Anatomy; Neurobiology; Neurosciences; Ophthalmology; Vision, Ocular
Our laboratory is interested in understanding how neural circuits form and function to elicit appropriate behavior, and how they can be modified by experience. Orderly and specific patterns of neuronal wiring are critical to trigger coherent responses to sensory inputs. Conversely, mistakes in connectivity may lead to altered behaviors observed in disorders such as autism or schizophrenia. It is therefore essential to learn how neurons choose synaptic partners as they “wire up” the developing brain and maintain such connections throughout life. To study mechanisms of neuronal wiring, we have focused on the visual system. The success of our research will provide novel insights into the cellular basis of visual perception and will allow to generate new methods to examine neural circuitry in the normal brain and in animal models of of neurological and psychiatric diseases.
Specialized Terms: Neuroscience; Development; Visual system; Neural circuits; Transgenic approaches; Direction selectivity; Visually-Driven Defense Response
Extensive Research Description
Our current research involves both retina (light-sensitive layer of eye) and brain targets: 1) Retina project includes investigating how retinal ganglion cells (RGCs) acquire specific morphological structure during development and how they eventually recognize distinct visual cues (e.g. color, motion). We are examining potential effects of overexpression and knock-out of candidate genes on structural development and functional specification of distinct subsets of RGCs that may lead to alteration in visual perception. 2) Brain project focuses on investigating how distinct visual information from the retina - perceived by different types of RGCs - is processed in the brain. Studies include the search of brain neurons receiving specific visual cues (e.g. direction selectivity) from the retina and examination of development of unique connections between the retina and the brain.
Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus.
Byun H, Kwon S, Ahn HJ, Liu H, Forrest D, Demb JB, Kim IJ (2016). J Comp Neurol. 524(11):2300-2321. PMCID: PMC4892959
Function and Circuitry of VIP+ Interneurons in the Mouse Retina.
Park SJ, Borghuis BG, Rahmani P, Zeng Q, Kim IJ*, Demb JB*. (2015). J Neurosci. 35(30):10685-10700. *co-corresponding authors. PMCID: PMC4518048
Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling.
Duan X, Qiao M, Bei F, Kim IJ, He Z, Sanes JR (2015). Neuron. 85(6):1244-1256. PMCID: PMC4391013
The most numerous ganglion cell type of the mouse retina is a selective feature detector
Zhang Y, Kim IJ, Sanes JR and Meister M (2012). Proc Natl Acad Sci U S A. 109(36):E2391-2398. PMCID: PMC3437843
Laminar Restriction of Retinal Ganglion Cell Dendrites and Axons: Subtype-Specific Developmental Patterns Revealed With Transgenic Markers.
Kim IJ, Zhang Y, Meister M, Sanes JR (2010). J. Neurosci. 30(4):1452-1462, PMCID: PMC2822471
Molecular Identification of a Retinal Cell Type That Responds to Upward Motion.
Kim IJ*, Zhang Y*, Yamagata M, Meister M, Sanes JR (2008) Nature. 452 (7186):478-482. * co-first authors
Full List of PubMed Publications
- Park SJH, Pottackal J, Ke JB, Jun NY, Rahmani P, Kim IJ, Singer JH, Demb JB: Convergence and Divergence of CRH Amacrine Cells in Mouse Retinal Circuitry. J Neurosci. 2018 Apr 11; 2018 Mar 23. PMID: 29572434
- Fink KL, López-Giráldez F, Kim IJ, Strittmatter SM, Cafferty WBJ: Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury. Cell Rep. 2017 Mar 14. PMID: 28297672
- Byun H, Kwon S, Ahn HJ, Liu H, Forrest D, Demb JB, Kim IJ: Molecular features distinguish ten neuronal types in the mouse superficial superior colliculus. J Comp Neurol. 2016 Aug 1; 2016 Jan 26. PMID: 26713509
- Park SJ, Borghuis BG, Rahmani P, Zeng Q, Kim IJ, Demb JB: Function and Circuitry of VIP+ Interneurons in the Mouse Retina. J Neurosci. 2015 Jul 29. PMID: 26224854
- Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y, Yoshida Y: Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015; 2015 Mar 31. PMID: 25826454
- Park SJ, Kim IJ, Looger LL, Demb JB, Borghuis BG: Excitatory synaptic inputs to mouse on-off direction-selective retinal ganglion cells lack direction tuning. J Neurosci. 2014 Mar 12. PMID: 24623775