2024
Artificial intelligence applied to electrocardiographic images for scalable screening of cardiac amyloidosis
Sangha V, Oikonomou E, Krumholz H, Miller E, Khera R. Artificial intelligence applied to electrocardiographic images for scalable screening of cardiac amyloidosis. European Heart Journal 2024, 45: ehae666.3436. DOI: 10.1093/eurheartj/ehae666.3436.Peer-Reviewed Original ResearchATTR-CMBone scintigraphy scansTransthyretin amyloid cardiomyopathyPositive predictive valueAI-ECG algorithmCardiac amyloidosisScintigraphy scanAmyloid cardiomyopathyAI-ECGSex-matchedDevelopment cohortMyocardial remodelingUnder-diagnosedUnder-treatedMatched controlsPredictive valueUnder-recognizedTransthyretin stabilizersConvolutional neural networkPatientsECGArtificial intelligenceHospitalPrevalenceTransthyretinDetection of ATTR cardiac amyloidosis using a novel artificial intelligence algorithm for wearable-adapted noisy single-lead electrocardiograms
Sangha V, Oikonomou E, Khunte A, Miller E, Khera R. Detection of ATTR cardiac amyloidosis using a novel artificial intelligence algorithm for wearable-adapted noisy single-lead electrocardiograms. European Heart Journal 2024, 45: ehae666.3438. DOI: 10.1093/eurheartj/ehae666.3438.Peer-Reviewed Original ResearchReal-world noiseSingle-lead ECGArtificial intelligence algorithmsMultiple signal-to-noise ratiosCommunity-dwelling adultsSignal-to-noise ratioIntelligence algorithmsATTR-CMMatched controlsECG signalsDevelopment cohortPreventive careHealthcare servicesBlack adultsHospital systemCommunity screeningAlgorithmBone scintigraphy scansATTR cardiac amyloidosisPrevalence levelsOnset of symptomsPositive predictive valuePrevalenceAI-ECG algorithmSex-matchedThe Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0).
Miller R, Lemley M, Shanbhag A, Ramirez G, Liang J, Builoff V, Kavanagh P, Sharir T, Hauser M, Ruddy T, Fish M, Bateman T, Acampa W, Einstein A, Dorbala S, Di Carli M, Feher A, Miller E, Sinusas A, Halcox J, Martins M, Kaufmann P, Dey D, Berman D, Slomka P. The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0). Journal Of Nuclear Medicine 2024, 65: 1795-1801. PMID: 39362762, PMCID: PMC11533915, DOI: 10.2967/jnumed.124.268292.Peer-Reviewed Original ResearchCoronary artery calciumCT attenuation correction imagesStress total perfusion deficitMyocardial perfusion imagingTotal perfusion deficitAttenuation correction imagesPerfusion imagingREFINE SPECTImprove prediction of adverse outcomesPerfusion deficitsSPECT myocardial perfusion imagingIncreased risk of MACEPredictive of adverse outcomesMedian follow-upInvasive coronary angiographyRisk of MACEAdverse cardiovascular eventsCAC scoreExperience MACECoronary angiographyArtery calciumInternational registryCardiovascular eventsFollow-upClinical dataMYOCARDIAL ISCHEMIC BURDEN IN PATIENTS WITH PERIPHERAL ARTERY DISEASE UNDERGOING MYOCARDIAL PERFUSION IMAGING
Wang K, Shanbhag A, Sharir T, Hauser M, Dorbala S, Di Carli M, Fish M, Ruddy T, Bateman T, Einstein A, Kaufmann P, Miller E, Sinusas A, Acampa W, Halcox J, Dey D, Berman D, Miller R, Slomka P. MYOCARDIAL ISCHEMIC BURDEN IN PATIENTS WITH PERIPHERAL ARTERY DISEASE UNDERGOING MYOCARDIAL PERFUSION IMAGING. Canadian Journal Of Cardiology 2024, 40: s120-s121. DOI: 10.1016/j.cjca.2024.08.182.Peer-Reviewed Original ResearchRISK STRATIFICATION WITH PRE-OPERATIVE MYOCARDIAL PERFUSION IMAGING
Kim D, Builoff V, Sharir T, Hauser M, Dorbala S, Ruddy T, Bateman T, Einstein A, Kaufmann P, Miller E, Sinusas A, Acampa W, Dey D, Berman D, Miller R, Slomka P, Fish M. RISK STRATIFICATION WITH PRE-OPERATIVE MYOCARDIAL PERFUSION IMAGING. Canadian Journal Of Cardiology 2024, 40: s122. DOI: 10.1016/j.cjca.2024.08.185.Peer-Reviewed Original ResearchAmerican Society of Nuclear Cardiology quality metrics for cardiac amyloid radionuclide imaging
