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Gail D'Onofrio, MD, MS

Albert E. Kent Professor of Emergency Medicine, Professor of Epidemiology (Chronic Diseases) and Professor of Medicine Core Addiction

Research & Publications
Biography
News

Research Summary

Gail D’Onofrio, MD, MS is internationally known for her work in substance use disorders, women’s cardiovascular health, and mentoring physician scientists in developing independent research careers. For the past 25 years she has developed and tested interventions for alcohol, opioids and other substance use disorders, serving as PI on several large NIH, SAMSHA, and CDC studies that have changed clinical practice. She is currently an MPI on the New England Consortium Node as part of the NIDA’s Clinical Trials Network. She as serves as MPI on two large multisite grants including the recently funded ED-INNOVATION, testing the implementation of ED-initiated buprenorphine in 30 diverse ED across the US; and a randomized control trial comparing a long acting 7 day injection with the traditional sublingual formation of buprenorphine in engaging patients in treatment.

In addition has completed on currently is the PI on 3 large SAMHSA grants. This included a UO1 that trains residents in all primary care specialties including Emergency Medicine Primary Care, Internal Medicine, Med/Peds, Pediatrics, OB/GYN and Psychiatry on Screening, Brief Intervention and Referral for substance use and substance use disorders. She is currently the PI on a training grant that provides medical, PA and nursing students and other MD/APP providers with the education required to obtain a the DATA 2000 Waiver to prescribe buprenorphine to individuals with an opioid use disorder. Finally she is the PI on a large service grant that provides Project ASSERT, health promotion advocates to the Yale New Haven Health System EDs, Addiction Services and Primary Care that offers SBIRT and provides medications for individuals with substance use disorders.

Along with Dr. Melnick she is the MPI on a EMBED: Pragmatic trial of user-centered clinical decision support to implement Emergency department-initiated Buprenorphine for opioid use Disorder.

A national expert in Women and Heart Disease, Dr. D’Onofrio has been an integral part of the Yale New Haven Hospital Women’s Heart Program. She was the PI on a Department of Health and Human Services (DHHS) grant evaluating targeted interventions for women with cardiac risk factors in the ED Chest Pain Center. She was also a senior investigator on a large NHLBI grant studying young women with acute MI, enrolling at over 100 sites nationally. VIRGO (Variation in Recovery: Role of Gender on Outcomes of Young AM Patients. (PI: Krumholz). She published multiple papers documenting the disparities in reperfusion of patients with ST Elevation Myocardial Infarctions, and differences in symptom presentation and classification of disease among young women and men with acute myocardial infarction.

Dr. D’Onofrio is committed to training the next generation of physician scientists. She is the MPI of a NIDA-funded K12 establishing the Yale Drug use, Addiction and HIV Research Scholars (Yale-DAHRS) program, a three-year post-doctoral, interdisciplinary, Mentored Career Development Program with focused training in prevention and treatment of drug use, addiction, and HIV in general medical settings.

Finally, she is a founding Board member of Addiction Medicine, now recognized as a new specialty, subspecialty by the ABMS. She is an advocate for individuals with addictions and helped craft the CT's Governor's Strategic Plan to Reduce Opioid Deaths.

Coauthors

Research Interests

Substance Withdrawal Syndrome; Substance Abuse, Intravenous; Amphetamine-Related Disorders; Cocaine-Related Disorders; Alcohol-Related Disorders; Drug Overdose; Addiction Medicine; Substance Abuse, Oral; Narcotic-Related Disorders

Public Health Interests

Substance Use, Addiction

Research Image

SAEM Pulse Cover article: "Physician at the Forefront" an interview with Gail D'Onofrio

Dr. Gail D'Onofrio is featured in SAEM Pulse, the magazine of the Society for Academic Emergency Medicine, for her groundbreaking research on ED-Initiated Treatment for Opioid Use Disorder

