Anne Eichmann

Anne Eichmann, PhD
Ensign Professor of Medicine (Cardiology) and Professor of Cellular And Molecular Physiology
Research Interests
Blood Vessels
Cardiology
Central Nervous System
Endothelium, Vascular
Physiology
- anne.eichmann@yale.edu
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Georgia Zarkada, MD, PhD
Associate Research Scientist
- georgia.zarkada@yale.edu
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Eichmann Lab

My laboratory studies vascular and lymphatic development, with particular emphasis on mechanisms that direct patterning and guidance. Specialized endothelial cells (EC) called tip cells located at the extremities of growing capillary sprouts mediate guided vascular patterning. Tip cells exhibit characteristic features, including extension of filopodia that explore the tip cell environment, lack of a lumen and a slow proliferation rate. EC behind tip cells, termed stalk cells form the capillary lumen and proliferate.

Publications

2021

Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation.Zarkada G, Howard JP, Xiao X, Park H, Bizou M, Leclerc S, Künzel SE, Boisseau B, Li J, Cagnone G, Joyal JS, Andelfinger G, Eichmann A, Dubrac A. Dev Cell. 2021 Jul 12; 2021 Jul 12. PMID: 34273276.
Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia.Park H, Furtado J, Poulet M, Chung M, Yun S, Lee S, Sessa WC, Franco CA, Schwartz MA, Eichmann A. Circulation. 2021 Jun 29; 2021 Jun 29. PMID: 34182767.
SLIT2/ROBO signaling in tumor-associated microglia/macrophages drives glioblastoma immunosuppression and vascular dysmorphia.Geraldo LH, Xu Y, Jacob L, Pibouin-Fragner L, Rao R, Maïssa N, Verreault M, Lemaire N, Knosp C, Lesaffre C, Daubon T, Dejaegher J, Solie L, Rudewicz J, Viel T, Tavitian B, De Vleeschouwer S, Sanson M, Bikfalvi A, Idbaih A, Lu QR, Lima FR, Thomas JL, Eichmann A, Mathivet T. J Clin Invest. 2021 Jun 29; 2021 Jun 29. PMID: 34181595.
Endothelial S1P₁ Signaling Counteracts Infarct Expansion in Ischemic Stroke.Nitzsche A, Poittevin M, Benarab A, Bonnin P, Faraco G, Uchida H, Favre J, Garcia-Bonilla L, Garcia MCL, Léger PL, Thérond P, Mathivet T, Autret G, Baudrie V, Couty L, Kono M, Chevallier A, Niazi H, Tharaux PL, Chun J, Schwab SR, Eichmann A, Tavitian B, Proia RL, Charriaut-Marlangue C, Sanchez T, Kubis N, Henrion D, Iadecola C, Hla T, Camerer E. Circ Res. 2021 Feb 5; 2020 Dec 2. PMID: 33301355.

2020

BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells.Tao B, Kraehling JR, Ghaffari S, Ramirez CM, Lee S, Fowler JW, Lee WL, Fernandez-Hernando C, Eichmann A, Sessa WC. J Biol Chem. 2020 Dec 25; 2020 Oct 23. PMID: 33097593.
Alphastatin-C a new inhibitor of endothelial cell activation is a pro-arteriogenic agent in vivo and retards B16-F10 melanoma growth in a preclinical model.Ferreira AK, Cristofaro B, Menezes MC, de Oliveira AK, Tashima AK, de Melo RL, Silva CCF, Rodriguez MGP, Carvalho DCOS, de Azevedo RA, Junior PLS, Mambelli LI, Portaro FV, Pardanaud L, Eichmann A, Sant'Anna OA, Faria M. Oncotarget. 2020 Dec 22; 2020 Dec 22. PMID: 33473260.
SLIT3 deficiency attenuates pressure overload-induced cardiac fibrosis and remodeling.Gong L, Wang S, Shen L, Liu C, Shenouda M, Li B, Liu X, Shaw JA, Wineman AL, Yang Y, Xiong D, Eichmann A, Evans SM, Weiss SJ, Si MS. JCI Insight. 2020 Jun 18; 2020 Jun 18. PMID: 32644051.
Lymphatic Endothelial Cell Junctions: Molecular Regulation in Physiology and Diseases.Zhang F, Zarkada G, Yi S, Eichmann A. Front Physiol. 2020; 2020 May 29. PMID: 32547411.