Hage F, Bourque J, Pandey S, Shah N, Soman P, Abbott B, Abidov A, Aggarwal N, AlJaroudi W, Bhambhvani P, Bokhari S, Dorbala S, Doukky R, Duran J, Einstein A, Gallagher D, Hendel R, Jaber W, Kattan C, Malhotra S, Masri A, Miller E, Murthy V, Sperry B. American Society of Nuclear Cardiology quality metrics for cardiac amyloid radionuclide imaging. Journal Of Nuclear Cardiology 2024, 40: 102041. DOI: 10.1016/j.nuclcard.2024.102041.Peer-Reviewed Original ResearchAssociation between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain
Gallegos C, Paredes C, Hu J, Posada E, Saito Y, Lansky A, Shah S, Liu Y, Smolderen K, Mena-Hurtado C, Sinusas A, Miller E. Association between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain. Advances In Radiotherapy & Nuclear Medicine 2024, 2: 3786. DOI: 10.36922/arnm.3786.Peer-Reviewed Original ResearchMyocardial flow reserveGlobal myocardial flow reserveQuantitative coronary angiographyAssociated with increased all-cause mortalityPositron emission tomographyCoronary artery stenosis severityMyocardial blood flowAll-cause mortalityCoronary angiographyChest painStenosis severityAngiographic coronary artery stenosisResting myocardial blood flowAcute chest painBlood flowInvasive coronary angiographyLeft circumflex arteryLeft descending arteryRight coronary arteryCoronary artery stenosisStress testCoronary stenosis severityCardiovascular eventsDescending arteryWeak correlationThe Updated REgistry of Fast Myocardial Perfusion Imaging With NExt Generation SPECT
Miller R, Lemley M, Shanbhag A, Bednarski B, Liang J, Builoff V, Kavanagh P, Sharir T, Hauser M, Ruddy T, Fish M, Einstein A, Dorbala S, Di Carli M, Feher A, Miller E, Sinusas A, Halcox J, Martins M, Kaufmann P, Dey D, Berman D, Slomka P. The Updated REgistry of Fast Myocardial Perfusion Imaging With NExt Generation SPECT. Journal Of Nuclear Cardiology 2024, 38: 101926. DOI: 10.1016/j.nuclcard.2024.101926.Peer-Reviewed Original ResearchAutomating Revascularization Decision Support: Clinical Application of Artificial Intelligence
Zhang W, Miller R, Patel K, Shanbhag A, Liang J, DiCarli M, Dorbala S, Einstein A, Fish M, Hauser M, Kaufmann P, Miller E, Ruddy T, Bateman T, Martins M, Sharir T, Halcox J, Acampa W, Dey D, Berman D, Slomka P. Automating Revascularization Decision Support: Clinical Application of Artificial Intelligence. Journal Of Nuclear Cardiology 2024, 38: 102001. DOI: 10.1016/j.nuclcard.2024.102001.Peer-Reviewed Original ResearchFrom transthyretin cardiac amyloidosis diagnosis to tafamidis treatment: Association of drop-off with patient sociodemographic characteristics
Walenczyk K, Singh A, Tong K, Burg M, Miller E. From transthyretin cardiac amyloidosis diagnosis to tafamidis treatment: Association of drop-off with patient sociodemographic characteristics. American Journal Of Health-System Pharmacy 2024, zxae183. PMID: 38963826, DOI: 10.1093/ajhp/zxae183.Peer-Reviewed Original ResearchPatient sociodemographic characteristicsATTR-CASociodemographic characteristicsSpecialty pharmacyPyrophosphate scintigraphyPopulation prevalence ratesEconomically disadvantaged areasTransthyretin cardiac amyloidosisBlack/African American raceReduce disparitiesPotential patient subgroupsPharmacy processesProportion of daysClinical pathwayCompare sociodemographicsDisadvantaged areasEquitable provisionTafamidis therapyCardiac amyloidosisTafamidis treatmentPrevalence ratesClinical programsAmerican racePatient subgroupsPosting manuscriptsReproducibility for quantification of myocardial Tc-99m PYP amyloid uptake in grade 1 patients