Selected Publications

Early emergency department experience with 7‐day extended‐release injectable buprenorphine for opioid use disorderD'Onofrio G, Perrone J, Hawk K, Cowan E, McCormack R, Coupet E, Owens P, Martel S, Huntley K, Walsh S, Lofwall M, Herring A, Investigators T. Early emergency department experience with 7‐day extended‐release injectable buprenorphine for opioid use disorder. Academic Emergency Medicine 2023, 30: 1264-1271. PMID: 37501652, PMCID: PMC10822018, DOI: 10.1111/acem.14782.
Fentanyl-Associated Overdose Deaths Outside the HospitalJeffery M, Stevens M, D'Onofrio G, Melnick E. Fentanyl-Associated Overdose Deaths Outside the Hospital. New England Journal Of Medicine 2023, 389: 87-88. PMID: 37342960, PMCID: PMC10388669, DOI: 10.1056/nejmc2304991.
National Institute on Drug Abuse Clinical Trials Network Meeting Report: Advancing Emergency Department Initiation of Buprenorphine for Opioid Use DisorderCowan E, Perrone J, Bernstein S, Coupet E, Fiellin D, Hawk K, Herring A, Huntley K, McCormack R, Venkatesh A, D'Onofrio G. National Institute on Drug Abuse Clinical Trials Network Meeting Report: Advancing Emergency Department Initiation of Buprenorphine for Opioid Use Disorder. Annals Of Emergency Medicine 2023, 82: 326-335. PMID: 37178101, PMCID: PMC10524880, DOI: 10.1016/j.annemergmed.2023.03.025.
Perspectives on and experiences of emergency department–initiated buprenorphine among clinical pharmacists: A multi-site qualitative studyJusten M, Edelman E, Chawarski M, Coupet E, Cowan E, Lyons M, Owens P, Martel S, Richardson L, Rothman R, Whiteside L, O'Connor P, Zahn E, D'Onofrio G, Fiellin D, Hawk K. Perspectives on and experiences of emergency department–initiated buprenorphine among clinical pharmacists: A multi-site qualitative study. Journal Of Substance Use And Addiction Treatment 2023, 155: 209058. PMID: 37149149, DOI: 10.1016/j.josat.2023.209058.
Implementing Programs to Initiate Buprenorphine for Opioid Use Disorder Treatment in High-Need, Low-Resource Emergency Departments: A Nonrandomized Controlled TrialMcCormack R, Rotrosen J, Gauthier P, D'Onofrio G, Fiellin D, Marsch L, Novo P, Liu D, Edelman E, Farkas S, Matthews A, Mulatya C, Salazar D, Wolff J, Knight R, Goodman W, Williams J, Hawk K. Implementing Programs to Initiate Buprenorphine for Opioid Use Disorder Treatment in High-Need, Low-Resource Emergency Departments: A Nonrandomized Controlled Trial. Annals Of Emergency Medicine 2023, 82: 272-287. PMID: 37140493, PMCID: PMC10524047, DOI: 10.1016/j.annemergmed.2023.02.013.
Sex Difference in Outcomes of Acute Myocardial Infarction in Young PatientsSawano M, Lu Y, Caraballo C, Mahajan S, Dreyer R, Lichtman J, D'Onofrio G, Spatz E, Khera R, Onuma O, Murugiah K, Spertus J, Krumholz H. Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients. Journal Of The American College Of Cardiology 2023, 81: 1797-1806. PMID: 37137590, DOI: 10.1016/j.jacc.2023.03.383.
Perspectives of Clinicians and Staff at Community-Based Opioid Use Disorder Treatment Settings on Linkages With Emergency Department–Initiated Buprenorphine ProgramsSue K, Chawarski M, Curry L, McNeil R, Coupet E, Schwartz R, Wilder C, Tsui J, Hawk K, D’Onofrio G, O’Connor P, Fiellin D, Edelman E. Perspectives of Clinicians and Staff at Community-Based Opioid Use Disorder Treatment Settings on Linkages With Emergency Department–Initiated Buprenorphine Programs. JAMA Network Open 2023, 6: e2312718. PMID: 37163263, PMCID: PMC10173026, DOI: 10.1001/jamanetworkopen.2023.12718.
Use of an Automated Bilingual Digital Health Tool to Reduce Unhealthy Alcohol Use Among Latino Emergency Department PatientsVaca F, Dziura J, Abujarad F, Pantalon M, Hsiao A, Reynolds J, Maciejewski K, Field C, D’Onofrio G. Use of an Automated Bilingual Digital Health Tool to Reduce Unhealthy Alcohol Use Among Latino Emergency Department Patients. JAMA Network Open 2023, 6: e2314848. PMID: 37219901, PMCID: PMC10208138, DOI: 10.1001/jamanetworkopen.2023.14848.
Sex Differences in Symptom Complexity and Door-to-Balloon Time in Patients With ST-Elevation Myocardial InfarctionBrush J, Chaudhry S, Dreyer R, D'Onofrio G, Greene E, Hajduk A, Lu Y, Krumholz H. Sex Differences in Symptom Complexity and Door-to-Balloon Time in Patients With ST-Elevation Myocardial Infarction. The American Journal Of Cardiology 2023, 197: 101-107. PMID: 37062667, PMCID: PMC10198892, DOI: 10.1016/j.amjcard.2023.03.009.
Implementation Facilitation to Promote Emergency Department–Initiated Buprenorphine for Opioid Use DisorderD’Onofrio G, Edelman E, Hawk K, Chawarski M, Pantalon M, Owens P, Martel S, Rothman R, Saheed M, Schwartz R, Cowan E, Richardson L, Salsitz E, Lyons M, Freiermuth C, Wilder C, Whiteside L, Tsui J, Klein J, Coupet E, O’Connor P, Matthews A, Murphy S, Huntley K, Fiellin D. Implementation Facilitation to Promote Emergency Department–Initiated Buprenorphine for Opioid Use Disorder. JAMA Network Open 2023, 6: e235439. PMID: 37017967, PMCID: PMC10077107, DOI: 10.1001/jamanetworkopen.2023.5439.
Modeling human health behavior with a new index that measures connectivityBernstein S, Li F, Abujarad F, Grant D, D'Onofrio G, Dziura J. Modeling human health behavior with a new index that measures connectivity. Preventive Medicine Reports 2023, 33: 102172. PMID: 37223571, PMCID: PMC10201843, DOI: 10.1016/j.pmedr.2023.102172.
Incidence of Precipitated Withdrawal During a Multisite Emergency Department–Initiated Buprenorphine Clinical Trial in the Era of FentanylD’Onofrio G, Hawk K, Perrone J, Walsh S, Lofwall M, Fiellin D, Herring A. Incidence of Precipitated Withdrawal During a Multisite Emergency Department–Initiated Buprenorphine Clinical Trial in the Era of Fentanyl. JAMA Network Open 2023, 6: e236108. PMID: 36995717, PMCID: PMC10064247, DOI: 10.1001/jamanetworkopen.2023.6108.
SEX DIFFERENCE IN CAUSES AND TIMING OF ONE-YEAR OUTCOMES AMONG YOUNG ACUTE MYOCARDIAL INFARCTION PATIENTS; RESULTS FROM THE VIRGO STUDYSawano M, Lu Y, Caraballo C, Mahajan S, Dreyer R, Lichtman J, D'Onofrio G, Spatz E, Khera R, Onuma O, Murugiah K, Spertus J, Krumholz H. SEX DIFFERENCE IN CAUSES AND TIMING OF ONE-YEAR OUTCOMES AMONG YOUNG ACUTE MYOCARDIAL INFARCTION PATIENTS; RESULTS FROM THE VIRGO STUDY. Journal Of The American College Of Cardiology 2023, 81: 1294. DOI: 10.1016/s0735-1097(23)01738-2.
Racial and ethnic disparities in emergency department–initiated buprenorphine across five health care systemsHolland W, Li F, Nath B, Jeffery M, Stevens M, Melnick E, Dziura J, Khidir H, Skains R, D'Onofrio G, Soares W. Racial and ethnic disparities in emergency department–initiated buprenorphine across five health care systems. Academic Emergency Medicine 2023, 30: 709-720. PMID: 36660800, PMCID: PMC10467357, DOI: 10.1111/acem.14668.
Time to Treat Alcohol Use Disorder in the Emergency DepartmentHawk K, D'Onofrio G. Time to Treat Alcohol Use Disorder in the Emergency Department. Annals Of Emergency Medicine 2023, 81: 450-452. PMID: 36775724, DOI: 10.1016/j.annemergmed.2022.11.013.
Real-World Observational Evaluation of Common Interventions to Reduce Emergency Department Prescribing of Opioid MedicationsSangal R, Rothenberg C, Hawk K, D'Onofrio G, Hsiao A, Solad Y, Venkatesh A. Real-World Observational Evaluation of Common Interventions to Reduce Emergency Department Prescribing of Opioid Medications. The Joint Commission Journal On Quality And Patient Safety 2023, 49: 239-246. PMID: 36914528, DOI: 10.1016/j.jcjq.2023.01.013.
Association of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial InfarctionOkafor C, Zhu C, Raparelli V, Murphy T, Arakaki A, D’Onofrio G, Tsang S, Smith M, Lichtman J, Spertus J, Pilote L, Dreyer R. Association of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial Infarction. JAMA Network Open 2023, 6: e2255843. PMID: 36787140, PMCID: PMC9929697, DOI: 10.1001/jamanetworkopen.2022.55843.
Concordance between controlled substance receipt and post-mortem toxicology in opioid-detected overdose deaths: A statewide analysisHowell B, Black A, Grau L, Lin H, Greene C, Lee H, Heimer R, Hawk K, D'Onofrio G, Fiellin D, Becker W. Concordance between controlled substance receipt and post-mortem toxicology in opioid-detected overdose deaths: A statewide analysis. Drug And Alcohol Dependence 2023, 244: 109788. PMID: 36738634, PMCID: PMC9975083, DOI: 10.1016/j.drugalcdep.2023.109788.
A DIGITAL ELDER ABUSE INTERVENTION FOR THE EMERGENCY DEPARTMENTAbujarad F, Choo E, Dziura J, Edwards C, Pantalon M, Jubanyik K, D'Onofrio G, Gill T. A DIGITAL ELDER ABUSE INTERVENTION FOR THE EMERGENCY DEPARTMENT. Innovation In Aging 2022, 6: 425-425. PMCID: PMC9766766, DOI: 10.1093/geroni/igac059.1669.
Young Women With Acute Myocardial Infarction: Risk Prediction Model for 1-Year Hospital ReadmissionDreyer R, Arakaki A, Raparelli V, Murphy T, Tsang S, D’Onofrio G, Wood M, Wright C, Pilote L. Young Women With Acute Myocardial Infarction: Risk Prediction Model for 1-Year Hospital Readmission. CJC Open 2022, 5: 335-344. PMID: 37377522, PMCID: PMC10290947, DOI: 10.1016/j.cjco.2022.12.004.
Development and testing of data infrastructure in the American College of Emergency Physicians’ Clinical Emergency Data Registry for opioid‐related researchTaylor A, Kinsman J, Hawk K, D'Onofrio G, Malicki C, Malcom B, Goyal P, Venkatesh A. Development and testing of data infrastructure in the American College of Emergency Physicians’ Clinical Emergency Data Registry for opioid‐related research. Journal Of The American College Of Emergency Physicians Open 2022, 3: e12816. PMID: 36311336, PMCID: PMC9597093, DOI: 10.1002/emp2.12816.
168 Impact of Connecticut’s Good Samaritan Laws in Preventing Opioid Overdose Deaths – An Applied System Dynamics ApproachAli S, Sabounchi N, Thompson R, Heimer R, D’Onofrio G, Heckmann R. 168 Impact of Connecticut’s Good Samaritan Laws in Preventing Opioid Overdose Deaths – An Applied System Dynamics Approach. Annals Of Emergency Medicine 2022, 80: s76-s77. DOI: 10.1016/j.annemergmed.2022.08.192.
Missed Opportunities for HIV and Hepatitis C Screening Among Emergency Department Patients With Untreated Opioid Use DisorderLyons MS, Chawarski MC, Rothman R, Whiteside L, Cowan E, Richardson LD, Hawk K, Tsui JI, Schwartz RP, O’Connor P, D’Onofrio G, Fiellin DA, Edelman EJ. Missed Opportunities for HIV and Hepatitis C Screening Among Emergency Department Patients With Untreated Opioid Use Disorder. Journal Of Addiction Medicine 2022, 17: 210-214. PMID: 36170184, PMCID: PMC10023471, DOI: 10.1097/adm.0000000000001074.
Sex Differences in Clopidogrel Effects Among Young Patients With Acute Coronary Syndrome: A Role for Genetics?Kaur A, Dreyer R, Marsh T, Thanassoulis G, Raparelli V, D’Onofrio G, Engert J, Pilote L. Sex Differences in Clopidogrel Effects Among Young Patients With Acute Coronary Syndrome: A Role for Genetics? CJC Open 2022, 4: 970-978. PMID: 36444366, PMCID: PMC9700217, DOI: 10.1016/j.cjco.2022.07.013.
