Ke Dong, MD, MS
Research Scientist
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Selected Publications
- Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney diseaseZhang C, Rehman M, Tian X, Pei S, Gu J, Bell T, Dong K, Tham M, Cai Y, Wei Z, Behrens F, Jetten A, Zhao H, Lek M, Somlo S. Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease. Nature Communications 2024, 15: 3698. PMID: 38693102, PMCID: PMC11063051, DOI: 10.1038/s41467-024-48025-6.
- A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stressFedeles B, Bhardwaj R, Ishikawa Y, Khumsubdee S, Krappitz M, Gubina N, Volpe I, Andrade D, Westergerling P, Staudner T, Campolo J, Liu S, Dong K, Cai Y, Rehman M, Gallagher A, Ruchirawat S, Croy R, Essigmann J, Fedeles S, Somlo S. A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2317344121. PMID: 38241440, PMCID: PMC10823221, DOI: 10.1073/pnas.2317344121.
- Dephosphorylation Facilitates Trafficking of Mutant Polycystin-2 to CiliaCai Y, Dong K, Spitzer M, Geiges L, Tian X, Krappitz M, Diggs L, Wei Z, Cordido A, Pei S, Fedeles S, Somlo S. Dephosphorylation Facilitates Trafficking of Mutant Polycystin-2 to Cilia. Journal Of The American Society Of Nephrology 2023, 34: 560-560. DOI: 10.1681/asn.20233411s1560b.
- Metabolic effects of polycystin-1 C-terminal tail (CTT) expression in Pkd1-KO miceOnuchic L, Padovano V, Schena G, Shi X, Dong K, Rajendran V, Rai V, Pandya R, Gresko N, Shen H, Somlo S, Caplan M. Metabolic effects of polycystin-1 C-terminal tail (CTT) expression in Pkd1-KO mice. Physiology 2023, 38: 5731616. DOI: 10.1152/physiol.2023.38.s1.5731616.
- The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashionOnuchic L, Padovano V, Schena G, Rajendran V, Dong K, Shi X, Pandya R, Rai V, Gresko N, Ahmed O, Lam T, Wang W, Shen H, Somlo S, Caplan M. The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion. Nature Communications 2023, 14: 1790. PMID: 36997516, PMCID: PMC10063565, DOI: 10.1038/s41467-023-37449-1.
- Pkd2 Re-Expression Can Reverse Liver Cysts and Improve GFR in Mouse Models of Autosomal Dominant Polycystic Kidney DiseaseDong K, Tham M, Cordido A, Cai Y, Pei S, Bhardwaj R, Wei Z, Rehman M, Roy K, Tian X, Somlo S. Pkd2 Re-Expression Can Reverse Liver Cysts and Improve GFR in Mouse Models of Autosomal Dominant Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2022, 33: 418-418. DOI: 10.1681/asn.20223311s1418c.
- The Polycystin-1 C-Terminal Tail (CTT) Suppresses Cystic Disease: Elucidating the Underlying MechanismsOnuchic L, Padovano V, Schena G, Rajendran V, Shi X, Dong K, Gresko N, Shen H, Somlo S, Caplan M. The Polycystin-1 C-Terminal Tail (CTT) Suppresses Cystic Disease: Elucidating the Underlying Mechanisms. Journal Of The American Society Of Nephrology 2022, 33: 398-399. DOI: 10.1681/asn.20223311s1398d.
- The C-Terminal Tail of Polycystin 1 Rescues Cystic Phenotype in a Mitochondrial Enzyme-Dependent FashionOnuchic L, Padovano V, Schena G, Rajendran V, Gresko N, Dong K, Shi X, Shen H, Somlo S, Caplan M. The C-Terminal Tail of Polycystin 1 Rescues Cystic Phenotype in a Mitochondrial Enzyme-Dependent Fashion. Journal Of The American Society Of Nephrology 2021, 32: 11-11. DOI: 10.1681/asn.20213210s111b.
- FC 008INTERDEPENDENT REGULATION OF POLYCYSTIN EXPRESSION INFLUENCES STARVATION-INDUCED AUTOPHAGY AND CELL DEATHDecuypere J, Van Giel D, Janssens P, Dong K, Somlo S, Cai Y, Mekahli D, Vennekens R. FC 008INTERDEPENDENT REGULATION OF POLYCYSTIN EXPRESSION INFLUENCES STARVATION-INDUCED AUTOPHAGY AND CELL DEATH. Nephrology Dialysis Transplantation 2021, 36: gfab125.001. DOI: 10.1093/ndt/gfab125.001.
- A shrinkage approach to joint estimation of multiple covariance matricesHu Z, Hu Z, Dong K, Tong T, Wang Y. A shrinkage approach to joint estimation of multiple covariance matrices. Metrika 2020, 84: 339-374. DOI: 10.1007/s00184-020-00781-3.
