Edward J Miller, MD, PhD
Cards
Research
About
Contact/Administration
Research
About
Contact/Administration
Research
Publications Overview
- 201 Publications
- 6,721 Citations
- 78 Yale Co-Authors
Titles
Associate Professor of Medicine (Cardiovascular Medicine)
Vice Chief of Cardiovascular Medicine (Education), Cardiovascular Medicine
Associate Professor of Medicine and Radiology
Director, Nuclear Cardiology, Cardiovascular Medicine
Director, Cardiology Fellowship Program, Cardiovascular Medicine
Affiliated Faculty, Yale Institute for Global Health
Appointments
Contact Info
Cardiovascular Medicine
Yale University School of Medicine, Section of Cardiovascular Medicine, PO Box 208017
New Haven, CT 06520-8017
United States
Publications Overview
- 201 Publications
- 6,721 Citations
- 78 Yale Co-Authors
Titles
Associate Professor of Medicine (Cardiovascular Medicine)
Vice Chief of Cardiovascular Medicine (Education), Cardiovascular Medicine
Associate Professor of Medicine and Radiology
Director, Nuclear Cardiology, Cardiovascular Medicine
Director, Cardiology Fellowship Program, Cardiovascular Medicine
Affiliated Faculty, Yale Institute for Global Health
Appointments
Contact Info
Cardiovascular Medicine
Yale University School of Medicine, Section of Cardiovascular Medicine, PO Box 208017
New Haven, CT 06520-8017
United States
Publications Overview
- 201 Publications
- 6,721 Citations
- 78 Yale Co-Authors
About
Titles
Associate Professor of Medicine (Cardiovascular Medicine)
Vice Chief of Cardiovascular Medicine (Education), Cardiovascular Medicine; Associate Professor of Medicine and Radiology; Director, Nuclear Cardiology, Cardiovascular Medicine; Director, Cardiology Fellowship Program, Cardiovascular Medicine; Affiliated Faculty, Yale Institute for Global Health
Biography
Dr. Edward J. Miller, MD, PhD is the Vice Chief of Cardiovascular Medicine (Education) and an Associate Professor of Medicine and Radiology in the Section of Cardiovascular Medicine. Dr. Miller directs the clinical nuclear cardiology laboratory at Yale-New Haven Hospital as well as the Cardiology Fellowship Program for the Yale School of Medicine. His clinical and research interests center on the evaluation and treatment of infiltrative cardiomyopathies, particularly cardiac sarcoidosis and amyloidosis, and are focused on the role of nuclear cardiac imaging in diagnosing and defining treatment response in these disorders.
Dr. Miller received his undergraduate degree from the University of Notre Dame, majoring in Preprofessional Studies with a concentration in Science, Technology and Values. He completed medical school at the Loyola-Stritch School of Medicine in Chicago where he was awarded an American Heart Association Student Research Fellowship. Dr. Miller completed his internal medicine residency at Yale-New Haven Hospital, as well as research and clinical cardiology fellowships at Yale. He also completed a PhD in Investigative Medicine from the Yale School of Medicine, working in the laboratory of Dr. Lawrence Young focused on "The Cardioprotective Effects of AMP-Activated Protein Kinase." Dr. Miller is a recipient of an NIH/NLHBI K08 award, mentored by Dr. Wilson Colucci at Boston University School of Medicine on "The Role and Regulation of the LKB1-AMPK Axis in Diabetic Cardiomyopathy."
Dr. Miller was recruited back to Yale in 2015 to direct the nuclear cardiology lab and the cardiology fellowship program. He was named Vice Chief (Education) for Yale Cardiovascular Medicine in 2021.