User centered clinical decision support to implement initiation of buprenorphine for opioid use disorder in the emergency department: EMBED pragmatic cluster randomized controlled trialMelnick ER, Nath B, Dziura JD, Casey MF, Jeffery MM, Paek H, Soares WE, Hoppe JA, Rajeevan H, Li F, Skains RM, Walter LA, Patel MD, Chari SV, Platts-Mills TF, Hess EP, D'Onofrio G. User centered clinical decision support to implement initiation of buprenorphine for opioid use disorder in the emergency department: EMBED pragmatic cluster randomized controlled trial. The BMJ 2022, 377: e069271. PMID: 35760423, PMCID: PMC9231533, DOI: 10.1136/bmj-2021-069271.
Models for Implementing Emergency Department–Initiated Buprenorphine With Referral for Ongoing Medication Treatment at Emergency Department Discharge in Diverse Academic CentersWhiteside LK, D'Onofrio G, Fiellin DA, Edelman EJ, Richardson L, O'Connor P, Rothman RE, Cowan E, Lyons MS, Fockele CE, Saheed M, Freiermuth C, Punches BE, Guo C, Martel S, Owens PH, Coupet E, Hawk KF. Models for Implementing Emergency Department–Initiated Buprenorphine With Referral for Ongoing Medication Treatment at Emergency Department Discharge in Diverse Academic Centers. Annals Of Emergency Medicine 2022, 80: 410-419. PMID: 35752520, PMCID: PMC9588652, DOI: 10.1016/j.annemergmed.2022.05.010.
Trends and Disparities in Access to Buprenorphine Treatment Following an Opioid-Related Emergency Department Visit Among an Insured Cohort, 2014-2020Stevens MA, Tsai J, Savitz ST, Nath B, Melnick ER, D’Onofrio G, Jeffery MM. Trends and Disparities in Access to Buprenorphine Treatment Following an Opioid-Related Emergency Department Visit Among an Insured Cohort, 2014-2020. JAMA Network Open 2022, 5: e2215287. PMID: 35657629, PMCID: PMC9166266, DOI: 10.1001/jamanetworkopen.2022.15287.
Clinical Profile and Sex-Specific Recovery With Cardiac Rehabilitation After Coronary Artery Bypass Grafting SurgerySafdar B, Mori M, Nowroozpoor A, Geirsson A, D'Onofrio G, Mangi AA. Clinical Profile and Sex-Specific Recovery With Cardiac Rehabilitation After Coronary Artery Bypass Grafting Surgery. Clinical Therapeutics 2022, 44: 846-858. PMID: 35570056, DOI: 10.1016/j.clinthera.2022.04.002.
Sex-Specific Risk Factors Associated With First Acute Myocardial Infarction in Young AdultsLu Y, Li SX, Liu Y, Rodriguez F, Watson KE, Dreyer RP, Khera R, Murugiah K, D’Onofrio G, Spatz ES, Nasir K, Masoudi FA, Krumholz HM. Sex-Specific Risk Factors Associated With First Acute Myocardial Infarction in Young Adults. JAMA Network Open 2022, 5: e229953. PMID: 35503221, PMCID: PMC9066284, DOI: 10.1001/jamanetworkopen.2022.9953.
Use of a Brief Negotiation Interview in the emergency department to reduce high‐risk alcohol use among older adults: A randomized trialShenvi CL, Wang Y, Revankar R, Phillips J, Bush M, Biese KJ, Aylward A, D'Onofrio G, Platts‐Mills T. Use of a Brief Negotiation Interview in the emergency department to reduce high‐risk alcohol use among older adults: A randomized trial. Journal Of The American College Of Emergency Physicians Open 2022, 3: e12651. PMID: 35156089, PMCID: PMC8828696, DOI: 10.1002/emp2.12651.
Association of State Social and Environmental Factors With Rates of Self-injury Mortality and Suicide in the United StatesRockett IRH, Jia H, Ali B, Banerjee A, Connery HS, Nolte KB, Miller T, White FMM, DiGregorio BD, Larkin GL, Stack S, Kõlves K, McHugh RK, Lulla VO, Cossman J, De Leo D, Hendricks B, Nestadt PS, Berry JH, D’Onofrio G, Caine ED. Association of State Social and Environmental Factors With Rates of Self-injury Mortality and Suicide in the United States. JAMA Network Open 2022, 5: e2146591. PMID: 35138401, PMCID: PMC8829661, DOI: 10.1001/jamanetworkopen.2021.46591.
In reply:D'Onofrio G, Melnick ER, Hawk KF. In reply:. Annals Of Emergency Medicine 2022, 79: 219-220. PMID: 35065746, DOI: 10.1016/j.annemergmed.2021.10.022.
Emergency department utilization for substance use disorders and mental health conditions during COVID-19Venkatesh AK, Janke AT, Kinsman J, Rothenberg C, Goyal P, Malicki C, D’Onofrio G, Taylor A, Hawk K. Emergency department utilization for substance use disorders and mental health conditions during COVID-19. PLOS ONE 2022, 17: e0262136. PMID: 35025921, PMCID: PMC8757912, DOI: 10.1371/journal.pone.0262136.
Assessing the impact of the Good Samaritan Law in the state of Connecticut: a system dynamics approachSabounchi NS, Heckmann R, D’Onofrio G, Walker J, Heimer R. Assessing the impact of the Good Samaritan Law in the state of Connecticut: a system dynamics approach. Health Research Policy And Systems 2022, 20: 5. PMID: 34991591, PMCID: PMC8734429, DOI: 10.1186/s12961-021-00807-w.
Perspectives About Emergency Department Care Encounters Among Adults With Opioid Use DisorderHawk K, McCormack R, Edelman EJ, Coupet E, Toledo N, Gauthier P, Rotrosen J, Chawarski M, Martel S, Owens P, Pantalon MV, O’Connor P, Whiteside LK, Cowan E, Richardson LD, Lyons MS, Rothman R, Marsch L, Fiellin DA, D’Onofrio G. Perspectives About Emergency Department Care Encounters Among Adults With Opioid Use Disorder. JAMA Network Open 2022, 5: e2144955. PMID: 35076700, PMCID: PMC8790663, DOI: 10.1001/jamanetworkopen.2021.44955.
Identifying Opioid-Related Electronic Health Record Phenotypes for Emergency Care Research and Surveillance: An Expert Consensus Driven Concept Mapping ProcessTaylor RA, Fiellin D, D'Onofrio G, Venkatesh A. Identifying Opioid-Related Electronic Health Record Phenotypes for Emergency Care Research and Surveillance: An Expert Consensus Driven Concept Mapping Process. Substance Abuse 2022, 43: 841-847. PMID: 35156912, DOI: 10.1080/08897077.2021.1975864.
Patient-Centered Digital Screener for Elder Abuse in the Emergency DepartmentAbujarad F, Choo E, Dziura J, Edwards C, Pantalon M, Jubanyik K, D'Onofrio G, Gill T. Patient-Centered Digital Screener for Elder Abuse in the Emergency Department. Innovation In Aging 2021, 5: 152-152. PMCID: PMC8682507, DOI: 10.1093/geroni/igab046.580.
Corrigendum to: Mild cognitive impairment in middle-aged adults with coronary microvascular dysfunctionNowroozpoor A, Sharp E, Gordon R, Malicki C, Hwang U, Dziura J, D'Onofrio' G, Safdar B. Corrigendum to: Mild cognitive impairment in middle-aged adults with coronary microvascular dysfunction. European Heart Journal 2021, 43: ehab845-. PMID: 34897369, DOI: 10.1093/eurheartj/ehab845.
Emergency department‐initiated buprenorphine protocols: A national evaluationGuo CZ, D'Onofrio G, Fiellin DA, Edelman EJ, Hawk K, Herring A, McCormack R, Perrone J, Cowan E. Emergency department‐initiated buprenorphine protocols: A national evaluation. Journal Of The American College Of Emergency Physicians Open 2021, 2: e12606. PMID: 34877567, PMCID: PMC8630357, DOI: 10.1002/emp2.12606.
Feasibility and acceptability of electronic administration of patient reported outcomes using mHealth platform in emergency department patients with non-medical opioid useHawk K, Malicki C, Kinsman J, D’Onofrio G, Taylor A, Venkatesh A. Feasibility and acceptability of electronic administration of patient reported outcomes using mHealth platform in emergency department patients with non-medical opioid use. Addiction Science & Clinical Practice 2021, 16: 66. PMID: 34758881, PMCID: PMC8579535, DOI: 10.1186/s13722-021-00276-0.
221 Changes in Emergency Department Visits for Opioid-Related Diagnosis, Opioid Overdose and Buprenorphine Use Across 14 US Emergency Departments During the SARS-CoV-2 PandemicGroup E, Hawk K, Taylor A, Phadke M, Li F, Dziura J, Perrone J, McCormack R, Herring A, Cowan E, Fiellin D, D'Onofrio G. 221 Changes in Emergency Department Visits for Opioid-Related Diagnosis, Opioid Overdose and Buprenorphine Use Across 14 US Emergency Departments During the SARS-CoV-2 Pandemic. Annals Of Emergency Medicine 2021, 78: s89-s90. PMCID: PMC8536288, DOI: 10.1016/j.annemergmed.2021.09.233.
Mild cognitive impairment in middle-aged adults with coronary microvascular dysfunctionNowroozpoor A, Sharp E, Gordon R, Malicki C, Hwang U, Dziura J, D'Onofrio' G, Safdar B. Mild cognitive impairment in middle-aged adults with coronary microvascular dysfunction. European Heart Journal 2021, 42: ehab724.2744. DOI: 10.1093/eurheartj/ehab724.2744.
Variations in Quality of Care by Sex and Social Determinants of Health Among Younger Adults With Acute Myocardial Infarction in the US and CanadaRaparelli V, Pilote L, Dang B, Behlouli H, Dziura JD, Bueno H, D’Onofrio G, Krumholz HM, Dreyer RP. Variations in Quality of Care by Sex and Social Determinants of Health Among Younger Adults With Acute Myocardial Infarction in the US and Canada. JAMA Network Open 2021, 4: e2128182. PMID: 34668947, PMCID: PMC8529414, DOI: 10.1001/jamanetworkopen.2021.28182.
199 Extended-Release Injectable Buprenorphine for Emergency Department Patients with Opioid Use Disorder in Minimal WithdrawalD'Onofrio G, Herring A, Perrone J, Hawk K, Samuels E, Cowan E, McCormack R, DeVogel N, Dziura J, Fiellin D. 199 Extended-Release Injectable Buprenorphine for Emergency Department Patients with Opioid Use Disorder in Minimal Withdrawal. Annals Of Emergency Medicine 2021, 78: s80. DOI: 10.1016/j.annemergmed.2021.09.210.
237 Urine Toxicology Profiles of Adult Emergency Department Patients With Untreated Opioid Use Disorder: National Data from 26 Emergency DepartmentsCowan E, Perrone J, Fiellin D, Edelman E, Hawk K, Herring A, McCormack R, D'Onofrio G. 237 Urine Toxicology Profiles of Adult Emergency Department Patients With Untreated Opioid Use Disorder: National Data from 26 Emergency Departments. Annals Of Emergency Medicine 2021, 78: s96. DOI: 10.1016/j.annemergmed.2021.09.249.
Improving Emergency Department Throughput Using Audit-and-Feedback With Peer Comparison Among Emergency Department PhysiciansScofi J, Parwani V, Rothenberg C, Patel A, Ravi S, Sevilla M, D'Onofrio G, Ulrich A, Venkatesh AK. Improving Emergency Department Throughput Using Audit-and-Feedback With Peer Comparison Among Emergency Department Physicians. Journal For Healthcare Quality 2021, 44: 69-77. PMID: 34570029, DOI: 10.1097/jhq.0000000000000329.
Emergency medicine research: 2030 strategic goalsNeumar RW, Blomkalns AL, Cairns CB, D’Onofrio G, Kuppermann N, Lewis RJ, Newgard CD, O’Neil B, Rathlev NK, Rothman RE, Wright DW. Emergency medicine research: 2030 strategic goals. Academic Emergency Medicine 2021, 29: 241-251. PMID: 34363718, DOI: 10.1111/acem.14367.
Emergency Department Treatment of Opioid Use DisorderSamuels E, Coupet E, D’Onofrio G. Emergency Department Treatment of Opioid Use Disorder. 2021, 57-75. DOI: 10.1007/978-3-030-80818-1_5.
