2024
Exploring equity in global health collaborations: a qualitative study of donor and recipient power dynamics in Liberia
Cakouros B, Gum J, Levine D, Lewis J, Wright A, Dahn B, Talbert-Slagle K. Exploring equity in global health collaborations: a qualitative study of donor and recipient power dynamics in Liberia. BMJ Global Health 2024, 9: e014399. PMID: 38485141, PMCID: PMC10946382, DOI: 10.1136/bmjgh-2023-014399.Peer-Reviewed Original ResearchConceptsGlobal health collaborationsHealth collaborationLow-resource settingsThematic analysisPriority settingQualitative studyImplementing partnersEquitable partnershipsInformant interviewsDecision makingGlobal health donorsPower structuresLived experiencePatterns of accountabilityImplementation planNon-governmental organisationsHigh resourcesFinancial controlPower differentialsQualitative analysisForeign donorsEquitable decision makingEquitable collaborationExternal aidsIntentional efforts
2014
Cellular Superspreaders: An Epidemiological Perspective on HIV Infection inside the Body
Talbert-Slagle K, Atkins KE, Yan KK, Khurana E, Gerstein M, Bradley EH, Berg D, Galvani AP, Townsend JP. Cellular Superspreaders: An Epidemiological Perspective on HIV Infection inside the Body. PLOS Pathogens 2014, 10: e1004092. PMID: 24811311, PMCID: PMC4014458, DOI: 10.1371/journal.ppat.1004092.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2013
A Single Amino Acid Substitution Converts a Transmembrane Protein Activator of the Platelet-derived Growth Factor β Receptor into an Inhibitor*
Petti LM, Talbert-Slagle K, Hochstrasser ML, DiMaio D. A Single Amino Acid Substitution Converts a Transmembrane Protein Activator of the Platelet-derived Growth Factor β Receptor into an Inhibitor*. Journal Of Biological Chemistry 2013, 288: 27273-27286. PMID: 23908351, PMCID: PMC3779723, DOI: 10.1074/jbc.m113.470054.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsBovine papillomavirus 1CattleCell LineCell Transformation, ViralEnzyme ActivatorsFibroblastsHumansMaleMiceMutation, MissenseOncogene Proteins v-sisOncogene Proteins, ViralPhosphorylationProtein Kinase InhibitorsReceptor, Platelet-Derived Growth Factor betaSignal TransductionConceptsTransmembrane domainTransmembrane proteinPlatelet-derived growth factor β receptorLimited sequence similarityGrowth factor β receptorParticular tyrosine residueLigand-independent mannerSequence similarityGenetic evidenceGrowth factor receptorE5 proteinOncogenic transformationWild typeProtein activatorViral homologueTyrosine residuesE5 bindsProtein inhibitorPDGFβRV-sisPDGFβ receptorBovine papillomavirusFactor receptorNonidentical sitesCell proliferationInnovation spread: lessons from HIV
Talbert-Slagle K, Berg D, Bradley EH. Innovation spread: lessons from HIV. International Journal For Quality In Health Care 2013, 25: 352-356. PMID: 23696582, PMCID: PMC3723303, DOI: 10.1093/intqhc/mzt038.Peer-Reviewed Original Research
2009
Artificial Transmembrane Oncoproteins Smaller than the Bovine Papillomavirus E5 Protein Redefine Sequence Requirements for Activation of the Platelet-Derived Growth Factor β Receptor
Talbert-Slagle K, Marlatt S, Barrera FN, Khurana E, Oates J, Gerstein M, Engelman DM, Dixon AM, DiMaio D. Artificial Transmembrane Oncoproteins Smaller than the Bovine Papillomavirus E5 Protein Redefine Sequence Requirements for Activation of the Platelet-Derived Growth Factor β Receptor. Journal Of Virology 2009, 83: 9773-9785. PMID: 19605488, PMCID: PMC2748040, DOI: 10.1128/jvi.00946-09.Peer-Reviewed Original ResearchConceptsPDGF beta receptorTransmembrane domainBPV E5Transmembrane proteinBovine papillomavirus E5 proteinPlatelet-derived growth factor beta receptorArtificial transmembrane proteinsLigand-independent receptor activationPrimary amino acid sequenceSimilar cellular proteinsSmall artificial proteinsGrowth factor β receptorHomodimeric transmembrane proteinAmino acid sequenceGrowth factor beta receptorConsecutive amino acidsC-terminal cysteineSame cellular targetsNew genetic techniquesBeta receptorsCellular proteinsAcid sequenceE5 proteinGenetic techniquesSequence requirements
2005
Endothelial Cells Promote Human Immunodeficiency Virus Replication in Nondividing Memory T Cells via Nef-, Vpr-, and T-Cell Receptor-Dependent Activation of NFAT
Choi J, Walker J, Talbert-Slagle K, Wright P, Pober JS, Alexander L. Endothelial Cells Promote Human Immunodeficiency Virus Replication in Nondividing Memory T Cells via Nef-, Vpr-, and T-Cell Receptor-Dependent Activation of NFAT. Journal Of Virology 2005, 79: 11194-11204. PMID: 16103171, PMCID: PMC1193601, DOI: 10.1128/jvi.79.17.11194-11204.2005.Peer-Reviewed Original ResearchConceptsMemory T cellsHuman immunodeficiency virus (HIV) replicationImmunodeficiency virus replicationT cellsViral replicationEndothelial cellsAntiretroviral therapyHIV replicationSuboptimal T cell receptor (TCR) stimulationHIV Type 1 ReplicationVirus replicationMajor histocompatibility complex (MHC) class II moleculesType 1 replicationTumor necrosis factorMHC class IIClass II moleculesT cell receptor stimulationVirus-producing cellsReceptor-dependent activationNef-dependent mannerEffector cytokinesHuman endothelial cellsHLA-DRIL-6Presence of EC