2019

Anatomy and function of the vertebral column lymphatic network in mice.Jacob L, Boisserand LSB, Geraldo LHM, de Brito Neto J, Mathivet T, Antila S, Barka B, Xu Y, Thomas JM, Pestel J, Aigrot MS, Song E, Nurmi H, Lee S, Alitalo K, Renier N, Eichmann A, Thomas JL. Nat Commun. 2019 Oct 9; 2019 Oct 9. PMID: 31597914.
Cardiomyocyte d-dopachrome tautomerase protects against heart failure.Ma Y, Su KN, Pfau D, Rao VS, Wu X, Hu X, Leng L, Du X, Piecychna M, Bedi K, Campbell SG, Eichmann A, Testani JM, Margulies KB, Bucala R, Young LH. JCI Insight. 2019 Sep 5; 2019 Sep 5. PMID: 31484822.
Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis.Genet G, Boyé K, Mathivet T, Ola R, Zhang F, Dubrac A, Li J, Genet N, Henrique Geraldo L, Benedetti L, Künzel S, Pibouin-Fragner L, Thomas JL, Eichmann A. Nat Commun. 2019 May 28; 2019 May 28. PMID: 31138815.
The Intestinal Lymphatic System: Functions and Metabolic Implications.Cifarelli V, Eichmann A. Cell Mol Gastroenterol Hepatol. 2019; 2018 Dec 14. PMID: 30557701.

2018

To BBB or Not to BBB?Thomas JL, Eichmann A. Dev Cell. 2018 Dec 17. PMID: 30562511.
SMAD4 Prevents Flow Induced Arteriovenous Malformations by Inhibiting Casein Kinase 2.Ola R, Künzel SH, Zhang F, Genet G, Chakraborty R, Pibouin-Fragner L, Martin K, Sessa W, Dubrac A, Eichmann A. Circulation. 2018 Nov 20. PMID: 29976569.
NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy.Dubrac A, Künzel SE, Künzel SH, Li J, Chandran RR, Martin K, Greif DM, Adams RH, Eichmann A. Nat Commun. 2018 Aug 27; 2018 Aug 27. PMID: 30150707.
Lacteal junction zippering protects against diet-induced obesity.Zhang F, Zarkada G, Han J, Li J, Dubrac A, Ola R, Genet G, Boyé K, Michon P, Künzel SE, Camporez JP, Singh AK, Fong GH, Simons M, Tso P, Fernández-Hernando C, Shulman GI, Sessa WC, Eichmann A. Science. 2018 Aug 10. PMID: 30093598.

2017

Development and plasticity of meningeal lymphatic vessels.Antila S, Karaman S, Nurmi H, Airavaara M, Voutilainen MH, Mathivet T, Chilov D, Li Z, Koppinen T, Park JH, Fang S, Aspelund A, Saarma M, Eichmann A, Thomas JL, Alitalo K. J Exp Med. 2017 Dec 4; 2017 Nov 15. PMID: 29141865.
Basic research: Where do new endothelial cells come from in the injured heart?Greif DM, Eichmann A. Nat Rev Cardiol. 2017 Sep; 2017 Aug 3. PMID: 28770866.
FGF-dependent metabolic control of vascular development.Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M. Nature. 2017 May 11; 2017 May 3. PMID: 28467822.
Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein-Induced Retinal Angiogenesis.Lee HW, Chong DC, Ola R, Dunworth WP, Meadows S, Ka J, Kaartinen VM, Qyang Y, Cleaver O, Bautch VL, Eichmann A, Jin SW. Arterioscler Thromb Vasc Biol. 2017 Apr; 2017 Feb 23. PMID: 28232325.

