Jessica Nouws, PhD
Associate Research Scientist; EMBO fellow
Research & Publications
Biography
News
Coauthors
Selected Publications
- Alveolar Type 2 Cells With Impaired Proteostasis Signal to Monocyte-derived Macrophages Via a MIF/DDT-CD74 Signaling Network to Promotes Pulmonary Fibrosis in IPFKim S, Nouws J, Cooley J, Ahangari F, Leng L, Elias J, Kaminski N, Lee P, Redente E, Kang M, Sun H, Herzog E, Bucala R, Prasse A, Sauler M. Alveolar Type 2 Cells With Impaired Proteostasis Signal to Monocyte-derived Macrophages Via a MIF/DDT-CD74 Signaling Network to Promotes Pulmonary Fibrosis in IPF. 2024, a3001-a3001. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3001.
- Reduced Epithelial NUPR1 Negatively Impacts Mitochondrial Function and Metabolism, and Increases Susceptibility to EmphysemaNouws J, Yang T, Santofimia-Castaño P, Iovanna J, Sauler M. Reduced Epithelial NUPR1 Negatively Impacts Mitochondrial Function and Metabolism, and Increases Susceptibility to Emphysema. 2024, a2620-a2620. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2620.
- Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesitySlusher A, Nouws J, Tokoglu F, Vash‐Margita A, Matthews M, Fitch M, Shankaran M, Hellerstein M, Caprio S. Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity. Obesity 2024, 32: 593-602. PMID: 38410080, PMCID: PMC11034857, DOI: 10.1002/oby.23974.
- Stem cell migration drives lung repair in living miceChioccioli M, Liu S, Magruder S, Tata A, Borriello L, McDonough J, Konkimalla A, Kim S, Nouws J, Gonzalez D, Traub B, Ye X, Yang T, Entenberg D, Krishnaswamy S, Hendry C, Kaminski N, Tata P, Sauler M. Stem cell migration drives lung repair in living mice. Developmental Cell 2024, 59: 830-840.e4. PMID: 38377991, PMCID: PMC11003834, DOI: 10.1016/j.devcel.2024.02.003.
- Alterations in Adipose Tissue Distribution, Cell Morphology, and Function Mark Primary Insulin Hypersecretion in Youth With ObesityTricò D, Chiriacò M, Nouws J, Vash-Margita A, Kursawe R, Tarabra E, Galderisi A, Natali A, Giannini C, Hellerstein M, Ferrannini E, Caprio S. Alterations in Adipose Tissue Distribution, Cell Morphology, and Function Mark Primary Insulin Hypersecretion in Youth With Obesity. Diabetes 2023, 73: 941-952. PMID: 37870826, PMCID: PMC11109779, DOI: 10.2337/db23-0450.
- Reduced Alveolar Type 2 Epithelial Expression of NUPR1 Is Associated with Severe COPD and Increases Susceptibility to Oxidative Stress and FerroptosisNouws J, Mcdonough J, Adams T, Werder R, Schupp J, Robertson M, Coarfa C, Poli De Frias S, Wilson A, Timshel P, Kaminski N, Rosas I, Sauler M. Reduced Alveolar Type 2 Epithelial Expression of NUPR1 Is Associated with Severe COPD and Increases Susceptibility to Oxidative Stress and Ferroptosis. 2022, a1040-a1040. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1040.
- The Role of CD74 in Bleomycin-Induced Pulmonary FibrosisYang T, Kim S, Leng L, Nouws J, Bucala R, Sauler M. The Role of CD74 in Bleomycin-Induced Pulmonary Fibrosis. 2022, a5334-a5334. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5334.
- Decreased NUPR1 in AT2 Cells Is Associated with Development of Emphysema in COPDMcDonough J, Adams T, Kothapalli N, Schupp J, Nouws J, Chioccioli M, Omote N, Cosme Jr. C, Poli De Frias S, Ayaub E, Chu S, Jensen K, Gomez J, Britto-Leon C, Raredon M, Niklason L, Timshel P, Kaminski N, Rosas I, Sauler M. Decreased NUPR1 in AT2 Cells Is Associated with Development of Emphysema in COPD. 2021, a4281-a4281. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4281.
- Protective Role of D-Dopachrome Tautomerase (MIF2) in Chronic Obstructive Pulmonary DiseaseArdito T, Nouws J, Kim S, Zhang Y, Bucala R, Lee P, Sauler M. Protective Role of D-Dopachrome Tautomerase (MIF2) in Chronic Obstructive Pulmonary Disease. 2019, a5374-a5374. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5374.
