2017
Hepatitis C virus treatment as prevention in an extended network of people who inject drugs in the USA: a modelling study
Zelenev A, Li J, Mazhnaya A, Basu S, Altice FL. Hepatitis C virus treatment as prevention in an extended network of people who inject drugs in the USA: a modelling study. The Lancet Infectious Diseases 2017, 18: 215-224. PMID: 29153265, PMCID: PMC5860640, DOI: 10.1016/s1473-3099(17)30676-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntiviral AgentsChemopreventionCitiesComputer SimulationDisease Transmission, InfectiousFemaleHepatitis CHumansMaleMiddle AgedModels, StatisticalPrevalenceSubstance Abuse, IntravenousSurveys and QuestionnairesTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsBaseline HCV prevalenceHepatitis C virusHCV prevalenceInjection partnersPrevention strategiesTreatment coverageTransmission of HCVHepatitis C virus (HCV) treatmentHCV elimination strategySuccessful HCV treatmentC virus treatmentInjection drug usersHCV treatment coverageAdditional network memberHCV treatmentActing antiviralsC virusChronic infectionVirus treatmentDrug usersPrevalenceDrug abuseDrugsNational InstitutePrevention
2012
Relying on Injection Drug Users to Access and Adhere to HIV Therapeutics
Broadhead R, Borch C, van Hulst Y, Gauchat G, Tehrani S, Stringer K, Heckathorn D, Altice F. Relying on Injection Drug Users to Access and Adhere to HIV Therapeutics. Journal Of Drug Issues 2012, 42: 127-146. DOI: 10.1177/0022042612446581.Peer-Reviewed Original ResearchPeer-driven interventionRespondent-driven samplingSocial supportDrug usersPositive health-seeking behaviourActive injection drug usersAdherence studiesInjection drug usersFuture adherence studiesHealth-seeking behaviourCash rewardsCorrelates of participationHIV therapeuticsMedical careNegative findingsIDUsImportant implications
2011
Testing an Optimized Community-Based Human Immunodeficiency Virus (HIV) Risk Reduction and Antiretroviral Adherence Intervention for HIV-Infected Injection Drug Users
Copenhaver MM, Lee IC, Margolin A, Bruce RD, Altice FL. Testing an Optimized Community-Based Human Immunodeficiency Virus (HIV) Risk Reduction and Antiretroviral Adherence Intervention for HIV-Infected Injection Drug Users. Substance Abuse 2011, 32: 16-26. PMID: 21302180, PMCID: PMC3071583, DOI: 10.1080/08897077.2011.540466.Peer-Reviewed Original ResearchConceptsAntiretroviral Adherence InterventionRisk reduction skillsAdherence interventionsDrug usersRisk behaviorsInjection drug usersSex risk behaviorsEvidence-based behavioral interventionsCommunity-based clinical settingsDrug use outcomesRisk reductionHIV medicationsHIV knowledgeCocaine useClinical settingBehavioral skillsIntervention effectsSexual riskTerms of improvementHIVBehavioral interventionsHolistic healthUse outcomesAssessment pointsIntervention
2009
Depression and symptomatic response among HIV-infected drug users enrolled in a randomized controlled trial of directly administered antiretroviral therapy
Springer SA, Chen S, Altice F. Depression and symptomatic response among HIV-infected drug users enrolled in a randomized controlled trial of directly administered antiretroviral therapy. AIDS Care 2009, 21: 976-983. PMID: 20024753, PMCID: PMC2797133, DOI: 10.1080/09540120802657555.Peer-Reviewed Original ResearchConceptsInjection drug usersCES-D scoresMajor depressive disorderAntiretroviral therapyCD4 countDepressive symptomsDrug usersDrug useHIV-1 RNA levelsProspective clinical trialsSubstance abuse treatment servicesSelf-administered therapyActive drug useNon-Caucasian raceSix-month followSix-month dataAntidepressant medicationAntiretroviral treatmentPoor adherenceSymptomatic responseMale genderClinical trialsDepressive disorderDepression ScaleDrug treatment
