Filipe A Moura
he/him/his
Assistant ProfessorCards
About
Research
Publications
2024
Diacerein reduces inflammasome activation and SARS-CoV-2 virus replication: a proof-of-concept translational study
Carmo H, Castillo A, Bonilha I, Gomes E, Barreto J, Moura F, Davanzo G, de Brito Monteiro L, Muraro S, de Souza G, Morari J, Galdino F, Brunetti N, Reis-de-Oliveira G, Carregari V, Nadruz W, Martins-de-Souza D, Farias A, Velloso L, Proenca-Modena J, Mori M, Loh W, Bhatt D, Yellon D, Davidson S, De Oliveira P, Moraes-Vieira P, Sposito A. Diacerein reduces inflammasome activation and SARS-CoV-2 virus replication: a proof-of-concept translational study. Frontiers In Pharmacology 2024, 15: 1402032. PMID: 39434905, PMCID: PMC11491754, DOI: 10.3389/fphar.2024.1402032.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsHuman peripheral blood mononuclear cellsSARS-CoV-2 infectionSARS-CoV-2Viral replicationInflammatory responseInflammasome activationMarkers of inflammasome activationPlacebo-controlled studySuppress viral replicationBlood mononuclear cellsInfection in vitroPrimary metabolitesCOVID-19 patientsDouble-blindPrimary endpointHealthy volunteersSevere acute respiratory syndrome coronavirus 2Plasma markersAcute respiratory syndrome coronavirus 2Mononuclear cellsClinical trialsRespiratory syndrome coronavirus 2Day 2Syndrome coronavirus 2Risk of new‐onset diabetes and efficacy of pharmacological weight loss therapy
Moura F, Bellavia A, Berg D, Melloni G, Feinberg M, Leiter L, Bohula E, Morrow D, Scirica B, Wiviott S, Sabatine M. Risk of new‐onset diabetes and efficacy of pharmacological weight loss therapy. Diabetes Obesity And Metabolism 2024, 26: 4441-4449. PMID: 39056220, PMCID: PMC11410501, DOI: 10.1111/dom.15798.Peer-Reviewed Original ResearchNew-onset diabetesRisk of new-onset diabetesClinical risk modelWeight loss therapyRisk groupsWeight loss pharmacotherapyMultivariate Cox regressionStable cardiovascular patientsTherapeutic decision makingAbsolute risk reductionHigh-risk groupType 2 diabetesIndependent predictorsValidation cohortFollow-upPersonalized patient careCox regressionHazard ratioPrimary outcomeRisk modelHigh riskInterquartile rangePatientsDiabetesCardiovascular patients1896-LB: Clinical Features and C-Peptide Levels Associated with Diabetic Ketoacidosis in Patients with Type 2 Diabetes on Dapagliflozin vs. Placebo—Insights from DECLARE-TIMI 58
MI KANG Y, MELLONI G, CAHN A, RAZ I, MOURA F, BHATT D, INZUCCHI S, LEITER L, MCGUIRE D, WILDING J, GAUSE-NILSSON I, OSCARSSON J, MARSTON N, RUFF C, SABATINE M, WIVIOTT S. 1896-LB: Clinical Features and C-Peptide Levels Associated with Diabetic Ketoacidosis in Patients with Type 2 Diabetes on Dapagliflozin vs. Placebo—Insights from DECLARE-TIMI 58. Diabetes 2024, 73 DOI: 10.2337/db24-1896-lb.Peer-Reviewed Original ResearchDuke Clinical Research InstituteC-pepClinical Research InstituteDKA eventsC-peptideLower fasting C-peptideMedian follow-upRandomized to dapagliflozinFasting C-peptideDuration of T2DC-peptide testingRisk of DKACV outcome trialsAmerican College of CardiologyAbsolute risk differenceRate of DKAImpaired insulin secretionType 2 diabetesPlacebo armClinical featuresPopulation Health Research InstituteCSL BehringDiabetic ketoacidosisFerring PharmaceuticalsOutcome trials1895-LB: Fasting C-Peptide and Type 1 Diabetes Polygenic Score Predict Diabetic Ketoacidosis in People with Type 2 Diabetes in DECLARE-TIMI 58
