The main research topics in my laboratory are integrin signaling and mechanotransduction in vascular biology, with emphasis on topics that are relevant to human disease. We use a variety of biophysical and cell biological tools as well as animal models in these studies.
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis.Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone NA, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz MA, Pober JS, Chittenden TW, Tellides G, Simons M. Nat Metab. 2019 Sep; 2019 Aug 26. PMID: 31572976.