2007
Strategies for Primary HIV Prevention That Target Behavioral Change
Safren SA, Wingood G, Altice FL. Strategies for Primary HIV Prevention That Target Behavioral Change. Clinical Infectious Diseases 2007, 45: s300-s307. PMID: 18190303, DOI: 10.1086/522554.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHIV infectionHigh-risk behaviorsPrimary HIV preventionBehavioral changesNew HIV infectionsInjection drug usersRoutes of transmissionHIV transmissionImmunodeficiency virusHIV preventionDrug usersObjective evidencePsychosocial influencesInfectionOverall rateTarget populationMinority racial groupsRacial groupsMenRiskGroupVaccinePublic awarenessComplex interplayIntegration and co-location of HIV/AIDS, tuberculosis and drug treatment services
Sylla L, Bruce RD, Kamarulzaman A, Altice FL. Integration and co-location of HIV/AIDS, tuberculosis and drug treatment services. International Journal Of Drug Policy 2007, 18: 306-312. PMID: 17689379, PMCID: PMC2696234, DOI: 10.1016/j.drugpo.2007.03.001.Peer-Reviewed Original ResearchConceptsInjection drug useSubstance use treatmentDrug usersEffective substance use treatmentTraining Community Health WorkersActive injection drug useUse treatmentIntegrated care delivery systemSpecialist care providersAdverse drug eventsCommunity health workersComplex patient populationInjection drug usersAdverse side effectsDrug treatment servicesDrug-drug interactionsDetection of tuberculosisCare delivery systemHIV/AIDSAntiretroviral medicationsMedication adherencePatient populationDrug eventsHIV epidemicHealth workers
2006
Trust and other Characteristics Associated with Health Care Utilization by Injection Drug Users
Ostertag S, Wright B, Broadhead R, Altice F. Trust and other Characteristics Associated with Health Care Utilization by Injection Drug Users. Journal Of Drug Issues 2006, 36: 953-974. DOI: 10.1177/002204260603600409.Peer-Reviewed Original Research
2005
Adherence to hepatitis B virus vaccination at syringe exchange sites
Altice FL, Bruce RD, Walton MR, Buitrago MI. Adherence to hepatitis B virus vaccination at syringe exchange sites. Journal Of Urban Health 2005, 82: 151-161. PMID: 15746385, PMCID: PMC3456633, DOI: 10.1093/jurban/jti016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionConnecticutDiagnostic Tests, RoutineFemaleHepatitis BHepatitis B AntibodiesHepatitis B Surface AntigensHepatitis B VaccinesHumansImmunization ProgramsMaleMiddle AgedMobile Health UnitsNeedle-Exchange ProgramsPatient ComplianceSubstance Abuse, IntravenousUrban Health ServicesConceptsInjection drug usersHepatitis B virusHBV infectionHealth care servicesHigh riskCare servicesHepatitis B virus (HBV) vaccinationActive injection drug usersPreventive health care servicesB virus vaccinationVaccine-eligible patientsChronic HBV infectionHepatitis C virusSyringe exchange programsSyringe exchange sitesMobile health care servicesDaily injectorsHBV vaccinationVaccination seriesVirus vaccinationC virusB virusPreventive vaccinationVaccinationDrug users
2004
Hepatitis C virus infection in United States correctional institutions
Altice F, Bruce R. Hepatitis C virus infection in United States correctional institutions. Current Hepatology Reports 2004, 3: 112-118. DOI: 10.1007/s11901-004-0018-5.Peer-Reviewed Original ResearchHepatitis C virus infectionC virus infectionInjection drug usersVirus infectionDrug usersRisk reduction interventionsCurable infectionEffective therapyHigh prevalenceCare approachHigh riskReduction interventionsMental illnessSexual partnersInfectionHealth carePublic healthCorrectional settingsSettingHCVIdeal settingHIVTherapyIllnessPrevalence
2003
