors in fluid shear stress-mediated vascular remodeling and disease.Min E, Schwartz MA. Exp Cell Res. 2019 Mar 1; 2019 Jan 8. PMID: 30633880.
ARHGAP18: A Flow-Responsive Gene That Regulates Endothelial Cell Alignment and Protects Against Atherosclerosis.Lay AJ, Coleman PR, Formaz-Preston A, Ting KK, Roediger B, Weninger W, Schwartz MA, Vadas MA, Gamble JR. J Am Heart Assoc. 2019 Jan 22. PMID: 30630384.
Registration of the extracellular matrix components constituting the fibroblastic focus in idiopathic pulmonary fibrosis.Herrera J, Forster C, Pengo T, Montero A, Swift J, Schwartz MA, Henke CA, Bitterman PB. JCI Insight. 2019 Jan 10; 2019 Jan 10. PMID: 30626754.

2018

Vinculin and the mechanical response of adherent fibroblasts to matrix deformation.Rosowski KA, Boltyanskiy R, Xiang Y, Van den Dries K, Schwartz MA, Dufresne ER. Sci Rep. 2018 Dec 19; 2018 Dec 19. PMID: 30568231.
Talin as a mechanosensitive signaling hub.Goult BT, Yan J, Schwartz MA. J Cell Biol. 2018 Nov 5; 2018 Sep 25. PMID: 30254032.
Local Tension on Talin in Focal Adhesions Correlates with F-Actin Alignment at the Nanometer Scale.Kumar A, Anderson KL, Swift MF, Hanein D, Volkmann N, Schwartz MA. Biophys J. 2018 Oct 16; 2018 Sep 10. PMID: 30274833.
hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis.Di Modugno F, Spada S, Palermo B, Visca P, Iapicca P, Di Carlo A, Antoniani B, Sperduti I, Di Benedetto A, Terrenato I, Mottolese M, Gandolfi F, Facciolo F, Chen EI, Schwartz MA, Santoni A, Bissell MJ, Nisticò P. Oncogene. 2018 Oct; 2018 Jun 15. PMID: 29907768.
Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy.Liao X, Shen Y, Zhang R, Sugi K, Vasudevan NT, Alaiti MA, Sweet DR, Zhou L, Qing Y, Gerson SL, Fu C, Wynshaw-Boris A, Hu R, Schwartz MA, Fujioka H, Richardson B, Cameron MJ, Hayashi H, Stamler JS, Jain MK. Proc Natl Acad Sci U S A. 2018 May 15; 2018 Apr 30. PMID: 29712858.
A unifying concept in vascular health and disease.Schwartz MA, Vestweber D, Simons M. Science. 2018 Apr 20. PMID: 29674582.
Addendum: Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification.Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK. Nat Commun. 2018 Feb 14; 2018 Feb 14. PMID: 29445140.
Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis.Budatha M, Zhang J, Zhuang ZW, Yun S, Dahlman JE, Anderson DG, Schwartz MA. J Am Heart Assoc. 2018 Jan 30; 2018 Jan 30. PMID: 29382667.

2017

Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification.Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK. Nat Commun. 2017 Dec 15; 2017 Dec 15. PMID: 29247167.
Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish.Lagendijk AK, Gomez GA, Baek S, Hesselson D, Hughes WE, Paterson S, Conway DE, Belting HG, Affolter M, Smith KA, Schwartz MA, Yap AS, Hogan BM. Nat Commun. 2017 Nov 10; 2017 Nov 10. PMID: 29123087.
VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN.Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA. Curr Biol. 2017 Sep 11. PMID: 28898639.
VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN.Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA. Curr Biol. 2017 Jul 24; 2017 Jul 14. PMID: 28712573.
A new synthetic matrix metalloproteinase inhibitor reduces human mesenchymal stem cell adipogenesis.Bosco DB, Roycik MD, Jin Y, Schwartz MA, Lively TJ, Zorio DA, Sang QA. PLoS One. 2017; 2017 Feb 24. PMID: 28234995.