2016

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia.Ola R, Dubrac A, Han J, Zhang F, Fang JS, Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals FV, Graupera M, Yan M, Young LH, Oh PS, Eichmann A. Nat Commun. 2016 Nov 29; 2016 Nov 29. PMID: 27897192.
The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization.Zhang F, Prahst C, Mathivet T, Pibouin-Fragner L, Zhang J, Genet G, Tong R, Dubrac A, Eichmann A. Nat Commun. 2016 Nov 24; 2016 Nov 24. PMID: 27882935.
Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells.Kraehling JR, Chidlow JH, Rajagopal C, Sugiyama MG, Fowler JW, Lee MY, Zhang X, Ramírez CM, Park EJ, Tao B, Chen K, Kuruvilla L, Larriveé B, Folta-Stogniew E, Ola R, Rotllan N, Zhou W, Nagle MW, Herz J, Williams KJ, Eichmann A, Lee WL, Fernández-Hernando C, Sessa WC. Nat Commun. 2016 Nov 21; 2016 Nov 21. PMID: 27869117.
Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia.Baeyens N, Larrivée B, Ola R, Hayward-Piatkowskyi B, Dubrac A, Huang B, Ross TD, Coon BG, Min E, Tsarfati M, Tong H, Eichmann A, Schwartz MA. J Cell Biol. 2016 Sep 26; 2016 Sep 19. PMID: 27646277.
BMP9/ALK1 inhibits neovascularization in mouse models of age-related macular degeneration.Ntumba K, Akla N, Oh SP, Eichmann A, Larrivée B. Oncotarget. 2016 Aug 30. PMID: 27517154.
Sympathetic Innervation Promotes Arterial Fate by Enhancing Endothelial ERK Activity.Pardanaud L, Pibouin-Fragner L, Dubrac A, Mathivet T, English I, Brunet I, Simons M, Eichmann A. Circ Res. 2016 Aug 19; 2016 Jun 27. PMID: 27354211.
Netrin-1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin-Induced Pulmonary Fibrosis.Sun H, Zhu Y, Pan H, Chen X, Balestrini JL, Lam TT, Kanyo JE, Eichmann A, Gulati M, Fares WH, Bai H, Feghali-Bostwick CA, Gan Y, Peng X, Moore MW, White ES, Sava P, Gonzalez AL, Cheng Y, Niklason LE, Herzog EL. Arthritis Rheumatol. 2016 May. PMID: 26749424.
miR-182 Modulates Myocardial Hypertrophic Response Induced by Angiogenesis in Heart.Li N, Hwangbo C, Jaba IM, Zhang J, Papangeli I, Han J, Mikush N, Larrivée B, Eichmann A, Chun HJ, Young LH, Tirziu D. Sci Rep. 2016 Feb 18; 2016 Feb 18. PMID: 26888314.
Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization.Dubrac A, Genet G, Ola R, Zhang F, Pibouin-Fragner L, Han J, Zhang J, Thomas JL, Chedotal A, Schwartz MA, Eichmann A. Circulation. 2016 Jan 26; 2015 Dec 9. PMID: 26659946.
Angiopoietin-2 May Be Involved in the Resistance to Bevacizumab in Recurrent Glioblastoma.Labussière M, Cheneau C, Prahst C, Gállego Pérez-Larraya J, Farina P, Lombardi G, Mokhtari K, Rahimian A, Delattre JY, Eichmann A, Sanson M. Cancer Invest. 2016; 2016 Jan 6. PMID: 26735326.