Safer Injection Sites in New York City: A Utilization Survey of Injection Drug Users
Broadhead R, Borch C, van Hulst Y, Farrell J, Villemez W, Altice F. Safer Injection Sites in New York City: A Utilization Survey of Injection Drug Users. Journal Of Drug Issues 2003, 33: 733-750. DOI: 10.1177/002204260303300311.Peer-Reviewed Original ResearchInjection drug usersSafe injection sitesDrug overdoseSample of IDUsDrug usersInjection siteDrug-related health problemsBlood-borne diseasesInnovative public health interventionsPublic health interventionsHarm Reduction ProjectHepatitis BDental servicesDrug treatmentPre-obtained drugsHigh riskHealth personnelHealth problemsHealth interventionsSignificant health riskSexual partnersNew York CityReferral servicesStreet outreachNew interventions
2002
The Impact of Needle Exchange–based Health Services on Emergency Department Use
Pollack HA, Khoshnood K, Blankenship KM, Altice FL. The Impact of Needle Exchange–based Health Services on Emergency Department Use. Journal Of General Internal Medicine 2002, 17: 341-348. PMID: 12047730, PMCID: PMC1495047, DOI: 10.1046/j.1525-1497.2002.10663.x.Peer-Reviewed Original ResearchConceptsInjection drug usersTreatment injection drug usersEmergency department useIncidence rate ratiosED utilizationED useDepartment useDrug usersHigh-risk injection drug usersHIV-negative injection drug usersMobile health clinicHealth care delivery systemHealth care servicesCare delivery systemHIV/AIDSPre-post comparisonAcute careEmergency departmentSubgroup analysisMedical recordsHealth clinicsLongitudinal cohortDrug treatmentED servicesBinomial regression analysisThe impact of needle exchange-based health services on emergency department use
Pollack H, Khoshnood K, Blankenship K, Altice F. The impact of needle exchange-based health services on emergency department use. Journal Of General Internal Medicine 2002, 17: 341-348. DOI: 10.1007/s11606-002-0037-2.Peer-Reviewed Original ResearchInjection drug usersTreatment injection drug usersEmergency department useIncidence rate ratiosED utilizationED useDepartment useDrug usersHigh-risk injection drug usersHIV-negative injection drug usersMobile health clinicHealth care delivery systemHealth care servicesCare delivery systemHIV/AIDSPre-post comparisonAcute careEmergency departmentSubgroup analysisMedical recordsHealth clinicsLongitudinal cohortDrug treatmentED servicesBinomial regression analysis
2001
Trust and the Acceptance of and Adherence to Antiretroviral Therapy.
Altice FL, Mostashari F, Friedland GH. Trust and the Acceptance of and Adherence to Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2001, 28: 47. PMID: 11579277, DOI: 10.1097/00042560-200109010-00008.Peer-Reviewed Original ResearchConceptsInjection drug usersAntiretroviral therapyPotent new therapyStandardized chart reviewSocial isolationDrugs of abuseAntiretroviral regimenHIV clinicChart reviewHIV infectionHIV medicationsObserved therapyCorrelates of acceptanceHealth beliefsClinical informationHealth locusNew therapiesSide effectsPharmacy reviewDrug usersHealth statusInfected prisonersAIDS incidenceTherapyTherapeutic agentsTrust and the Acceptance of and Adherence to Antiretroviral Therapy
Altice F, Mostashari F, Friedland G. Trust and the Acceptance of and Adherence to Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2001, 28: 47-58. DOI: 10.1097/00126334-200109010-00008.Peer-Reviewed Original ResearchInjection drug usersAntiretroviral therapyPotent new therapyStandardized chart reviewSocial isolationDrugs of abuseAntiretroviral regimenHIV clinicChart reviewHIV infectionHIV medicationsObserved therapyCorrelates of acceptanceHealth beliefsClinical informationHealth locusNew therapiesSide effectsPharmacy reviewDrug usersHealth statusInfected prisonersAIDS incidenceTherapyTherapeutic agents
