Abinet Aklilu, MD, MPH
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Research
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Personalised recommendations for hospitalised patients with Acute Kidney Injury using a Kidney Action Team (KAT-AKI): protocol and early data of a randomised controlled trial
Aklilu A, O’Connor K, Martin M, Yamamoto Y, Coronel-Moreno C, Shvets K, Jones C, Kadhim B, Corona-Villalobos C, Baker M, Tan J, Freeman N, Groener M, Menez S, Brown D, Culli S, Lindsley J, Orias M, Parikh C, Smith A, Sundararajan A, Wilson F. Personalised recommendations for hospitalised patients with Acute Kidney Injury using a Kidney Action Team (KAT-AKI): protocol and early data of a randomised controlled trial. BMJ Open 2023, 13: e071968. PMID: 37068906, PMCID: PMC10111926, DOI: 10.1136/bmjopen-2023-071968.Peer-Reviewed Original ResearchConceptsPrimary teamAcute Kidney Injury OutcomesAKI alert systemInvestigator-blinded trialUsual care armKey secondary outcomesClinical decision support toolIntensive care unitUS hospital systemAKI alertsAKI detectionAKI progressionCare armSecondary outcomesPrimary outcomeCare unitMedian timeMedical floorPercentage of recommendationsDiagnostic interventionsInjury outcomesRandomisationHospital systemEthics CommitteeDedicated teamRenal Considerations in Critically Ill Hematopoietic Stem Cell Transplant Patients
Aklilu A, Renaghan A. Renal Considerations in Critically Ill Hematopoietic Stem Cell Transplant Patients. 2023, 351-364. DOI: 10.1007/978-3-031-28797-8_27.Peer-Reviewed Original ResearchHematopoietic stem cell transplantationAcute kidney injuryKidney injuryRisk factorsIncidence of AKIPrognosis of AKIHematopoietic stem cell transplant patientsPost-transplant risk factorsTransplant-associated thrombotic microangiopathyStem cell transplant patientsHepatic sinusoidal obstruction syndromePost-transplant complicationsChronic kidney diseaseIndependent risk factorSinusoidal obstruction syndromeCell transplant patientsKidney replacement therapyStem cell transplantationIntensive care unitHospital mortalityNephrotoxic medicationsRenal considerationsVentilator requirementEngraftment syndromeHSCT recipientsA randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes
Wilson F, Yamamoto Y, Martin M, Coronel-Moreno C, Li F, Cheng C, Aklilu A, Ghazi L, Greenberg J, Latham S, Melchinger H, Mansour S, Moledina D, Parikh C, Partridge C, Testani J, Ugwuowo U. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes. Nature Communications 2023, 14: 2826. PMID: 37198160, PMCID: PMC10192367, DOI: 10.1038/s41467-023-38532-3.Peer-Reviewed Original ResearchConceptsAcute kidney injuryUsual care groupKidney injuryCare groupAcute Kidney Injury OutcomesAlert groupNon-steroidal anti-inflammatory drugsComposite of progressionHours of randomizationMedications of interestAldosterone system inhibitorsClasses of medicationsProton pump inhibitorsRandomized clinical trialsAnti-inflammatory drugsClinical decision support systemNephrotoxic medicationsHospitalized adultsDiscontinuation ratesCertain medicationsPrimary outcomeSubstantial morbiditySystem inhibitorsPump inhibitorsParallel groupChemotherapy-Associated Thrombotic Microangiopathy
Aklilu A, Shirali A. Chemotherapy-Associated Thrombotic Microangiopathy. Kidney360 2023, 4: 409-422. PMID: 36706238, PMCID: PMC10103319, DOI: 10.34067/kid.0000000000000061.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDrug-induced thrombotic microangiopathyThrombotic microangiopathyPlasma exchangePrimary atypical hemolytic uremic syndromeAtypical hemolytic uremic syndromeEnd-organ dysfunctionMicroangiopathic hemolytic anemiaSecondary thrombotic microangiopathyTherapeutic plasma exchangeTerminal complement inhibitorLarge multicenter studyHemolytic uremic syndromeRole of complementPotential treatment strategyProteinuria reductionSupportive careBlood pressureMulticenter studyTreatment courseUremic syndromeComplement inhibitionTreatment strategiesHemolytic anemiaAntiangiogenesis agentsComplement inhibitorsDiagnosis of Chronic Kidney Disease and Assessing Glomerular Filtration Rate
Aklilu A. Diagnosis of Chronic Kidney Disease and Assessing Glomerular Filtration Rate. Medical Clinics Of North America 2023, 107: 641-658. PMID: 37258004, DOI: 10.1016/j.mcna.2023.03.001.Peer-Reviewed Original ResearchDiversity in Studies Developing Kidney Function Estimating Equations: Improving Representation, Interpretation, and Utility of Clinical Research