2016

Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.Wang Y, Baeyens N, Corti F, Tanaka K, Fang JS, Zhang J, Jin Y, Coon B, Hirschi KK, Schwartz MA, Simons M. Development. 2016 Dec 1; 2016 Oct 27. PMID: 27789626.
Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling.Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz MA. Nat Cell Biol. 2016 Oct; 2016 Sep 5. PMID: 27595237.
Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia.Baeyens N, Larrivée B, Ola R, Hayward-Piatkowskyi B, Dubrac A, Huang B, Ross TD, Coon BG, Min E, Tsarfati M, Tong H, Eichmann A, Schwartz MA. J Cell Biol. 2016 Sep 26; 2016 Sep 19. PMID: 27646277.
An Osteopontin/CD44 Axis in RhoGDI2-Mediated Metastasis Suppression.Ahmed M, Sottnik JL, Dancik GM, Sahu D, Hansel DE, Theodorescu D, Schwartz MA. Cancer Cell. 2016 Sep 12; 2016 Sep 1. PMID: 27593345.
Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine.Balestrini JL, Gard AL, Gerhold KA, Wilcox EC, Liu A, Schwan J, Le AV, Baevova P, Dimitrievska S, Zhao L, Sundaram S, Sun H, Rittié L, Dyal R, Broekelmann TJ, Mecham RP, Schwartz MA, Niklason LE, White ES. Biomaterials. 2016 Sep; 2016 Jun 16. PMID: 27344365.
Ion Channels in Endothelial Responses to Fluid Shear Stress.Gerhold KA, Schwartz MA. Physiology (Bethesda). 2016 Sep. PMID: 27511462.
Correction: Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.Kumar A, Ouyang M, Van den Dries K, McGhee EJ, Tanaka K, Anderson MD, Groisman A, Goult BT, Anderson KI, Schwartz MA. J Cell Biol. 2016 Jul 18. PMID: 27432899.
Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity.Kumar A, Ouyang M, Van den Dries K, McGhee EJ, Tanaka K, Anderson MD, Groisman A, Goult BT, Anderson KI, Schwartz MA. J Cell Biol. 2016 May 9. PMID: 27161398.
Spider Silk Peptide Is a Compact, Linear Nanospring Ideal for Intracellular Tension Sensing.Brenner MD, Zhou R, Conway DE, Lanzano L, Gratton E, Schwartz MA, Ha T. Nano Lett. 2016 Mar 9; 2016 Feb 3. PMID: 26824190.
Endothelial fluid shear stress sensing in vascular health and disease.Baeyens N, Bandyopadhyay C, Coon BG, Yun S, Schwartz MA. J Clin Invest. 2016 Mar 1; 2016 Mar 1. PMID: 26928035.
Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization.Dubrac A, Genet G, Ola R, Zhang F, Pibouin-Fragner L, Han J, Zhang J, Thomas JL, Chedotal A, Schwartz MA, Eichmann A. Circulation. 2016 Jan 26; 2015 Dec 9. PMID: 26659946.
Biomechanics of vascular mechanosensation and remodeling.Baeyens N, Schwartz MA. Mol Biol Cell. 2016 Jan 1. PMID: 26715421.