MI KANG Y, MELLONI G, CAHN A, RAZ I, MOURA F, BHATT D, INZUCCHI S, LEITER L, MCGUIRE D, WILDING J, GAUSE-NILSSON I, OSCARSSON J, MARSTON N, RUFF C, SABATINE M, WIVIOTT S. 1895-LB: Fasting C-Peptide and Type 1 Diabetes Polygenic Score Predict Diabetic Ketoacidosis in People with Type 2 Diabetes in DECLARE-TIMI 58. Diabetes 2024, 73 DOI: 10.2337/db24-1895-lb.Peer-Reviewed Original ResearchRisk of DKADuke Clinical Research InstituteC-pepC-peptidePolygenic scoresClinical Research InstitutePopulation Health Research InstituteHigh-risk ptsFasting C-peptideHealth Research InstituteCV outcome trialsAmerican College of CardiologyHigher-risk groupsPredicting DKAType 2 diabetesCSL BehringDiabetic ketoacidosisFerring PharmaceuticalsBristol-Myers SquibbSt. Jude MedicalNon-HLAIncreased riskCleveland ClinicDapagliflozinAmerican CollegeOlezarsen for Hypertriglyceridemia in Patients at High Cardiovascular Risk
Bergmark B, Marston N, Prohaska T, Alexander V, Zimerman A, Moura F, Murphy S, Goodrich E, Zhang S, Gaudet D, Karwatowska-Prokopczuk E, Tsimikas S, Giugliano R, Sabatine M. Olezarsen for Hypertriglyceridemia in Patients at High Cardiovascular Risk. New England Journal Of Medicine 2024, 390: 1770-1780. PMID: 38587249, DOI: 10.1056/nejmoa2402309.Peer-Reviewed Original ResearchConceptsNon-HDL cholesterolElevated cardiovascular riskLevels of triglyceridesTriglyceride levelsCardiovascular riskModerate hypertriglyceridemiaApolipoprotein BAdverse eventsNon-high-density lipoprotein (HDL) cholesterolLow-density lipoprotein (LDL) cholesterolBaseline to 6 monthsMedian triglyceride levelsRisk of adverse eventsLDL cholesterol levelsHigh cardiovascular riskTriglyceride-rich lipoproteinsApolipoprotein C-IIISevere hypertriglyceridemiaMedian ageTriglyceride loweringPlatelet abnormalitiesNo significant changesPlaceboPhase 2bPrimary outcomeDETECTION OF HYPERTROPHIC CARDIOMYOPATHY ON ELECTROCARDIOGRAM USING ARTIFICIAL INTELLIGENCE
Hillis J, Bizzo B, Mercaldo S, Ghatak A, Macdonald A, Halle M, Schultz A, L'Italien E, Tam V, Awad A, Bargiela D, Dagen S, Moura F, Toland D, Blood A, Gross D, Jering K, Lopes M, Marston N, Nauffal V, Dreyer K, Scirica B, Ho C. DETECTION OF HYPERTROPHIC CARDIOMYOPATHY ON ELECTROCARDIOGRAM USING ARTIFICIAL INTELLIGENCE. Journal Of The American College Of Cardiology 2024, 83: 2609. DOI: 10.1016/s0735-1097(24)04599-6.Peer-Reviewed Original ResearchAssessment of valve regurgitation severity via contrastive learning and multi-view video integration
Kim S, Ren H, Charton J, Hu J, Gonzalez C, Khambhati J, Cheng J, DeFrancesco J, Waheed A, Marciniak S, Moura F, Cardoso R, Lima B, McKinney S, Picard M, Li X, Li Q. Assessment of valve regurgitation severity via contrastive learning and multi-view video integration. Physics In Medicine And Biology 2024, 69: 045020. PMID: 38271727, DOI: 10.1088/1361-6560/ad22a4.Peer-Reviewed Original ResearchConceptsRepresentation learningContrastive learningMulti-view video processingState-of-the-art methodsContrastive learning frameworkState-of-the-artIn-house datasetVideo processingContrastive networkEmbedding spaceImage inputLearning frameworkVideo integrationIntricate taskLoss termMulti-modal clinical dataLearningRepresentationLabor-intensiveAccuracyEfficient methodVideo seriesEmbeddingDatasetNetwork
