2014
Elevated CK-MB with a Normal Troponin Does Not Predict 30-Day Adverse Cardiac Events in Emergency Department Chest Pain Observation Unit Patients
Safdar B, Bezek SK, Sinusas AJ, Russell RR, Klein MR, Dziura JD, D’onofrio G. Elevated CK-MB with a Normal Troponin Does Not Predict 30-Day Adverse Cardiac Events in Emergency Department Chest Pain Observation Unit Patients. Critical Pathways In Cardiology A Journal Of Evidence-Based Medicine 2014, 13: 14-19. PMID: 24526146, DOI: 10.1097/hpc.0000000000000001.Peer-Reviewed Original ResearchConceptsAdverse cardiac eventsCPU patientsNormal troponinAdverse eventsCardiac eventsMultiple logistic regression modelComposite adverse eventsElevated creatinine kinaseObservation unit patientsSerial troponin testingStandardized chart reviewRetrospective cohort studyAcute coronary syndromeNational Death RegistryCoronary artery diseaseLogistic regression modelsPositive troponinPrior CADRenal insufficientCoronary syndromeHemodynamic instabilityChart reviewCohort studyDeath RegistryIschemic electrocardiogram
2010
S100b Immunoassay: An Assessment of Diagnostic Utility in Minor Head Trauma
Kotlyar S, Larkin GL, Moore CL, D’Onofrio G. S100b Immunoassay: An Assessment of Diagnostic Utility in Minor Head Trauma. Journal Of Emergency Medicine 2010, 41: 285-293. PMID: 20692788, DOI: 10.1016/j.jemermed.2010.05.040.Peer-Reviewed Original ResearchConceptsMinor head traumaHead traumaS100B levelsUnited States emergency departmentsMean age 48 yearsMedian S100B levelStates emergency departmentsProspective observational studyGlasgow Coma ScaleAge 48 yearsLoss of consciousnessNon-specific markerReceiver operator characteristic analysisEnzyme-linked immunosorbentOperator characteristic analysisCentral nervous system peptideHCT patientsComa ScaleIntracranial injuryEmergency departmentHead injuryObservational studyUnnecessary headDiagnostic utilityInjury