Development and Validation of a Risk Prediction Model for 1‐Year Readmission Among Young Adults Hospitalized for Acute Myocardial InfarctionDreyer RP, Raparelli V, Tsang SW, D’Onofrio G, Lorenze N, Xie CF, Geda M, Pilote L, Murphy TE. Development and Validation of a Risk Prediction Model for 1‐Year Readmission Among Young Adults Hospitalized for Acute Myocardial Infarction. Journal Of The American Heart Association 2021, 10: e021047. PMID: 34514837, PMCID: PMC8649501, DOI: 10.1161/jaha.121.021047.
Impact of Race on the In‐Hospital Quality of Care Among Young Adults With Acute Myocardial InfarctionRaparelli V, Benea D, Smith M, Behlouli H, Murphy TE, D’Onofrio G, Pilote L, Dreyer RP. Impact of Race on the In‐Hospital Quality of Care Among Young Adults With Acute Myocardial Infarction. Journal Of The American Heart Association 2021, 10: e021408. PMID: 34431311, PMCID: PMC8649291, DOI: 10.1161/jaha.121.021408.
Implementation of Oral and Extended-Release Naltrexone for the Treatment of Emergency Department Patients With Moderate to Severe Alcohol Use Disorder: Feasibility and Initial OutcomesAnderson ES, Chamberlin M, Zuluaga M, Ullal M, Hawk K, McCormack R, D'Onofrio G, Herring AA. Implementation of Oral and Extended-Release Naltrexone for the Treatment of Emergency Department Patients With Moderate to Severe Alcohol Use Disorder: Feasibility and Initial Outcomes. Annals Of Emergency Medicine 2021, 78: 752-758. PMID: 34353648, DOI: 10.1016/j.annemergmed.2021.05.013.
Use of peripheral arterial tonometry in detection of abnormal coronary flow reserveGaeta M, Nowroozpoor A, Dziura J, D'Onofrio G, Sinusas AJ, Safdar B. Use of peripheral arterial tonometry in detection of abnormal coronary flow reserve. Microvascular Research 2021, 138: 104223. PMID: 34256085, PMCID: PMC10227886, DOI: 10.1016/j.mvr.2021.104223.
High-Dose Buprenorphine Induction in the Emergency Department for Treatment of Opioid Use DisorderHerring AA, Vosooghi AA, Luftig J, Anderson ES, Zhao X, Dziura J, Hawk KF, McCormack RP, Saxon A, D’Onofrio G. High-Dose Buprenorphine Induction in the Emergency Department for Treatment of Opioid Use Disorder. JAMA Network Open 2021, 4: e2117128. PMID: 34264326, PMCID: PMC8283555, DOI: 10.1001/jamanetworkopen.2021.17128.
Accounting for quality improvement during the conduct of embedded pragmatic clinical trials within healthcare systems: NIH Collaboratory case studiesTuzzio L, Meyers CM, Dember LM, Grudzen CR, Melnick ER, Staman KL, Huang SS, Richards J, DeBar L, Vazquez MA, Green BB, Coronado GD, Jarvik JG, Braciszewski J, Ho PM, Wells BL, James K, Toto R, D’Onofrio G, Volandes A, Kuklinski MR, Catalano RF, Sterling SA, Morse EF, Curtis L, Larson EB. Accounting for quality improvement during the conduct of embedded pragmatic clinical trials within healthcare systems: NIH Collaboratory case studies. Healthcare 2021, 8: 100432. PMID: 34175091, PMCID: PMC8900087, DOI: 10.1016/j.hjdsi.2020.100432.
Consensus Recommendations on the Treatment of Opioid Use Disorder in the Emergency DepartmentHawk K, Hoppe J, Ketcham E, LaPietra A, Moulin A, Nelson L, Schwarz E, Shahid S, Stader D, Wilson MP, D'Onofrio G. Consensus Recommendations on the Treatment of Opioid Use Disorder in the Emergency Department. Annals Of Emergency Medicine 2021, 78: 434-442. PMID: 34172303, DOI: 10.1016/j.annemergmed.2021.04.023.
Analysis of Health Trajectories Leading to Adverse Opioid-Related Events.Gilson AS, Chartash D, Chang D, Hawk K, D'Onofrio G, Haimovich AD, Fiellin DA, Taylor RA. Analysis of Health Trajectories Leading to Adverse Opioid-Related Events. AMIA Joint Summits On Translational Science Proceedings 2021, 2021: 248-256. PMID: 34457139, PMCID: PMC8378649.
Improve Access to Care for Opioid Use Disorder: A Call to Eliminate the X-Waiver Requirement NowD'Onofrio G, Melnick ER, Hawk KF. Improve Access to Care for Opioid Use Disorder: A Call to Eliminate the X-Waiver Requirement Now. Annals Of Emergency Medicine 2021, 78: 220-222. PMID: 33966933, PMCID: PMC8324519, DOI: 10.1016/j.annemergmed.2021.03.023.
ROLE OF GENETICS IN SEX-SPECIFIC EFFECTS OF CLOPIDOGREL ON ATHEROTHROMBOTIC EVENTSKaur A, Dreyer R, Marsh T, Thanassoulis G, Raparelli V, D'Onofrio G, Engert J, Pilote L. ROLE OF GENETICS IN SEX-SPECIFIC EFFECTS OF CLOPIDOGREL ON ATHEROTHROMBOTIC EVENTS. Journal Of The American College Of Cardiology 2021, 77: 181. DOI: 10.1016/s0735-1097(21)01540-0.
A Brief Negotiation Interview Adherence Scale for Smoking Cessation: A psychometric evaluationPantalon MV, Dziura J, Li FY, D'Onofrio G, Weiss J, Bernstein SL. A Brief Negotiation Interview Adherence Scale for Smoking Cessation: A psychometric evaluation. Journal Of Substance Use And Addiction Treatment 2021, 126: 108398. PMID: 34116807, DOI: 10.1016/j.jsat.2021.108398.
Corrigendum to “Who provides what care? An analysis of clinical focus among the national emergency care workforce” [Am J Emerg Med. 2021 Apr;42:228–232]Gettel CJ, Canavan ME, D'Onofrio G, Carr BG, Venkatesh AK. Corrigendum to “Who provides what care? An analysis of clinical focus among the national emergency care workforce” [Am J Emerg Med. 2021 Apr;42:228–232]. The American Journal Of Emergency Medicine 2021, 46: 804. PMID: 33875317, PMCID: PMC8338896, DOI: 10.1016/j.ajem.2021.04.015.
Emergency Department Visits for Nonfatal Opioid Overdose During the COVID-19 Pandemic Across Six US Health Care SystemsSoares WE, Melnick ER, Nath B, D'Onofrio G, Paek H, Skains RM, Walter LA, Casey MF, Napoli A, Hoppe JA, Jeffery MM. Emergency Department Visits for Nonfatal Opioid Overdose During the COVID-19 Pandemic Across Six US Health Care Systems. Annals Of Emergency Medicine 2021, 79: 158-167. PMID: 34119326, PMCID: PMC8449788, DOI: 10.1016/j.annemergmed.2021.03.013.
The design and conduct of a randomized clinical trial comparing emergency department initiation of sublingual versus a 7-day extended-release injection formulation of buprenorphine for opioid use disorder: Project ED InnovationD'Onofrio G, Hawk KF, Herring AA, Perrone J, Cowan E, McCormack RP, Dziura J, Taylor RA, Coupet E, Edelman EJ, Pantalon MV, Owens PH, Martel SH, O'Connor PG, Van Veldhuisen P, DeVogel N, Huntley K, Murphy SM, Lofwall MR, Walsh SL, Fiellin DA. The design and conduct of a randomized clinical trial comparing emergency department initiation of sublingual versus a 7-day extended-release injection formulation of buprenorphine for opioid use disorder: Project ED Innovation. Contemporary Clinical Trials 2021, 104: 106359. PMID: 33737199, PMCID: PMC9153252, DOI: 10.1016/j.cct.2021.106359.
Implementation facilitation to introduce and support emergency department-initiated buprenorphine for opioid use disorder in high need, low resource settings: protocol for multi-site implementation-feasibility studyMcCormack RP, Rotrosen J, Gauthier P, D’Onofrio G, Fiellin DA, Marsch LA, Novo P, Liu D, Edelman EJ, Farkas S, Matthews AG, Mulatya C, Salazar D, Wolff J, Knight R, Goodman W, Hawk K. Implementation facilitation to introduce and support emergency department-initiated buprenorphine for opioid use disorder in high need, low resource settings: protocol for multi-site implementation-feasibility study. Addiction Science & Clinical Practice 2021, 16: 16. PMID: 33750454, PMCID: PMC7941881, DOI: 10.1186/s13722-021-00224-y.
“I wanted to participate in my own care”: Evaluation of a Patient Navigation ProgramSamuels EA, Kelley L, Pham T, Cross J, Carmona J, Ellis P, Cobbs-Lomax D, D’Onofrio G, Capp R. “I wanted to participate in my own care”: Evaluation of a Patient Navigation Program. Western Journal Of Emergency Medicine 2021, 22: 417-426. PMID: 33856334, PMCID: PMC7972383, DOI: 10.5811/westjem.2020.9.48105.
A qualitative study of emergency department patients who survived an opioid overdose: Perspectives on treatment and unmet needsHawk K, Grau LE, Fiellin DA, Chawarski M, O’Connor P, Cirillo N, Breen C, D’Onofrio G. A qualitative study of emergency department patients who survived an opioid overdose: Perspectives on treatment and unmet needs. Academic Emergency Medicine 2021, 28: 542-552. PMID: 33346926, PMCID: PMC8281441, DOI: 10.1111/acem.14197.
Fatal self-injury in the United States, 1999–2018: Unmasking a national mental health crisisRockett IRH, Caine ED, Banerjee A, Ali B, Miller T, Connery HS, Lulla VO, Nolte KB, Larkin GL, Stack S, Hendricks B, McHugh RK, White FMM, Greenfield SF, Bohnert ASB, Cossman JS, D'Onofrio G, Nelson LS, Nestadt PS, Berry JH, Jia H. Fatal self-injury in the United States, 1999–2018: Unmasking a national mental health crisis. EClinicalMedicine 2021, 32: 100741. PMID: 33681743, PMCID: PMC7910714, DOI: 10.1016/j.eclinm.2021.100741.
Merging statewide data in a public/university collaboration to address opioid use disorder and overdoseBecker WC, Heimer R, Dormitzer CM, Doernberg M, D’Onofrio G, Grau LE, Hawk K, Lin HJ, Secora AM, Fiellin DA. Merging statewide data in a public/university collaboration to address opioid use disorder and overdose. Addiction Science & Clinical Practice 2021, 16: 1. PMID: 33397480, PMCID: PMC7780404, DOI: 10.1186/s13722-020-00211-9.
Digital Health Tool to Assist Older Adults in Self-Disclosing Elder MistreatmentAbujarad F, Choo E, Pantalon M, Jubanyik K, Dziura J, Edwards C, D’Onofrio G, Gill T. Digital Health Tool to Assist Older Adults in Self-Disclosing Elder Mistreatment. Innovation In Aging 2020, 4: 755-756. PMCID: PMC7743726, DOI: 10.1093/geroni/igaa057.2724.
Perceived Value of Using a Digital Tool to Screen for Elder Mistreatment in the Emergency DepartmentAbujarad F, Gill T, Pantalon M, Jubanyik K, Dziura J, D’Onofrio G, Choo E. Perceived Value of Using a Digital Tool to Screen for Elder Mistreatment in the Emergency Department. Innovation In Aging 2020, 4: 195-195. PMCID: PMC7740753, DOI: 10.1093/geroni/igaa057.631.
Emergency department patients with untreated opioid use disorder: A comparison of those seeking versus not seeking referral to substance use treatmentCoupet E, D’Onofrio G, Chawarski M, Edelman E, O’Connor P, Owens P, Martel S, Fiellin DA, Cowan E, Richardson L, Huntley K, Whiteside LK, Lyons MS, Rothman RE, Pantalon M, Hawk K. Emergency department patients with untreated opioid use disorder: A comparison of those seeking versus not seeking referral to substance use treatment. Drug And Alcohol Dependence 2020, 219: 108428. PMID: 33307301, PMCID: PMC8110210, DOI: 10.1016/j.drugalcdep.2020.108428.
The impact of sex, gender and healthcare system on quality of care among young adults with acute myocardial infarctionRaparelli V, Pilote L, Behlouli H, Dziura J, Bueno H, D'Onofrio G, Krumholz H, Dreyer R. The impact of sex, gender and healthcare system on quality of care among young adults with acute myocardial infarction. European Heart Journal 2020, 41 DOI: 10.1093/ehjci/ehaa946.3175.
