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Anne Eichmann

Eichmann Lab

My laboratory studies vascular and lymphatic development, with particular emphasis on mechanisms that direct patterning and guidance. Specialized endothelial cells (EC) called tip cells located at the extremities of growing capillary sprouts mediate guided vascular patterning. Tip cells exhibit characteristic features, including extension of filopodia that explore the tip cell environment, lack of a lumen and a slow proliferation rate. EC behind tip cells, termed stalk cells form the capillary lumen and proliferate.