Deep‐targeted sequencing of endothelial nitric oxide synthase gene exons uncovers exercise intensity and ethnicity‐dependent associations with post‐exercise hypotension
Pescatello LS, Schifano ED, Ash GI, Panza GA, Corso LML, Chen M, Deshpande V, Zaleski A, Cilhoroz B, Farinatti P, Taylor BA, O'Neill RJ, Thompson PD. Deep‐targeted sequencing of endothelial nitric oxide synthase gene exons uncovers exercise intensity and ethnicity‐dependent associations with post‐exercise hypotension. Physiological Reports 2017, 5: e13510. PMID: 29180482, PMCID: PMC5704084, DOI: 10.14814/phy2.13510.Peer-Reviewed Original ResearchConceptsPost-exercise hypotensionAmbulatory blood pressure responsesBlood pressure responseAmbulatory BP monitorObese African AmericansModerate-intensity exerciseModerate-intensity cyclingMultiple testing thresholdDiastolic BPAcute exerciseValidation cohortBP measurementsBP monitorIntensity exerciseVigorous intensityVariant genotypesIntensity cyclingMmHgTesting thresholdMinor alleleModerate intensityPressure responseHypotensionHypertensionAfrican Americans