Naloxone Use by Emergency Medical Services During the COVID-19 Pandemic: A National SurveyCone DC, Bogucki S, Burns K, D’Onofrio G, Hawk K, Joseph D, Fiellin DA. Naloxone Use by Emergency Medical Services During the COVID-19 Pandemic: A National Survey. Journal Of Addiction Medicine 2020, 14: e369-e371. PMID: 33031212, PMCID: PMC7647432, DOI: 10.1097/adm.0000000000000746.
Digital health screening tool for identification of elder mistreatment.Abujarad F, Edwards C, Choo E, Pantalon M, Jubanyik K, Dziura J, D'Onofrio G, Gill T. Digital health screening tool for identification of elder mistreatment. Gerontechnology 2020, 19: 1-1. PMID: 33574738, PMCID: PMC7875481, DOI: 10.4017/gt.2020.19.s.70138.
Trends in Emergency Department Visits and Hospital Admissions in Health Care Systems in 5 States in the First Months of the COVID-19 Pandemic in the USJeffery MM, D’Onofrio G, Paek H, Platts-Mills TF, Soares WE, Hoppe JA, Genes N, Nath B, Melnick ER. Trends in Emergency Department Visits and Hospital Admissions in Health Care Systems in 5 States in the First Months of the COVID-19 Pandemic in the US. JAMA Internal Medicine 2020, 180: 1328-1333. PMID: 32744612, PMCID: PMC7400214, DOI: 10.1001/jamainternmed.2020.3288.
Trends in the Use of Buprenorphine in US Emergency Departments, 2002-2017Rhee TG, D’Onofrio G, Fiellin DA. Trends in the Use of Buprenorphine in US Emergency Departments, 2002-2017. JAMA Network Open 2020, 3: e2021209. PMID: 33079195, PMCID: PMC7576404, DOI: 10.1001/jamanetworkopen.2020.21209.
404 Emergency Department Tablet-Based Screening Tool for Elder AbuseJubanyik K, Choo E, Pantalon M, Dziura J, Edwards C, Gill T, D'Onofrio G, Abujarad F. 404 Emergency Department Tablet-Based Screening Tool for Elder Abuse. Annals Of Emergency Medicine 2020, 76: s154. DOI: 10.1016/j.annemergmed.2020.09.420.
Where Skilled Nursing Facility Residents Get Acute Care: Is the Emergency Department the Medical Home?Venkatesh AK, Gettel CJ, Mei H, Chou SC, Rothenberg C, Liu SL, D’Onofrio G, Lin Z, Krumholz HM. Where Skilled Nursing Facility Residents Get Acute Care: Is the Emergency Department the Medical Home? Journal Of Applied Gerontology 2020, 40: 828-836. PMID: 32842827, PMCID: PMC7904961, DOI: 10.1177/0733464820950125.
Assessing the readiness of digital data infrastructure for opioid use disorder researchVenkatesh A, Malicki C, Hawk K, D’Onofrio G, Kinsman J, Taylor A. Assessing the readiness of digital data infrastructure for opioid use disorder research. Addiction Science & Clinical Practice 2020, 15: 24. PMID: 32650817, PMCID: PMC7350566, DOI: 10.1186/s13722-020-00198-3.
Cross‐sectional Analysis of Emergency Department and Acute Care Utilization Among Medicare BeneficiariesVenkatesh AK, Mei H, Shuling L, D’Onofrio G, Rothenberg C, Lin Z, Krumholz HM. Cross‐sectional Analysis of Emergency Department and Acute Care Utilization Among Medicare Beneficiaries. Academic Emergency Medicine 2020, 27: 570-579. PMID: 32302034, DOI: 10.1111/acem.13971.
Barriers and Facilitators to Clinician Readiness to Provide Emergency Department–Initiated BuprenorphineHawk KF, D’Onofrio G, Chawarski MC, O’Connor P, Cowan E, Lyons MS, Richardson L, Rothman RE, Whiteside LK, Owens PH, Martel SH, Coupet E, Pantalon M, Curry L, Fiellin DA, Edelman EJ. Barriers and Facilitators to Clinician Readiness to Provide Emergency Department–Initiated Buprenorphine. JAMA Network Open 2020, 3: e204561. PMID: 32391893, PMCID: PMC7215257, DOI: 10.1001/jamanetworkopen.2020.4561.
Abstract 334: Impact of Sex, Gender and Healthcare System on the Quality of Care in Young Adults With Acute Myocardial InfarctionRaparelli V, Pilote L, Behlouli H, James D, Bueno H, D'Onofrio G, Krumholz H, Dreyer R. Abstract 334: Impact of Sex, Gender and Healthcare System on the Quality of Care in Young Adults With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2020, 13 DOI: 10.1161/hcq.13.suppl_1.334.
Progress Report on EMBED: A Pragmatic Trial of User-Centered Clinical Decision Support to Implement EMergency Department-Initiated BuprenorphinE for Opioid Use Disorder †Melnick ER, Nath B, Ahmed OM, Brandt C, Chartash D, Dziura JD, Hess EP, Holland WC, Hoppe JA, Jeffery MM, Katsovich L, Li F, Lu CC, Maciejewski K, Maleska M, Mao JA, Martel S, Michael S, Paek H, Patel MD, Platts-Mills TF, Rajeevan H, Ray JM, Skains RM, Soares WE, Deutsch A, Solad Y, D’Onofrio G. Progress Report on EMBED: A Pragmatic Trial of User-Centered Clinical Decision Support to Implement EMergency Department-Initiated BuprenorphinE for Opioid Use Disorder †. Journal Of Psychiatry And Brain Science 2020, 2: e200003. PMID: 32309637, PMCID: PMC7164817, DOI: 10.20900/jpbs.20200003.
An integrated web application for decision support and automation of EHR workflow: a case study of current challenges to standards-based messaging and scalability from the EMBED trialMelnick ER, Holland WC, Ahmed OM, K A, Michael SS, Goldberg HS, Lagier C, D’Onofrio G, Stachowiak T, Brandt C, Solad Y. An integrated web application for decision support and automation of EHR workflow: a case study of current challenges to standards-based messaging and scalability from the EMBED trial. JAMIA Open 2019, 2: 434-439. PMID: 32025639, PMCID: PMC6994013, DOI: 10.1093/jamiaopen/ooz053.
260 Perceptions and Experiences of Emergency Department Patients With Opioid Use DisorderHawk K, McCormack R, Edelman E, Coupet E, Toledo N, Gauiter P, Rotrosen J, Chawarski M, 0069 and 0079 and Researchers C, Fiellin D, D'Onofrio G. 260 Perceptions and Experiences of Emergency Department Patients With Opioid Use Disorder. Annals Of Emergency Medicine 2019, 74: s102. DOI: 10.1016/j.annemergmed.2019.08.218.
159 Implementing Emergency Department-Initiated Buprenorphine in Low-Resource, High-Need SettingsMcCormack R, Hawk K, D'Onofrio G, Rotrosen J, Gauthier P, Edelman E, Fiellin D, Novo P, Marsch L, Knight R, Goodman W. 159 Implementing Emergency Department-Initiated Buprenorphine in Low-Resource, High-Need Settings. Annals Of Emergency Medicine 2019, 74: s62-s63. DOI: 10.1016/j.annemergmed.2019.08.165.
Correction to: Emergency department screening and interventions for substance use disordersHawk K, D’Onofrio G. Correction to: Emergency department screening and interventions for substance use disorders. Addiction Science & Clinical Practice 2019, 14: 26. PMID: 31311584, PMCID: PMC6636051, DOI: 10.1186/s13722-019-0155-3.
User-centred clinical decision support to implement emergency department-initiated buprenorphine for opioid use disorder: protocol for the pragmatic group randomised EMBED trialMelnick ER, Jeffery MM, Dziura JD, Mao JA, Hess EP, Platts-Mills TF, Solad Y, Paek H, Martel S, Patel MD, Bankowski L, Lu C, Brandt C, D’Onofrio G. User-centred clinical decision support to implement emergency department-initiated buprenorphine for opioid use disorder: protocol for the pragmatic group randomised EMBED trial. BMJ Open 2019, 9: e028488. PMID: 31152039, PMCID: PMC6550013, DOI: 10.1136/bmjopen-2018-028488.
Implementation facilitation to promote emergency department-initiated buprenorphine for opioid use disorder: protocol for a hybrid type III effectiveness-implementation study (Project ED HEALTH)D’Onofrio G, Edelman EJ, Hawk KF, Pantalon MV, Chawarski MC, Owens PH, Martel SH, VanVeldhuisen P, Oden N, Murphy SM, Huntley K, O’Connor P, Fiellin DA. Implementation facilitation to promote emergency department-initiated buprenorphine for opioid use disorder: protocol for a hybrid type III effectiveness-implementation study (Project ED HEALTH). Implementation Science 2019, 14: 48. PMID: 31064390, PMCID: PMC6505286, DOI: 10.1186/s13012-019-0891-5.
Association Between Insurance Status and Access to Hospital Care in Emergency Department DispositionVenkatesh AK, Chou SC, Li SX, Choi J, Ross JS, D’Onofrio G, Krumholz HM, Dharmarajan K. Association Between Insurance Status and Access to Hospital Care in Emergency Department Disposition. JAMA Internal Medicine 2019, 179: 686-693. PMID: 30933243, PMCID: PMC6503571, DOI: 10.1001/jamainternmed.2019.0037.
Computerized Clinical Decision Support System for Emergency Department–Initiated Buprenorphine for Opioid Use Disorder: User-Centered DesignRay JM, Ahmed OM, Solad Y, Maleska M, Martel S, Jeffery MM, Platts-Mills TF, Hess EP, D’Onofrio G, Melnick ER. Computerized Clinical Decision Support System for Emergency Department–Initiated Buprenorphine for Opioid Use Disorder: User-Centered Design. JMIR Human Factors 2019, 6: e13121. PMID: 30810531, PMCID: PMC6414819, DOI: 10.2196/13121.
A Quality Framework for Emergency Department Treatment of Opioid Use DisorderSamuels EA, D'Onofrio G, Huntley K, Levin S, Schuur JD, Bart G, Hawk K, Tai B, Campbell CI, Venkatesh AK. A Quality Framework for Emergency Department Treatment of Opioid Use Disorder. Annals Of Emergency Medicine 2018, 73: 237-247. PMID: 30318376, PMCID: PMC6817947, DOI: 10.1016/j.annemergmed.2018.08.439.
5EMF Developing an Emergency Department-Based Intervention to Prevent Opioid Overdose: Listening to Patient VoicesHawk K, Grau L, Fiellin D, Pantalon M, Chawarski M, O'Connor P, D'Onofrio G. 5EMF Developing an Emergency Department-Based Intervention to Prevent Opioid Overdose: Listening to Patient Voices. Annals Of Emergency Medicine 2018, 72: s155. DOI: 10.1016/j.annemergmed.2018.08.402.
Emergency department screening and interventions for substance use disordersHawk K, D’Onofrio G. Emergency department screening and interventions for substance use disorders. Addiction Science & Clinical Practice 2018, 13: 18. PMID: 30078375, PMCID: PMC6077851, DOI: 10.1186/s13722-018-0117-1.
Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO StudySafdar B, Spatz ES, Dreyer RP, Beltrame JF, Lichtman JH, Spertus JA, Reynolds HR, Geda M, Bueno H, Dziura JD, Krumholz HM, D'Onofrio G. Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study. Journal Of The American Heart Association 2018, 7: e009174. PMID: 29954744, PMCID: PMC6064896, DOI: 10.1161/jaha.118.009174.
Prevalence and characteristics of coronary microvascular dysfunction among chest pain patients in the emergency departmentSafdar B, D’Onofrio G, Dziura J, Russell RR, Johnson C, Sinusas AJ. Prevalence and characteristics of coronary microvascular dysfunction among chest pain patients in the emergency department. European Heart Journal Acute Cardiovascular Care 2018, 9: 5-13. PMID: 29543037, DOI: 10.1177/2048872618764418.
Sex Differences in the Presentation and Perception of Symptoms Among Young Patients With Myocardial InfarctionLichtman JH, Leifheit EC, Safdar B, Bao H, Krumholz HM, Lorenze NP, Daneshvar M, Spertus JA, D'Onofrio G. Sex Differences in the Presentation and Perception of Symptoms Among Young Patients With Myocardial Infarction. Circulation 2018, 137: 781-790. PMID: 29459463, PMCID: PMC5822747, DOI: 10.1161/circulationaha.117.031650.
