Publications

2025

A Retrospective Analysis of FDA Recalls of Artificial Tear Solutions from 2014-2025.
Bhattacharya A, Kang PC. A Retrospective Analysis of FDA Recalls of Artificial Tear Solutions from 2014-2025. J Cataract Refract Surg 2025 PMID: 41250303, DOI: 10.1097/j.jcrs.0000000000001835.
Peer-Reviewed Original Research
Transcriptomic Architecture of Weak Versus Strong Contextual Fear Extinction Learning Uncovers Extinction-Suppressive Role of TIA1
Bonilla M, Lee H, Foster S, Kim I, Rudenko A. Transcriptomic Architecture of Weak Versus Strong Contextual Fear Extinction Learning Uncovers Extinction-Suppressive Role of TIA1. Biological Psychiatry Global Open Science 2025, 5: 100591. DOI: 10.1016/j.bpsgos.2025.100591.
Peer-Reviewed Original Research
Concepts
AgentMD: Empowering language agents for risk prediction with large-scale clinical tool learning
Jin Q, Wang Z, Yang Y, Zhu Q, Wright D, Huang T, Khandekar N, Wan N, Ai X, Wilbur W, He Z, Taylor R, Chen Q, Lu Z. AgentMD: Empowering language agents for risk prediction with large-scale clinical tool learning. Nature Communications 2025, 16: 9377. PMID: 41130954, PMCID: PMC12549800, DOI: 10.1038/s41467-025-64430-x.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Digital Health Tool for Preventing Blindness From Diabetic Retinopathy: Protocol for a Qualitative Study
Frimpong A, Granados A, Chang T, Fu J, Applebaum SS, Moore SG, Kaur M, Adepoju B, Hari Krishnan V, Levi A, McCall T, Nwanyanwu KH. Digital health tool for preventing blindness from diabetic retinopathy: protocol for a qualitative study. JMIR Res Protoc. In press. 2025.
Peer-Reviewed Original Research In Press
Olive tree at the intersection of environment, public health, and One Health: a sustainable path to global wellbeing
Katsafadou A, Prodromou S, Aalizadeh R, White J, Thomaidis N, Vizirianakis I, Anastas P, Kyriakides T, Pastides H, Piscitelli P, Colao A, Thompson D, Vasiliou V. Olive tree at the intersection of environment, public health, and One Health: a sustainable path to global wellbeing. Frontiers In Public Health 2025, 13: 1658525. DOI: 10.3389/fpubh.2025.1658525.
Peer-Reviewed Original Research
Concepts
Risk Factors and Consequences of Lapses in Proliferative Diabetic Retinopathy Care in a National Cohort.
Applebaum S, Deng Y, Fu J, Kane M, Nwanyanwu K, Amin S, Edwards P, Srikumaran D, Woreta F, Schultz J, Shrivastava A, Ahmad B, Pasquale L, Bryar P, French D, Hribar M, Thomas M, Vanderbeek B, Pershing S, Wang S, Deiner M, Sun C, Patnaik J, Subramanian P, Munir S, Munir W, Stein J, De Lott L, Ramachandran R, Feldman R, Stagg B, Wirostko B, McMillian B, Sheybani A, Sarrafpour S, Harris-Nwanyanwu K, Stein J, Andrews C. Risk Factors and Consequences of Lapses in Proliferative Diabetic Retinopathy Care in a National Cohort. Diabetes Care 2025 PMID: 40956999, DOI: 10.2337/dc25-1202.
Peer-Reviewed Original Research
Concepts
Integrating rule-based NLP and large language models for statin information extraction from clinical notes
Liu S, McCoy A, Chen Q, Wright A. Integrating rule-based NLP and large language models for statin information extraction from clinical notes. International Journal Of Medical Informatics 2025, 205: 106104. PMID: 40925145, DOI: 10.1016/j.ijmedinf.2025.106104.
Peer-Reviewed Original Research
Concepts
Assessment of adipokine and inflammation biomarkers with cancer risk among Chinese men: A prospective cohort study.
DeMoulin D, Cai H, Cai Q, Zheng W, Shu X. Assessment of adipokine and inflammation biomarkers with cancer risk among Chinese men: A prospective cohort study. Cancer Epidemiology Biomarkers & Prevention 2025, of1-of13. PMID: 40900641, DOI: 10.1158/1055-9965.epi-25-0342.