2000
Prevention of HIV Infection in Street-Recruited Injection Drug Users
Monterroso E, Hamburger M, Vlahov D, Jarlais D, Ouellet L, Altice F, Byers R, Kerndt P, Watters J, Bowser B, Fernando D, Holmberg S. Prevention of HIV Infection in Street-Recruited Injection Drug Users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 25: 63-70. DOI: 10.1097/00126334-200009010-00009.Peer-Reviewed Original ResearchConceptsInjection drug usersDrug usersHIV infectionInitial serum specimensLarge multicity studyHIV prevention strategiesHIV infection riskHIV prevention programsSyringe exchange programsDrug treatment programsUse of needlesNew AIDSHIV acquisitionHIV serostatusHIV casesPrevention strategiesSerum specimensSex partnersInfection ratePrevention programsTreatment programInfection riskStandard questionnaireHIVMultivariate modelPrevention of HIV Infection in Street-Recruited Injection Drug Users
Monterroso E, Hamburger M, Vlahov D, Jarlais D, Ouellet L, Altice F, Byers R, Kerndt P, Watters J, Bowser B, Fernando M, Holmberg S. Prevention of HIV Infection in Street-Recruited Injection Drug Users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 25: 63-70. PMID: 11064506, DOI: 10.1097/00042560-200009010-00009.Peer-Reviewed Original ResearchConceptsInjection drug usersDrug usersHIV infectionInitial serum specimensLarge multicity studyHIV prevention strategiesHIV infection riskHIV prevention programsSyringe exchange programsDrug treatment programsUse of needlesNew AIDSHIV acquisitionHIV serostatusHIV casesPrevention strategiesSerum specimensSex partnersInfection ratePrevention programsTreatment programInfection riskStandard questionnaireHIVMultivariate modelSyringe source, use, and discard among injection-drug users in New Haven, Connecticut.
Khoshnood K, Blankenship KM, Pollack HA, Roan CT, Altice FL. Syringe source, use, and discard among injection-drug users in New Haven, Connecticut. AIDS & Public Policy Journal 2000, 15: 88-94. PMID: 12189714.Peer-Reviewed Original Research
1999
Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadone
Altice F, Friedland G, Cooney E. Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadone. AIDS 1999, 13: 957-962. PMID: 10371177, DOI: 10.1097/00002030-199905280-00012.Peer-Reviewed Original ResearchConceptsPharmacokinetic interactionsOpiate withdrawalMethadone levelsWithdrawal symptomsChronic methadone maintenance therapyNon-nucleoside reverse transcriptase inhibitorSubstance abuseInitiation of therapyMethadone maintenance therapyOpiate withdrawal symptomsRetrospective chart reviewSignificant pharmacokinetic interactionsInjection drug usersReverse transcriptase inhibitorHIV therapeutic agentsAntiretroviral therapyMaintenance therapyMethadone doseChart reviewHIV diseaseHIV infectionIncreased doseTranscriptase inhibitorTherapeutic benefitPatients
1995
Zygomycosis (Mucormycosis) and HIV Infection: Report of Three Cases and Review
Nagy-Agren S, Chu P, Smith G, Waskin H, Altice F. Zygomycosis (Mucormycosis) and HIV Infection: Report of Three Cases and Review. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1995, 10: 441-449. PMID: 7583440, DOI: 10.1097/00042560-199512000-00007.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusAIDS patientsBasal gangliaAdvanced HIV diseaseSite of involvementCases of zygomycosisInjection drug usersSite of diseaseIntravenous amphotericinLow CD4Renal zygomycosisFulminant courseHIV diseaseLymphocyte countSurgical debridementHIV infectionOverall mortalityOpportunistic infectionsImmunodeficiency virusCase reportRisk factorsRespiratory tractSuccessful therapyZygomycosisTransient episodes