2017
Adverse outcome has a U-shaped relation with acute phase change in insulin sensitivity after ST-Elevation Myocardial Infarction
Moura F, Cintra R, Carvalho L, Santos S, Modolo R, Munhoz D, Quinaglia e Silva J, Coelho O, Nadruz W, Sposito A. Adverse outcome has a U-shaped relation with acute phase change in insulin sensitivity after ST-Elevation Myocardial Infarction. International Journal Of Cardiology 2017, 254: 16-22. PMID: 29246426, DOI: 10.1016/j.ijcard.2017.11.111.Peer-Reviewed Original ResearchConceptsST-elevation MIGRACE risk scoreInsulin sensitivity changesIntra-hospital deathMyocardial infarctionFollow-upMI hospitalizationAssociated with increased mortalityMarkers of glucose metabolismCox regression modelsInsulin provision therapyProspective cohortRisk scoreNet reclassification indexCardiac eventsAdverse cardiac eventsUpstream markersCox regressionAdverse outcomesHomeostasis model assessmentEstimate insulin sensitivityReclassification indexU-shaped relationStress hyperglycemiaInsulin sensitivity
2015
Abstract 13615: High-Dose Simvastatin Induce Insulin Resistance During Acute Myocardial Infarction by Inhibiting Intracellular Insulin Signaling, Without Attenuating Its Clinical Benefit
Carvalho L, Moura F, Cintra R, Prada P, Saad M, Coelho O, Sposito A. Abstract 13615: High-Dose Simvastatin Induce Insulin Resistance During Acute Myocardial Infarction by Inhibiting Intracellular Insulin Signaling, Without Attenuating Its Clinical Benefit. Circulation 2015, 132 DOI: 10.1161/circ.132.suppl_3.13615.Peer-Reviewed Original ResearchInsulin sensitivity indexEuglycemic hyperinsulinemic clampMyocardial infarctionPlasma glucoseStress hyperglycemiaLong-term clinical impactAbdominal adipose tissue biopsiesHigh-dose statinsHigh-dose simvastatinDoses of statinsTreated with statinsMeasurement of plasma glucoseInsulin secretionMarker of mortalityST-elevation MIIncidence of deathImpact of hyperglycemiaRisk of deathAdipose tissue biopsiesS80 groupAcute myocardial infarctionIntracellular insulin signalingHigh-doseStatin useClinical benefit
2011
Abstract 18367: High Density Lipoprotein Independently Modulates Insulin Sensitivity and Secretion During Acute Phase of Myocardial Infarction
Carvalho L, Cintra R, Araújo A, Moura F, Quináglia e Silva J, Coelho O, Sposito A. Abstract 18367: High Density Lipoprotein Independently Modulates Insulin Sensitivity and Secretion During Acute Phase of Myocardial Infarction. Circulation 2011, 124 DOI: 10.1161/circ.124.suppl_21.a18367.Peer-Reviewed Original ResearchHDL-C quartileHDL-CC-peptideMyocardial infarctionDisposition indexStress hyperglycemiaPlasma insulinInsulin sensitivityBlood glucoseConsecutive non-diabetic patientsAcute phaseHDL plasma levelsNon-diabetic patientsPlasma C-peptideAcute phase of MIAcute phase of myocardial infarctionHDL-C levelsST-elevation MIMultivariate analysis modelPhase of myocardial infarctionInfluence of HDLPhase of MIPlasma levelsTransient decreasePatientsHigh plasma HDL-C attenuates stress hyperglycemia during acute phase of myocardial infarction
Carvalho L, Cintra R, Moura F, Martins N, Quinaglia e Silva J, Coelho O, Sposito A, Group O. High plasma HDL-C attenuates stress hyperglycemia during acute phase of myocardial infarction. Atherosclerosis 2011, 220: 231-236. PMID: 22018645, DOI: 10.1016/j.atherosclerosis.2011.09.044.Peer-Reviewed Original ResearchConceptsHDL-C levelsHDL-C quartilePlasma HDL-C levelsHDL-CC-peptideMyocardial infarctionAcute phaseStress hyperglycemiaInsulin sensitivityAssociated with HDL-C levelsConsecutive non-diabetic patientsNon-diabetic patientsAcute phase of MILow plasma HDL-C levelsAcute phase of myocardial infarctionST-segment elevationPhase of myocardial infarctionBeta-cell functionAssess insulin sensitivityPhase of MIImproved insulin sensitivityBlood glucose changesPlasma glucoseQuartilePlasma insulin