Xiaojia (Sasha) Guo, PhD
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Research Summary
We are interested in the control of vascular remodeling. Endothelial and smooth muscle cell-derived neuropilin-like protein (ESDN) is up-regulated in the neointima of remodeling arteries and modulates vascular smooth muscle cell (VSMC) growth. Receptor tyrosine kinases (RTKs) constitute a family of cell-surface receptors, including PDGFR, EGFR, VEGFR, and FGFR, controlling a variety of cellular processes, such as proliferation, differentiation, migration, and survival. RTKs are activated by binding of extracellular ligands, resulting in increased tyrosine kinase activity and phosphorylation of target proteins. Once activated, RTKs are ubiquitinated, internalized and targeted for degradation to the lysosomal compartment or locally destroyed in proteasomes. Many of these processes are regulated by ubiquitination, a post-traslational modifi cation where the small protein ubiquitin is covalently attached to a target protein by ubiquitin ligases such as c-Cbl. While polyubiquitination marks proteins for proteasomal degradation, mono- or multi-ubiquitination is sufficient to direct endocytosis and lysosomal degradation of membrane receptors.
Specialized Terms: vascular remodeling, receptor tyrosine kinases (RTKs)
Extensive Research Description
Continued detailed analyses of the involvement of ESDN in the regulation of RTK-driven pathologies is thus predicted to pave the way for therapeutic strategy for vascular diseases and other diseases involving RTK-driven tissue remodeling.
Coauthors
Research Interests
Nephrology; Vascular Remodeling
Selected Publications
- Renalase Identified by Machine Learning Methods as A Novel Independent Predictor of Mortality in Hospitalized Patients with COVID-19Safdar B, Sobiesk M, Bertsimas D, Nowroozpoor A, Deng Y, D’Onofrio G, Dziura J, El-Khoury J, Guo X, Simonov M, Taylor R, Wang M, Desir G. Renalase Identified by Machine Learning Methods as A Novel Independent Predictor of Mortality in Hospitalized Patients with COVID-19. Journal Of Biotechnology And Biomedicine 2024, 07 DOI: 10.26502/jbb.2642-91280139.
- Clinical predictive value of renalase in post-ERCP pancreatitisMuniraj T, Desir G, Gorelick F, Guo X, Ciarleglio M, Deng Y, Jamidar P, Farrell J, Aslanian H, Laine L. Clinical predictive value of renalase in post-ERCP pancreatitis. Gastrointestinal Endoscopy 2023, 99: 822-825.e1. PMID: 38103747, DOI: 10.1016/j.gie.2023.12.020.
- APOBEC-1 deletion enhances cisplatin-induced acute kidney injuryGuo X, Blanc V, Davidson N, Velazquez H, Chen T, Moledina D, Moeckel G, Safirstein R, Desir G. APOBEC-1 deletion enhances cisplatin-induced acute kidney injury. Scientific Reports 2023, 13: 22255. PMID: 38097707, PMCID: PMC10721635, DOI: 10.1038/s41598-023-49575-3.
- mRNA Editing via the Apobec1 Gene Promotes Recovery from AKIGuo X, Velazquez H, Xu L, Cheng Z, Chen T, Tian Y, Bewersdorf J, Blanc V, Davidson N, Safirstein R, Desir G. mRNA Editing via the Apobec1 Gene Promotes Recovery from AKI. Journal Of The American Society Of Nephrology 2023, 34: 451-451. DOI: 10.1681/asn.20233411s1451b.
- Renalase Ameliorates AKI by Altering Mitochondrial Function to Induce Cellular Repair MechanismsGuo X, Chen R, Chen T, Safirstein R, Jonas E, Desir G. Renalase Ameliorates AKI by Altering Mitochondrial Function to Induce Cellular Repair Mechanisms. Journal Of The American Society Of Nephrology 2023, 34: 117-117. DOI: 10.1681/asn.20233411s1117b.
- Sa1408 PREDICTIVE VALUE OF RENALASE IN POST-ERCP PANCREATITISMuniraj T, Desir G, Gorelick F, Guo X, Ciarleglio M, Deng Y, Jamidar P, Farrell J, Aslanian H, Laine L. Sa1408 PREDICTIVE VALUE OF RENALASE IN POST-ERCP PANCREATITIS. Gastroenterology 2023, 164: s-384-s-385. DOI: 10.1016/s0016-5085(23)01894-2.
- Plasma renalase levels are associated with the development of acute pancreatitisWang M, Weiss F, Guo X, Kolodecik T, Bewersdorf J, Laine L, Lerch M, Desir G, Gorelick F. Plasma renalase levels are associated with the development of acute pancreatitis. Pancreatology 2023, 23: 158-162. PMID: 36697349, DOI: 10.1016/j.pan.2023.01.001.