Appointments
Cardiovascular Medicine
Associate Professor on TermPrimaryRadiology & Biomedical Imaging
Associate Professor on TermSecondary
Other Departments & Organizations
- Cardiomyopathy & Inherited Cardiovascular Disease Program
- Cardiovascular Imaging Program
- Cardiovascular Medicine
- Internal Medicine
- Nuclear Cardiology
- Radiology & Biomedical Imaging
- Scleroderma Program
- Yale Medicine
Education & Training
- Clinical Fellow
- Yale School of Medicine (2008)
- PhD
- Yale University School of Medicine, Investigative Medicine (2008)
- Research Fellow
- Yale School of Medicine (2005)
- Resident
- Yale-New Haven Hospital (2003)
- Intern
- Yale-New Haven Hospital (2000)
- MD
- Loyola-Stritch School of Medicine, Medicine (1999)
- BS
- University of Notre Dame, Preprofessional Studies (1994)
Research
Overview
Medical Subject Headings (MeSH)
ORCID
0000-0002-2156-5962
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Albert Sinusas, MD
Attila Feher, MD, PhD
Yi-Hwa Liu, PhD
Chi Liu, PhD
Lawrence Young, MD
Rohan Khera, MD, MS
Sarcoidosis
Amyloidosis
Radionuclide Imaging
Single Photon Emission Computed Tomography Computed Tomography
Positron Emission Tomography Computed Tomography
Cardiology
Publications
2024
The Updated REgistry of Fast Myocardial Perfusion Imaging With NExt Generation SPECT
Miller R, Lemley M, Shanbhag A, Bednarski B, Liang J, Builoff V, Kavanagh P, Sharir T, Hauser M, Ruddy T, Fish M, Einstein A, Dorbala S, Di Carli M, Feher A, Miller E, Sinusas A, Halcox J, Martins M, Kaufmann P, Dey D, Berman D, Slomka P. The Updated REgistry of Fast Myocardial Perfusion Imaging With NExt Generation SPECT. Journal Of Nuclear Cardiology 2024, 38: 101926. DOI: 10.1016/j.nuclcard.2024.101926.Peer-Reviewed Original ResearchAutomating Revascularization Decision Support: Clinical Application of Artificial Intelligence
Zhang W, Miller R, Patel K, Shanbhag A, Liang J, DiCarli M, Dorbala S, Einstein A, Fish M, Hauser M, Kaufmann P, Miller E, Ruddy T, Bateman T, Martins M, Sharir T, Halcox J, Acampa W, Dey D, Berman D, Slomka P. Automating Revascularization Decision Support: Clinical Application of Artificial Intelligence. Journal Of Nuclear Cardiology 2024, 38: 102001. DOI: 10.1016/j.nuclcard.2024.102001.Peer-Reviewed Original ResearchFrom transthyretin cardiac amyloidosis diagnosis to tafamidis treatment: Association of drop-off with patient sociodemographic characteristics
Walenczyk K, Singh A, Tong K, Burg M, Miller E. From transthyretin cardiac amyloidosis diagnosis to tafamidis treatment: Association of drop-off with patient sociodemographic characteristics. American Journal Of Health-System Pharmacy 2024, zxae183. PMID: 38963826, DOI: 10.1093/ajhp/zxae183.Peer-Reviewed Original ResearchAltmetricConceptsPatient sociodemographic characteristicsATTR-CASociodemographic characteristicsSpecialty pharmacyPyrophosphate scintigraphyPopulation prevalence ratesEconomically disadvantaged areasTransthyretin cardiac amyloidosisBlack/African American raceReduce disparitiesPotential patient subgroupsPharmacy processesProportion of daysClinical pathwayCompare sociodemographicsDisadvantaged areasEquitable provisionTafamidis therapyCardiac amyloidosisTafamidis treatmentPrevalence ratesClinical programsAmerican racePatient subgroupsPosting manuscriptsReproducibility for quantification of myocardial Tc-99m PYP amyloid uptake in grade 1 patients
Sandoval V, Goyal D, Miller E, Liu Y. Reproducibility for quantification of myocardial Tc-99m PYP amyloid uptake in grade 1 patients. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.047. DOI: 10.1093/ehjci/jeae142.047.Peer-Reviewed Original ResearchConceptsStandardized uptake valueTc-99m PYP uptakeTc-99Cardiac amyloidosisHeart failureStandard uptake value quantificationStandardized uptake value calculationSPECT imagesIntractable heart failureSystolic heart failureIntroduction of therapyPlanar imagingTc-99m pyrophosphateAmyloid patientsSPECT/CT imagingInter-reproducibilityUptake valueContralateral ratioCoefficient of variationDisease progressionH/M ratioGrade 1Blood poolPatientsH/CL ratioEvaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA)