2015

Endothelial-to-mesenchymal transition drives atherosclerosis progression.Chen PY, Qin L, Baeyens N, Li G, Afolabi T, Budatha M, Tellides G, Schwartz MA, Simons M. J Clin Invest. 2015 Oct 26; 2015 Oct 26. PMID: 26517696.
The importance of indifference in scientific research.Schwartz MA. J Cell Sci. 2015 Aug 1; 2015 Jul 1. PMID: 26136366.
Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction.Daneshjou N, Sieracki N, van Nieuw Amerongen GP, Conway DE, Schwartz MA, Komarova YA, Malik AB. J Cell Biol. 2015 Apr 13; 2015 Apr 6. PMID: 25847538.
Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections.Humphrey JD, Schwartz MA, Tellides G, Milewicz DM. Circ Res. 2015 Apr 10. PMID: 25858068.
Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex.Coon BG, Baeyens N, Han J, Budatha M, Ross TD, Fang JS, Yun S, Thomas JL, Schwartz MA. J Cell Biol. 2015 Mar 30; 2015 Mar 23. PMID: 25800053.
ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.Tornavaca O, Chia M, Dufton N, Almagro LO, Conway DE, Randi AM, Schwartz MA, Matter K, Balda MS. J Cell Biol. 2015 Mar 16; 2015 Mar 9. PMID: 25753039.
Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point.Baeyens N, Nicoli S, Coon BG, Ross TD, Van den Dries K, Han J, Lauridsen HM, Mejean CO, Eichmann A, Thomas JL, Humphrey JD, Schwartz MA. Elife. 2015 Feb 2; 2015 Feb 2. PMID: 25643397.
Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction.Daneshjou N, Sieracki N, van Nieuw Amerongen GP, Conway DE, Schwartz MA, Komarova YA, Malik AB. J Cell Biol. 2015 Jan 5. PMID: 25559184.
Change of direction in the biomechanics of atherosclerosis.Mohamied Y, Rowland EM, Bailey EL, Sherwin SJ, Schwartz MA, Weinberg PD. Ann Biomed Eng. 2015 Jan; 2014 Aug 20. PMID: 25138165.
Mechanotransduction of shear stress occurs through changes in VE-cadherin and PECAM-1 tension: implications for cell migration.Conway DE, Schwartz MA. Cell Adh Migr. 2015; 2014 Oct 3. PMID: 25482618.
Integrin adjunct therapy for melanoma.Andarawewa KL, Moissoglu K, Sup Lee C, Ando Y, Yu M, Debnath P, Shannon JD, Sirinivasan S, Conaway MR, Weber MJ, Schwartz MA. Pigment Cell Melanoma Res. 2015 Jan; 2014 Nov 3. PMID: 25264294.

2014

Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling.Baeyens N, Mulligan-Kehoe MJ, Corti F, Simon DD, Ross TD, Rhodes JM, Wang TZ, Mejean CO, Simons M, Humphrey J, Schwartz MA. Proc Natl Acad Sci U S A. 2014 Dec 2; 2014 Nov 17. PMID: 25404299.
Mechanotransduction and extracellular matrix homeostasis.Humphrey JD, Dufresne ER, Schwartz MA. Nat Rev Mol Cell Biol. 2014 Dec; 2014 Oct 22. PMID: 25355505.
Discovery and characterization of small molecules that target the GTPase Ral.Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D. Nature. 2014 Nov 20; 2014 Sep 14. PMID: 25219851.
Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis.Morrison AR, Yarovinsky TO, Young BD, Moraes F, Ross TD, Ceneri N, Zhang J, Zhuang ZW, Sinusas AJ, Pardi R, Schwartz MA, Simons M, Bender JR. J Exp Med. 2014 Sep 22; 2014 Sep 1. PMID: 25180062.
Tension-sensitive actin assembly supports contractility at the epithelial zonula adherens.Leerberg JM, Gomez GA, Verma S, Moussa EJ, Wu SK, Priya R, Hoffman BD, Grashoff C, Schwartz MA, Yap AS. Curr Biol. 2014 Aug 4; 2014 Jul 24. PMID: 25065757.
Cell biology. Dysfunctional mechanosensing in aneurysms.Humphrey JD, Milewicz DM, Tellides G, Schwartz MA. Science. 2014 May 2. PMID: 24786066.

2013

Flow-dependent cellular mechanotransduction in atherosclerosis.Conway DE, Schwartz MA. J Cell Sci. 2013 Nov 15; 2013 Nov 4. PMID: 24190880.
Integrins in mechanotransduction.Ross TD, Coon BG, Yun S, Baeyens N, Tanaka K, Ouyang M, Schwartz MA. Curr Opin Cell Biol. 2013 Oct; 2013 Jun 21. PMID: 23797029.
Cell migration: Towards the void.Dufresne ER, Schwartz MA. Nat Mater. 2013 Sep. PMID: 23966050.
Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core.Jin Y, Roycik MD, Bosco DB, Cao Q, Constantino MH, Schwartz MA, Sang QX. J Med Chem. 2013 Jun 13; 2013 May 16. PMID: 23631440.
Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1.Conway DE, Breckenridge MT, Hinde E, Gratton E, Chen CS, Schwartz MA. Curr Biol. 2013 Jun 3; 2013 May 16. PMID: 23684974.
Cell biology. Deconstructing dimensionality.Schwartz MA, Chen CS. Science. 2013 Jan 25. PMID: 23349278.
N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.Ouyang M, Lu S, Kim T, Chen CE, Seong J, Leckband DE, Wang F, Reynolds AB, Schwartz MA, Wang Y. Nat Commun. 2013. PMID: 23481397.