2023
Abstract 18949: Bariatric Surgery is Associated With Improved Coronary Microvascular Function and Cardiorespiratory Fitness in Patients With Ischemia and Non-Obstructive Coronary Arteries (INOCA)
de Souza A, Moura F, Divakaran S, Sirianni K, Sheu E, Di Carli M, Redline S, Tavakkoli A, Taqueti V. Abstract 18949: Bariatric Surgery is Associated With Improved Coronary Microvascular Function and Cardiorespiratory Fitness in Patients With Ischemia and Non-Obstructive Coronary Arteries (INOCA). Circulation 2023, 148: a18949-a18949. DOI: 10.1161/circ.148.suppl_1.18949.Peer-Reviewed Original ResearchCoronary flow reservePeripheral arterial tonometryCardiopulmonary exercise testingStress myocardial blood flowCoronary microvascular functionReactive hyperemia indexSevere obesityPeripheral endothelial functionPositron emission tomographyMyocardial blood flowBariatric surgeryEndothelial functionCardiorespiratory fitnessConsecutive patientsMedian ageIncidence of diabetic microvascular complicationsMicrovascular functionPost-surgeryNon-obstructive coronary arteriesImpaired coronary flow reserveMarkers of endothelial functionImpact of bariatric surgeryStress positron emission tomographyMethods Consecutive patientsResults Median ageComparative effectiveness and cost-effectiveness of cardioprotective glucose-lowering therapies for type 2 diabetes in Brazil: a Bayesian network model
Nogueira A, Barreto J, Moura F, Luchiari B, Abuhab A, Bonilha I, Nadruz W, Gaziano J, Gaziano T, de Carvalho L, Sposito A. Comparative effectiveness and cost-effectiveness of cardioprotective glucose-lowering therapies for type 2 diabetes in Brazil: a Bayesian network model. Health Economics Review 2023, 13: 50. PMID: 37878108, PMCID: PMC10599033, DOI: 10.1186/s13561-023-00466-3.Peer-Reviewed Original ResearchIncremental cost-effectiveness ratioGlucose-lowering therapyType 2 diabetesNetwork meta-analysisSecondary preventionPrevalence of type 2 diabetesBrazilian public health systemRisk of cardiovascular outcomesPublic health systemCost-effectiveReduced relative riskNon-fatal cardiovascular eventsContext of primary preventionConclusionsIn BrazilClasses of glucose-lowering therapiesHealth systemManagement of T2DMGLP-1aCost-effectiveness modelStandard carePrimary preventionCost-effectiveness ratioRelative riskEvidence-basedInternational dollarsMulti-task Learning for Hierarchically-Structured Images: Study on Echocardiogram View Classification
Charton J, Ren H, Kim S, Gonzalez C, Khambhati J, Cheng J, DeFrancesco J, Waheed A, Marciniak S, Moura F, Cardoso R, Lima B, Picard M, Li X, Li Q. Multi-task Learning for Hierarchically-Structured Images: Study on Echocardiogram View Classification. Lecture Notes In Computer Science 2023, 14337: 185-194. DOI: 10.1007/978-3-031-44521-7_18.Peer-Reviewed Original ResearchDeep learningMulti-task learning schemeVideo classification tasksMulti-task learningImage classification scenariosResidual neural networkData labelsClassification taskLearning schemeAblation studiesClassification scenariosNeural networkTree structureMedical imagesImage-processing techniquesSuperior performanceVideo viewingMonitoring cardiovascular diseasesTraining methodsHierarchically-structuredImage acquisitionLearningHierarchical structureTaskClassification