Alvarado F, Aklilu A, Powe N, Vart P, Delgado C. Diversity in Studies Developing Kidney Function Estimating Equations: Improving Representation, Interpretation, and Utility of Clinical Research. American Journal Of Kidney Diseases 2022, 81: 1-6. PMID: 35842013, DOI: 10.1053/j.ajkd.2022.05.014.Peer-Reviewed Original ResearchThe removal of race from kidney function estimation: Key points for primary providers
Aklilu A, Delgado C. The removal of race from kidney function estimation: Key points for primary providers. Journal Of The National Medical Association 2022, 114: s25-s33. PMID: 35595580, DOI: 10.1016/j.jnma.2022.05.008.Peer-Reviewed Original ResearchConceptsKidney functionKidney function estimationChronic kidney diseasePrimary care providersGlomerular filtration rate estimationKidney dysfunctionKidney diseaseRisk factorsCare providersNephrology societiesSocial determinantsPrimary providersEarly detectionInclusion of raceTask ForceMedical algorithmsRecent recognitionWidespread implementationGFRProvidersDysfunctionRaceDiseaseProgressionAssessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19
Nugent J, Aklilu A, Yamamoto Y, Simonov M, Li F, Biswas A, Ghazi L, Greenberg J, Mansour S, Moledina D, Wilson FP. Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19. JAMA Network Open 2021, 4: e211095. PMID: 33688965, PMCID: PMC7948062, DOI: 10.1001/jamanetworkopen.2021.1095.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overBlack or African AmericanCohort StudiesComorbidityCOVID-19CreatinineFemaleFollow-Up StudiesGlomerular Filtration RateHispanic or LatinoHumansHypertensionKidney Function TestsLongitudinal StudiesMaleMiddle AgedPatient DischargeProportional Hazards ModelsRenal Insufficiency, ChronicRetrospective StudiesSARS-CoV-2United StatesConceptsCOVID-19-associated acute kidney injuryAcute kidney injuryHospital acute kidney injurySubgroup of patientsKidney functionKidney injuryCohort studyHospital dischargeAKI recoveryKidney diseaseCOVID-19Peak creatinine levelsRetrospective cohort studyChronic kidney diseaseDays of dischargeHalf of patientsGlomerular filtration rateCoronavirus disease 2019AKI severityBaseline comorbiditiesEGFR decreaseDialysis requirementEGFR slopeKidney recoveryCreatinine levelsDialysis Patient Experiences During the COVID-19 Pandemic: A Survey Study
Noce E, Brereton L, Zorzanello M, Aklilu A, Anders E, Bernal M, Sundararajan A, Dahl N, Kodali R, Patel D. Dialysis Patient Experiences During the COVID-19 Pandemic: A Survey Study. Kidney Medicine 2023, 5: 100673. PMID: 37305377, PMCID: PMC10186967, DOI: 10.1016/j.xkme.2023.100673.Peer-Reviewed Original ResearchCoronavirus disease 2019 (COVID-19) pandemicMental health conditionsDisease 2019 pandemicCare teamPatient experienceCare experiencesMost patientsCenter hemodialysisKidney failureDialysis treatmentDialysis careCOVID-19 pandemicHealth conditionsDialysis care teamNon-white patientsSubpopulation of patientsCare of patientsPercent of participantsPatient care experiencesNephrology practicePatient's perspectiveDerive themesPatientsAbstractTextPractice settingsOutcomes Associated with Sodium-Glucose Cotransporter-2 Inhibitor Use in Acute Heart Failure Hospitalizations Complicated by AKI
Aklilu A, Kumar S, Yamamoto Y, Moledina D, Sinha F, Testani J, Wilson F. Outcomes Associated with Sodium-Glucose Cotransporter-2 Inhibitor Use in Acute Heart Failure Hospitalizations Complicated by AKI. Kidney360 2023, 4: 1371-1381. PMID: 37644648, PMCID: PMC10615381, DOI: 10.34067/kid.0000000000000250.Peer-Reviewed Original ResearchConceptsAcute kidney injuryHeart failure hospitalizationSodium-glucose cotransporter-2 inhibitor useSodium-glucose cotransporter 2 inhibitorsAcute heart failure hospitalizationCotransporter 2 inhibitorsCox regression analysisRenal recoveryFailure hospitalizationAKI diagnosisKidney injuryInhibitor useLower riskStage 5 chronic kidney diseaseTime-varying Cox regression analysisKidney Disease Improving Global OutcomesInverse probability-weighted analysisMulticenter retrospective cohort studyMultivariable Cox regression analysisStage 5 CKDAcute heart failureRetrospective cohort studyChronic kidney diseaseKidney function recoveryGlomerular filtration rate