2012

Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching.Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, Simons M. Circulation. 2012 Nov 27; 2012 Oct 22. PMID: 23091063.
Profilin phosphorylation as a VEGFR effector in angiogenesis.Simons M, Schwartz MA. Nat Cell Biol. 2012 Oct. PMID: 23033049.
Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels.Batra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX. Proc Natl Acad Sci U S A. 2012 Feb 28; 2012 Feb 13. PMID: 22331870.
Lymphatics thrive on stress: mechanical force in lymphatic development.Schwartz MA, Simons M. EMBO J. 2012 Feb 15; 2012 Feb 15. PMID: 22334045.
Lessons from the endothelial junctional mechanosensory complex.Conway D, Schwartz MA. F1000 Biol Rep. 2012; 2012 Jan 3. PMID: 22238515.

2011

Effects of integrin-mediated cell adhesion on plasma membrane lipid raft components and signaling.Norambuena A, Schwartz MA. Mol Biol Cell. 2011 Sep; 2011 Jul 27. PMID: 21795400.
Dynamic molecular processes mediate cellular mechanotransduction.Hoffman BD, Grashoff C, Schwartz MA. Nature. 2011 Jul 20; 2011 Jul 20. PMID: 21776077.
Light-triggered myosin activation for probing dynamic cellular processes.Goguen BN, Hoffman BD, Sellers JR, Schwartz MA, Imperiali B. Angew Chem Int Ed Engl. 2011 Jun 14; 2011 May 3. PMID: 21542072.
Enhancing QM/MM molecular dynamics sampling in explicit environments via an orthogonal-space-random-walk-based strategy.Min D, Chen M, Zheng L, Jin Y, Schwartz MA, Sang QX, Yang W. J Phys Chem B. 2011 Apr 14; 2011 Mar 21. PMID: 21417256.
Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancer.Thomas S, Overdevest JB, Nitz MD, Williams PD, Owens CR, Sanchez-Carbayo M, Frierson HF, Schwartz MA, Theodorescu D. Cancer Res. 2011 Feb 1; 2010 Dec 10. PMID: 21148751.

2010

Spatiotemporal organization, regulation, and functions of tractions during neutrophil chemotaxis.Shin ME, He Y, Li D, Na S, Chowdhury F, Poh YC, Collin O, Su P, de Lanerolle P, Schwartz MA, Wang N, Wang F. Blood. 2010 Oct 28; 2010 Jul 8. PMID: 20616216.
Cell adhesion: integrating cytoskeletal dynamics and cellular tension.Parsons JT, Horwitz AR, Schwartz MA. Nat Rev Mol Cell Biol. 2010 Sep. PMID: 20729930.
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics.Grashoff C, Hoffman BD, Brenner MD, Zhou R, Parsons M, Yang MT, McLean MA, Sligar SG, Chen CS, Ha T, Schwartz MA. Nature. 2010 Jul 8. PMID: 20613844.
Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation.Feaver RE, Gelfand BD, Wang C, Schwartz MA, Blackman BR. Circ Res. 2010 Jun 11; 2010 Apr 8. PMID: 20378855.
Remembrance of dead cells past: discovering that the extracellular matrix is a cell survival factor.Schwartz MA. Mol Biol Cell. 2010 Feb 15. PMID: 20150528.

2009

Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway.Elfenbein A, Rhodes JM, Meller J, Schwartz MA, Matsuda M, Simons M. J Cell Biol. 2009 Jul 13; 2009 Jul 6. PMID: 19581409.
Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function.Wu Y, Moissoglu K, Wang H, Wang X, Frierson HF, Schwartz MA, Theodorescu D. Proc Natl Acad Sci U S A. 2009 Apr 7; 2009 Mar 25. PMID: 19321744.
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases.Moissoglu K, McRoberts KS, Meier JA, Theodorescu D, Schwartz MA. Cancer Res. 2009 Apr 1; 2009 Mar 10. PMID: 19276387.
Cadherin adhesion, tissue tension, and noncanonical Wnt signaling regulate fibronectin matrix organization.Dzamba BJ, Jakab KR, Marsden M, Schwartz MA, DeSimone DW. Dev Cell. 2009 Mar. PMID: 19289087.
Cell biology. The force is with us.Schwartz MA. Science. 2009 Jan 30. PMID: 19179515.
Regulation of LKB1/STRAD localization and function by E-cadherin.Sebbagh M, Santoni MJ, Hall B, Borg JP, Schwartz MA. Curr Biol. 2009 Jan 13; 2008 Dec 24. PMID: 19110428.
Mechanotransduction in vascular physiology and atherogenesis.Hahn C, Schwartz MA. Nat Rev Mol Cell Biol. 2009 Jan. PMID: 19197332.