- SAT-443 INTERDEPENDENT REGULATION OF POLYCYSTINS INFLUENCES AUTOPHAGY, CELL DEATH AND PROLIFERATIONDecuypere J, Janssens P, Dong K, Cai Y, Mekahli D, Vennekens R. SAT-443 INTERDEPENDENT REGULATION OF POLYCYSTINS INFLUENCES AUTOPHAGY, CELL DEATH AND PROLIFERATION. Kidney International Reports 2020, 5: s185. DOI: 10.1016/j.ekir.2020.02.470.
- A Comparison of Methods for Estimating the Determinant of High-Dimensional Covariance MatrixHu Z, Dong K, Dai W, Tong T. A Comparison of Methods for Estimating the Determinant of High-Dimensional Covariance Matrix. The International Journal Of Biostatistics 2017, 13: 20170013. PMID: 28953454, DOI: 10.1515/ijb-2017-0013.
- Isolated polycystic liver disease genes define effectors of polycystin-1 functionBesse W, Dong K, Choi J, Punia S, Fedeles SV, Choi M, Gallagher AR, Huang EB, Gulati A, Knight J, Mane S, Tahvanainen E, Tahvanainen P, Sanna-Cherchi S, Lifton RP, Watnick T, Pei YP, Torres VE, Somlo S. Isolated polycystic liver disease genes define effectors of polycystin-1 function. Journal Of Clinical Investigation 2017, 127: 3558-3558. PMID: 28862642, PMCID: PMC5669574, DOI: 10.1172/jci96729.
- NBLDA: negative binomial linear discriminant analysis for RNA-Seq dataDong K, Zhao H, Tong T, Wan X. NBLDA: negative binomial linear discriminant analysis for RNA-Seq data. BMC Bioinformatics 2016, 17: 369. PMID: 27623864, PMCID: PMC5022247, DOI: 10.1186/s12859-016-1208-1.
- Shrinkage-based diagonal Hotelling’s tests for high-dimensional small sample size dataDong K, Pang H, Tong T, Genton M. Shrinkage-based diagonal Hotelling’s tests for high-dimensional small sample size data. Journal Of Multivariate Analysis 2016, 143: 127-142. DOI: 10.1016/j.jmva.2015.08.022.
- Simultaneous confidence bands and hypothesis testing for single-index modelsLi G, Peng H, Tong T, Dong K. Simultaneous confidence bands and hypothesis testing for single-index models. Statistica Sinica 2014 DOI: 10.5705/ss.2012.127.
- Rolle von KATP-Kanälen bei der Ischämie intestinaler OrganeBuschmann A, Vanoye C, MacGregor G, Dong K, Tang L, Hall A, Lu M, Giebisch G, Hebert S. Rolle von KATP-Kanälen bei der Ischämie intestinaler Organe. 2005, 34: 307-310. DOI: 10.1007/3-540-26560-0_108.
- An Amino Acid Triplet in the NH2 Terminus of Rat ROMK1 Determines Interaction with SUR2B*Dong K, Xu J, Vanoye C, Welch R, MacGregor G, Giebisch G, Hebert S. An Amino Acid Triplet in the NH2 Terminus of Rat ROMK1 Determines Interaction with SUR2B*. Journal Of Biological Chemistry 2001, 276: 44347-44353. PMID: 11567030, DOI: 10.1074/jbc.m108072200.
- ROMK is the apical membrane K+ recycling pathway in the gastric giandSritharan K, Wagner C, Dong K, Radebold K, Hebert S, Geibel J. ROMK is the apical membrane K+ recycling pathway in the gastric giand. Gastroenterology 2001, 120: a102. DOI: 10.1016/s0016-5085(08)80500-8.
- ROMK is the apical membrane K+ recycling pathway in the gastric giandSRITHARAN K, WAGNER C, DONG K, RADEBOLD K, HEBERT S, GEIBEL J. ROMK is the apical membrane K+ recycling pathway in the gastric giand. Gastroenterology 2001, 120: a102-a102. DOI: 10.1016/s0016-5085(01)80500-x.
- Regulation of ROMK1 Channels by Protein-tyrosine Kinase and -tyrosine Phosphatase*Moral Z, Dong K, Wei Y, Sterling H, Deng H, Ali S, Gu R, Huang X, Hebert S, Giebisch G, Wang W. Regulation of ROMK1 Channels by Protein-tyrosine Kinase and -tyrosine Phosphatase*. Journal Of Biological Chemistry 2000, 276: 7156-7163. PMID: 11114300, PMCID: PMC2822675, DOI: 10.1074/jbc.m008671200.
- Rat homolog of sulfonylurea receptor 2B determines glibenclamide sensitivity of ROMK2 in Xenopus laevisoocyteTanemoto M, Vanoye C, Dong K, Welch R, Abe T, Hebert S, Xu J. Rat homolog of sulfonylurea receptor 2B determines glibenclamide sensitivity of ROMK2 in Xenopus laevisoocyte. American Journal Of Physiology. Renal Physiology 2000, 278: f659-f666. PMID: 10751228, DOI: 10.1152/ajprenal.2000.278.4.f659.