Sandoval V, Goyal D, Miller E, Liu Y. Reproducibility for quantification of myocardial Tc-99m PYP amyloid uptake in grade 1 patients. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.047. DOI: 10.1093/ehjci/jeae142.047.Peer-Reviewed Original ResearchStandardized uptake valueTc-99m PYP uptakeTc-99Cardiac amyloidosisHeart failureStandard uptake value quantificationStandardized uptake value calculationSPECT imagesIntractable heart failureSystolic heart failureIntroduction of therapyPlanar imagingTc-99m pyrophosphateAmyloid patientsSPECT/CT imagingInter-reproducibilityUptake valueContralateral ratioCoefficient of variationDisease progressionH/M ratioGrade 1Blood poolPatientsH/CL ratioEvaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA)
Maayah M, Latif N, Vijay A, Gallegos C, Cigarroa N, Martinez E, Mazure C, Miller E, Spatz E, Shah S. Evaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA). Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102195. PMID: 39166160, PMCID: PMC11330936, DOI: 10.1016/j.jscai.2024.102195.Peer-Reviewed Original ResearchIschemic heart diseaseNonobstructive coronary arteriesCoronary artery diseaseArtery diseaseObstructive coronary artery diseaseCoronary arteryLong-term cardiovascular prognosisHeart diseaseSuspected ischemic heart diseaseAtherosclerotic coronary artery diseaseCoronary vasomotor disordersPretest probability of diseasePragmatic diagnostic algorithmExpert consensus documentEvaluating ischemic heart diseaseImpact quality of lifeQuality of lifeSymptomatic patientsPretest probabilityANOCACardiovascular prognosisVasomotor disordersDiagnostic evaluationPersistent symptomsDiagnostic strategiesAddressing Health Disparities—The Case for Variant Transthyretin Cardiac Amyloidosis Grows Stronger
Maurer M, Miller E, Ruberg F. Addressing Health Disparities—The Case for Variant Transthyretin Cardiac Amyloidosis Grows Stronger. JAMA 2024, 331: 1809-1811. PMID: 38734953, DOI: 10.1001/jama.2024.2868.Peer-Reviewed Original ResearchLinks Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes
Aneni E, Sinusas A, Emokpae M, Thorn S, Yaggi H, Miller E. Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes. Current Cardiology Reports 2024, 26: 723-734. PMID: 38806976, DOI: 10.1007/s11886-024-02072-z.Peer-Reviewed Original ResearchObstructive sleep apneaCoronary microvascular dysfunctionAbnormal myocardial blood flowSevere obstructive sleep apneaMyocardial flow reserveMyocardial blood flowSleep apneaModerate to severe obstructive sleep apneaAbnormal myocardial flow reserveRecent FindingsRecent studiesDisease-related outcomesBlood flow changesMyocardial blood flow changesCardiovascular disease-related outcomesMicrovascular dysfunctionClinical impactCPAPReviewRecent studiesStructural abnormalitiesCoronary microcirculationFindingsRecent studiesFlow reserveCardiac workBlood flowApneaUnlocking Diversity in Cardiovascular Clinical Research: Lessons from the SCAN-MP (Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations) Study
Wardhere A, Bampatsias D, Cohn E, Fine D, Freitas C, Gallegos C, Helmke S, Ionescu N, Ivrose J, Rodriguez C, Sabogal N, Fils S, Henry T, Teruya S, Ullah I, Kurian D, Raiszadeh F, Miller E, Ruberg F, Maurer M. Unlocking Diversity in Cardiovascular Clinical Research: Lessons from the SCAN-MP (Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations) Study. Journal Of Cardiac Failure 2024 PMID: 38740174, PMCID: PMC11551251, DOI: 10.1016/j.cardfail.2024.04.019.Peer-Reviewed Original ResearchTAI-GAN: A Temporally and Anatomically Informed Generative Adversarial Network for early-to-late frame conversion in dynamic cardiac PET inter-frame motion correction