2015

NG2 glia are required for vessel network formation during embryonic development.Minocha S, Valloton D, Brunet I, Eichmann A, Hornung JP, Lebrand C. Elife. 2015 Dec 10; 2015 Dec 10. PMID: 26651999.
Vascular Mural Cells Promote Noradrenergic Differentiation of Embryonic Sympathetic Neurons.Fortuna V, Pardanaud L, Brunet I, Ola R, Ristori E, Santoro MM, Nicoli S, Eichmann A. Cell Rep. 2015 Jun 23; 2015 Jun 11. PMID: 26074079.
Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.Aspalter IM, Gordon E, Dubrac A, Ragab A, Narloch J, Vizán P, Geudens I, Collins RT, Franco CA, Abrahams CL, Thurston G, Fruttiger M, Rosewell I, Eichmann A, Gerhardt H. Nat Commun. 2015 Jun 17; 2015 Jun 17. PMID: 26081042.
State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association.Simons M, Alitalo K, Annex BH, Augustin HG, Beam C, Berk BC, Byzova T, Carmeliet P, Chilian W, Cooke JP, Davis GE, Eichmann A, Iruela-Arispe ML, Keshet E, Sinusas AJ, Ruhrberg C, Woo YJ, Dimmeler S. Circ Res. 2015 May 22; 2015 Apr 30. PMID: 25931450.
Molecular controls of arterial morphogenesis.Simons M, Eichmann A. Circ Res. 2015 May 8. PMID: 25953926.
Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization.Rama N, Dubrac A, Mathivet T, Ní Chárthaigh RA, Genet G, Cristofaro B, Pibouin-Fragner L, Ma L, Eichmann A, Chédotal A. Nat Med. 2015 May; 2015 Apr 20. PMID: 25894826.
Vascular endothelial growth factor receptor 3 controls neural stem cell activation in mice and humans.Han J, Calvo CF, Kang TH, Baker KL, Park JH, Parras C, Levittas M, Birba U, Pibouin-Fragner L, Fragner P, Bilguvar K, Duman RS, Nurmi H, Alitalo K, Eichmann AC, Thomas JL. Cell Rep. 2015 Feb 24; 2015 Feb 19. PMID: 25704818.
Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point.Baeyens N, Nicoli S, Coon BG, Ross TD, Van den Dries K, Han J, Lauridsen HM, Mejean CO, Eichmann A, Thomas JL, Humphrey JD, Schwartz MA. Elife. 2015 Feb 2; 2015 Feb 2. PMID: 25643397.

2014

PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells.Lanahan AA, Lech D, Dubrac A, Zhang J, Zhuang ZW, Eichmann A, Simons M. Circulation. 2014 Sep 9; 2014 Jun 30. PMID: 24982127.
Arterial innervation in development and disease.Eichmann A, Brunet I. Sci Transl Med. 2014 Sep 3. PMID: 25186174.
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC. Proc Natl Acad Sci U S A. 2014 Sep 2; 2014 Aug 18. PMID: 25136137.
The H2.0-like homeobox transcription factor modulates yolk sac vascular remodeling in mouse embryos.Prahst C, Kasaai B, Moraes F, Jahnsen ED, Larrivee B, Villegas D, Pardanaud L, Pibouin-Fragner L, Zhang F, Zaun HC, Eichmann A, Jones EA. Arterioscler Thromb Vasc Biol. 2014 Jul; 2014 Apr 24. PMID: 24764455.
Netrin-1 controls sympathetic arterial innervation.Brunet I, Gordon E, Han J, Cristofaro B, Broqueres-You D, Liu C, Bouvrée K, Zhang J, del Toro R, Mathivet T, Larrivée B, Jagu J, Pibouin-Fragner L, Pardanaud L, Machado MJ, Kennedy TE, Zhuang Z, Simons M, Levy BI, Tessier-Lavigne M, Grenz A, Eltzschig H, Eichmann A. J Clin Invest. 2014 Jul; 2014 Jun 17. PMID: 24937433.
Vascular biology: Brain vessels squeezed to death.Greif DM, Eichmann A. Nature. 2014 Apr 3; 2014 Mar 26. PMID: 24670635.
Tumor and endothelial cell hybrids participate in glioblastoma vasculature.El Hallani S, Colin C, El Houfi Y, Idbaih A, Boisselier B, Marie Y, Ravassard P, Labussière M, Mokhtari K, Thomas JL, Delattre JY, Eichmann A, Sanson M. Biomed Res Int. 2014; 2014 Apr 24. PMID: 24868550.