2008

The role of cellular adaptation to mechanical forces in atherosclerosis.Hahn C, Schwartz MA. Arterioscler Thromb Vasc Biol. 2008 Dec; 2008 Sep 11. PMID: 18787190.
Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice.Harry BL, Sanders JM, Feaver RE, Lansey M, Deem TL, Zarbock A, Bruce AC, Pryor AW, Gelfand BD, Blackman BR, Schwartz MA, Ley K. Arterioscler Thromb Vasc Biol. 2008 Nov; 2008 Aug 7. PMID: 18688018.
Integrin agonists as adjuvants in chemotherapy for melanoma.Schwartz MA, McRoberts K, Coyner M, Andarawewa KL, Frierson HF Jr, Sanders JM, Swenson S, Markland F, Conaway MR, Theodorescu D. Clin Cancer Res. 2008 Oct 1. PMID: 18829498.
Cell adhesion receptors in mechanotransduction.Schwartz MA, DeSimone DW. Curr Opin Cell Biol. 2008 Oct; 2008 Jun 24. PMID: 18583124.
The importance of stupidity in scientific research.Schwartz MA. J Cell Sci. 2008 Jun 1. PMID: 18492790.
A fluorescence resonance energy transfer activation sensor for Arf6.Hall B, McLean MA, Davis K, Casanova JE, Sligar SG, Schwartz MA. Anal Biochem. 2008 Mar 15; 2007 Dec 3. PMID: 18162163.
Function of the N-terminus of zizimin1: autoinhibition and membrane targeting.Meller N, Westbrook MJ, Shannon JD, Guda C, Schwartz MA. Biochem J. 2008 Jan 15. PMID: 17935486.

2007

Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration.Reutershan J, Stockton R, Zarbock A, Sullivan GW, Chang D, Scott D, Schwartz MA, Ley K. Am J Respir Crit Care Med. 2007 May 15; 2007 Feb 22. PMID: 17322107.
Rac, membrane heterogeneity, caveolin and regulation of growth by integrins.Del Pozo MA, Schwartz MA. Trends Cell Biol. 2007 May; 2007 Mar 23. PMID: 17363257.

2006

Matrix-specific suppression of integrin activation in shear stress signaling.Orr AW, Ginsberg MH, Shattil SJ, Deckmyn H, Schwartz MA. Mol Biol Cell. 2006 Nov; 2006 Aug 23. PMID: 16928957.
Integrin-mediated adhesion regulates membrane order.Gaus K, Le Lay S, Balasubramanian N, Schwartz MA. J Cell Biol. 2006 Aug 28. PMID: 16943184.
Integrating adhesion, protrusion, and contraction during cell migration.Schwartz MA, Horwitz AR. Cell. 2006 Jun 30. PMID: 16814706.
In vivo dynamics of Rac-membrane interactions.Moissoglu K, Slepchenko BM, Meller N, Horwitz AF, Schwartz MA. Mol Biol Cell. 2006 Jun; 2006 Apr 5. PMID: 16597700.
Matrix metalloproteinase inhibitors as prospective agents for the prevention and treatment of cardiovascular and neoplastic diseases.Sang QX, Jin Y, Newcomer RG, Monroe SC, Fang X, Hurst DR, Lee S, Cao Q, Schwartz MA. Curr Top Med Chem. 2006. PMID: 16611144.
Mechanisms of mechanotransduction.Orr AW, Helmke BP, Blackman BR, Schwartz MA. Dev Cell. 2006 Jan. PMID: 16399074.