- Abstract 13764: Renalase Peptide Agonist Therapy Normalizes the Cardiac Response to Pressure Overload in Chronic Kidney DiseaseNair G, Zhang J, Guo X, guerrera N, Wu X, Hu X, Gorelick F, Safirstein R, Giordano F, Young L, Desir G. Abstract 13764: Renalase Peptide Agonist Therapy Normalizes the Cardiac Response to Pressure Overload in Chronic Kidney Disease. Circulation 2022, 146: a13764-a13764. DOI: 10.1161/circ.146.suppl_1.13764.
- Apobec-1 Limits Cisplatin and Ischemia-Reperfusion-Induced AKIGuo X, Xu L, Velazquez H, Chen T, Blanc V, Davidson N, Moeckel G, Safirstein R, Desir G. Apobec-1 Limits Cisplatin and Ischemia-Reperfusion-Induced AKI. Journal Of The American Society Of Nephrology 2022, 33: 359-360. DOI: 10.1681/asn.20223311s1359e.
- Renalase Protects Renal Injury by Maintaining Mitochondrial Dynamic HomeostasisGuo X, Chen R, Chen T, Moeckel G, Safirstein R, Jonas E, Desir G. Renalase Protects Renal Injury by Maintaining Mitochondrial Dynamic Homeostasis. Journal Of The American Society Of Nephrology 2022, 33: 359-359. DOI: 10.1681/asn.20223311s1359d.
- Heightened Innate Immune Response to COVID-19 Infection in CKD: Implications to Poorer Outcome During CKDGuo X, Xu L, Chen T, Gorelick F, Desir G, Safirstein R. Heightened Innate Immune Response to COVID-19 Infection in CKD: Implications to Poorer Outcome During CKD. Journal Of The American Society Of Nephrology 2021, 32: 749-749. DOI: 10.1681/asn.20213210s1749c.
- Kidney Targeted Renalase Agonist Peptide Rescues Severe Model of Cisplatin-Induced AKI and CKDGuo X, Xu L, Velazquez H, Chen T, Williams R, Heller D, Safirstein R, Desir G. Kidney Targeted Renalase Agonist Peptide Rescues Severe Model of Cisplatin-Induced AKI and CKD. Journal Of The American Society Of Nephrology 2020, 31: 230-230. DOI: 10.1681/asn.20203110s1230b.
- Apobec 1 Limits Cisplatin-Induced AKI by Regulating the Disposal of Pro-Ferroptotic LipidsGuo X, Velazquez H, Chen T, Blanc V, Davidson N, Safirstein R, Desir G. Apobec 1 Limits Cisplatin-Induced AKI by Regulating the Disposal of Pro-Ferroptotic Lipids. Journal Of The American Society Of Nephrology 2020, 31: 123-123. DOI: 10.1681/asn.20203110s1123d.
- MON-334 TWO FORMS OF RENALASE (BOUND AND FREE) IDENTIFIED IN HUMAN PLASMA BY A NEW ELISARao V, Guo X, Chang J, Peixoto A, Testani J, Desir G. MON-334 TWO FORMS OF RENALASE (BOUND AND FREE) IDENTIFIED IN HUMAN PLASMA BY A NEW ELISA. Kidney International Reports 2019, 4: s67. DOI: 10.1016/j.ekir.2019.05.180.
- SAT-183 % FREE RENALASE IS ASSOCIATED WITH PROGRESSION OF CKD, AND IS AN INDEPENDENT PREDICTOR OF ALL CAUSE MORTALITYDesir G, Chang J, Guo X, Gromisch E, Peixoto A. SAT-183 % FREE RENALASE IS ASSOCIATED WITH PROGRESSION OF CKD, AND IS AN INDEPENDENT PREDICTOR OF ALL CAUSE MORTALITY. Kidney International Reports 2019, 4: s84-s85. DOI: 10.1016/j.ekir.2019.05.217.
- Adrenomedullin 2 activates extracellular-signal-regulated kinase in endothelial cells via a protein kinase C α-independent pathwayGuo X, Ju R, Cha C, Simons M. Adrenomedullin 2 activates extracellular-signal-regulated kinase in endothelial cells via a protein kinase C α-independent pathway. F1000Research 2016, 5: 26. DOI: 10.12688/f1000research.2420.1.
- The novel tumor angiogenic factor, adrenomedullin-2, predicts survival in pancreatic adenocarcinomaHollander LL, Guo X, Salem RR, Cha CH. The novel tumor angiogenic factor, adrenomedullin-2, predicts survival in pancreatic adenocarcinoma. Journal Of Surgical Research 2015, 197: 219-224. PMID: 25982376, DOI: 10.1016/j.jss.2014.11.002.