2013

Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis.Nie L, Guo X, Esmailzadeh L, Zhang J, Asadi A, Collinge M, Li X, Kim JD, Woolls M, Jin SW, Dubrac A, Eichmann A, Simons M, Bender JR, Sadeghi MM. J Clin Invest. 2013 Dec; 2013 Nov 1. PMID: 24177422.
Need glucose to sprout: local metabolic control of angiogenesis.Eichmann A, Simons M. EMBO Mol Med. 2013 Oct; 2013 Aug 27. PMID: 23982994.
Endothelial signaling and the molecular basis of arteriovenous malformation.Atri D, Larrivée B, Eichmann A, Simons M. Cell Mol Life Sci. 2013 Sep 28; 2013 Sep 28. PMID: 24077895.
Physiology. Lymphatics are in my veins.Simons M, Eichmann A. Science. 2013 Aug 9. PMID: 23929973.
Endothelial RAF1/ERK activation regulates arterial morphogenesis.Deng Y, Larrivée B, Zhuang ZW, Atri D, Moraes F, Prahst C, Eichmann A, Simons M. Blood. 2013 May 9; 2013 Mar 25. PMID: 23529931.
Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells.Thomas JL, Baker K, Han J, Calvo C, Nurmi H, Eichmann AC, Alitalo K. Cell Mol Life Sci. 2013 May; 2013 Mar 12. PMID: 23479133.
The power of VEGF (vascular endothelial growth factor) family molecules.Thomas JL, Eichmann A. Cell Mol Life Sci. 2013 May; 2013 Mar 12. PMID: 23475064.
Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models.Cristofaro B, Shi Y, Faria M, Suchting S, Leroyer AS, Trindade A, Duarte A, Zovein AC, Iruela-Arispe ML, Nih LR, Kubis N, Henrion D, Loufrani L, Todiras M, Schleifenbaum J, Gollasch M, Zhuang ZW, Simons M, Eichmann A, le Noble F. Development. 2013 Apr. PMID: 23533173.
Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, Brunet I, Wan LX, Rey F, Wang T, Firestein SJ, Yanagisawa M, Gordon JI, Eichmann A, Peti-Peterdi J, Caplan MJ. Proc Natl Acad Sci U S A. 2013 Mar 12; 2013 Feb 11. PMID: 23401498.
Endothelial ERK signaling controls lymphatic fate specification.Deng Y, Atri D, Eichmann A, Simons M. J Clin Invest. 2013 Mar; 2013 Feb 8. PMID: 23391722.
Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons.Di Meglio T, Kratochwil CF, Vilain N, Loche A, Vitobello A, Yonehara K, Hrycaj SM, Roska B, Peters AH, Eichmann A, Wellik D, Ducret S, Rijli FM. Science. 2013 Jan 11. PMID: 23307742.
Molecular parallels between neural and vascular development.Eichmann A, Thomas JL. Cold Spring Harb Perspect Med. 2013 Jan 1; 2013 Jan 1. PMID: 23024177.

2012

Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages.Camelo S, Raoul W, Lavalette S, Calippe B, Cristofaro B, Levy O, Houssier M, Sulpice E, Jonet L, Klein C, Devevre E, Thuret G, Duarte A, Eichmann A, Leconte L, Guillonneau X, Sennlaub F. Angiogenesis. 2012 Dec; 2012 Aug 7. PMID: 22869002.
Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching.Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, Simons M. Circulation. 2012 Nov 27; 2012 Oct 22. PMID: 23091063.
Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2.Kim JD, Kang H, Larrivée B, Lee MY, Mettlen M, Schmid SL, Roman BL, Qyang Y, Eichmann A, Jin SW. Dev Cell. 2012 Aug 14. PMID: 22898784.
"On-target" cardiac effects of anticancer drugs: lessons from new biology.Simons M, Eichmann A. J Am Coll Cardiol. 2012 Aug 14; 2012 Jun 13. PMID: 22703925.
Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.Bouvrée K, Brunet I, Del Toro R, Gordon E, Prahst C, Cristofaro B, Mathivet T, Xu Y, Soueid J, Fortuna V, Miura N, Aigrot MS, Maden CH, Ruhrberg C, Thomas JL, Eichmann A. Circ Res. 2012 Aug 3; 2012 Jun 21. PMID: 22723296.
VEGF signaling inside vascular endothelial cells and beyond.Eichmann A, Simons M. Curr Opin Cell Biol. 2012 Apr; 2012 Feb 25. PMID: 22366328.
ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.Larrivée B, Prahst C, Gordon E, del Toro R, Mathivet T, Duarte A, Simons M, Eichmann A. Dev Cell. 2012 Mar 13. PMID: 22421041.

