2017
Local synaptic integration enables ON-OFF asymmetric and layer-specific visual information processing in vGluT3 amacrine cell dendrites
Chen M, Lee S, Zhou ZJ. Local synaptic integration enables ON-OFF asymmetric and layer-specific visual information processing in vGluT3 amacrine cell dendrites. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 11518-11523. PMID: 28973895, PMCID: PMC5664540, DOI: 10.1073/pnas.1711622114.Peer-Reviewed Original ResearchConceptsInner plexiform layerAmacrine cellsSynaptic inhibitionSegregation of ONVGluT3 amacrine cellsGanglion cell typesBipolar cell terminalsSmall-field amacrine cellsOFF sublayersDendritic varicositiesPlexiform layerReceptive field sizeSynaptic processingSynaptic integrationDendritic responsesMammalian retinaOFF segregationNeuronal organizationTwo-photon imagingDendritic treeIPL depthOFF pathwaysCell terminalsDendritic functionVisual information processing
2016
Segregated Glycine-Glutamate Co-transmission from vGluT3 Amacrine Cells to Contrast-Suppressed and Contrast-Enhanced Retinal Circuits
Lee S, Zhang Y, Chen M, Zhou ZJ. Segregated Glycine-Glutamate Co-transmission from vGluT3 Amacrine Cells to Contrast-Suppressed and Contrast-Enhanced Retinal Circuits. Neuron 2016, 90: 27-34. PMID: 26996083, PMCID: PMC4824647, DOI: 10.1016/j.neuron.2016.02.023.Peer-Reviewed Original ResearchConceptsUniformity detectorsAmacrine cellsGanglion cellsOFF alpha ganglion cellsSpecific synaptic circuitryVGluT3 amacrine cellsAlpha ganglion cellsSeparate neuronal circuitsInhibitory driveExcitatory neurotransmitterSynaptic circuitryGlycinergic synapsesRetinal circuitsMouse retinaNeuronal circuitsSingle interneuronSingle neuronsDale's principleNeuronsNeurotransmittersTrigger featuresCoordinated inhibitionSynapsesGlutamateCells
2014
An Unconventional Glutamatergic Circuit in the Retina Formed by vGluT3 Amacrine Cells
Lee S, Chen L, Chen M, Ye M, Seal RP, Zhou ZJ. An Unconventional Glutamatergic Circuit in the Retina Formed by vGluT3 Amacrine Cells. Neuron 2014, 84: 708-715. PMID: 25456497, PMCID: PMC4254642, DOI: 10.1016/j.neuron.2014.10.021.Peer-Reviewed Original ResearchConceptsDirection-selective ganglion cellsAmacrine cellsGlutamatergic circuitsGanglion cellsCalcium-dependent glutamate releaseVGluT3 amacrine cellsExcitatory glutamatergic inputGanglion cell activityOFF light responsesReceptive field structureOFF channelsGlutamate releaseGlutamatergic inputsInner retinaExcitatory inputsInhibitory neuronsBipolar cellsMouse retinaCell activityOFF responsesRetinaExcitatory interactionsVertebrate retinaCellsVisual signals
2010
Role of ACh-GABA Cotransmission in Detecting Image Motion and Motion Direction
Lee S, Kim K, Zhou ZJ. Role of ACh-GABA Cotransmission in Detecting Image Motion and Motion Direction. Neuron 2010, 68: 1159-1172. PMID: 21172616, PMCID: PMC3094727, DOI: 10.1016/j.neuron.2010.11.031.Peer-Reviewed Original ResearchConceptsDirection-selective ganglion cellsStarburst amacrine cellsGamma-aminobutyric acidGABAergic mechanismsGABAergic synapsesCholinergic inputAmacrine cellsGanglion cellsCholinergic connectionsSynaptic organizationCholinergic synapsesDirection selectivityAcetylcholineLight onsetCotransmissionMotion sensitivitySynapsesHigh levelsCellsCoreleaseVisual signalsRetina
2004
A Developmental Switch in the Excitability and Function of the Starburst Network in the Mammalian Retina
Zheng JJ, Lee S, Zhou ZJ. A Developmental Switch in the Excitability and Function of the Starburst Network in the Mammalian Retina. Neuron 2004, 44: 851-864. PMID: 15572115, DOI: 10.1016/j.neuron.2004.11.015.Peer-Reviewed Original ResearchConceptsStarburst cellsGABAergic synapsesStarburst networkDual patch-clamp recordingsSpontaneous retinal wavesPatch-clamp recordingsVisual system developmentNicotinic synapsesNetwork excitabilityRetinal wavesRabbit retinaMammalian retinaRecurrent excitationSynapsesDependent mannerGABAExcitabilityRetinaCellsCa2Early developmentCoreleaseExcitatoryNicotinicACh