Skip to Main Content

Translational Geroscience Initiative


The translational geroscience initiative stretches across campus to bring together diverse physician investigators and scientists in areas that are relevant to aging, such as geriatrics, infectious diseases, pulmonary medicine, rheumatology, cardiology, ophthalmology, hematology, endocrinology, and other sections and departments across Yale School of Medicine.

The primary premise underlying the field of translational geroscience is that aging is the major risk factor for most chronic diseases. The geroscience hypothesis purports that significant gains in healthspan, as opposed to lifespan, can only be achieved by intervening upon the fundamental mechanisms of aging. Candidate mechanisms (or hallmarks) of aging include mitochondrial dysfunction, cellular senescence, epigenomic alterations, telomere shortening, loss of proteostasis, deregulated nutrient sensing, stem cell exhaustion, altered intercellular communication, autophagy, and genome instability. First-generation gerotherapeutics that target these mechanisms of aging are currently being tested in early-stage clinical trials. After proof-of-principle has been established, such agents will be tested in larger clinical trials that focus on clinical and geriatric outcomes, including multimorbidity, frailty and cognitive decline.

By helping to facilitate brainstorming sessions, develop joint grant proposals, and support scientific collaborations across disciplines, the initiative will provide a platform for faculty, trainees, and others to advance geroscience.

Pilot Grant Program

Key Dates

  • Due date for letter of intent: January 16, 2024 by 5:00 PM
  • Invitation for full proposal issued by: February 2, 2024
  • Due date for full application: March 18, 2024 by 5:00 PM
  • Earliest anticipated start date: July 1, 2024

Download Letter of Intent Instructions

Past Recipients

2023 Daniel Jane-Wit “Senescence-Associated Endosomes and Vascular Healthspan” abstract

Visiting Professor Program

The goals of the Visiting Professor Program are to enhance the visibility and prestige of translational geroscience at Yale and to further strengthen collaborations across campus in translational geroscience. Activities include meetings with early-stage investigators, small group discussions of high priority areas, and a scientific presentation at Medical Grand Rounds.

2024 Ana Maria Cuervo

2023 Luigi Ferrucci

Executive Committee

  • Humana Foundation Professor of Medicine (Geriatrics) and Professor of Epidemiology (Chronic Diseases) and of Investigative Medicine; Director, Yale Program on Aging; Director, Claude D. Pepper Older Americans Independence Center; Director, Yale Center for Disability and Disabling Disorders; Director, Yale Training Program in Geriatric Clinical Epidemiology and Aging-Related Research

Committee Members