2011

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomäki A, Aranda E, Miura N, Ylä-Herttuala S, Fruttiger M, Mäkinen T, Eichmann A, Pollard JW, Gerhardt H, Alitalo K. Nat Cell Biol. 2011 Sep 11; 2011 Sep 11. PMID: 21909098.
Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis.Calvo CF, Fontaine RH, Soueid J, Tammela T, Makinen T, Alfaro-Cervello C, Bonnaud F, Miguez A, Benhaim L, Xu Y, Barallobre MJ, Moutkine I, Lyytikkä J, Tatlisumak T, Pytowski B, Zalc B, Richardson W, Kessaris N, Garcia-Verdugo JM, Alitalo K, Eichmann A, Thomas JL. Genes Dev. 2011 Apr 15. PMID: 21498572.
Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B.Koch AW, Mathivet T, Larrivée B, Tong RK, Kowalski J, Pibouin-Fragner L, Bouvrée K, Stawicki S, Nicholes K, Rathore N, Scales SJ, Luis E, del Toro R, Freitas C, Bréant C, Michaud A, Corvol P, Thomas JL, Wu Y, Peale F, Watts RJ, Tessier-Lavigne M, Bagri A, Eichmann A. Dev Cell. 2011 Jan 18. PMID: 21238923.
Extraembryonic origin of circulating endothelial cells.Pardanaud L, Eichmann A. PLoS One. 2011; 2011 Oct 14. PMID: 22022461.

2010

Identification and functional analysis of endothelial tip cell-enriched genes.del Toro R, Prahst C, Mathivet T, Siegfried G, Kaminker JS, Larrivee B, Breant C, Duarte A, Takakura N, Fukamizu A, Penninger J, Eichmann A. Blood. 2010 Nov 11; 2010 Aug 12. PMID: 20705756.
VEGF and ephrin-B2: a bloody duo.Germain S, Eichmann A. Nat Med. 2010 Jul. PMID: 20613750.
Axon guidance molecules in vascular patterning.Adams RH, Eichmann A. Cold Spring Harb Perspect Biol. 2010 May; 2010 Mar 31. PMID: 20452960.
Hypoxia-driven angiogenesis: role of tip cells and extracellular matrix scaffolding.Germain S, Monnot C, Muller L, Eichmann A. Curr Opin Hematol. 2010 May. PMID: 20308893.
A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry.El Hallani S, Boisselier B, Peglion F, Rousseau A, Colin C, Idbaih A, Marie Y, Mokhtari K, Thomas JL, Eichmann A, Delattre JY, Maniotis AJ, Sanson M. Brain. 2010 Apr. PMID: 20375132.
Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia.Lebrin F, Srun S, Raymond K, Martin S, van den Brink S, Freitas C, Bréant C, Mathivet T, Larrivée B, Thomas JL, Arthur HM, Westermann CJ, Disch F, Mager JJ, Snijder RJ, Eichmann A, Mummery CL. Nat Med. 2010 Apr; 2010 Apr 4. PMID: 20364125.
Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3.Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivée B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A. J Cell Biol. 2010 Jan 11. PMID: 20065093.

2009

Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development.Corsi JM, Houbron C, Billuart P, Brunet I, Bouvrée K, Eichmann A, Girault JA, Enslen H. J Biol Chem. 2009 Dec 11; 2009 Sep 23. PMID: 19776009.
Stem cells: The stress of forming blood cells.Pardanaud L, Eichmann A. Nature. 2009 Jun 25. PMID: 19553988.
Jagged gives endothelial tip cells an edge.Suchting S, Eichmann A. Cell. 2009 Jun 12. PMID: 19524499.
Guidance of vascular development: lessons from the nervous system.Larrivée B, Freitas C, Suchting S, Brunet I, Eichmann A. Circ Res. 2009 Feb 27. PMID: 19246687.