Discerning suicide in drug intoxication deaths: Paucity and primacy of suicide notes and psychiatric historyRockett IRH, Caine ED, Connery HS, D’Onofrio G, Gunnell DJ, Miller TR, Nolte KB, Kaplan MS, Kapusta ND, Lilly CL, Nelson LS, Putnam SL, Stack S, Värnik P, Webster LR, Jia H. Discerning suicide in drug intoxication deaths: Paucity and primacy of suicide notes and psychiatric history. PLOS ONE 2018, 13: e0190200. PMID: 29320540, PMCID: PMC5761891, DOI: 10.1371/journal.pone.0190200.
Patient Ethnicity Predicts Poor Health Access and Gaps in Perception of Personal Cardiovascular Risk FactorsKim Y, Hogan K, D’Onofrio G, Chekijian S, Safdar B. Patient Ethnicity Predicts Poor Health Access and Gaps in Perception of Personal Cardiovascular Risk Factors. Critical Pathways In Cardiology A Journal Of Evidence-Based Medicine 2017, 16: 147-157. PMID: 29135623, DOI: 10.1097/hpc.0000000000000132.
Cost‐effectiveness of emergency department‐initiated treatment for opioid dependenceBusch SH, Fiellin DA, Chawarski MC, Owens PH, Pantalon MV, Hawk K, Bernstein SL, O'Connor PG, D'Onofrio G. Cost‐effectiveness of emergency department‐initiated treatment for opioid dependence. Addiction 2017, 112: 2002-2010. PMID: 28815789, PMCID: PMC5657503, DOI: 10.1111/add.13900.
Screening, treatment initiation, and referral for substance use disordersBernstein SL, D’Onofrio G. Screening, treatment initiation, and referral for substance use disorders. Addiction Science & Clinical Practice 2017, 12: 18. PMID: 28780906, PMCID: PMC5545867, DOI: 10.1186/s13722-017-0083-z.
Sexual Activity and Function in the Year After an Acute Myocardial Infarction Among Younger Women and Men in the United States and SpainLindau S, Abramsohn E, Bueno H, D’Onofrio G, Lichtman J, Lorenze N, Sanghani R, Spatz E, Spertus J, Strait K, Wroblewski K, Zhou S, Krumholz H. Sexual Activity and Function in the Year After an Acute Myocardial Infarction Among Younger Women and Men in the United States and Spain. Obstetrical & Gynecological Survey 2017, 72: 334-335. DOI: 10.1097/01.ogx.0000516136.75506.a3.
Abstract P092: Patient Ethnicity Predicts Poor Health Access and Gaps in Perception of Personal Cardiovascular Risk FactorsKim Y, D’Onofrio G, Safdar B. Abstract P092: Patient Ethnicity Predicts Poor Health Access and Gaps in Perception of Personal Cardiovascular Risk Factors. Circulation 2017, 135 DOI: 10.1161/circ.135.suppl_1.p092.
MECHANISMS OF ACUTE MYOCARDIAL INFARCTION IN YOUNG WOMEN AND DISCHARGE MEDICATION PATTERNSSciria C, Dreyer R, Safdar B, D'Onofrio G, Krumholz H, Spatz E. MECHANISMS OF ACUTE MYOCARDIAL INFARCTION IN YOUNG WOMEN AND DISCHARGE MEDICATION PATTERNS. Journal Of The American College Of Cardiology 2017, 69: 195. DOI: 10.1016/s0735-1097(17)33584-2.
Emergency Department-Initiated Buprenorphine for Opioid Dependence with Continuation in Primary Care: Outcomes During and After InterventionD’Onofrio G, Chawarski MC, O’Connor P, Pantalon MV, Busch SH, Owens PH, Hawk K, Bernstein SL, Fiellin DA. Emergency Department-Initiated Buprenorphine for Opioid Dependence with Continuation in Primary Care: Outcomes During and After Intervention. Journal Of General Internal Medicine 2017, 32: 660-666. PMID: 28194688, PMCID: PMC5442013, DOI: 10.1007/s11606-017-3993-2.
Multiple Fentanyl Overdoses — New Haven, Connecticut, June 23, 2016Tomassoni AJ, Hawk KF, Jubanyik K, Nogee DP, Durant T, Lynch KL, Patel R, Dinh D, Ulrich A, D’Onofrio G. Multiple Fentanyl Overdoses — New Haven, Connecticut, June 23, 2016. MMWR Morbidity And Mortality Weekly Report 2017, 66: 107-111. PMID: 28151928, PMCID: PMC5657834, DOI: 10.15585/mm6604a4.
Prescribing opioids safely in the emergency department study: Predictors of emergency department discharge with high morphine milligram equivalent prescriptionHawk K, Weiner S, Dziura J, Fiellin D, DaEun D, Nelson L, Hoppe J, Perrone J, D’Onofrio G. Prescribing opioids safely in the emergency department study: Predictors of emergency department discharge with high morphine milligram equivalent prescription. Drug And Alcohol Dependence 2017, 171: e86. DOI: 10.1016/j.drugalcdep.2016.08.242.
Ranolazine and Microvascular Angina by PET in the Emergency Department: Results From a Pilot Randomized Controlled TrialSafdar B, D’Onofrio G, Dziura J, Russell RR, Johnson C, Sinusas AJ. Ranolazine and Microvascular Angina by PET in the Emergency Department: Results From a Pilot Randomized Controlled Trial. Clinical Therapeutics 2017, 39: 55-63. PMID: 28081848, PMCID: PMC10345862, DOI: 10.1016/j.clinthera.2016.12.002.
Perceived Stress After Acute Myocardial InfarctionXu X, Bao H, Strait KM, Edmondson DE, Davidson KW, Beltrame JF, Bueno H, Lin H, Dreyer RP, Brush JE, Spertus JA, Lichtman JH, D'Onofrio G, Krumholz HM. Perceived Stress After Acute Myocardial Infarction. Psychosomatic Medicine 2017, 79: 50-58. PMID: 27984507, PMCID: PMC5459399, DOI: 10.1097/psy.0000000000000429.
Sexual Activity and Function in the Year After an Acute Myocardial Infarction Among Younger Women and Men in the United States and SpainLindau ST, Abramsohn E, Bueno H, D’Onofrio G, Lichtman JH, Lorenze NP, Sanghani RM, Spatz ES, Spertus JA, Strait KM, Wroblewski K, Zhou S, Krumholz HM. Sexual Activity and Function in the Year After an Acute Myocardial Infarction Among Younger Women and Men in the United States and Spain. JAMA Cardiology 2016, 1: 754-764. PMID: 27579897, PMCID: PMC5459405, DOI: 10.1001/jamacardio.2016.2362.
Editor’s Choice-Sex differences in young patients with acute myocardial infarction: A VIRGO study analysisBucholz EM, Strait KM, Dreyer RP, Lindau ST, D’Onofrio G, Geda M, Spatz ES, Beltrame JF, Lichtman JH, Lorenze NP, Bueno H, Krumholz HM. Editor’s Choice-Sex differences in young patients with acute myocardial infarction: A VIRGO study analysis. European Heart Journal Acute Cardiovascular Care 2016, 6: 610-622. PMID: 27485141, PMCID: PMC5459677, DOI: 10.1177/2048872616661847.
MICROVASCULAR ANGINA IN THE ABSENCE OF CORONARY ARTERY DISEASE IS COMMON IN UNDIFFERENTIATED CHEST PAIN PATIENTS IN THE EMERGENCY DEPARTMENTSafdar B, D’Onofrio G, Dziura J, Russell R, Naftilan M, Johnson C, Sinusas A. MICROVASCULAR ANGINA IN THE ABSENCE OF CORONARY ARTERY DISEASE IS COMMON IN UNDIFFERENTIATED CHEST PAIN PATIENTS IN THE EMERGENCY DEPARTMENT. Journal Of The American College Of Cardiology 2016, 67: 1824. DOI: 10.1016/s0735-1097(16)31825-3.
Microvascular Dysfunction as Opposed to Conduit Artery Disease Explains Sex-specific Chest Pain in Emergency Department Patients With Low to Moderate Cardiac RiskSafdar B, Ali A, D’Onofrio G, Katz SD. Microvascular Dysfunction as Opposed to Conduit Artery Disease Explains Sex-specific Chest Pain in Emergency Department Patients With Low to Moderate Cardiac Risk. Clinical Therapeutics 2016, 38: 240-255.e1. PMID: 26778090, DOI: 10.1016/j.clinthera.2015.12.010.
Abstract 12317: Sex Differences in Lipid Phenotypes Among Young Patients With Acute Myocardial InfarctionLu Y, Dreyer R, Herbert P, Caulfield M, Murugiah K, Geda M, Jackson E, Lichtman J, Lorenze N, D'Onofrio G, Spatz E, Spertus J, Krumholz H. Abstract 12317: Sex Differences in Lipid Phenotypes Among Young Patients With Acute Myocardial Infarction. Circulation 2015, 132 DOI: 10.1161/circ.132.suppl_3.12317.
Sex Differences in Cardiac Risk Factors, Perceived Risk, and Health Care Provider Discussion of Risk and Risk Modification Among Young Patients With Acute Myocardial Infarction The VIRGO StudyLeifheit-Limson EC, D’Onofrio G, Daneshvar M, Geda M, Bueno H, Spertus JA, Krumholz HM, Lichtman JH. Sex Differences in Cardiac Risk Factors, Perceived Risk, and Health Care Provider Discussion of Risk and Risk Modification Among Young Patients With Acute Myocardial Infarction The VIRGO Study. Journal Of The American College Of Cardiology 2015, 66: 1949-1957. PMID: 26515996, PMCID: PMC4628727, DOI: 10.1016/j.jacc.2015.08.859.
Health service use in a randomized clinical trial comparing three methods of emergency department interventions for opioid dependenceBusch S, Hawk K, Fiellin D, O’Connor P, Chawarski M, Owens P, Pantalon M, Bernstein S, D’Onofrio G. Health service use in a randomized clinical trial comparing three methods of emergency department interventions for opioid dependence. Drug And Alcohol Dependence 2015, 156: e32. DOI: 10.1016/j.drugalcdep.2015.07.1005.
A randomized clinical trial of emergency department initiated treatment for opioid dependence: Two and six month outcomesD’Onofrio G, O’Connor P, Pantalon M, Chawarski M, Busch S, Owens P, Bernstein S, Fiellin D. A randomized clinical trial of emergency department initiated treatment for opioid dependence: Two and six month outcomes. Drug And Alcohol Dependence 2015, 156: e53. DOI: 10.1016/j.drugalcdep.2015.07.1062.
Do chief complaints allow targeting of SBIRT in the Emergency Department?McCormack R, Gauthier P, McClure B, Moy L, Hu M, Pavlicova M, Nunes E, Thompson D, Mandler R, Bogenschutz M, D'Onofrio G, Rotrosen J. Do chief complaints allow targeting of SBIRT in the Emergency Department? Addiction Science & Clinical Practice 2015, 10: o42. PMCID: PMC4596949, DOI: 10.1186/1940-0640-10-s2-o42.
Opioid Dependence Treatment in the Emergency Department—ReplyFiellin DA, O’Connor P, D’Onofrio G. Opioid Dependence Treatment in the Emergency Department—Reply. JAMA 2015, 314: 835-835. PMID: 26305657, DOI: 10.1001/jama.2015.8527.
Abstract 308: Predictors of Depression Recognition and Site Variability in Depression Recognition in Young AMI SurvivorsSmolderen K, Spertus J, Gosch K, Dreyer R, D'Onofrio G, Lichtman J, Geda M, Beltrame J, Safdar B, Krumholz H. Abstract 308: Predictors of Depression Recognition and Site Variability in Depression Recognition in Young AMI Survivors. Circulation Cardiovascular Quality And Outcomes 2015, 8 DOI: 10.1161/circoutcomes.8.suppl_2.308.
Emergency Department–Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence: A Randomized Clinical TrialD’Onofrio G, O’Connor P, Pantalon MV, Chawarski MC, Busch SH, Owens PH, Bernstein SL, Fiellin DA. Emergency Department–Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence: A Randomized Clinical Trial. JAMA 2015, 313: 1636-1644. PMID: 25919527, PMCID: PMC4527523, DOI: 10.1001/jama.2015.3474.
Successful Tobacco Dependence Treatment in Low-Income Emergency Department Patients: A Randomized TrialBernstein SL, D’Onofrio G, Rosner J, O’Malley S, Makuch R, Busch S, Pantalon MV, Toll B. Successful Tobacco Dependence Treatment in Low-Income Emergency Department Patients: A Randomized Trial. Annals Of Emergency Medicine 2015, 66: 140-147. PMID: 25920384, PMCID: PMC4819432, DOI: 10.1016/j.annemergmed.2015.03.030.