Maayah M, Latif N, Vijay A, Gallegos C, Cigarroa N, Martinez E, Mazure C, Miller E, Spatz E, Shah S. Evaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA). Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102195. PMID: 39166160, PMCID: PMC11330936, DOI: 10.1016/j.jscai.2024.102195.Peer-Reviewed Original ResearchAltmetricConceptsIschemic heart diseaseNonobstructive coronary arteriesCoronary artery diseaseArtery diseaseObstructive coronary artery diseaseCoronary arteryLong-term cardiovascular prognosisHeart diseaseSuspected ischemic heart diseaseAtherosclerotic coronary artery diseaseCoronary vasomotor disordersPretest probability of diseasePragmatic diagnostic algorithmExpert consensus documentEvaluating ischemic heart diseaseImpact quality of lifeQuality of lifeSymptomatic patientsPretest probabilityANOCACardiovascular prognosisVasomotor disordersDiagnostic evaluationPersistent symptomsDiagnostic strategiesAddressing Health Disparities—The Case for Variant Transthyretin Cardiac Amyloidosis Grows Stronger
Maurer M, Miller E, Ruberg F. Addressing Health Disparities—The Case for Variant Transthyretin Cardiac Amyloidosis Grows Stronger. JAMA 2024, 331: 1809-1811. PMID: 38734953, DOI: 10.1001/jama.2024.2868.Peer-Reviewed Original ResearchAltmetricLinks Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes
Aneni E, Sinusas A, Emokpae M, Thorn S, Yaggi H, Miller E. Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes. Current Cardiology Reports 2024, 26: 723-734. PMID: 38806976, DOI: 10.1007/s11886-024-02072-z.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCoronary microvascular dysfunctionAbnormal myocardial blood flowSevere obstructive sleep apneaMyocardial flow reserveMyocardial blood flowSleep apneaModerate to severe obstructive sleep apneaAbnormal myocardial flow reserveRecent FindingsRecent studiesDisease-related outcomesBlood flow changesMyocardial blood flow changesCardiovascular disease-related outcomesMicrovascular dysfunctionClinical impactCPAPReviewRecent studiesStructural abnormalitiesCoronary microcirculationFindingsRecent studiesFlow reserveCardiac workBlood flowApneaUnlocking Diversity in Cardiovascular Clinical Research: Lessons from the SCAN-MP (Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations) Study
Wardhere A, Bampatsias D, Cohn E, Fine D, Freitas C, Gallegos C, Helmke S, Ionescu N, Ivrose J, Rodriguez C, Sabogal N, Fils S, Henry T, Teruya S, Ullah I, Kurian D, Raiszadeh F, Miller E, Ruberg F, Maurer M. Unlocking Diversity in Cardiovascular Clinical Research: Lessons from the SCAN-MP (Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations) Study. Journal Of Cardiac Failure 2024 PMID: 38740174, DOI: 10.1016/j.cardfail.2024.04.019.Peer-Reviewed Original ResearchAltmetricTAI-GAN: A Temporally and Anatomically Informed Generative Adversarial Network for early-to-late frame conversion in dynamic cardiac PET inter-frame motion correction
Guo X, Shi L, Chen X, Liu Q, Zhou B, Xie H, Liu Y, Palyo R, Miller E, Sinusas A, Staib L, Spottiswoode B, Liu C, Dvornek N. TAI-GAN: A Temporally and Anatomically Informed Generative Adversarial Network for early-to-late frame conversion in dynamic cardiac PET inter-frame motion correction. Medical Image Analysis 2024, 96: 103190. PMID: 38820677, PMCID: PMC11180595, DOI: 10.1016/j.media.2024.103190.Peer-Reviewed Original ResearchConceptsGenerative adversarial networkAdversarial networkMotion estimation accuracyInter-frame motionIntensity-based image registration techniqueAll-to-oneSegmentation masksImage registration techniquesOriginal frameTemporal informationDiagnosis accuracyMyocardial blood flowEstimation accuracyFrame conversionPositron emission tomographyNovel methodImage qualityPET datasetsRegistration techniqueNetworkCardiac positron emission tomographyBlood flowDynamic cardiac positron emission tomographyMotion correctionCoronary artery diseaseReal-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study