2008

Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos.Jones EA, Yuan L, Breant C, Watts RJ, Eichmann A. Development. 2008 Aug; 2008 Jun 11. PMID: 18550715.
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.Tammela T, Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, Waltari M, Hellström M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Ylä-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C, Alitalo K. Nature. 2008 Jul 31; 2008 Jun 25. PMID: 18594512.
Netrin-1 inhibits sprouting angiogenesis in developing avian embryos.Bouvrée K, Larrivée B, Lv X, Yuan L, DeLafarge B, Freitas C, Mathivet T, Bréant C, Tessier-Lavigne M, Bikfalvi A, Eichmann A, Pardanaud L. Dev Biol. 2008 Jun 1; 2008 Mar 26. PMID: 18439993.
Netrins and UNC5 receptors in angiogenesis.Freitas C, Larrivée B, Eichmann A. Angiogenesis. 2008; 2008 Feb 12. PMID: 18266062.

2007

Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis.Larrivée B, Freitas C, Trombe M, Lv X, Delafarge B, Yuan L, Bouvrée K, Bréant C, Del Toro R, Bréchot N, Germain S, Bono F, Dol F, Claes F, Fischer C, Autiero M, Thomas JL, Carmeliet P, Tessier-Lavigne M, Eichmann A. Genes Dev. 2007 Oct 1. PMID: 17908930.
[Angiogenesis under Delta-Notch couple control].Suchting S, Freitas C, Eichmann A. Med Sci (Paris). 2007 Apr. PMID: 17433219.
Use of health care guidelines in patients with Down syndrome by family physicians across Canada.Virji-Babul N, Eichmann A, Kisly D, Down J, Haslam RH. Paediatr Child Health. 2007 Mar. PMID: 19030356.
The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching.Suchting S, Freitas C, le Noble F, Benedito R, Bréant C, Duarte A, Eichmann A. Proc Natl Acad Sci U S A. 2007 Feb 27; 2007 Feb 12. PMID: 17296941.
Negative regulators of vessel patterning.Suchting S, Freitas C, le Noble F, Benedito R, Bréant C, Duarte A, Eichmann A. Novartis Found Symp. 2007. PMID: 18300415.

2006

What determines blood vessel structure? Genetic prespecification vs. hemodynamics.Jones EA, le Noble F, Eichmann A. Physiology (Bethesda). 2006 Dec. PMID: 17119151.
Identification, emergence and mobilization of circulating endothelial cells or progenitors in the embryo.Pardanaud L, Eichmann A. Development. 2006 Jul; 2006 May 25. PMID: 16728473.
Dynamics of vascular branching morphogenesis: the effect of blood and tissue flow.Nguyen TH, Eichmann A, Le Noble F, Fleury V. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jun; 2006 Jun 14. PMID: 16906864.
Neuronal clues to vascular guidance.Suchting S, Bicknell R, Eichmann A. Exp Cell Res. 2006 Mar 10; 2005 Dec 5. PMID: 16330027.
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Bréant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL. Nat Neurosci. 2006 Mar; 2006 Feb 5. PMID: 16462734.

2005

A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis.Klagsbrun M, Eichmann A. Cytokine Growth Factor Rev. 2005 Aug-Oct. PMID: 15979925.
Neural guidance molecules regulate vascular remodeling and vessel navigation.Eichmann A, Makinen T, Alitalo K. Genes Dev. 2005 May 1. PMID: 15879551.
Guidance of vascular and neural network formation.Eichmann A, Le Noble F, Autiero M, Carmeliet P. Curr Opin Neurobiol. 2005 Feb. PMID: 15721752.
Accessing key steps of human tumor progression in vivo by using an avian embryo model.Hagedorn M, Javerzat S, Gilges D, Meyre A, de Lafarge B, Eichmann A, Bikfalvi A. Proc Natl Acad Sci U S A. 2005 Feb 1; 2005 Jan 21. PMID: 15665100.
Vascular development: from precursor cells to branched arterial and venous networks.Eichmann A, Yuan L, Moyon D, Lenoble F, Pardanaud L, Breant C. Int J Dev Biol. 2005. PMID: 15906240.

2004

The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system.Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, Bréant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A. Nature. 2004 Nov 11; 2004 Oct 27. PMID: 15510105.
Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells.Suzuki Y, Komi Y, Ashino H, Yamashita J, Inoue J, Yoshiki A, Eichmann A, Amanuma H, Kojima S. Blood. 2004 Jul 1; 2004 Mar 16. PMID: 15026310.