Sex Differences in Reperfusion in Young Patients With ST-Segment–Elevation Myocardial InfarctionD'Onofrio G, Safdar B, Lichtman JH, Strait KM, Dreyer RP, Geda M, Spertus JA, Krumholz HM. Sex Differences in Reperfusion in Young Patients With ST-Segment–Elevation Myocardial Infarction. Circulation 2015, 131: 1324-1332. PMID: 25792558, PMCID: PMC4652789, DOI: 10.1161/circulationaha.114.012293.
SEX DIFFERENCES IN 12-MONTH HEALTH STATUS IN YOUNG PATIENTS FOLLOWING ACUTE MYOCARDIAL INFARCTION: RESULTS FROM THE VIRGO STUDY (VARIATION IN RECOVERY: ROLE OF GENDER ON OUTCOMES OF YOUNG ACUTE MYOCARDIAL INFARCTION PATIENTS)Dreyer R, Wang Y, Strait K, Lorenze N, D’Onofrio G, Bueno H, Lichtman J, Spertus J, Krumholz H. SEX DIFFERENCES IN 12-MONTH HEALTH STATUS IN YOUNG PATIENTS FOLLOWING ACUTE MYOCARDIAL INFARCTION: RESULTS FROM THE VIRGO STUDY (VARIATION IN RECOVERY: ROLE OF GENDER ON OUTCOMES OF YOUNG ACUTE MYOCARDIAL INFARCTION PATIENTS). Journal Of The American College Of Cardiology 2015, 65: a6. DOI: 10.1016/s0735-1097(15)60006-7.
Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysisDreyer RP, Smolderen KG, Strait KM, Beltrame JF, Lichtman JH, Lorenze NP, D’Onofrio G, Bueno H, Krumholz HM, Spertus JA. Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis. European Heart Journal Acute Cardiovascular Care 2015, 5: 43-54. PMID: 25681487, PMCID: PMC4658311, DOI: 10.1177/2048872615568967.
Addiction Medicine: The Birth of a New DisciplineO’Connor P, Sokol RJ, D’Onofrio G. Addiction Medicine: The Birth of a New Discipline. JAMA Internal Medicine 2014, 174: 1717-1718. PMID: 25201642, DOI: 10.1001/jamainternmed.2014.4211.
228 The Repeal of Connecticut Sunday Alcohol Sale Restrictions did not Increase Emergency Department VisitationLord K, D'Onofrio G, Venkatesh A. 228 The Repeal of Connecticut Sunday Alcohol Sale Restrictions did not Increase Emergency Department Visitation. Annals Of Emergency Medicine 2014, 64: s82. DOI: 10.1016/j.annemergmed.2014.07.255.
Abstract 207: Gender Differences in Pre-Event Health Status of Young Patients with Acute Myocardial Infarction: Insights from the VIRGO StudyDreyer R, Smolderen K, Strait K, Beltrame J, Lichtman J, Lorenze N, D'Onofrio G, Bueno H, Krumholz H, Spertus J. Abstract 207: Gender Differences in Pre-Event Health Status of Young Patients with Acute Myocardial Infarction: Insights from the VIRGO Study. Circulation Cardiovascular Quality And Outcomes 2014, 7 DOI: 10.1161/circoutcomes.7.suppl_1.207.
Abstract 110: Long-Term Health Status Outcomes in Young Women with Acute Myocardial Infarction: Results from the VIRGO StudyDreyer R, Strait K, Lichtman J, Lorenze N, D'Onofrio G, Bueno H, Spertus J, Krumholz H. Abstract 110: Long-Term Health Status Outcomes in Young Women with Acute Myocardial Infarction: Results from the VIRGO Study. Circulation Cardiovascular Quality And Outcomes 2014, 7 DOI: 10.1161/circoutcomes.7.suppl_1.110.
Abstract 104: The Effect of Low Perceived Social Support on Health Outcomes in Young Patients with Acute Myocardial Infarction: Results from the VIRGO StudyBucholz E, Strait K, Dreyer R, Geda M, Lichtman J, D'Onofrio G, Spertus J, Krumholz H. Abstract 104: The Effect of Low Perceived Social Support on Health Outcomes in Young Patients with Acute Myocardial Infarction: Results from the VIRGO Study. Circulation Cardiovascular Quality And Outcomes 2014, 7 DOI: 10.1161/circoutcomes.7.suppl_1.104.
Abstract 106: Association between Insurance Status and Presentation Delay in Young Patients with Acute Myocardial Infarction: Insights from the VIRGO StudyChen S, Wang Y, Dreyer R, Strait K, Spatz E, Xu X, Smolderen K, Desai N, Lorenze N, Lichtman J, Spertus J, D'Onofrio G, Krumholz H. Abstract 106: Association between Insurance Status and Presentation Delay in Young Patients with Acute Myocardial Infarction: Insights from the VIRGO Study. Circulation Cardiovascular Quality And Outcomes 2014, 7 DOI: 10.1161/circoutcomes.7.suppl_1.106.
Abstract 139: A Novel Taxonomy for Acute Myocardial Infarction in Young WomenSpatz E, Curry L, Gross C, Masoudi F, Dryer R, Bueno H, Lampropulos J, Chaudhry S, Zhou S, D'Onofrio G, Spertus J, Safdar B, Lansky A, Krumholz H. Abstract 139: A Novel Taxonomy for Acute Myocardial Infarction in Young Women. Circulation Cardiovascular Quality And Outcomes 2014, 7 DOI: 10.1161/circoutcomes.7.suppl_1.139.
Abstract 138: Characterizing Depressed Symptoms in Younger Women and Men Who Experienced an Acute Myocardial Infarction: Insights from the VIRGO StudySmolderen K, Strait K, Rachel D, D’Onofrio G, Zhou S, Lichtman J, Safdar B, Krumholz H, Spertus J. Abstract 138: Characterizing Depressed Symptoms in Younger Women and Men Who Experienced an Acute Myocardial Infarction: Insights from the VIRGO Study. Circulation Cardiovascular Quality And Outcomes 2014, 7 DOI: 10.1161/circoutcomes.7.suppl_1.138.
Elevated CK-MB with a Normal Troponin Does Not Predict 30-Day Adverse Cardiac Events in Emergency Department Chest Pain Observation Unit PatientsSafdar B, Bezek SK, Sinusas AJ, Russell RR, Klein MR, Dziura JD, D’onofrio G. Elevated CK-MB with a Normal Troponin Does Not Predict 30-Day Adverse Cardiac Events in Emergency Department Chest Pain Observation Unit Patients. Critical Pathways In Cardiology A Journal Of Evidence-Based Medicine 2014, 13: 14-19. PMID: 24526146, DOI: 10.1097/hpc.0000000000000001.
A Promising Approach For Emergency Departments To Care For Patients With Substance Use And Behavioral DisordersBernstein SL, D’Onofrio G. A Promising Approach For Emergency Departments To Care For Patients With Substance Use And Behavioral Disorders. Health Affairs 2013, 32: 2122-2128. PMID: 24301395, DOI: 10.1377/hlthaff.2013.0664.
Abstract 96: Sex Differences in Pre-Event Health Status of Young Patients with Acute Myocardial Infarction: The VIRGO StudyDreyer R, Smolderen K, Strait K, Beltrame J, Lichtman J, Lorenze N, D’Onofrio G, Krumholz H, Spertus J. Abstract 96: Sex Differences in Pre-Event Health Status of Young Patients with Acute Myocardial Infarction: The VIRGO Study. Circulation Cardiovascular Quality And Outcomes 2013, 6 DOI: 10.1161/circoutcomes.6.suppl_1.a96.
SEX-SPECIFIC TRENDS IN HOSPITALIZATIONS AMONG YOUNG PATIENTS WITH ACUTE MYOCARDIAL INFARCTION IN UNITED STATES, 2001-2010Gupta A, Wang Y, Spertus J, Geda M, Lorenze N, D'Onofrio G, Lichtman J, Krumholz H. SEX-SPECIFIC TRENDS IN HOSPITALIZATIONS AMONG YOUNG PATIENTS WITH ACUTE MYOCARDIAL INFARCTION IN UNITED STATES, 2001-2010. Journal Of The American College Of Cardiology 2013, 61: e1483. DOI: 10.1016/s0735-1097(13)61483-7.
Use of Hospital-Based Acute Care Among Patients Recently Discharged From the HospitalVashi AA, Fox JP, Carr BG, D’Onofrio G, Pines JM, Ross JS, Gross CP. Use of Hospital-Based Acute Care Among Patients Recently Discharged From the Hospital. JAMA 2013, 309: 364-371. PMID: 23340638, PMCID: PMC3598620, DOI: 10.1001/jama.2012.216219.
Project ART-ED: alcohol reduction and HIV testing in the emergency departmentEdelman E, Dinh A, Radu-Radulescu L, Lurie B, Tetrault J, D'Onofrio G, Fiellin D, Fiellin L. Project ART-ED: alcohol reduction and HIV testing in the emergency department. Addiction Science & Clinical Practice 2012, 7: a35. PMCID: PMC3480109, DOI: 10.1186/1940-0640-7-s1-a35.
Screening, brief intervention, and referral to treatment for alcohol and other drug use among adolescents: evaluation of a pediatric residency curriculumRyan S, Martel S, Pantalon M, Martino S, Tetrault J, Thung S, Bernstein S, Auinger P, D’Onofrio G. Screening, brief intervention, and referral to treatment for alcohol and other drug use among adolescents: evaluation of a pediatric residency curriculum. Addiction Science & Clinical Practice 2012, 7: a98. PMCID: PMC3480164, DOI: 10.1186/1940-0640-7-s1-a98.
Combining Rapid HIV Testing and a Brief Alcohol Intervention in Young Unhealthy Drinkers in the Emergency Department: A Pilot StudyEdelman EJ, Dinh A, Radulescu R, Lurie B, D'Onofrio G, Tetrault JM, Fiellin DA, Fiellin LE. Combining Rapid HIV Testing and a Brief Alcohol Intervention in Young Unhealthy Drinkers in the Emergency Department: A Pilot Study. The American Journal Of Drug And Alcohol Abuse 2012, 38: 539-543. PMID: 22794939, PMCID: PMC3522092, DOI: 10.3109/00952990.2012.701359.
Screening, Brief Intervention, and Referral to Treatment (SBIRT) for Alcohol and Other Drug Use among Adolescents: Evaluation of a Pediatric Residency CurriculumRyan SA, Martel S, Pantalon M, Martino S, Tetrault J, Thung SF, Bernstein SL, Auinger P, Green ML, Fiellin DA, O'Connor P, D'Onofrio G. Screening, Brief Intervention, and Referral to Treatment (SBIRT) for Alcohol and Other Drug Use among Adolescents: Evaluation of a Pediatric Residency Curriculum. Substance Abuse 2012, 33: 251-260. PMID: 22738002, DOI: 10.1080/08897077.2011.640182.
Developing and Implementing a Multispecialty Graduate Medical Education Curriculum on Screening, Brief Intervention, and Referral to Treatment (SBIRT)Tetrault JM, Green ML, Martino S, Thung SF, Degutis LC, Ryan SA, Martel S, Pantalon MV, Bernstein SL, O'Connor P, Fiellin DA, D'Onofrio G. Developing and Implementing a Multispecialty Graduate Medical Education Curriculum on Screening, Brief Intervention, and Referral to Treatment (SBIRT). Substance Abuse 2012, 33: 168-181. PMID: 22489589, DOI: 10.1080/08897077.2011.640220.
A Brief Intervention Reduces Hazardous and Harmful Drinking in Emergency Department PatientsD'Onofrio G, Fiellin DA, Pantalon MV, Chawarski MC, Owens PH, Degutis LC, Busch SH, Bernstein SL, O'Connor PG. A Brief Intervention Reduces Hazardous and Harmful Drinking in Emergency Department Patients. Annals Of Emergency Medicine 2012, 60: 181-192. PMID: 22459448, PMCID: PMC3811141, DOI: 10.1016/j.annemergmed.2012.02.006.
NIH Roundtable on Opportunities to Advance Research on Neurologic and Psychiatric EmergenciesD'Onofrio G, Jauch E, Jagoda A, Allen MH, Anglin D, Barsan WG, Berger RP, Bobrow BJ, Boudreaux ED, Bushnell C, Chan YF, Currier G, Eggly S, Ichord R, Larkin GL, Laskowitz D, Neumar RW, Newman-Toker DE, Quinn J, Shear K, Todd KH, Zatzick D, Participants R. NIH Roundtable on Opportunities to Advance Research on Neurologic and Psychiatric Emergencies. Annals Of Emergency Medicine 2010, 56: 551-564. PMID: 21036295, DOI: 10.1016/j.annemergmed.2010.06.562.
Health risk behaviors and injured patients: an exploratory studyDegutis C, Busch S, Pantalon M, Fiellin D, O'Connor P, D'Onofrio G. Health risk behaviors and injured patients: an exploratory study. Injury Prevention 2010, 16: a133. DOI: 10.1136/ip.2010.029215.477.
Simulation Training in Central Venous Catheter Insertion: Improved Performance in Clinical PracticeEvans LV, Dodge KL, Shah TD, Kaplan LJ, Siegel MD, Moore CL, Hamann CJ, Lin Z, D'Onofrio G. Simulation Training in Central Venous Catheter Insertion: Improved Performance in Clinical Practice. Academic Medicine 2010, 85: 1462-1469. PMID: 20736674, DOI: 10.1097/acm.0b013e3181eac9a3.