Guo X, Shi L, Chen X, Liu Q, Zhou B, Xie H, Liu Y, Palyo R, Miller E, Sinusas A, Staib L, Spottiswoode B, Liu C, Dvornek N. TAI-GAN: A Temporally and Anatomically Informed Generative Adversarial Network for early-to-late frame conversion in dynamic cardiac PET inter-frame motion correction. Medical Image Analysis 2024, 96: 103190. PMID: 38820677, PMCID: PMC11180595, DOI: 10.1016/j.media.2024.103190.Peer-Reviewed Original ResearchGenerative adversarial networkAdversarial networkMotion estimation accuracyInter-frame motionIntensity-based image registration techniqueAll-to-oneSegmentation masksImage registration techniquesOriginal frameTemporal informationDiagnosis accuracyMyocardial blood flowEstimation accuracyFrame conversionPositron emission tomographyNovel methodImage qualityPET datasetsRegistration techniqueNetworkCardiac positron emission tomographyBlood flowDynamic cardiac positron emission tomographyMotion correctionCoronary artery diseaseReal-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study
Oikonomou E, Aminorroaya A, Dhingra L, Partridge C, Velazquez E, Desai N, Krumholz H, Miller E, Khera R. Real-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study. European Heart Journal - Digital Health 2024, 5: 303-313. PMID: 38774380, PMCID: PMC11104476, DOI: 10.1093/ehjdh/ztae023.Peer-Reviewed Original ResearchRisk of acute myocardial infarctionAssociated with lower oddsHospital health systemCoronary artery diseaseCardiac testingRisk of adverse outcomesUK BiobankHealth systemProvider-drivenLower oddsAssociated with better outcomesAcute myocardial infarctionBlack raceStable chest painFemale sexReal world evaluationDiabetes historyMulticohort studyFunction testsSuspected coronary artery diseaseYounger ageRisk profileAdverse outcomesMultinational cohortPost hoc analysisDeep learning-based epicardial adipose tissue measurement, maximizing prognostic information from attenuation correction imaging
Shanbhag A, Miller R, Killekar A, Lemley M, Bednarski B, Van Kriekinge S, Kavanagh P, Feher A, Miller E, Bateman T, Liang J, Builoff V, Berman D, Dey D, Slomka P. Deep learning-based epicardial adipose tissue measurement, maximizing prognostic information from attenuation correction imaging. Progress In Biomedical Optics And Imaging 2024, 12930: 129300b-129300b-6. DOI: 10.1117/12.3007914.Peer-Reviewed Original ResearchEpicardial adipose tissueUngated CTMyocardial infarctionEAT volumeRisk stratificationComputed tomographyEAT volume measurementEpicardial adipose tissue measurementsEpicardial adipose tissue volumeAssociated with risk of cardiovascular eventsRisk of cardiovascular eventsMedian follow-upIncreased risk of deathGated computed tomographyImprove risk stratificationAdipose tissue measurementsAssociated with riskRisk of deathAttenuation correction imagesGated CTChest CTNo significant differencePrognostic informationCardiovascular eventsFollow-upTRANSTHYRETIN AMYLOID CARDIOMYOPATHY IS ASSOCIATED WITH WORSE OUTCOMES WHEN COMPARED TO PATIENTS WITH NON-AMYLOID RELATED HEART FAILURE OF SIMILAR RACE AND ETHNICITY: THE SCAN-MP STUDY
Schmidt A, Ullah I, Teruya S, Fine D, Sabogal N, Foster R, Helmke S, Rodriguez C, Spencer B, Winburn M, Bampatsias D, Wardhere A, De Freitas C, Prokaeva T, Kattan C, Miller E, LaValley M, Maurer M, Ruberg F. TRANSTHYRETIN AMYLOID CARDIOMYOPATHY IS ASSOCIATED WITH WORSE OUTCOMES WHEN COMPARED TO PATIENTS WITH NON-AMYLOID RELATED HEART FAILURE OF SIMILAR RACE AND ETHNICITY: THE SCAN-MP STUDY. Journal Of The American College Of Cardiology 2024, 83: 520. DOI: 10.1016/s0735-1097(24)02510-5.Peer-Reviewed Original ResearchA COMPARATIVE ANALYSIS OF PET, CZT SPECT, AND CONVENTIONAL SPECT IN MODERN CARDIOLOGY
Ahmed A, Agarwal R, Khera R, Liu Y, Sinusas A, Miller E, Feher A. A COMPARATIVE ANALYSIS OF PET, CZT SPECT, AND CONVENTIONAL SPECT IN MODERN CARDIOLOGY. Journal Of The American College Of Cardiology 2024, 83: 1365. DOI: 10.1016/s0735-1097(24)03355-2.Peer-Reviewed Original Research