Oikonomou E, Aminorroaya A, Dhingra L, Partridge C, Velazquez E, Desai N, Krumholz H, Miller E, Khera R. Real-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study. European Heart Journal - Digital Health 2024, 5: 303-313. PMID: 38774380, PMCID: PMC11104476, DOI: 10.1093/ehjdh/ztae023.Peer-Reviewed Original ResearchAltmetricConceptsRisk of acute myocardial infarctionAssociated with lower oddsHospital health systemCoronary artery diseaseCardiac testingRisk of adverse outcomesUK BiobankHealth systemProvider-drivenLower oddsAssociated with better outcomesAcute myocardial infarctionBlack raceStable chest painFemale sexReal world evaluationDiabetes historyMulticohort studyFunction testsSuspected coronary artery diseaseYounger ageRisk profileAdverse outcomesMultinational cohortPost hoc analysis
Academic Achievements & Community Involvement
activity Certification Board of Nuclear Cardiology
Professional OrganizationsMemberDetailsBoard of Directors2013 - Presentactivity Society of Nuclear Medicine and Molecular Imaging - Cardiovascular Council
Professional OrganizationsMemberDetailsBoard of Directors2015 - Presenthonor Fellow, American College of Cardiology
National AwardAmerican College of CardiologyDetails03/29/2017United Stateshonor Fellow, American Society of Nuclear Cardiology
National AwardAmerican Society of Nuclear CardiologyDetails01/01/2014United Statesactivity American Society of Nuclear Cardiology
CommitteesMemberDetailsLeadership Development Program07/01/2009 - 06/30/2010
Clinical Care
Overview
Edward J. Miller, MD, PhD, treats chronic heart including infiltrative cardiomyopathies. “The Yale Medicine Cardiomyopathy Inherited Cardiovascular Disease Program has a wonderful interdisciplinary team of experts in the diagnosis and management of infiltrative cardiomyopathies,” says Dr. Miller, who also directs the clinical nuclear cardiology laboratory at Yale New Haven Hospital.
An expert at using imaging to diagnose and treat heart disease, Dr. Miller is especially interested in the use of new imaging techniques in cardiac sarcoidosis (an inflammatory disorder) and cardiac amyloidosis (a disorder of protein deposits). He is also focused on the role of obesity in certain types of heart disease.
Dr. Miller is an associate professor of medicine, and of radiology and biomedical imaging at Yale School of Medicine.
Clinical Specialties
Fact Sheets
Cardiac Amyloidosis
Learn More on Yale MedicineHeart Disease in Women
Learn More on Yale MedicineAmyloidosis
Learn More on Yale MedicineSarcoidosis
Learn More on Yale Medicine
Board Certifications
Cardiovascular Disease
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2018
- Original Certification Date
- 2008
Yale Medicine News
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Media
News
- September 18, 2024
Drs. Gallegos and Akintoye Named New Leaders of Yale’s Advanced Cardiac Imaging Fellowship Program
- April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions
- February 05, 2024
Yale Team Wins American Society of Nuclear Cardiology Award for Cardiology Decision Support Tool
- September 14, 2023
Smilow Shares: AL Amyloidosis
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Contacts
Cardiovascular Medicine
Yale University School of Medicine, Section of Cardiovascular Medicine, PO Box 208017
New Haven, CT 06520-8017
United States
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Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.