Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression
Chromosomal instability (CIN) and epigenetic alterations have been implicated in tumor progression and metastasis; yet how these two hallmarks of cancer are related remains poorly understood. By integrating genetic, epigenetic, and functional analyses at the single cell level, we show that progression of uveal melanoma (UM), the most common intraocular primary cancer in adults, is driven by loss of Polycomb Repressive Complex 1 (PRC1) in a subpopulation of tumor cells. This leads to transcriptional de-repression of PRC1-target genes and mitotic chromosome segregation errors. Ensuing CIN leads to the formation of rupture-prone micronuclei, exposing genomic double-stranded DNA (dsDNA) to the cytosol. This provokes tumor cell-intrinsic inflammatory signaling, mediated by aberrant activation of the cGAS-STING pathway. Read more...
- August 31, 2021Source: News 8 WTNH.com
NEW HAVEN, Conn. (WTNH) — Another COVID-19 pandemic health-related issue doctors are now treating is children’s vision after months and months of too much screen time. That can lead to a condition called myopia, which is nearsightedness.
- August 04, 2021
This award financially supports early career physician scientists to assist them in transitioning to independent research careers.
- May 11, 2021
We are proud to announce that one of our current and one of our former residents have been named 2021-2022 Heed Fellows.
- February 04, 2021Source: New York Times
“I can’t see!” the 57-year-old man bellowed. His wife and two of his adult children ran in and saw the man standing before a mirror. “If I cover my right eye, the top of my face just disappears,” he said.
- February 02, 2021Source: Yale Medicine
Helping those hit harder by COVID-19
- January 14, 2021
He was recognized as a pioneer in the field of strabismus, including writing one of the first textbooks on the subject. He was also a prolific researcher, a world-renowned speaker, and a passionate educator.
- June 16, 2020Source: YaleNews
Since June 1, the start of a broad, three-phase reactivation of campus, an estimated 4,000 faculty members, graduate students, and staff representing more than 500 labs around Yale have fired up microscopes, opened fume hoods, or dusted off other essential research equipment.
- June 04, 2020
Connecticut Magazine has named 82 Yale Cancer Center and Smilow Cancer Hospital physicians to its 2020 Best Doctors guide
- June 04, 2020Source: WTNH.com
An interview with Yale Ophthalmology's Dr. Vicente Diaz on the link between COVID-19 and your eyes.