- RenalaseGuo X, Wang L, Velazquez H, Safirstein R, Desir GV. Renalase. Current Opinion In Nephrology & Hypertension 2014, 23: 513-518. PMID: 24992568, PMCID: PMC4383282, DOI: 10.1097/mnh.0000000000000044.
- Automated Quantitative Analysis of Tissue Microarray of 443 Patients with Colorectal Adenocarcinoma: Low Expression of Bcl-2 Predicts Poor SurvivalNicholson AD, Guo X, Sullivan CA, Cha CH. Automated Quantitative Analysis of Tissue Microarray of 443 Patients with Colorectal Adenocarcinoma: Low Expression of Bcl-2 Predicts Poor Survival. Journal Of The American College Of Surgeons 2014, 219: 977-987. PMID: 25127509, DOI: 10.1016/j.jamcollsurg.2014.07.007.
- The Novel Tumor Angiogenic Factor, Adrenomedullin-2 (ADM2) Predicts Survival in Pancreatic AdenocarcinomaHollander L, Guo X, Salem R, Cha C. The Novel Tumor Angiogenic Factor, Adrenomedullin-2 (ADM2) Predicts Survival in Pancreatic Adenocarcinoma. Journal Of Surgical Research 2014, 186: 635-636. DOI: 10.1016/j.jss.2013.11.651.
- Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesisNie L, Guo X, Esmailzadeh L, Zhang J, Asadi A, Collinge M, Li X, Kim JD, Woolls M, Jin SW, Dubrac A, Eichmann A, Simons M, Bender JR, Sadeghi MM. Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. Journal Of Clinical Investigation 2013, 123: 5082-5097. PMID: 24177422, PMCID: PMC3859420, DOI: 10.1172/jci67752.
- Triple-negative breast cancer: molecular characterization and targeted therapiesNicholson A, Bishop J, Lannin D, Killelea B, Guo X, Cha C, Dixon J. Triple-negative breast cancer: molecular characterization and targeted therapies. Breast Cancer Management 2013, 2: 417-430. DOI: 10.2217/bmt.13.40.
- Loss of Bcl-2 expression impacts survival in colorectal cancer using a high throughput tissue microarray analysis (AQUA)Nicholson A, Guo X, Sullivan C, Cha C. Loss of Bcl-2 expression impacts survival in colorectal cancer using a high throughput tissue microarray analysis (AQUA). Journal Of The American College Of Surgeons 2012, 215: s127. DOI: 10.1016/j.jamcollsurg.2012.06.329.
- Intermedin is overexpressed in hepatocellular carcinoma and regulates cell proliferation and survivalGuo X, Schmitz JC, Kenney BC, Uchio EM, Kulkarni S, Cha CH. Intermedin is overexpressed in hepatocellular carcinoma and regulates cell proliferation and survival. Cancer Science 2012, 103: 1474-1480. PMID: 22625651, PMCID: PMC7659195, DOI: 10.1111/j.1349-7006.2012.02341.x.
- Abstract 5149: Intermedin stimulates cell growth, migration, and angiogenesis in human colorectal adenocarcinoma and hepatocellular carcinomaGuo X, Schmitz J, Uchio E, Kenney B, Kulkarni S, Cha C. Abstract 5149: Intermedin stimulates cell growth, migration, and angiogenesis in human colorectal adenocarcinoma and hepatocellular carcinoma. Cancer Research 2011, 71: 5149-5149. DOI: 10.1158/1538-7445.am2011-5149.
- Endothelial and Smooth Muscle-derived Neuropilin-like Protein Regulates Platelet-derived Growth Factor Signaling in Human Vascular Smooth Muscle Cells by Modulating Receptor Ubiquitination*Guo X, Nie L, Esmailzadeh L, Zhang J, Bender JR, Sadeghi MM. Endothelial and Smooth Muscle-derived Neuropilin-like Protein Regulates Platelet-derived Growth Factor Signaling in Human Vascular Smooth Muscle Cells by Modulating Receptor Ubiquitination*. Journal Of Biological Chemistry 2009, 284: 29376-29382. PMID: 19696027, PMCID: PMC2785569, DOI: 10.1074/jbc.m109.049684.
- ESDN Is a Marker of Vascular Remodeling and Regulator of Cell Proliferation in Graft ArteriosclerosisSadeghi MM, Esmailzadeh L, Zhang J, Guo X, Asadi A, Krassilnikova S, Fassaei HR, Luo G, Al‐Lamki R, Takahashi T, Tellides G, Bender JR, Rodriguez ER. ESDN Is a Marker of Vascular Remodeling and Regulator of Cell Proliferation in Graft Arteriosclerosis. American Journal Of Transplantation 2007, 7: 2098-2105. PMID: 17697260, DOI: 10.1111/j.1600-6143.2007.01919.x.