Yale Cardiovascular Medicine Grand Rounds: "Human Genetics – A Tool to Uncover New Biology and Enable Enhanced Clinical Care"
- Rare genetic variants can identify a subset of individuals with risk for disease driven by a specific pathway.
- For the remainder, polygenic scores can stratify the population according to inherited risk with very different disease trajectories.
- New evidence and new infrastructure is needed to realize the full potential of genomic medicine.
Cardiovascular Disease Initiative, Broad Institute of MIT and HarvardAmit V. Khera, MDAssociate Director