Peer-Reviewed Original Research
Concepts
Ophthalmological Question Answering and Reasoning Using OpenAI o1 vs Other Large Language Models
Srinivasan S, Ai X, Zou M, Zou K, Kim H, Lo T, Pushpanathan K, Yang G, Goh J, Kong Y, Li A, Singer M, Jin K, Antaki F, Chen D, Liu D, Adelman R, Chen Q, Tham Y. Ophthalmological Question Answering and Reasoning Using OpenAI o1 vs Other Large Language Models. JAMA Ophthalmology 2025, 143: 740-748. PMID: 40742581, PMCID: PMC12314776, DOI: 10.1001/jamaophthalmol.2025.2413.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Associations of Pre-diagnostic Serum Liver Enzyme Levels with Lung Cancer Risk in Predominantly Low-income African and European Americans
Xu S, Cai H, Wu J, Shi J, Courtney R, Yoon H, Shu X, Blot W, Zheng W, Cai Q. Associations of Pre-diagnostic Serum Liver Enzyme Levels with Lung Cancer Risk in Predominantly Low-income African and European Americans. Carcinogenesis 2025, bgaf052. PMID: 40879454, DOI: 10.1093/carcin/bgaf052.
Peer-Reviewed Original Research
Concepts
Reply
Shen L, Del Priore L. Reply. Ophthalmology 2025 PMID: 40856673, DOI: 10.1016/j.ophtha.2025.07.022.
Peer-Reviewed Original Research
Bringing our genomes to medicine – the 2026 human genome meeting
Patrinos G, Reichardt J, Carninci P, Hamosh A, Mitropoulou C, Vasiliou V. Bringing our genomes to medicine – the 2026 human genome meeting. Human Genomics 2025, 19: 93. PMID: 40813697, PMCID: PMC12355788, DOI: 10.1186/s40246-025-00804-y.
Peer-Reviewed Original Research
Clinical Trial Eligibility Criteria Decomposition and Parsing with Large Language Models.
Chen H, Qian L, He X, Chen A, Huang Y, Gou Q, Wang Y, Wang Y, Ai X, Zhou Y, Cohen I, Chen Q, Xu H, Bian J. Clinical Trial Eligibility Criteria Decomposition and Parsing with Large Language Models. Studies In Health Technology And Informatics 2025, 329: 688-692. PMID: 40775946, DOI: 10.3233/shti250928.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Sex‐Specific Aging Patterns of Gut Microbiota in Urban Chinese Adults: Guild‐Based Analysis and Implications for Healthy Aging
Fu J, Xu W, Yu D, Jiang Y, Wang L, Cai H, Xia Q, Shu X, Zheng W. Sex‐Specific Aging Patterns of Gut Microbiota in Urban Chinese Adults: Guild‐Based Analysis and Implications for Healthy Aging. Aging Cell 2025, e70192. PMID: 40757475, DOI: 10.1111/acel.70192.
Peer-Reviewed Original Research
Concepts
Does my patient need testing for PFAS ‘forever chemicals’?
Zuccaro P, Valvi D, Vasiliou V. Does my patient need testing for PFAS ‘forever chemicals’? Cleveland Clinic Journal Of Medicine 2025, 92: 463-465. PMID: 40750320, DOI: 10.3949/ccjm.92a.24082.
Peer-Reviewed Original Research
Can a Natural Image-Based Foundation Model Outperform a Retina-Specific Model in Detecting Ocular and Systemic Diseases?
Hou Q, Zhou Y, Goh J, Zou K, Yew S, Srinivasan S, Wang M, Lo T, Lei X, Wagner S, Chia M, Yang G, Jiang H, Ran A, Santos R, Somfai G, Zhou J, Chen H, Chen Q, Cheung C, Keane P, Tham Y. Can a Natural Image-Based Foundation Model Outperform a Retina-Specific Model in Detecting Ocular and Systemic Diseases? Ophthalmology Science 2025, 100923. DOI: 10.1016/j.xops.2025.100923.
Peer-Reviewed Original Research
Concepts
Synergistic toxicity in alcohol-associated liver disease and PFAS exposure
Stem A, Tieghi R, Chatzi V, Kleinstreuer N, Valvi D, Thompson D, Vasiliou V. Synergistic toxicity in alcohol-associated liver disease and PFAS exposure. Toxicological Sciences 2025, kfaf110. PMID: 40737496, DOI: 10.1093/toxsci/kfaf110.