S100b Immunoassay: An Assessment of Diagnostic Utility in Minor Head TraumaKotlyar S, Larkin GL, Moore CL, D’Onofrio G. S100b Immunoassay: An Assessment of Diagnostic Utility in Minor Head Trauma. Journal Of Emergency Medicine 2010, 41: 285-293. PMID: 20692788, DOI: 10.1016/j.jemermed.2010.05.040.
Integrating Project ASSERT: A Screening, Intervention, and Referral to Treatment Program for Unhealthy Alcohol and Drug Use Into an Urban Emergency DepartmentD’Onofrio G, Degutis LC. Integrating Project ASSERT: A Screening, Intervention, and Referral to Treatment Program for Unhealthy Alcohol and Drug Use Into an Urban Emergency Department. Academic Emergency Medicine 2010, 17: 903-911. PMID: 20670330, DOI: 10.1111/j.1553-2712.2010.00824.x.
Emergency Medicine Public Health Research Funded by Federal Agencies: Progress and PrioritiesD’Onofrio G, Goldstein AB, Denisco RA, Hingson R, Heffelfinger JD, Post LA. Emergency Medicine Public Health Research Funded by Federal Agencies: Progress and Priorities. Academic Emergency Medicine 2009, 16: 1065-1071. PMID: 20053224, DOI: 10.1111/j.1553-2712.2009.00555.x.
Alcohol, Tobacco, and Other Drugs: Future Directions for Screening and Intervention in the Emergency DepartmentCunningham RM, Bernstein SL, Walton M, Broderick K, Vaca FE, Woolard R, Bernstein E, Blow F, D’Onofrio G. Alcohol, Tobacco, and Other Drugs: Future Directions for Screening and Intervention in the Emergency Department. Academic Emergency Medicine 2009, 16: 1078-1088. PMID: 20053226, DOI: 10.1111/j.1553-2712.2009.00552.x.
Study Designs and Evaluation Models for Emergency Department Public Health ResearchBroderick KB, Ranney ML, Vaca FE, D’Onofrio G, Rothman RE, Rhodes KV, Becker B, Haukoos JS. Study Designs and Evaluation Models for Emergency Department Public Health Research. Academic Emergency Medicine 2009, 16: 1124-1131. PMID: 20053232, PMCID: PMC3082772, DOI: 10.1111/j.1553-2712.2009.00557.x.
Alcohol and Other DrugsKirrane B, Degutis L, D'onofrio G. Alcohol and Other Drugs. 2008, 624-634. DOI: 10.1002/9781444303674.ch62.
242: Sex Differences in Patient- and Emergency Physician-Perceived Risk of Heart Disease in an Emergency Department Chest Pain CenterSafdar B, Hogan K, Chekijian S, D'Onofrio G. 242: Sex Differences in Patient- and Emergency Physician-Perceived Risk of Heart Disease in an Emergency Department Chest Pain Center. Annals Of Emergency Medicine 2008, 52: s116. DOI: 10.1016/j.annemergmed.2008.06.260.
227: Care Coordination in the Emergency Department: Avoiding Inappropriate Hospital AdmissionsKulkarni R, Pell F, Agocs-Holler E, D’Onofrio G. 227: Care Coordination in the Emergency Department: Avoiding Inappropriate Hospital Admissions. Annals Of Emergency Medicine 2007, 50: s71-s72. DOI: 10.1016/j.annemergmed.2007.06.210.
286: Use of Lean Techniques to Simplify Admission Procedures and Decrease ED Process TimeSchuur J, Collins D, Smith A, Lisitano R, Kulkarni R, D’Onofrio G. 286: Use of Lean Techniques to Simplify Admission Procedures and Decrease ED Process Time. Annals Of Emergency Medicine 2007, 50: s90. DOI: 10.1016/j.annemergmed.2007.06.272.
Public health considerations in knowledge translation in the emergency department.Bernstein S, Bernstein E, Boudreaux E, Babcock-Irvin C, Mello M, Kapur A, Becker B, Sattin R, Cohen V, D'Onofrio G. Public health considerations in knowledge translation in the emergency department. Academic Emergency Medicine 2007, 14: 1036-41. PMID: 17699805, DOI: 10.1197/j.aem.2007.06.012.
Depression is a Common Coronary Risk Factor in Women Admitted to an ED Chest Pain CenterSafdar B, Foody J, D'Onofrio G. Depression is a Common Coronary Risk Factor in Women Admitted to an ED Chest Pain Center. Academic Emergency Medicine 2007, 14: s131-s131. DOI: 10.1197/j.aem.2007.03.1069.
375 A Multi-Faceted Community-Based Educational Program Promotes Cardiovascular Health in Women: 5 Year AnalysisSafdar B, Parkosewich J, Freed L, Foody J, Tandon S, Jubanyik K, Lin Z, D’Onofrio G. 375 A Multi-Faceted Community-Based Educational Program Promotes Cardiovascular Health in Women: 5 Year Analysis. Annals Of Emergency Medicine 2006, 48: 112-113. DOI: 10.1016/j.annemergmed.2006.07.841.
Alcohol-related seizuresRathlev NK, Ulrich AS, Delanty N, D’Onofrio G. Alcohol-related seizures. Journal Of Emergency Medicine 2006, 31: 157-163. PMID: 17044577, DOI: 10.1016/j.jemermed.2005.09.012.
Intravenous Morphine Plus Ketorolac Is Superior to Either Drug Alone for Treatment of Acute Renal ColicSafdar B, Degutis LC, Landry K, Vedere SR, Moscovitz HC, D’Onofrio G. Intravenous Morphine Plus Ketorolac Is Superior to Either Drug Alone for Treatment of Acute Renal Colic. Annals Of Emergency Medicine 2006, 48: 173-181.e1. PMID: 16953530, DOI: 10.1016/j.annemergmed.2006.03.013.
Alcohol-related problems: Emergency physicians’ current practice and attitudesO’Rourke M, Richardson LD, Wilets I, D’Onofrio G. Alcohol-related problems: Emergency physicians’ current practice and attitudes. Journal Of Emergency Medicine 2006, 30: 263-268. PMID: 16677975, DOI: 10.1016/j.jemermed.2005.05.031.
Development and Implementation of an Emergency Practitioner–Performed Brief Intervention for Hazardous and Harmful Drinkers in the Emergency DepartmentD'Onofrio G, Pantalon M, Degutis L, Fiellin D, O'Connor P. Development and Implementation of an Emergency Practitioner–Performed Brief Intervention for Hazardous and Harmful Drinkers in the Emergency Department. Academic Emergency Medicine 2005, 12: 249-256. DOI: 10.1111/j.1553-2712.2005.tb00879.x.
Teaching brief intervention for alcohol problems to emergency practitioners: Development, implementation, and testing of a modelD'Onofrio G, Pantalon M, Degutis L, Fiellin D. Teaching brief intervention for alcohol problems to emergency practitioners: Development, implementation, and testing of a model. Annals Of Emergency Medicine 2004, 44: s78. DOI: 10.1016/j.annemergmed.2004.07.256.
The saliva strip test is an accurate method to determine blood alcohol concentration in trauma patients.Degutis L, Rabinovici R, Sabbaj A, Mascia R, D'Onofrio G. The saliva strip test is an accurate method to determine blood alcohol concentration in trauma patients. Academic Emergency Medicine 2004, 11: 885-7. PMID: 15289199, DOI: 10.1111/j.1553-2712.2004.tb00775.x.
Compliance with the Centers for Disease Control and Prevention Recommendations for the Diagnosis and Treatment of Sexually Transmitted DiseasesKane B, Degutis L, Sayward H, D'Onofrio G. Compliance with the Centers for Disease Control and Prevention Recommendations for the Diagnosis and Treatment of Sexually Transmitted Diseases. Academic Emergency Medicine 2004, 11: 371-377. DOI: 10.1111/j.1553-2712.2004.tb01455.x.
Etiology and weekly occurrence of alcohol-related seizures.Rathlev N, Ulrich A, Shieh T, Callum M, Bernstein E, D'Onofrio G. Etiology and weekly occurrence of alcohol-related seizures. Academic Emergency Medicine 2002, 9: 824-8. PMID: 12153888, DOI: 10.1111/j.1553-2712.2002.tb02171.x.
Preventive care in the emergency department: screening and brief intervention for alcohol problems in the emergency department: a systematic review.D'Onofrio G, Degutis L. Preventive care in the emergency department: screening and brief intervention for alcohol problems in the emergency department: a systematic review. Academic Emergency Medicine 2002, 9: 627-38. PMID: 12045080, DOI: 10.1111/j.1553-2712.2002.tb02304.x.
Alcohol and SeizuresD'Onofrio G, Ulrich A, Rathlev N. Alcohol and Seizures. 2001, 0: 167-182. DOI: 10.1385/1-59259-094-2:167.
Women in Academic Emergency MedicineCydulka R, D'Onofrio G, Schneider S, Emerman C, Sullivan L, Force T. Women in Academic Emergency Medicine. Academic Emergency Medicine 2000, 7: 999-1007. PMID: 11043995, DOI: 10.1111/j.1553-2712.2000.tb02091.x.
Clinical Characteristics as Predictors of Recurrent Alcohol‐related SeizuresRathlev N, Ulrich A, Fish S, D'Onofrio G. Clinical Characteristics as Predictors of Recurrent Alcohol‐related Seizures. Academic Emergency Medicine 2000, 7: 886-891. PMID: 10958128, DOI: 10.1111/j.1553-2712.2000.tb02066.x.
Screening and Brief Intervention for Alcohol and Other Drug Problems: What Will It Take?D'Onofrio G. Screening and Brief Intervention for Alcohol and Other Drug Problems: What Will It Take? Academic Emergency Medicine 2000, 7: 69-71. PMID: 10894246, DOI: 10.1111/j.1553-2712.2000.tb01896.x.
Lorazepam for the Prevention of Recurrent Seizures Related to AlcoholD'Onofrio G, Rathlev N, Ulrich A, Fish S, Freedland E. Lorazepam for the Prevention of Recurrent Seizures Related to Alcohol. New England Journal Of Medicine 1999, 340: 915-919. PMID: 10094637, DOI: 10.1056/nejm199903253401203.
Patients with Alcohol Problems in the Emergency Department, Part 2: Intervention and ReferralD'Onofrio G, Bernstein E, Bernstein J, Woolard R, Brewer P, Craig S, Zink B, Force F. Patients with Alcohol Problems in the Emergency Department, Part 2: Intervention and Referral. Academic Emergency Medicine 1998, 5: 1210-1217. PMID: 9864135, DOI: 10.1111/j.1553-2712.1998.tb02697.x.
Patients with Alcohol Problems in the Emergency Department, Part 1: Improving Detection*D'Onofrio G, Bernstein E, Bernstein J, Woolard R, Brewer P, Craig S, Zink B, Force F. Patients with Alcohol Problems in the Emergency Department, Part 1: Improving Detection*. Academic Emergency Medicine 1998, 5: 1200-1209. PMID: 9864134, DOI: 10.1111/j.1553-2712.1998.tb02696.x.
Emergency Medicine in Undergraduate EducationBurdick W, Jouriles N, D'Onofrio G, Kass L, Mahoney J, Restifo K, Committee U. Emergency Medicine in Undergraduate Education. Academic Emergency Medicine 1998, 5: 1105-1110. PMID: 9835475, DOI: 10.1111/j.1553-2712.1998.tb02671.x.
The lack of efficacy of phenytoin in the prevention of recurrent alcohol-related seizuresRathlev N, D'Onofrio G, Fish S, Harrison P, Bernstein E, Hossack R, Pickens L. The lack of efficacy of phenytoin in the prevention of recurrent alcohol-related seizures. Annals Of Emergency Medicine 1994, 23: 513-518. PMID: 8135426, DOI: 10.1016/s0196-0644(94)70070-2.
Alcohol and TraumaFreedland E, McMicken D, D'Onofrio G. Alcohol and Trauma. Emergency Medicine Clinics Of North America 1993, 11: 225-239. PMID: 8432251, DOI: 10.1016/s0733-8627(20)30668-4.
Sample size & selection criteriaRathlev N, D'onofrio G, Fish S. Sample size & selection criteria. Annals Of Emergency Medicine 1992, 21: 344-345. PMID: 1536500, DOI: 10.1016/s0196-0644(05)80920-5.
Managing the patient with abdominal aortic aneurysm.Long GD. Managing the patient with abdominal aortic aneurysm. Nursing 1978, 8: 20-7. PMID: 248638.

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Gail D'Onofrio, MD, MS

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