- MicroRNA Regulation of Cell Fate in the Pathogenesis of COPDSauler M, Nouws J, Feng W, Lee P. MicroRNA Regulation of Cell Fate in the Pathogenesis of COPD. 2019, a5375-a5375. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5375.
- Ethnicity and Common Genetic Variants Modulate Nonalcoholic Fatty Liver Disease (NAFLD) Metabolic Phenotype in Obese YouthTRICO D, CAPRIO S, UMANO G, GALDERISI A, MATA M, NOUWS J, PIERPONT B, KIM G, SANTORO N. Ethnicity and Common Genetic Variants Modulate Nonalcoholic Fatty Liver Disease (NAFLD) Metabolic Phenotype in Obese Youth. Diabetes 2018, 67 DOI: 10.2337/db18-313-or.
- A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese AdolescentsKursawe R, Dixit VD, Scherer PE, Santoro N, Narayan D, Gordillo R, Giannini C, Lopez X, Pierpont B, Nouws J, Shulman GI, Caprio S. A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents. Diabetes 2015, 65: 610-618. PMID: 26718495, PMCID: PMC4764142, DOI: 10.2337/db15-1478.
- ACAD9, a complex I assembly factor with a moonlighting function in fatty acid oxidation deficienciesNouws J, Brinke H, Nijtmans L, Houten S. ACAD9, a complex I assembly factor with a moonlighting function in fatty acid oxidation deficiencies. Human Molecular Genetics 2013, 23: 1311-1319. PMID: 24158852, DOI: 10.1093/hmg/ddt521.
- A Patient with Complex I Deficiency Caused by a Novel ACAD9 Mutation Not Responding to Riboflavin TreatmentNouws J, Wibrand F, van den Brand M, Venselaar H, Duno M, Lund A, Trautner S, Nijtmans L, Østergard E. A Patient with Complex I Deficiency Caused by a Novel ACAD9 Mutation Not Responding to Riboflavin Treatment. 2013, 12: 37-45. PMID: 23996478, PMCID: PMC3897792, DOI: 10.1007/8904_2013_242.
- 3‐Methylglutaconic aciduria—lessons from 50 genes and 977 patientsWortmann S, Kluijtmans L, Rodenburg R, Sass J, Nouws J, van Kaauwen E, Kleefstra T, Tranebjaerg L, de Vries M, Isohanni P, Walter K, Alkuraya F, Smuts I, Reinecke C, van der Westhuizen F, Thorburn D, Smeitink J, Morava E, Wevers R. 3‐Methylglutaconic aciduria—lessons from 50 genes and 977 patients. Journal Of Inherited Metabolic Disease 2013, 36: 913-921. PMID: 23355087, DOI: 10.1007/s10545-012-9579-6.
- The Assembly of Human Complex INouws J, Calvaruso M, Nijtmans L. The Assembly of Human Complex I. 2012, 193-217. DOI: 10.1007/978-94-007-4138-6_10.
- Assembly factors as a new class of disease genes for mitochondrial complex I deficiency: cause, pathology and treatment optionsNouws J, Nijtmans L, Smeitink J, Vogel R. Assembly factors as a new class of disease genes for mitochondrial complex I deficiency: cause, pathology and treatment options. Brain 2011, 135: 12-22. PMID: 22036961, DOI: 10.1093/brain/awr261.
- NDUFB7 and NDUFA8 are located at the intermembrane surface of complex ISzklarczyk R, Wanschers B, Nabuurs S, Nouws J, Nijtmans L, Huynen M. NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I. FEBS Letters 2011, 585: 737-743. PMID: 21310150, DOI: 10.1016/j.febslet.2011.01.046.
- Acyl-CoA Dehydrogenase 9 Is Required for the Biogenesis of Oxidative Phosphorylation Complex INouws J, Nijtmans L, Houten S, van den Brand M, Huynen M, Venselaar H, Hoefs S, Gloerich J, Kronick J, Hutchin T, Willems P, Rodenburg R, Wanders R, van den Heuvel L, Smeitink J, Vogel R. Acyl-CoA Dehydrogenase 9 Is Required for the Biogenesis of Oxidative Phosphorylation Complex I. Cell Metabolism 2010, 12: 283-294. PMID: 20816094, DOI: 10.1016/j.cmet.2010.08.002.