Peer-Reviewed Original Research
Concepts
TMBIM4 affects left-right patterning via pluripotency exit during gastrulation
Diab N, Kostiuk V, Tyan L, Mis E, Zenisek D, Khokha M. TMBIM4 affects left-right patterning via pluripotency exit during gastrulation. Developmental Biology 2025, 527: 136-146. PMID: 40744297, DOI: 10.1016/j.ydbio.2025.07.018.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Artificial Intelligence in Age-Related Macular Degeneration (AMD)
Mukherjee S, Peng Y, Chen Q, Keenan T, Chew E, Lu Z. Artificial Intelligence in Age-Related Macular Degeneration (AMD). 2025, 121-135. DOI: 10.1007/978-3-031-83756-2_8.
Peer-Reviewed Original Research
Concepts
The Retinal Fundus Verdict on Intensive Blood-Pressure Therapy Lower Is Better
Bakhoum M, Wong M, Jayaraj C, Goldbaum M, Bakhoum C. The Retinal Fundus Verdict on Intensive Blood-Pressure Therapy Lower Is Better. Journal Of The American College Of Cardiology 2025, 86: 1389-1391. PMID: 41105074, DOI: 10.1016/j.jacc.2025.06.009.
Peer-Reviewed Original Research
Integrating gut microbiome and neuroplasticity genomics in alcohol use disorder therapy
Koutromanos I, Legaki E, Dovrolis N, Vassilopoulos E, Stem A, Vasiliou V, Tzavellas E, Gazouli M. Integrating gut microbiome and neuroplasticity genomics in alcohol use disorder therapy. Human Genomics 2025, 19: 78. PMID: 40646629, PMCID: PMC12255058, DOI: 10.1186/s40246-025-00793-y.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids
Miller S, Dhodapkar R, Sutova H, Xue Y, Lee S, Logan R, Ran C, Bhatta S, Gomm A, Ju I, Heyang M, Darji R, DiStasio M, Tanzi R, Zhang C, Zhou Z, Hafler B. SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids. Science Advances 2025, 11: eads5006. PMID: 40614201, PMCID: PMC12227045, DOI: 10.1126/sciadv.ads5006.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Lessons learned from aldehyde dehydrogenases as non-P450 aldehyde-oxidizing enzymes: implications for the ‘exposome’ and human health
Lisgara A, Thompson D, Nebert D, Vasiliou V. Lessons learned from aldehyde dehydrogenases as non-P450 aldehyde-oxidizing enzymes: implications for the ‘exposome’ and human health. Expert Opinion On Drug Metabolism & Toxicology 2025, 21: 915-919. PMID: 40591371, DOI: 10.1080/17425255.2025.2524872.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
AI Workflow, External Validation, and Development in Eye Disease Diagnosis
Chen Q, Keenan T, Agron E, Allot A, Guan E, Duong B, Elsawy A, Hou B, Xue C, Bhandari S, Broadhead G, Cousineau-Krieger C, Davis E, Gensheimer W, Golshani C, Grasic D, Gupta S, Haddock L, Konstantinou E, Lamba T, Maiberger M, Mantopoulos D, Mehta M, Elnahry A, AL-Nawaflh M, Oshinsky A, Powell B, Purt B, Shin S, Stiefel H, Thavikulwat A, Wroblewski K, Tham Y, Cheung C, Cheng C, Chew E, Hribar M, Chiang M, Lu Z. AI Workflow, External Validation, and Development in Eye Disease Diagnosis. JAMA Network Open 2025, 8: e2517204. PMID: 40668583, PMCID: PMC12268484, DOI: 10.1001/jamanetworkopen.2025.17204.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Digital health tool for preventing blindness from diabetic retinopathy: protocol for a qualitative study. Submitted for publication
Frimpong A, Granados A, Chang T, Fu J, Applebaum SS, Moore SG, Kaur M, Adepoju B, Hari Krishnan V, Levi A, McCall T, Harris Nwanyanwu K. Digital health tool for preventing blindness from diabetic retinopathy: protocol for a qualitative study. Submitted for publication. JMIR Research Protocols. 2025.
Peer-Reviewed Original Research

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